HUE048646T2 - Ráksejtek motilitásának csökkentése tumorkezelõ mezõket (TTFields) alkalmazva - Google Patents
Ráksejtek motilitásának csökkentése tumorkezelõ mezõket (TTFields) alkalmazvaInfo
- Publication number
- HUE048646T2 HUE048646T2 HUE17716642A HUE17716642A HUE048646T2 HU E048646 T2 HUE048646 T2 HU E048646T2 HU E17716642 A HUE17716642 A HU E17716642A HU E17716642 A HUE17716642 A HU E17716642A HU E048646 T2 HUE048646 T2 HU E048646T2
- Authority
- HU
- Hungary
- Prior art keywords
- ttfields
- cancer cells
- tumor treating
- treating fields
- reducing motility
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 2
- 201000011510 cancer Diseases 0.000 title 1
- 230000004899 motility Effects 0.000 title 1
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- General Physics & Mathematics (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317985P | 2016-04-04 | 2016-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE048646T2 true HUE048646T2 (hu) | 2020-08-28 |
Family
ID=58530601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17716642A HUE048646T2 (hu) | 2016-04-04 | 2017-04-04 | Ráksejtek motilitásának csökkentése tumorkezelõ mezõket (TTFields) alkalmazva |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10821283B2 (enExample) |
| EP (3) | EP3693054B1 (enExample) |
| JP (2) | JP6896839B2 (enExample) |
| KR (1) | KR102430229B1 (enExample) |
| CN (2) | CN109475735B (enExample) |
| CA (1) | CA3019474A1 (enExample) |
| DK (1) | DK3439733T3 (enExample) |
| ES (1) | ES2779990T3 (enExample) |
| HU (1) | HUE048646T2 (enExample) |
| PL (1) | PL3439733T3 (enExample) |
| PT (1) | PT3439733T (enExample) |
| WO (1) | WO2017175116A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10779875B2 (en) | 2013-05-06 | 2020-09-22 | Novocure Gmbh | Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| US10821283B2 (en) * | 2016-04-04 | 2020-11-03 | Novocure Gmbh | Reducing motility of cancer cells using tumor treating fields (TTFields) |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| EP4209190A1 (en) | 2016-06-27 | 2023-07-12 | Galvanize Therapeutics, Inc. | System comprising a generator and a catheter with an electrode for treating a lung passageway |
| US10441776B2 (en) | 2016-06-30 | 2019-10-15 | Novocure Gmbh | Arrays for longitudinal delivery of TTFields to a body |
| US11573221B2 (en) | 2017-01-19 | 2023-02-07 | Novocure Gmbh | System for viewing cell cultures under a microscope whilst applying TTFields |
| US11338135B2 (en) | 2017-10-23 | 2022-05-24 | Cardiac Pacemakers, Inc. | Medical devices for cancer therapy with electric field shaping elements |
| US20190117969A1 (en) * | 2017-10-23 | 2019-04-25 | Cardiac Pacemakers, Inc. | Medical devices for treatment of cancer with electric fields |
| US12403306B2 (en) * | 2017-10-23 | 2025-09-02 | Cardiac Pacemakers, Inc. | Electric field shaping leads for treatment of cancer |
| JP2021503360A (ja) * | 2017-11-17 | 2021-02-12 | アッヴィ・インコーポレイテッド | 膠芽腫の処置方法 |
| JP2021508533A (ja) | 2017-12-26 | 2021-03-11 | ギャラリー，インコーポレイテッド | 様々な用途のためのエネルギー送達の最適化 |
