ES2772131T3 - Un nuevo proceso para la preparación de Febuxostat - Google Patents
Un nuevo proceso para la preparación de Febuxostat Download PDFInfo
- Publication number
- ES2772131T3 ES2772131T3 ES14750307T ES14750307T ES2772131T3 ES 2772131 T3 ES2772131 T3 ES 2772131T3 ES 14750307 T ES14750307 T ES 14750307T ES 14750307 T ES14750307 T ES 14750307T ES 2772131 T3 ES2772131 T3 ES 2772131T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- compound
- formula
- copper
- febuxostat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 Cc1c(C(*)=O)[s]c(-c(cc2C#N)ccc2O)n1 Chemical compound Cc1c(C(*)=O)[s]c(-c(cc2C#N)ccc2O)n1 0.000 description 5
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2013002361 | 2013-08-07 | ||
PCT/EP2014/002079 WO2015018507A2 (en) | 2013-08-07 | 2014-07-30 | A novel process for the preparation of febuxostat |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2772131T3 true ES2772131T3 (es) | 2020-07-07 |
Family
ID=51302690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14750307T Active ES2772131T3 (es) | 2013-08-07 | 2014-07-30 | Un nuevo proceso para la preparación de Febuxostat |
Country Status (4)
Country | Link |
---|---|
JP (2) | JP6585044B2 (ja) |
CN (1) | CN105452228B (ja) |
ES (1) | ES2772131T3 (ja) |
WO (1) | WO2015018507A2 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108440443A (zh) * | 2018-05-16 | 2018-08-24 | 无棣锐新医药化工有限公司 | 非布索坦中间体的制备方法 |
CN109503512B (zh) * | 2018-12-28 | 2021-05-07 | 大连理工大学 | 一种非布司他及其中间体的合成方法 |
CN109503513B (zh) * | 2018-12-29 | 2020-09-25 | 嘉实(湖南)医药科技有限公司 | 一种非布司他中间体的“一锅法”合成方法 |
CN113072519A (zh) * | 2021-04-01 | 2021-07-06 | 福建海西新药创制有限公司 | 一种利用微反应装置连续生产非布司他的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE122008000051I1 (de) | 1990-11-30 | 2009-02-05 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
JP2834971B2 (ja) * | 1993-05-25 | 1998-12-14 | 帝人株式会社 | 2−(4−アルコキシ−3−シアノフェニル)チアゾール誘導体の製造法およびその新規製造中間体 |
JP3202607B2 (ja) * | 1996-08-01 | 2001-08-27 | 帝人株式会社 | 2−(4−アルコキシ−3−シアノフェニル)チアゾール誘導体の製造法 |
EP2786995A1 (en) * | 2004-03-30 | 2014-10-08 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
CN101412700B (zh) * | 2007-10-19 | 2011-06-08 | 上海医药工业研究院 | 非布司他的晶型及其制备方法 |
EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
CN102079731A (zh) * | 2009-11-26 | 2011-06-01 | 上海和臣医药工程有限公司 | 一种2-(3-氰基-4-(2-甲基丙氧基)苯基)-4-甲基-5-噻唑甲酸的合成方法 |
CN101723915B (zh) * | 2009-12-25 | 2012-01-25 | 北京赛科药业有限责任公司 | 一种制备非布索坦中间体的方法 |
WO2011141933A2 (en) * | 2010-05-12 | 2011-11-17 | Msn Laboratories Limited | Process for preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid and its pharmaceutically acceptable salts |
US20130303780A1 (en) * | 2010-11-08 | 2013-11-14 | Siva Rama Prasad Vellanki | Process for the preparation of 2-arylthiazole derivatives |
-
2014
- 2014-07-30 CN CN201480044498.XA patent/CN105452228B/zh active Active
- 2014-07-30 WO PCT/EP2014/002079 patent/WO2015018507A2/en active Application Filing
- 2014-07-30 ES ES14750307T patent/ES2772131T3/es active Active
- 2014-07-30 JP JP2016532260A patent/JP6585044B2/ja active Active
-
2019
- 2019-06-12 JP JP2019109184A patent/JP2019194203A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN105452228B (zh) | 2018-10-09 |
WO2015018507A3 (en) | 2015-10-22 |
CN105452228A (zh) | 2016-03-30 |
JP2019194203A (ja) | 2019-11-07 |
JP6585044B2 (ja) | 2019-10-02 |
JP2017509581A (ja) | 2017-04-06 |
WO2015018507A2 (en) | 2015-02-12 |
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