ES2729378T3 - Ablación de tejido con electroporación irreversible - Google Patents
Ablación de tejido con electroporación irreversible Download PDFInfo
- Publication number
- ES2729378T3 ES2729378T3 ES12002108T ES12002108T ES2729378T3 ES 2729378 T3 ES2729378 T3 ES 2729378T3 ES 12002108 T ES12002108 T ES 12002108T ES 12002108 T ES12002108 T ES 12002108T ES 2729378 T3 ES2729378 T3 ES 2729378T3
- Authority
- ES
- Spain
- Prior art keywords
- electroporation
- tissue
- electrodes
- cells
- irreversible electroporation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
- A61B18/1233—Generators therefor with circuits for assuring patient safety
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1477—Needle-like probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00613—Irreversible electroporation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00761—Duration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00827—Current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrotherapy Devices (AREA)
- Surgical Instruments (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53258803P | 2003-12-24 | 2003-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2729378T3 true ES2729378T3 (es) | 2019-11-04 |
Family
ID=34748811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12002108T Expired - Lifetime ES2729378T3 (es) | 2003-12-24 | 2004-12-21 | Ablación de tejido con electroporación irreversible |
| ES04815540.2T Expired - Lifetime ES2543832T3 (es) | 2003-12-24 | 2004-12-21 | Ablación de tejido con electroporación irreversible |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04815540.2T Expired - Lifetime ES2543832T3 (es) | 2003-12-24 | 2004-12-21 | Ablación de tejido con electroporación irreversible |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US20050171574A1 (https=) |
| EP (2) | EP1696812B1 (https=) |
| JP (2) | JP5138229B2 (https=) |
| AU (2) | AU2004311842C1 (https=) |
| CA (1) | CA2550846C (https=) |
| DK (1) | DK1696812T3 (https=) |
| ES (2) | ES2729378T3 (https=) |
| PL (1) | PL1696812T3 (https=) |
| WO (1) | WO2005065284A2 (https=) |
Families Citing this family (344)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355425B1 (en) * | 1999-03-26 | 2002-03-12 | Billups-Rothenberg, Inc. | Mutations associated with iron disorders |
| US6300108B1 (en) * | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US8251986B2 (en) | 2000-08-17 | 2012-08-28 | Angiodynamics, Inc. | Method of destroying tissue cells by eletroporation |
| US6697670B2 (en) * | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6892099B2 (en) * | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| USRE42016E1 (en) | 2001-08-13 | 2010-12-28 | Angiodynamics, Inc. | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US7130697B2 (en) * | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
| US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
| US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
| US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
| US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
| US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US8150520B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods for catheter-based renal denervation |
| US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
| US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US8298222B2 (en) * | 2003-12-24 | 2012-10-30 | The Regents Of The University Of California | Electroporation to deliver chemotherapeutics and enhance tumor regression |
| EP1696812B1 (en) * | 2003-12-24 | 2015-07-22 | The Regents of The University of California | Tissue ablation with irreversible electroporation |
| JP4443278B2 (ja) * | 2004-03-26 | 2010-03-31 | テルモ株式会社 | 拡張体付カテーテル |
| US7937143B2 (en) * | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
| US7601149B2 (en) | 2005-03-07 | 2009-10-13 | Boston Scientific Scimed, Inc. | Apparatus for switching nominal and attenuated power between ablation probes |
| US20060264752A1 (en) * | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| US20060293725A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating fatty tissue sites using electroporation |
| US20060293731A1 (en) * | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating tumors using electroporation |
| US20060293730A1 (en) | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| US8114070B2 (en) * | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
| US8214221B2 (en) * | 2005-06-30 | 2012-07-03 | Lg Electronics Inc. | Method and apparatus for decoding an audio signal and identifying information included in the audio signal |
| US12433837B2 (en) | 2005-07-22 | 2025-10-07 | The Foundry, Llc | Systems and methods for delivery of a therapeutic agent |
| US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
| ES2342790T3 (es) * | 2006-01-03 | 2010-07-14 | Alcon, Inc. | Sistema para la disociacion y retirada de tejido proteinico. |
| AU2007221182B2 (en) * | 2006-02-24 | 2011-11-03 | Eastern Virginia Medical School | Nanosecond pulsed electric fields cause melanomas to self-destruct |
| JP5457183B2 (ja) * | 2006-09-14 | 2014-04-02 | ラジュール・テクノロジーズ・エルエルシイ | 癌細胞を破壊する装置及び方法 |
| US7674249B2 (en) | 2006-10-16 | 2010-03-09 | The Regents Of The University Of California | Gels with predetermined conductivity used in electroporation of tissue |
| US20080132884A1 (en) * | 2006-12-01 | 2008-06-05 | Boris Rubinsky | Systems for treating tissue sites using electroporation |
| EP2091453B1 (en) * | 2006-12-08 | 2010-05-05 | Koninklijke Philips Electronics N.V. | A system, method, computer-readable medium, and use for planning combined therapy |
| US20080200911A1 (en) * | 2007-02-15 | 2008-08-21 | Long Gary L | Electrical ablation apparatus, system, and method |
| US7655004B2 (en) * | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
| US20080200762A1 (en) * | 2007-02-16 | 2008-08-21 | Stokes Michael J | Flexible endoscope shapelock |
| US7815662B2 (en) | 2007-03-08 | 2010-10-19 | Ethicon Endo-Surgery, Inc. | Surgical suture anchors and deployment device |
| DE602008002247D1 (de) * | 2007-03-29 | 2010-09-30 | Novozymes As | Verfahren zur behandlung von pflanzlichem material mit einem enzym |
| US8075572B2 (en) | 2007-04-26 | 2011-12-13 | Ethicon Endo-Surgery, Inc. | Surgical suturing apparatus |
| US8100922B2 (en) * | 2007-04-27 | 2012-01-24 | Ethicon Endo-Surgery, Inc. | Curved needle suturing tool |
