ES2774428T3 - Anticuerpos que se unen a AXL - Google Patents

Anticuerpos que se unen a AXL Download PDF

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Publication number
ES2774428T3
ES2774428T3 ES15738884T ES15738884T ES2774428T3 ES 2774428 T3 ES2774428 T3 ES 2774428T3 ES 15738884 T ES15738884 T ES 15738884T ES 15738884 T ES15738884 T ES 15738884T ES 2774428 T3 ES2774428 T3 ES 2774428T3
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ES
Spain
Prior art keywords
axl
region
antibody
seq
binding
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ES15738884T
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English (en)
Spanish (es)
Inventor
Esther Breij
David Satijn
Den Brink Edward Norbert Van
Dennis Verzijl
Jong Rob N De
Paul Parren
Dijkhuizen Radersma Riemke Van
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Genmab AS
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Genmab AS
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Publication of ES2774428T3 publication Critical patent/ES2774428T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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PT3169706T (pt) 2020-03-13
WO2016005593A1 (en) 2016-01-14
MX370807B (es) 2020-01-08
US20190275149A1 (en) 2019-09-12
AU2025201717A1 (en) 2025-03-27
LT3169706T (lt) 2020-03-25
RS60012B1 (sr) 2020-04-30
AU2015286569B2 (en) 2021-04-15
US20200171152A1 (en) 2020-06-04
US20240091352A1 (en) 2024-03-21
JP2020141682A (ja) 2020-09-10
KR20170030585A (ko) 2017-03-17
NZ766131A (en) 2024-07-05
BR112017000316A2 (pt) 2017-10-31
US10500276B2 (en) 2019-12-10
SI3169706T1 (sl) 2020-04-30
IL249512A0 (en) 2017-02-28
CN107074948B (zh) 2022-01-28
DK3169706T3 (da) 2020-03-09
AU2021205074A1 (en) 2021-08-12
HUE048667T2 (hu) 2020-08-28
SG10202006715SA (en) 2020-08-28
AU2021205074B2 (en) 2024-12-12
ME03665B (de) 2020-10-20
PL3169706T3 (pl) 2020-05-18
EP3169706B1 (de) 2019-12-04
CY1122721T1 (el) 2021-03-12
US20180214549A1 (en) 2018-08-02
EA201790173A1 (ru) 2017-06-30
EP3169706A1 (de) 2017-05-24
HRP20200283T1 (hr) 2020-05-29
KR102586656B1 (ko) 2023-10-11
US10512688B2 (en) 2019-12-24
CN114621347A (zh) 2022-06-14
NZ728019A (en) 2022-09-30
JP6701162B2 (ja) 2020-05-27

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