| US10953209B2 (en) | 2018-03-28 | 2021-03-23 | Board Of Regents Of The University Of Texas System | Treating tumors using TTFields combined with a PARP inhibitor |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| CN112424626B (zh) | 2018-04-10 | 2025-07-08 | 诺沃库勒有限责任公司 | 优化多个电极位置并创建3d模型的方法 |
| CN116236688A (zh) * | 2018-07-03 | 2023-06-09 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| MX2020013427A (es) * | 2018-07-10 | 2021-05-27 | Novocure Gmbh | Inhibicion de infecciones virales usando campos electricos alternos. |
| EP3823715A1 (en) | 2018-07-18 | 2021-05-26 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) |
| CA3242209A1 (en) * | 2018-08-23 | 2020-02-27 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| US11623085B2 (en) | 2018-08-29 | 2023-04-11 | Regents Of The University Of Minnesota | Devices and methods for treatment of tumors using electromagnetic signal |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11986647B2 (en) | 2018-09-07 | 2024-05-21 | Novocure Gmbh | Treating autoinflammatory and mitochondrial diseases using an alternating electric field |
| US11020585B2 (en) | 2018-09-07 | 2021-06-01 | Novocure Gmbh | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| HUE061361T2 (hu) | 2018-10-15 | 2023-06-28 | Novocure Gmbh | Az egész agyban nagy egyenletességû tumorkezelõ mezõk (TT-mezõk) generálása |
| EP3870271A1 (en) | 2018-10-25 | 2021-09-01 | Zeev Bomzon | Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy |
| US12186575B2 (en) | 2018-11-13 | 2025-01-07 | The Methodist Hospital | Method and apparatus for oncomagnetic treatment |
| CN113015553B (zh) * | 2018-11-19 | 2025-01-14 | 诺沃库勒有限责任公司 | 用于递送具有选择性可寻址子元件的肿瘤治疗场（TTField）的阵列 |
| MX2021002625A (es) | 2018-11-29 | 2021-05-12 | Novocure Gmbh | Arreglos de transductores de mayor flexibilidad para suministrar campos tt (campos de tratamiento de tumores). |
| JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
| CA3127276A1 (en) | 2019-02-26 | 2020-09-03 | Novocure Gmbh | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| US11471676B2 (en) | 2019-02-27 | 2022-10-18 | Novocure Gmbh | Delivering tumor treating fields (TTFields) using implantable transducer arrays |
| US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
| CN111803792A (zh) * | 2019-04-12 | 2020-10-23 | 上海必修福企业管理有限公司 | 空间电场的发生装置 |
| ES2940749T3 (es) | 2019-04-17 | 2023-05-11 | Novocure Gmbh | Carga de datos desde un sistema aislado sin comprometer el aislamiento |
| EP3958954B1 (en) | 2019-04-22 | 2024-04-24 | Boston Scientific Scimed Inc. | Electrical stimulation devices for cancer treatment |
| CN113766949B (zh) * | 2019-04-22 | 2025-04-08 | 波士顿科学国际有限公司 | 用于施用电刺激以治疗癌症的系统 |
| US12109412B2 (en) | 2019-04-22 | 2024-10-08 | Boston Scientific Scimed, Inc. | Combination electrical and chemotherapeutic treatment of cancer |
| JP7476231B2 (ja) * | 2019-04-23 | 2024-04-30 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 温熱療法又は熱モニタと共に行われる電気刺激 |
| WO2020219517A2 (en) | 2019-04-23 | 2020-10-29 | Boston Scientific Scimed, Inc. | Electrical stimulation for cancer treatment with internal and external electrodes |
| CN113747936B (zh) | 2019-04-23 | 2024-06-18 | 波士顿科学国际有限公司 | 用于电刺激来治疗癌症的电极 |