| WO2009009398A1 (en) | 2007-07-06 | 2009-01-15 | Tsunami Medtech, Llc | Medical system and method of use |
| US20090054728A1 (en) * | 2007-08-21 | 2009-02-26 | Trusty Robert M | Manipulatable guide system and methods for natural orifice translumenal endoscopic surgery |
| US8197470B2 (en) | 2007-08-23 | 2012-06-12 | Aegea Medical, Inc. | Uterine therapy device and method |
| US8262655B2 (en) | 2007-11-21 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Bipolar forceps |
| US8579897B2 (en) | 2007-11-21 | 2013-11-12 | Ethicon Endo-Surgery, Inc. | Bipolar forceps |
| US8568410B2 (en) | 2007-08-31 | 2013-10-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation surgical instruments |
| US8673623B2 (en) * | 2007-08-31 | 2014-03-18 | Board Of Regents, The University Of Texas System | Apparatus for performing magnetic electroporation |
| WO2009036457A1 (en) | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-layer electrode ablation probe and related methods |
| WO2009036459A1 (en) * | 2007-09-14 | 2009-03-19 | Lazure Technologies, Llc | Multi-tine probe and treatment by activation of opposing tines |
| CA2699782C (en) * | 2007-09-14 | 2017-04-11 | Lazure Technologies, Llc | Prostate cancer ablation |
| US20160184006A1 (en) * | 2007-09-14 | 2016-06-30 | Lazure Scientific, Inc. | Ablation probe with deployable electrodes |
| WO2009042501A1 (en) * | 2007-09-28 | 2009-04-02 | Board Of Regents, The University Of Texas System | Apparatus for performing electrodistention on algae cells |
| US20090112059A1 (en) | 2007-10-31 | 2009-04-30 | Nobis Rudolph H | Apparatus and methods for closing a gastrotomy |
| US8480657B2 (en) | 2007-10-31 | 2013-07-09 | Ethicon Endo-Surgery, Inc. | Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ |
| US9707403B2 (en) | 2007-12-12 | 2017-07-18 | Neuro Code Tech Holdings, Llc | Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics |
| US20090177219A1 (en) * | 2008-01-03 | 2009-07-09 | Conlon Sean P | Flexible tissue-penetration instrument with blunt tip assembly and methods for penetrating tissue |
| US8656930B2 (en) | 2008-01-10 | 2014-02-25 | Neuro-Code Tech Holdings, LLC | Method and system for processing cancer cell electrical signals for medical therapy |
| US8262680B2 (en) | 2008-03-10 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Anastomotic device |
| US20090248012A1 (en) * | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Irreversible electroporation device and method for attenuating neointimal |
| US20100004623A1 (en) * | 2008-03-27 | 2010-01-07 | Angiodynamics, Inc. | Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation |
| WO2009151783A1 (en) * | 2008-04-17 | 2009-12-17 | The Neuro-Signaling Foundation | System and method to elicit apoptosis in malignant tumor cells for medical treatment |
| US8992517B2 (en) | 2008-04-29 | 2015-03-31 | Virginia Tech Intellectual Properties Inc. | Irreversible electroporation to treat aberrant cell masses |
| US10238447B2 (en) | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| US11254926B2 (en) | 2008-04-29 | 2022-02-22 | Virginia Tech Intellectual Properties, Inc. | Devices and methods for high frequency electroporation |
| US9283051B2 (en) | 2008-04-29 | 2016-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating a treatment volume for administering electrical-energy based therapies |
| US11272979B2 (en) | 2008-04-29 | 2022-03-15 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US10272178B2 (en) | 2008-04-29 | 2019-04-30 | Virginia Tech Intellectual Properties Inc. | Methods for blood-brain barrier disruption using electrical energy |
| US9867652B2 (en) | 2008-04-29 | 2018-01-16 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds |
| US10702326B2 (en) | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
| US9598691B2 (en) | 2008-04-29 | 2017-03-21 | Virginia Tech Intellectual Properties, Inc. | Irreversible electroporation to create tissue scaffolds |
| US9198733B2 (en) | 2008-04-29 | 2015-12-01 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electroporation-based therapies |
| US10245098B2 (en) | 2008-04-29 | 2019-04-02 | Virginia Tech Intellectual Properties, Inc. | Acute blood-brain barrier disruption using electrical energy based therapy |
| US10117707B2 (en) | 2008-04-29 | 2018-11-06 | Virginia Tech Intellectual Properties, Inc. | System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies |
| US8348938B2 (en) | 2008-05-06 | 2013-01-08 | Old Dominian University Research Foundation | Apparatus, systems and methods for treating a human tissue condition |
| US20090281559A1 (en) * | 2008-05-06 | 2009-11-12 | Ethicon Endo-Surgery, Inc. | Anastomosis patch |
| WO2009137800A2 (en) * | 2008-05-09 | 2009-11-12 | Angiodynamics, Inc. | Electroporation device and method |
| US8771260B2 (en) | 2008-05-30 | 2014-07-08 | Ethicon Endo-Surgery, Inc. | Actuating and articulating surgical device |
| US8114072B2 (en) | 2008-05-30 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | Electrical ablation device |
| US8070759B2 (en) | 2008-05-30 | 2011-12-06 | Ethicon Endo-Surgery, Inc. | Surgical fastening device |
| US8679003B2 (en) | 2008-05-30 | 2014-03-25 | Ethicon Endo-Surgery, Inc. | Surgical device and endoscope including same |
| US8652150B2 (en) | 2008-05-30 | 2014-02-18 | Ethicon Endo-Surgery, Inc. | Multifunction surgical device |
| US8317806B2 (en) | 2008-05-30 | 2012-11-27 | Ethicon Endo-Surgery, Inc. | Endoscopic suturing tension controlling and indication devices |
| US8906035B2 (en) | 2008-06-04 | 2014-12-09 | Ethicon Endo-Surgery, Inc. | Endoscopic drop off bag |
| US8403926B2 (en) | 2008-06-05 | 2013-03-26 | Ethicon Endo-Surgery, Inc. | Manually articulating devices |
| WO2009155526A2 (en) * | 2008-06-20 | 2009-12-23 | Angiodynamics, Inc. | Device and method for the ablation of fibrin sheath formation on a venous catheter |
| US9681909B2 (en) * | 2008-06-23 | 2017-06-20 | Angiodynamics, Inc. | Treatment devices and methods |
| US8361112B2 (en) | 2008-06-27 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Surgical suture arrangement |
| US20100010294A1 (en) * | 2008-07-10 | 2010-01-14 | Ethicon Endo-Surgery, Inc. | Temporarily positionable medical devices |
| US20100010298A1 (en) * | 2008-07-14 | 2010-01-14 | Ethicon Endo-Surgery, Inc. | Endoscopic translumenal flexible overtube |
| US8262563B2 (en) | 2008-07-14 | 2012-09-11 | Ethicon Endo-Surgery, Inc. | Endoscopic translumenal articulatable steerable overtube |
| US8888792B2 (en) | 2008-07-14 | 2014-11-18 | Ethicon Endo-Surgery, Inc. | Tissue apposition clip application devices and methods |
| US8221411B2 (en) * | 2008-07-28 | 2012-07-17 | Medtronic, Inc. | Systems and methods for cardiac tissue electroporation ablation |
| US8211125B2 (en) | 2008-08-15 | 2012-07-03 | Ethicon Endo-Surgery, Inc. | Sterile appliance delivery device for endoscopic procedures |
| US8529563B2 (en) | 2008-08-25 | 2013-09-10 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8241204B2 (en) | 2008-08-29 | 2012-08-14 | Ethicon Endo-Surgery, Inc. | Articulating end cap |
| US8480689B2 (en) | 2008-09-02 | 2013-07-09 | Ethicon Endo-Surgery, Inc. | Suturing device |
| US8409200B2 (en) | 2008-09-03 | 2013-04-02 | Ethicon Endo-Surgery, Inc. | Surgical grasping device |
| US20100056862A1 (en) * | 2008-09-03 | 2010-03-04 | Ethicon Endo-Surgery, Inc. | Access needle for natural orifice translumenal endoscopic surgery |
| US8114119B2 (en) | 2008-09-09 | 2012-02-14 | Ethicon Endo-Surgery, Inc. | Surgical grasping device |
| US20100100093A1 (en) * | 2008-09-16 | 2010-04-22 | Lazure Technologies, Llc. | System and method for controlled tissue heating for destruction of cancerous cells |
| US8337394B2 (en) | 2008-10-01 | 2012-12-25 | Ethicon Endo-Surgery, Inc. | Overtube with expandable tip |
| US20100114680A1 (en) * | 2008-10-01 | 2010-05-06 | Ryan Steelberg | On-site barcode advertising |
| US8157834B2 (en) | 2008-11-25 | 2012-04-17 | Ethicon Endo-Surgery, Inc. | Rotational coupling device for surgical instrument with flexible actuators |
| US8172772B2 (en) * | 2008-12-11 | 2012-05-08 | Ethicon Endo-Surgery, Inc. | Specimen retrieval device |
| US20100152725A1 (en) * | 2008-12-12 | 2010-06-17 | Angiodynamics, Inc. | Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation |
| US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
| US8828031B2 (en) | 2009-01-12 | 2014-09-09 | Ethicon Endo-Surgery, Inc. | Apparatus for forming an anastomosis |
| US8361066B2 (en) | 2009-01-12 | 2013-01-29 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8753335B2 (en) * | 2009-01-23 | 2014-06-17 | Angiodynamics, Inc. | Therapeutic energy delivery device with rotational mechanism |
| US8252057B2 (en) | 2009-01-30 | 2012-08-28 | Ethicon Endo-Surgery, Inc. | Surgical access device |
| US9226772B2 (en) | 2009-01-30 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Surgical device |
| US8037591B2 (en) | 2009-02-02 | 2011-10-18 | Ethicon Endo-Surgery, Inc. | Surgical scissors |
| US20100198248A1 (en) * | 2009-02-02 | 2010-08-05 | Ethicon Endo-Surgery, Inc. | Surgical dissector |
| US11284931B2 (en) | 2009-02-03 | 2022-03-29 | Tsunami Medtech, Llc | Medical systems and methods for ablating and absorbing tissue |
| WO2010093692A2 (en) * | 2009-02-10 | 2010-08-19 | Hobbs Eamonn P | Irreversible electroporation and tissue regeneration |
| US9599591B2 (en) | 2009-03-06 | 2017-03-21 | California Institute Of Technology | Low cost, portable sensor for molecular assays |
| US20110004096A1 (en) * | 2009-07-06 | 2011-01-06 | California Institute Of Technology | Electromagnetic cellular tomography |
| US20100240995A1 (en) * | 2009-03-17 | 2010-09-23 | Bioelectromed Corp. | System and method for treating tumors |
| US20100249700A1 (en) * | 2009-03-27 | 2010-09-30 | Ethicon Endo-Surgery, Inc. | Surgical instruments for in vivo assembly |
| EP2413833A1 (en) * | 2009-03-31 | 2012-02-08 | AngioDynamics, Inc. | System and method for estimating a treatment region for a medical treatment device and for interactively planning a treatment of a patient |
| US8632534B2 (en) | 2009-04-03 | 2014-01-21 | Angiodynamics, Inc. | Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD) |
| US11382681B2 (en) | 2009-04-09 | 2022-07-12 | Virginia Tech Intellectual Properties, Inc. | Device and methods for delivery of high frequency electrical pulses for non-thermal ablation |
| US11638603B2 (en) | 2009-04-09 | 2023-05-02 | Virginia Tech Intellectual Properties, Inc. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| WO2010118387A1 (en) * | 2009-04-09 | 2010-10-14 | Virginia Tech Intellectual Properties, Inc. | Integration of very short electric pulses for minimally to noninvasive electroporation |
| US8728139B2 (en) | 2009-04-16 | 2014-05-20 | Lazure Technologies, Llc | System and method for energy delivery to a tissue using an electrode array |
| IT1394143B1 (it) * | 2009-05-04 | 2012-05-25 | Igea S P A | Dispositivo per elettroporazione reversibile atto ad indurre apoptosi cellulare |
| USD630321S1 (en) | 2009-05-08 | 2011-01-04 | Angio Dynamics, Inc. | Probe handle |
| WO2014143014A1 (en) | 2013-03-15 | 2014-09-18 | Triagenics, Llc | Therapeutic tooth bud ablation |
| US10022202B2 (en) | 2013-03-15 | 2018-07-17 | Triagenics, Llc | Therapeutic tooth bud ablation |
| CA2761652C (en) * | 2009-05-11 | 2019-10-01 | Leigh E. Colby | Therapeutic tooth bud ablation |
| US12514679B2 (en) | 2009-05-11 | 2026-01-06 | TriAgenics, Inc. | Therapeutic tooth bud ablation |
| WO2010138919A2 (en) | 2009-05-28 | 2010-12-02 | Angiodynamics, Inc. | System and method for synchronizing energy delivery to the cardiac rhythm |
| US9895189B2 (en) | 2009-06-19 | 2018-02-20 | Angiodynamics, Inc. | Methods of sterilization and treating infection using irreversible electroporation |
| WO2011028937A1 (en) * | 2009-09-04 | 2011-03-10 | The Regents Of The University Of California | Extracellular matrix material created using non-thermal irreversible electroporation |
| US20110065161A1 (en) * | 2009-09-14 | 2011-03-17 | Board Of Regents, The University Of Texas System | Bipolar solid state marx generator |
| US9775664B2 (en) | 2009-09-22 | 2017-10-03 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
| US9474565B2 (en) | 2009-09-22 | 2016-10-25 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
| US9750563B2 (en) | 2009-09-22 | 2017-09-05 | Mederi Therapeutics, Inc. | Systems and methods for treating tissue with radiofrequency energy |
| US10386990B2 (en) | 2009-09-22 | 2019-08-20 | Mederi Rf, Llc | Systems and methods for treating tissue with radiofrequency energy |
| US20110093009A1 (en) * | 2009-10-16 | 2011-04-21 | Ethicon Endo-Surgery, Inc. | Otomy closure device |