| JP7586890B2 (ja) | 2019-07-16 | 2024-11-19 | ガルヴァナイズ セラピューティクス，インコーポレイテッド | パルス電界による生殖器の治療 |
| US11654279B2 (en) | 2019-07-31 | 2023-05-23 | Novocure Gmbh | Applying tumor treating fields (TTFields) via electrodes embedded into skull implants |
| WO2021024170A1 (en) | 2019-08-05 | 2021-02-11 | Voloshin Sela Tali | Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity |
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| US20210199640A1 (en) * | 2019-12-26 | 2021-07-01 | The Board of Trustees of the Leland Stanford Junior Unviersity | Methods of Normalizing Aberrant Glycolytic Metabolism in Cancer Cells |
| WO2021137094A1 (en) | 2019-12-31 | 2021-07-08 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with individually accessible electrode elements and temperature sensors |
| US20230147250A1 (en) * | 2019-12-31 | 2023-05-11 | Novocure Gmbh | Methods, systems, and apparatuses for combined tumor treating fields and mental health therapy |
| US12121739B2 (en) | 2019-12-31 | 2024-10-22 | Novocure Gmbh | Methods, systems, and apparatuses for managing temperatures induced by alternating fields |
| MX2022006135A (es) | 2019-12-31 | 2022-06-17 | Novocure Gmbh | Generador de ondas sinusoidales de alta eficiencia, alto voltaje, que evita los picos durante los ajustes de amplitud y la conmutacion de canales. |
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| KR102644003B1 (ko) | 2020-04-01 | 2024-03-07 | 한국전자통신연구원 | 암 치료 장치 |
| JP2023522817A (ja) * | 2020-04-24 | 2023-06-01 | ノボキュア ゲーエムベーハー | 血液脳関門の透過性を増加させるための交流電界の使用 |
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| US12114991B2 (en) | 2020-09-25 | 2024-10-15 | Novocure Gmbh | Varying the metallization area on individual electrode elements in a tumor treating fields (TTFields) system to maximize current without overheating |
| JP7145280B2 (ja) * | 2020-10-13 | 2022-09-30 | Ｔｖｓ Ｒｅｇｚａ株式会社 | 送受信方法 |
| KR102519139B1 (ko) | 2020-11-25 | 2023-04-25 | 주식회사 필드큐어 | 회전하는 교류 전기장을 이용한 전기장 인가 장치 및 방법 |
| EP4570303A3 (en) | 2020-12-21 | 2025-07-30 | Novocure GmbH | Optimization of composite electrode |
| CN112553075A (zh) * | 2020-12-28 | 2021-03-26 | 湖南安泰康成生物科技有限公司 | 一种用敏感频率电场抑制肿瘤细胞快速生长的方法及装置 |
| US12161876B2 (en) * | 2020-12-30 | 2024-12-10 | Novocure Gmbh | Amplitude modulation for tumor treating fields |
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| IT202100000119A1 (it) * | 2021-01-05 | 2022-07-05 | Telea Electronic Eng Srl | Dispositivo e farmaco antitumorale per il trattamento di cellule neoplastiche |
| US20220241603A1 (en) * | 2021-02-03 | 2022-08-04 | Novocure Gmbh | Varying Parameters of Tumor Treating Fields (TTFields) Treatment to Overcome Treatment Resistance |
| WO2022175803A1 (en) | 2021-02-17 | 2022-08-25 | Novocure Gmbh | Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas |
| EP4304704A1 (en) | 2021-03-12 | 2024-01-17 | Novocure GmbH | Methods of treating disease by skewing macrophage phenotype with alternating electric fields |
| EP4596025A1 (en) | 2021-03-31 | 2025-08-06 | Novocure Gmbh | Impedance tomography using electrodes of a tumor treating fields (ttfields) system |
| CA3224731A1 (en) * | 2021-06-22 | 2022-12-29 | Lifebridge Innovations, Pbc | Apparatus and method for improving electric field therapy to reduce solid tumors |