| US20110098704A1 (en) | 2009-10-28 | 2011-04-28 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices |
| US8608652B2 (en) | 2009-11-05 | 2013-12-17 | Ethicon Endo-Surgery, Inc. | Vaginal entry surgical devices, kit, system, and method |
| US20110118729A1 (en) * | 2009-11-13 | 2011-05-19 | Alcon Research, Ltd | High-intensity pulsed electric field vitrectomy apparatus with load detection |
| US20110118734A1 (en) * | 2009-11-16 | 2011-05-19 | Alcon Research, Ltd. | Capsularhexis device using pulsed electric fields |
| US20110118732A1 (en) * | 2009-11-19 | 2011-05-19 | The Regents Of The University Of California | Controlled irreversible electroporation |
| US20110135626A1 (en) * | 2009-12-08 | 2011-06-09 | Alcon Research, Ltd. | Localized Chemical Lysis of Ocular Tissue |
| US20110144562A1 (en) * | 2009-12-14 | 2011-06-16 | Alcon Research, Ltd. | Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields |
| US20110144641A1 (en) * | 2009-12-15 | 2011-06-16 | Alcon Research, Ltd. | High-Intensity Pulsed Electric Field Vitrectomy Apparatus |
| US8353487B2 (en) | 2009-12-17 | 2013-01-15 | Ethicon Endo-Surgery, Inc. | User interface support devices for endoscopic surgical instruments |
| US8496574B2 (en) | 2009-12-17 | 2013-07-30 | Ethicon Endo-Surgery, Inc. | Selectively positionable camera for surgical guide tube assembly |
| US8506564B2 (en) | 2009-12-18 | 2013-08-13 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US9028483B2 (en) | 2009-12-18 | 2015-05-12 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US9005198B2 (en) | 2010-01-29 | 2015-04-14 | Ethicon Endo-Surgery, Inc. | Surgical instrument comprising an electrode |
| US20110202052A1 (en) * | 2010-02-12 | 2011-08-18 | Daniel Gelbart | System for treating benign prostatic hyperplasia |
| CN103068330B (zh) | 2010-04-09 | 2016-06-29 | Vessix血管股份有限公司 | 用于治疗组织的功率发生和控制装置 |
| GB201006841D0 (en) * | 2010-04-26 | 2010-06-09 | Thomsen Lars | Method, device and system for targetted cell lysis |
| US9526911B1 (en) | 2010-04-27 | 2016-12-27 | Lazure Scientific, Inc. | Immune mediated cancer cell destruction, systems and methods |
| US8546979B2 (en) | 2010-08-11 | 2013-10-01 | Alcon Research, Ltd. | Self-matching pulse generator with adjustable pulse width and pulse frequency |
| US9943353B2 (en) | 2013-03-15 | 2018-04-17 | Tsunami Medtech, Llc | Medical system and method of use |
| US8652130B2 (en) * | 2010-08-18 | 2014-02-18 | Invasix Ltd. | Method and device for soft tissue ablation |
| EP2627274B1 (en) | 2010-10-13 | 2022-12-14 | AngioDynamics, Inc. | System for electrically ablating tissue of a patient |
| CN103313671B (zh) | 2010-10-25 | 2017-06-06 | 美敦力Af卢森堡有限责任公司 | 用于神经调节治疗的估算及反馈的装置、系统及方法 |
| US9743974B2 (en) | 2010-11-09 | 2017-08-29 | Aegea Medical Inc. | Positioning method and apparatus for delivering vapor to the uterus |
| EP2642937A4 (en) * | 2010-11-23 | 2014-05-07 | Virginia Tech Intell Prop | IRREVERSIBLE ELECTROPORATION USING TISSUE BLOOD VESSELS FOR THE TREATMENT OF BUTTERED CELL MASS OR FOR THE PRODUCTION OF TISSUE OBSTACLES |
| EP2651505A4 (en) | 2010-12-15 | 2014-06-11 | Old Dominion Univ Res Found | ELECTROPORATION-INDUCED ELECTROSENSIBILIZATION |
| WO2012088149A2 (en) | 2010-12-20 | 2012-06-28 | Virginia Tech Intellectual Properties, Inc. | High-frequency electroporation for cancer therapy |
| US10092291B2 (en) | 2011-01-25 | 2018-10-09 | Ethicon Endo-Surgery, Inc. | Surgical instrument with selectively rigidizable features |
| US9254169B2 (en) | 2011-02-28 | 2016-02-09 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9314620B2 (en) | 2011-02-28 | 2016-04-19 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9233241B2 (en) | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
| US9049987B2 (en) | 2011-03-17 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Hand held surgical device for manipulating an internal magnet assembly within a patient |
| US11304746B2 (en) | 2011-06-14 | 2022-04-19 | Aerin Medical Inc. | Method of treating airway tissue to reduce mucus secretion |
| US20240050143A1 (en) | 2011-06-14 | 2024-02-15 | Aerin Medical Inc. | Methods and devices to treat nasal airways |
| WO2012174161A1 (en) | 2011-06-14 | 2012-12-20 | Aerin Medical, Inc. | Devices for treating nasal airways |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US9078665B2 (en) | 2011-09-28 | 2015-07-14 | Angiodynamics, Inc. | Multiple treatment zone ablation probe |
| CN104135960B (zh) | 2011-10-07 | 2017-06-06 | 埃杰亚医疗公司 | 一种子宫治疗装置 |
| US9414881B2 (en) | 2012-02-08 | 2016-08-16 | Angiodynamics, Inc. | System and method for increasing a target zone for electrical ablation |
| US8986199B2 (en) | 2012-02-17 | 2015-03-24 | Ethicon Endo-Surgery, Inc. | Apparatus and methods for cleaning the lens of an endoscope |
| AU2013230781B2 (en) | 2012-03-08 | 2015-12-03 | Medtronic Af Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
| JP6195856B2 (ja) | 2012-03-08 | 2017-09-13 | メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ | 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法 |
| MX357200B (es) * | 2012-05-07 | 2018-06-29 | Univ Ottawa | Fabricacion de nanoporos utilizando campos electricos elevados. |
| US9427255B2 (en) | 2012-05-14 | 2016-08-30 | Ethicon Endo-Surgery, Inc. | Apparatus for introducing a steerable camera assembly into a patient |
| CA3158197C (en) | 2012-05-29 | 2026-04-21 | Autonomix Medical, Inc. | Endoscopic sympathectomy systems and methods |
| US9078662B2 (en) | 2012-07-03 | 2015-07-14 | Ethicon Endo-Surgery, Inc. | Endoscopic cap electrode and method for using the same |
| US9545290B2 (en) | 2012-07-30 | 2017-01-17 | Ethicon Endo-Surgery, Inc. | Needle probe guide |
| US10314649B2 (en) | 2012-08-02 | 2019-06-11 | Ethicon Endo-Surgery, Inc. | Flexible expandable electrode and method of intraluminal delivery of pulsed power |
| US9572623B2 (en) | 2012-08-02 | 2017-02-21 | Ethicon Endo-Surgery, Inc. | Reusable electrode and disposable sheath |
| JP6301926B2 (ja) | 2012-08-09 | 2018-03-28 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | カテーテル、カテーテルシステム、及び組織構造を刺通する方法 |
| US9277957B2 (en) | 2012-08-15 | 2016-03-08 | Ethicon Endo-Surgery, Inc. | Electrosurgical devices and methods |
| US9113911B2 (en) * | 2012-09-06 | 2015-08-25 | Medtronic Ablation Frontiers Llc | Ablation device and method for electroporating tissue cells |
| US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
| US10080907B1 (en) | 2012-10-26 | 2018-09-25 | University Of South Florida | Systems and methods for controlling the spatial distribution of an electromagnetic field |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| US10098527B2 (en) | 2013-02-27 | 2018-10-16 | Ethidcon Endo-Surgery, Inc. | System for performing a minimally invasive surgical procedure |
| US9438264B1 (en) | 2015-09-10 | 2016-09-06 | Realtek Semiconductor Corp. | High-speed capacitive digital-to-analog converter and method thereof |
| US20140378963A1 (en) * | 2013-06-20 | 2014-12-25 | Gyrus Acmi, Inc., D.B.A. Olympus Surgical Technologies America | Treatment of uterine fibroids by arterial ablation |
| WO2015085162A1 (en) | 2013-12-05 | 2015-06-11 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb) |
| US10154869B2 (en) | 2013-08-02 | 2018-12-18 | Gary M. Onik | System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation |
| EP3030185B1 (en) | 2013-08-06 | 2023-05-10 | Memorial Sloan Kettering Cancer Center | System and computer-accessible medium for in-vivo tissue ablation and/or damage |
| WO2015073877A1 (en) | 2013-11-14 | 2015-05-21 | Paul Mikus | Methods, systems, and apparatuses for delivery of electrolysis products |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US10314648B2 (en) | 2013-12-13 | 2019-06-11 | The Trustees of the Universoty of Pennsylvania | Coaxial ablation probe and method and system for real-time monitoring of ablation therapy |
| WO2015103574A1 (en) | 2014-01-06 | 2015-07-09 | Iowa Approach Inc. | Apparatus and methods for renal denervation ablation |
| US10166321B2 (en) | 2014-01-09 | 2019-01-01 | Angiodynamics, Inc. | High-flow port and infusion needle systems |
| US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
| US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
| US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
| US20150289923A1 (en) * | 2014-04-14 | 2015-10-15 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for electrical-energy based therapies based on cell characteristics |
| EP4670627A3 (en) | 2014-05-07 | 2026-03-25 | Boston Scientific Scimed, Inc. | Methods and apparatus for selective tissue ablation |
| AU2015259303B2 (en) | 2014-05-12 | 2021-10-28 | Arena, Christopher B. | Selective modulation of intracellular effects of cells using pulsed electric fields |
| WO2015175944A1 (en) | 2014-05-16 | 2015-11-19 | Gary Long | Methods and apparatus for multi-catheter tissue ablation |
| ES2942296T3 (es) | 2014-05-22 | 2023-05-31 | Aegea Medical Inc | Método de prueba de integridad y aparato para administrar vapor al útero |
| CN106794030B (zh) | 2014-05-22 | 2019-09-03 | 埃杰亚医疗公司 | 用于执行子宫内膜消融术的系统和方法 |
| WO2015192018A1 (en) | 2014-06-12 | 2015-12-17 | Iowa Approach Inc. | Method and apparatus for rapid and selective tissue ablation with cooling |
| EP3154463B1 (en) | 2014-06-12 | 2019-03-27 | Farapulse, Inc. | Apparatus for rapid and selective transurethral tissue ablation |
| US12114911B2 (en) | 2014-08-28 | 2024-10-15 | Angiodynamics, Inc. | System and method for ablating a tissue site by electroporation with real-time pulse monitoring |
| EP3206613B1 (en) | 2014-10-14 | 2019-07-03 | Farapulse, Inc. | Apparatus for rapid and safe pulmonary vein cardiac ablation |
| US10835311B2 (en) | 2014-10-24 | 2020-11-17 | Northwestern University | Electroporation apparatus and method of using same for ablation of an arbitrary volume |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| US10271893B2 (en) | 2014-12-15 | 2019-04-30 | Medtronic Ablation Frontiers Llc | Timed energy delivery |
| US10694972B2 (en) | 2014-12-15 | 2020-06-30 | Virginia Tech Intellectual Properties, Inc. | Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment |
| US11141216B2 (en) | 2015-01-30 | 2021-10-12 | Immunsys, Inc. | Radio-frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
| CA2975938A1 (en) * | 2015-02-04 | 2016-08-11 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for reducing restenosis |
| WO2016130385A2 (en) * | 2015-02-10 | 2016-08-18 | George Mbella Ekema | Tissue ablation by rapid and sustained alteration in membrane potential |
| HK1254629A1 (zh) * | 2015-04-10 | 2019-07-26 | 安吉戴尼克公司 | 使用热控电极进行不可逆电穿孔的系统和方法 |
| EP3288471A1 (en) * | 2015-05-01 | 2018-03-07 | Inter Science GmbH | Methods, systems, and apparatuses for tissue ablation using pulse shape designs |
| US12268433B2 (en) | 2015-05-12 | 2025-04-08 | National University Of Ireland, Galway | Devices for therapeutic nasal neuromodulation and associated methods and systems |
| US20160361109A1 (en) * | 2015-06-11 | 2016-12-15 | Massachusetts Institute Of Technology | Methods for inducing electroporation and tissue ablation |
| US11154238B2 (en) | 2015-08-07 | 2021-10-26 | Electroceuticals, Llc | Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals |
| AU2016335755B2 (en) | 2015-10-07 | 2021-07-01 | Mayo Foundation For Medical Education And Research | Electroporation for obesity or diabetes treatment |
| US20170189097A1 (en) | 2016-01-05 | 2017-07-06 | Iowa Approach Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
| US10172673B2 (en) | 2016-01-05 | 2019-01-08 | Farapulse, Inc. | Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue |
| US10130423B1 (en) | 2017-07-06 | 2018-11-20 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
| US10660702B2 (en) | 2016-01-05 | 2020-05-26 | Farapulse, Inc. | Systems, devices, and methods for focal ablation |
| US12144541B2 (en) | 2016-01-05 | 2024-11-19 | Boston Scientific Scimed, Inc. | Systems, apparatuses and methods for delivery of ablative energy to tissue |
| KR20180108655A (ko) | 2016-01-15 | 2018-10-04 | 알에프이엠비 홀딩스, 엘엘씨 | 암의 면역학적 치료 |
| CN114983553A (zh) | 2016-02-19 | 2022-09-02 | 埃杰亚医疗公司 | 用于确定体腔的完整性的方法和设备 |
| WO2017152061A1 (en) | 2016-03-04 | 2017-09-08 | Aerin Medical, Inc. | Eustachian tube modification |
| EP3471631A4 (en) | 2016-06-16 | 2020-03-04 | Farapulse, Inc. | Systems, apparatuses, and methods for guide wire delivery |
| EP3474760B1 (en) | 2016-06-27 | 2023-01-11 | Galvanize Therapeutics, Inc. | Generator and a catheter with an electrode for treating a lung passageway |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| JP7158820B2 (ja) * | 2016-10-26 | 2022-10-24 | ロレアル | エレクトロポレーションデバイスおよびエレクトロポレーションデバイスを制御するための方法 |