| US12377280B2 (en) | 2021-12-30 | 2025-08-05 | Novocure Gmbh | Selecting values of parameters for treatment using tumor treating fields (TTFields) |
| CA3255016A1 (en) * | 2022-03-30 | 2023-10-05 | Novocure Gmbh | REDUCING ELECTROSENSITIVITY WHILE TREATING A SUBJECT WITH ALTERNATING ELECTRIC FIELDS BY MATCHING TRANSDUCER NETWORKS TOGETHER |
| IL314390A (en) * | 2022-03-30 | 2024-09-01 | Novocure Gmbh | Using interleaved cooling periods to increase the peak intensity of tumor treating fields |
| US20230310854A1 (en) * | 2022-03-31 | 2023-10-05 | Novocure Gmbh | Alternating electric field waveform for electrosensation reduction |
| CN119173302A (zh) | 2022-04-01 | 2024-12-20 | 得克萨斯大学体系董事会 | 用于应用与个性化超分割立体定向适应性放射疗法相组合的肿瘤治疗电场的方法和仪器 |
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| US20180008708A1 (en) | 2016-07-10 | 2018-01-11 | Novocure Limited | Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents |
| DK3500334T3 (da) | 2016-08-18 | 2023-10-09 | Novocure Gmbh | Temperaturmåling i arrays til levering af ttfields |
| ES2916252T3 (es) | 2016-12-13 | 2022-06-29 | Novocure Gmbh | Tratamiento de pacientes con campos TT con las posiciones de los electrodos optimizadas utilizando plantillas deformables |
| US11573221B2 (en) | 2017-01-19 | 2023-02-07 | Novocure Gmbh | System for viewing cell cultures under a microscope whilst applying TTFields |
| EP3773726B1 (en) | 2018-04-09 | 2024-06-05 | Novocure GmbH | Treating tumors with ttfields and an aurora kinase inhibitor |
| CN112424626B (zh) | 2018-04-10 | 2025-07-08 | 诺沃库勒有限责任公司 | 优化多个电极位置并创建3d模型的方法 |
| CN116236688A (zh) | 2018-07-03 | 2023-06-09 | 埃德温·阊 | 使用交变电场提高细胞膜通透性 |
| US11179322B2 (en) | 2018-07-10 | 2021-11-23 | Novocure Gmbh | Methods and compositions for treating tumors with TTFields and sorafenib |
| EP3823715A1 (en) | 2018-07-18 | 2021-05-26 | Novocure GmbH | Using power loss density and related measures to quantify the dose of tumor treating fields (ttfields) |
| CA3242209A1 (en) | 2018-08-23 | 2020-02-27 | Novocure Gmbh | Using alternating electric fields to increase permeability of the blood brain barrier |
| US11160977B2 (en) | 2018-09-04 | 2021-11-02 | Novocure Gmbh | Delivering tumor treating fields (TTFields) to the infratentorial brain |
| US11020585B2 (en) | 2018-09-07 | 2021-06-01 | Novocure Gmbh | Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells |
| US20200108031A1 (en) | 2018-10-05 | 2020-04-09 | Novocure Gmbh | Treating Tumors Using TTFields Combined with ABT-751 |
| EP3870188B1 (en) | 2018-10-23 | 2024-06-19 | The Board of Trustees of the Leland Stanford Junior University | Prevention and treatment of teratoma formation in stem cell-based thereapies using alternating electric fields |
| EP3870271A1 (en) | 2018-10-25 | 2021-09-01 | Zeev Bomzon | Delivering alternating electric fields (e.g., ttfields) to a subject's spinal anatomy |
| US20200146586A1 (en) | 2018-11-14 | 2020-05-14 | Novocure Gmbh | Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images |
| CN113015553B (zh) | 2018-11-19 | 2025-01-14 | 诺沃库勒有限责任公司 | 用于递送具有选择性可寻址子元件的肿瘤治疗场（TTField）的阵列 |