| US10905492B2 (en) | 2016-11-17 | 2021-02-02 | Angiodynamics, Inc. | Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode |
| US11717337B2 (en) * | 2016-11-29 | 2023-08-08 | St. Jude Medical, Cardiology Division, Inc. | Electroporation systems and catheters for electroporation systems |
| US11806071B2 (en) | 2016-12-22 | 2023-11-07 | Aerin Medical Inc. | Soft palate treatment |
| EP3576839B1 (en) | 2017-04-10 | 2022-10-26 | St. Jude Medical, Cardiology Division, Inc. | Electroporation system and method of preconditioning tissue for electroporation therapy |
| US9987081B1 (en) | 2017-04-27 | 2018-06-05 | Iowa Approach, Inc. | Systems, devices, and methods for signal generation |
| US10617867B2 (en) | 2017-04-28 | 2020-04-14 | Farapulse, Inc. | Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue |
| SE541651C2 (en) | 2017-07-28 | 2019-11-19 | Scandinavian Chemotech Ab | An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal |
| CN115844523A (zh) | 2017-09-12 | 2023-03-28 | 波士顿科学医学有限公司 | 用于心室局灶性消融的系统、设备和方法 |
| US11045648B2 (en) | 2017-11-14 | 2021-06-29 | Boston Scientific Scimed, Inc. | Irreversible electroporation through a combination of substance injection and electrical field application |
| US11607537B2 (en) | 2017-12-05 | 2023-03-21 | Virginia Tech Intellectual Properties, Inc. | Method for treating neurological disorders, including tumors, with electroporation |
| DK3731771T3 (da) | 2017-12-26 | 2023-08-28 | Galvanize Therapeutics Inc | V462033dk00 |
| US11364070B2 (en) | 2018-01-23 | 2022-06-21 | Boston Scientific Scimed, Inc. | Enhanced needle array and therapies for tumor ablation |
| EP3749238B1 (en) | 2018-02-08 | 2023-08-16 | Farapulse, Inc. | Apparatus for controlled delivery of pulsed electric field ablative energy to tissue |
| US12390262B2 (en) | 2018-03-13 | 2025-08-19 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| US11311329B2 (en) | 2018-03-13 | 2022-04-26 | Virginia Tech Intellectual Properties, Inc. | Treatment planning for immunotherapy based treatments using non-thermal ablation techniques |
| US11925405B2 (en) | 2018-03-13 | 2024-03-12 | Virginia Tech Intellectual Properties, Inc. | Treatment planning system for immunotherapy enhancement via non-thermal ablation |
| JP7043317B2 (ja) * | 2018-03-29 | 2022-03-29 | 富士フイルムヘルスケア株式会社 | 医療システム |
| US11007317B2 (en) | 2018-05-02 | 2021-05-18 | Cequr Sa | Devices and methods for providing a bolus dose in a microfluidic circuit of a pump |
| US20190336198A1 (en) | 2018-05-03 | 2019-11-07 | Farapulse, Inc. | Systems, devices, and methods for ablation using surgical clamps |
| CN115836908A (zh) | 2018-05-07 | 2023-03-24 | 波士顿科学医学有限公司 | 用于将消融能量递送到组织的系统、设备和方法 |
| CN116327352A (zh) | 2018-05-07 | 2023-06-27 | 波士顿科学医学有限公司 | 心外膜消融导管 |
| EP3790483B1 (en) | 2018-05-07 | 2024-08-28 | Boston Scientific Scimed, Inc. | Systems for filtering high voltage noise induced by pulsed electric field ablation |
| CN108830017B (zh) * | 2018-07-05 | 2022-06-24 | 上海美杰医疗科技有限公司 | 基于个体阻抗的射频加热温度场预测系统 |
| WO2020051241A1 (en) | 2018-09-04 | 2020-03-12 | Inter Science Gmbh | Methods, systems, and apparatuses for tissue ablation using a modulated exponential decay pulse |
| CN112955088B (zh) | 2018-09-20 | 2024-11-26 | 波士顿科学医学有限公司 | 用于将脉冲电场消融能量输送到心内膜组织的系统、装置和方法 |
| US12226148B2 (en) | 2018-11-05 | 2025-02-18 | Region Hovedstaden V/Herlev Hospital | Electrode assembly for improved electric field distribution |
| US11684414B2 (en) | 2018-12-11 | 2023-06-27 | Neurent Medical Limited | Systems and methods for therapeutic nasal neuromodulation |
| EP3849447A4 (en) | 2019-01-14 | 2021-11-17 | Cryoelectric Science Ltd. | PROCESSES, SYSTEMS AND APPARATUS FOR CRYOSURGERY, COLD SURGERY AND ELECTROLYSIS |
| JP2022524979A (ja) | 2019-03-01 | 2022-05-11 | ランパート ヘルス リミテッド ライアビリティー カンパニー | 癌治療のための免疫学的方法及び化学療法を併用する医薬組成物 |
| CN113853174B (zh) | 2019-03-15 | 2024-10-11 | 波士顿科学国际有限公司 | 用于选择性细胞消融的时间多路复用波形 |
| WO2020190693A1 (en) | 2019-03-15 | 2020-09-24 | Boston Scientific Scimed, Inc. | Waveform generator and control for selective cell ablation |
| CN113573655B (zh) * | 2019-03-15 | 2025-05-27 | 波士顿科学国际有限公司 | 用于选择性细胞消融的空间复用波形 |
| CN118203401A (zh) | 2019-04-18 | 2024-06-18 | 盖能适治疗股份有限公司 | 用于治疗异常组织的装置、系统和方法 |
| CA3140710A1 (en) | 2019-06-06 | 2020-12-10 | Leigh E. Colby | Ablation probe systems |
| US11950835B2 (en) | 2019-06-28 | 2024-04-09 | Virginia Tech Intellectual Properties, Inc. | Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy |
| EP3998973A4 (en) | 2019-07-16 | 2023-07-26 | Galvanize Therapeutics, Inc. | TREATMENT OF THE REPRODUCTIVE TRACT WITH PULSED ELECTRIC FIELDS |
| US12214189B2 (en) | 2019-07-24 | 2025-02-04 | Virginia Tech Intellectual Properties, Inc. | Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies |
| US10625080B1 (en) | 2019-09-17 | 2020-04-21 | Farapulse, Inc. | Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation |
| CN114945338A (zh) | 2019-10-15 | 2022-08-26 | 波士顿科学国际有限公司 | 用于消融系统的控制系统和用户界面 |
| CN114786605A (zh) | 2019-10-21 | 2022-07-22 | 英杜基奈克斯公司 | 用于十二指肠脉冲电场治疗的装置、系统和方法 |
| US11065047B2 (en) | 2019-11-20 | 2021-07-20 | Farapulse, Inc. | Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses |
| US11497541B2 (en) | 2019-11-20 | 2022-11-15 | Boston Scientific Scimed, Inc. | Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses |
| US10842572B1 (en) | 2019-11-25 | 2020-11-24 | Farapulse, Inc. | Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines |
| US12102374B2 (en) | 2019-12-03 | 2024-10-01 | Biosense Webster (Israel) Ltd. | Pulse generator for irreversible electroporation with switchable pulse application |
| US11540877B2 (en) | 2019-12-03 | 2023-01-03 | Biosense Webster (Israel) Ltd. | Pulse generator for irreversible electroporation |
| US11660135B2 (en) | 2019-12-05 | 2023-05-30 | Biosense Webster (Israel) Ltd. | Generating and interleaving of irreversible-electroporation and radiofrequnecy ablation (IRE/RFA) waveforms |
| US12042216B2 (en) | 2019-12-09 | 2024-07-23 | Biosense Webster (Israel) Ltd. | Irreversible-electroporation (IRE) balloon catheter with membrane-insulated high-voltage balloon wires |
| US11903638B2 (en) | 2019-12-11 | 2024-02-20 | Biosense Webster (Israel) Ltd. | Regulating delivery of irreversible electroporation pulses according to transferred energy |
| US11707320B2 (en) * | 2019-12-24 | 2023-07-25 | Biosense Webster (Israel) Ltd. | Irreversible electroporation (IRE) based on field, contact force and time |
| US11583332B2 (en) | 2019-12-24 | 2023-02-21 | Biosense Webster (Israel) Ltd. | Combined cardiac pacing and irreversible electroporation (IRE) treatment |
| US11992260B2 (en) | 2020-03-31 | 2024-05-28 | Boston Scientific Scimed, Inc. | Smart probe identification for ablation modalities |
| US11883091B2 (en) | 2020-04-09 | 2024-01-30 | Neurent Medical Limited | Systems and methods for improving sleep with therapeutic nasal treatment |
| WO2021205230A1 (en) | 2020-04-09 | 2021-10-14 | Neurent Medical Limited | Systems and methods for therapeutic nasal treatment |
| US12285206B2 (en) | 2020-06-01 | 2025-04-29 | Biosense Webster (Israel) Ltd. | Application of irreversible electroporation (IRE) ablation using catheter with electrode array |
| US11794004B2 (en) | 2020-06-10 | 2023-10-24 | Biosense Webster (Israel) Ltd. | Electroporation with cooling |
| US12349962B2 (en) | 2020-07-13 | 2025-07-08 | Biosense Webster (Israel) Ltd. | Sequential activation of electrode-pairs during irreversible electroporation (IRE) |
| US12310652B2 (en) | 2020-07-24 | 2025-05-27 | Boston Scientific Scimed, Inc. | Hybrid electroporation ablation catheter |
| JP7536995B2 (ja) | 2020-07-24 | 2024-08-20 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 不可逆電気穿孔によるシングル・ショット心臓アブレーションのための電界印加 |
| US11819265B2 (en) | 2020-07-28 | 2023-11-21 | Biosense Webster (Israel) Ltd. | Cautious irreversible-electroporation (IRE) protocol for avoiding bubble generation |
| US12426944B2 (en) | 2020-07-28 | 2025-09-30 | Biosense Webster (Israel) Ltd. | Automatically performing irreversible electroporation ablation during heart refractory period |
| US12076071B2 (en) | 2020-08-14 | 2024-09-03 | Kardium Inc. | Systems and methods for treating tissue with pulsed field ablation |
| US11532082B2 (en) | 2020-08-31 | 2022-12-20 | Biosense Webster (Israel) Ltd. | Real-time correction of anatomical maps |
| US12496123B2 (en) | 2020-09-08 | 2025-12-16 | Boston Scientific Scimed, Inc. | Contoured electrodes for pulsed electric field ablation, and systems, devices, and methods thereof |
| WO2022072385A2 (en) | 2020-09-30 | 2022-04-07 | Boston Scientific Scimed Inc | Pretreatment waveform for irreversible electroporation |
| US12290306B2 (en) | 2020-10-19 | 2025-05-06 | Biosense Webster (Israel) Ltd. | Using unipolar configuration for irreversible-electroporation (IRE) |
| EP4470491A3 (en) | 2020-10-26 | 2025-01-22 | TriAgenics, Inc. | Ablation probe systems |
| US12485279B2 (en) | 2020-11-25 | 2025-12-02 | Virginia Tech Intellectual Properties, Inc. | Methods for modulating temporal infrastructure of pulsed electric fields |
| US11911096B2 (en) | 2020-12-17 | 2024-02-27 | Biosense Webster (Israel) Ltd. | Detecting contact and proximity between ablation electrodes by sensing changes in voltage morphology of non-activated electrodes |
| EP4284276A1 (en) | 2021-01-27 | 2023-12-06 | Boston Scientific Scimed, Inc. | Voltage controlled pulse sequences for irreversible electroporation ablations |
| BR112023016320A2 (pt) | 2021-02-12 | 2023-11-14 | Rampart Health L L C | Composição terapêutica e método de combinação de imunoterapia multiplex com vacina contra câncer para tratamento de câncer |
| US12357817B2 (en) | 2021-04-06 | 2025-07-15 | Aerin Medical Inc. | Nasal neuromodulation devices and methods |
| KR102868326B1 (ko) | 2021-04-07 | 2025-10-13 | 비티엘 메디컬 디벨롭먼트 에이.에스. | 펄스 필드 절제 디바이스 및 방법 |
| US20220361944A1 (en) | 2021-05-17 | 2022-11-17 | Boston Scientific Scimed, Inc. | Energy Delivery System, Method and Device |
| HRP20250794T1 (hr) | 2021-07-06 | 2025-08-29 | Btl Medical Development A.S. | Uređaj za ablaciju pulsnim poljem |
| KR20240110882A (ko) | 2021-11-29 | 2024-07-16 | 보스톤 싸이엔티픽 싸이메드 인코포레이티드 | 생물학적 조직의 기하학적으로 제어된 열 절제를 위한 조정 가능한 전극을 가진 쌍극 니들 |
| US12514633B2 (en) | 2021-11-30 | 2026-01-06 | Medtronic Vascular, Inc. | Vessel modification using heat therapy |
| WO2023161796A1 (en) * | 2022-02-23 | 2023-08-31 | Cochlear Limited | Adaptive electroporation |
| CN119730804A (zh) | 2022-06-21 | 2025-03-28 | 阿尔普发医疗股份有限公司 | 用于肾去神经支配的设备和方法 |
| IT202200019635A1 (it) | 2022-09-23 | 2024-03-23 | Igea S P A | Dispositivo per l'elettroporazione migliorato |
| JP2025534208A (ja) | 2022-09-30 | 2025-10-15 | アルファ メディカル,インコーポレイテッド | 組織アブレーションのための装置及び方法 |
| CR20250188A (es) | 2022-10-05 | 2025-08-22 | Btl Medical Dev A S | Dispositivo y método de ablación de campo pulsado |
| US12484963B2 (en) | 2024-04-03 | 2025-12-02 | Field Medical, Inc. | Systems and methods for affecting a target tissue via a pulsed field |
Family Cites Families (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1653819A (en) | 1926-08-07 | 1927-12-27 | Northcott Ephraim | Electrotherapeutical apparatus |
| DE863111C (de) | 1951-07-03 | 1953-01-15 | Walter Hallegger | Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung |
| US4016886A (en) | 1974-11-26 | 1977-04-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for localizing heating in tumor tissue |
| US4407943A (en) | 1976-12-16 | 1983-10-04 | Millipore Corporation | Immobilized antibody or antigen for immunoassay |
| CH617590A5 (https=) | 1977-05-27 | 1980-06-13 | Carba Ag | |
| DE2800039C2 (de) | 1978-01-02 | 1984-06-20 | Horst Dr.Med. 6700 Ludwigshafen Kief | Akupunkturgerät |
| US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
| US5385544A (en) | 1992-08-12 | 1995-01-31 | Vidamed, Inc. | BPH ablation method and apparatus |
| GB8408529D0 (en) | 1984-04-03 | 1984-05-16 | Health Lab Service Board | Concentration of biological particles |
| US4946793A (en) | 1986-05-09 | 1990-08-07 | Electropore, Inc. | Impedance matching for instrumentation which electrically alters vesicle membranes |
| US5098843A (en) | 1987-06-04 | 1992-03-24 | Calvin Noel M | Apparatus for the high efficiency transformation of living cells |
| US5749847A (en) | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| DE68925030T2 (de) | 1988-01-21 | 1996-07-25 | Massachusetts Inst Technology | Molekültransport durch gewebe mit der verwendung von elektroporation. |
| EP0346513A1 (de) | 1988-06-15 | 1989-12-20 | Etama Ag | Anordnung zur Elektrotherapie |
| ES2012944A6 (es) | 1989-01-09 | 1990-04-16 | Tomas Justribo Jose Ramon | Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales. |