| MX2021002625A (es) | 2018-11-29 | 2021-05-12 | Novocure Gmbh | Arreglos de transductores de mayor flexibilidad para suministrar campos tt (campos de tratamiento de tumores). |
| JP7246486B2 (ja) | 2019-01-08 | 2023-03-27 | ノボキュア ゲーエムベーハー | 腫瘍治療電場（ｔｔｆｉｅｌｄｓ）を使用した治療を計画するための異なるタイプの組織への画像のセグメンテーションの品質評価 |
| SG11202106435QA (en) | 2019-02-22 | 2021-07-29 | Novocure Gmbh | Treating gastric cancer using ttfields combined with xelox or folfox |
| CA3127276A1 (en) | 2019-02-26 | 2020-09-03 | Novocure Gmbh | Determining a frequency for ttfields treatment based on an electrical characteristic of targeted cancer cells |
| US11471676B2 (en) | 2019-02-27 | 2022-10-18 | Novocure Gmbh | Delivering tumor treating fields (TTFields) using implantable transducer arrays |
| US11911610B2 (en) | 2019-03-29 | 2024-02-27 | Novocure Gmbh | Methods for restoring sensitivity to TTFields in TTFields-resistant cancer cells with PTGER3 inhibitors |
| ES2940749T3 (es) | 2019-04-17 | 2023-05-11 | Novocure Gmbh | Carga de datos desde un sistema aislado sin comprometer el aislamiento |
-
2017
- 2017-04-03 US US15/478,066 patent/US10821283B2/en active Active
- 2017-04-04 JP JP2019502289A patent/JP6896839B2/ja active Active
- 2017-04-04 DK DK17716642.8T patent/DK3439733T3/da active
- 2017-04-04 CA CA3019474A patent/CA3019474A1/en active Pending
- 2017-04-04 HU HUE17716642A patent/HUE048646T2/hu unknown
- 2017-04-04 CN CN201780024212.5A patent/CN109475735B/zh active Active
- 2017-04-04 WO PCT/IB2017/051898 patent/WO2017175116A1/en not_active Ceased
- 2017-04-04 EP EP19219639.2A patent/EP3693054B1/en active Active
- 2017-04-04 PL PL17716642T patent/PL3439733T3/pl unknown
- 2017-04-04 PT PT177166428T patent/PT3439733T/pt unknown
- 2017-04-04 CN CN202310518476.3A patent/CN116549848A/zh active Pending
- 2017-04-04 KR KR1020187030890A patent/KR102430229B1/ko active Active
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2020
- 2020-09-30 US US17/038,950 patent/US11191956B2/en active Active
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2021
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| Publication number | Publication date |
|---|---|
| EP3439733B1 (en) | 2019-12-25 |
| EP3693054C0 (en) | 2023-06-28 |
| JP2019510606A (ja) | 2019-04-18 |
| EP3693054B1 (en) | 2023-06-28 |
| KR20180133431A (ko) | 2018-12-14 |
| EP3439733A1 (en) | 2019-02-13 |
| EP4234005A2 (en) | 2023-08-30 |
| CA3019474A1 (en) | 2017-10-12 |
| PL3439733T3 (pl) | 2020-07-27 |
| ES2779990T3 (es) | 2020-08-21 |
| EP3693054A3 (en) | 2020-10-28 |
| PT3439733T (pt) | 2020-03-25 |
| JP7171827B2 (ja) | 2022-11-15 |
| US20210008367A1 (en) | 2021-01-14 |
| US10821283B2 (en) | 2020-11-03 |
| CN109475735A (zh) | 2019-03-15 |
| DK3439733T3 (da) | 2020-03-23 |
| CN109475735B (zh) | 2023-05-23 |
| KR102430229B1 (ko) | 2022-08-05 |
| JP6896839B2 (ja) | 2021-06-30 |
| EP3693054A2 (en) | 2020-08-12 |
| US20170281934A1 (en) | 2017-10-05 |
| JP2021126552A (ja) | 2021-09-02 |
| EP4234005A3 (en) | 2024-01-10 |
| US11191956B2 (en) | 2021-12-07 |
| WO2017175116A1 (en) | 2017-10-12 |
| CN116549848A (zh) | 2023-08-08 |
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