| CS275292B2 (en) | 1989-02-22 | 1992-02-19 | Cvut Fakulta Elektrotechnick | Private rehabilitation apparatus with ion transcutaneous acceleration |
| DE4000893A1 (de) | 1990-01-15 | 1991-07-18 | Bosch Gmbh Robert | Mehrkanaliges geraet zur elektrostimulation |
| US5134070A (en) | 1990-06-04 | 1992-07-28 | Casnig Dael R | Method and device for cell cultivation on electrodes |
| US5193537A (en) | 1990-06-12 | 1993-03-16 | Zmd Corporation | Method and apparatus for transcutaneous electrical cardiac pacing |
| US5052391A (en) | 1990-10-22 | 1991-10-01 | R.F.P., Inc. | High frequency high intensity transcutaneous electrical nerve stimulator and method of treatment |
| US5990095A (en) | 1991-07-03 | 1999-11-23 | Hyal Pharmaceutical Corporation | Use of hyaluronic acid and forms to prevent arterial restenosis |
| US5173158A (en) | 1991-07-22 | 1992-12-22 | Schmukler Robert E | Apparatus and methods for electroporation and electrofusion |
| US5328451A (en) | 1991-08-15 | 1994-07-12 | Board Of Regents, The University Of Texas System | Iontophoretic device and method for killing bacteria and other microbes |
| US5425752A (en) | 1991-11-25 | 1995-06-20 | Vu'nguyen; Dung D. | Method of direct electrical myostimulation using acupuncture needles |
| US6500173B2 (en) * | 1992-01-07 | 2002-12-31 | Ronald A. Underwood | Methods for electrosurgical spine surgery |
| US6210402B1 (en) | 1995-11-22 | 2001-04-03 | Arthrocare Corporation | Methods for electrosurgical dermatological treatment |
| US6132419A (en) | 1992-05-22 | 2000-10-17 | Genetronics, Inc. | Electroporetic gene and drug therapy |
| US5318563A (en) | 1992-06-04 | 1994-06-07 | Valley Forge Scientific Corporation | Bipolar RF generator |
| US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5634899A (en) | 1993-08-20 | 1997-06-03 | Cortrak Medical, Inc. | Simultaneous cardiac pacing and local drug delivery method |
| US5807306A (en) | 1992-11-09 | 1998-09-15 | Cortrak Medical, Inc. | Polymer matrix drug delivery apparatus |
| GB9226376D0 (en) | 1992-12-18 | 1993-02-10 | British Tech Group | Tomography |
| JPH08506259A (ja) | 1993-02-02 | 1996-07-09 | ヴィーダメッド インコーポレイテッド | 経尿道ニードル切除装置および方法 |
| US5792187A (en) | 1993-02-22 | 1998-08-11 | Angeion Corporation | Neuro-stimulation to control pain during cardioversion defibrillation |
| US5403311A (en) | 1993-03-29 | 1995-04-04 | Boston Scientific Corporation | Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue |
| FR2703253B1 (fr) | 1993-03-30 | 1995-06-23 | Centre Nat Rech Scient | Applicateur d'impulsions electriques pour traitement de tissus biologiques. |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US6832996B2 (en) | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
| US5464437A (en) | 1993-07-08 | 1995-11-07 | Urologix, Inc. | Benign prostatic hyperplasia treatment catheter with urethral cooling |
| US5533999A (en) | 1993-08-23 | 1996-07-09 | Refractec, Inc. | Method and apparatus for modifications of visual acuity by thermal means |
| JP3054319B2 (ja) * | 1994-03-04 | 2000-06-19 | 矢崎総業株式会社 | 防水ゴム栓およびその製造方法 |
| US5458625A (en) | 1994-05-04 | 1995-10-17 | Kendall; Donald E. | Transcutaneous nerve stimulation device and method for using same |
| US5836905A (en) | 1994-06-20 | 1998-11-17 | Lemelson; Jerome H. | Apparatus and methods for gene therapy |
| DE59602545D1 (de) | 1995-01-17 | 1999-09-02 | Hehrlein | Ballon-katheter zur verhinderung der re-stenose nach angioplastie, und verfahren zum herstellen eines ballon-katheters |
| US5720921A (en) | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
| US5810762A (en) | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US6607529B1 (en) | 1995-06-19 | 2003-08-19 | Medtronic Vidamed, Inc. | Electrosurgical device |
| US5919142A (en) | 1995-06-22 | 1999-07-06 | Btg International Limited | Electrical impedance tomography method and apparatus |
| US5983131A (en) | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| EP0776678A1 (en) | 1995-11-30 | 1997-06-04 | Hewlett-Packard Company | System for administering transcutaneous cardiac pacing with transcutaneous electrical nerve stimuli |
| US6010613A (en) * | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| US5718246A (en) * | 1996-01-03 | 1998-02-17 | Preferential, Inc. | Preferential induction of electrically mediated cell death from applied pulses |
| US6090106A (en) | 1996-01-09 | 2000-07-18 | Gyrus Medical Limited | Electrosurgical instrument |
| US6016452A (en) | 1996-03-19 | 2000-01-18 | Kasevich; Raymond S. | Dynamic heating method and radio frequency thermal treatment |
| US5778894A (en) | 1996-04-18 | 1998-07-14 | Elizabeth Arden Co. | Method for reducing human body cellulite by treatment with pulsed electromagnetic energy |
| SE509241C2 (sv) | 1996-07-18 | 1998-12-21 | Radinvent Ab | Anordningar för elektrodynamisk strålterapi av tumörsjukdomar |
| US6102885A (en) | 1996-08-08 | 2000-08-15 | Bass; Lawrence S. | Device for suction-assisted lipectomy and method of using same |
| US6106521A (en) | 1996-08-16 | 2000-08-22 | United States Surgical Corporation | Apparatus for thermal treatment of tissue |
| US5991697A (en) | 1996-12-31 | 1999-11-23 | The Regents Of The University Of California | Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media |
| US6109270A (en) | 1997-02-04 | 2000-08-29 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Multimodality instrument for tissue characterization |
| JPH10243947A (ja) * | 1997-03-04 | 1998-09-14 | Olympus Optical Co Ltd | 高周波装置 |
| US5873849A (en) * | 1997-04-24 | 1999-02-23 | Ichor Medical Systems, Inc. | Electrodes and electrode arrays for generating electroporation inducing electrical fields |
| US6085115A (en) | 1997-05-22 | 2000-07-04 | Massachusetts Institite Of Technology | Biopotential measurement including electroporation of tissue surface |
| US5978704A (en) | 1997-06-03 | 1999-11-02 | Uab Research Foundation | Method and apparatus for treating cardiac arrhythmia |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| EP1003847A4 (en) | 1997-09-04 | 2005-04-06 | Science Res Lab Inc | SEPARATION OF CELLS BY USE OF ELECTRIC FIELDS |
| US5999847A (en) | 1997-10-21 | 1999-12-07 | Elstrom; John A. | Apparatus and method for delivery of surgical and therapeutic agents |
| AU1114699A (en) | 1997-10-24 | 1999-05-17 | Children's Medical Center Corporation | Methods for promoting cell transfection (in vivo) |
| US6009347A (en) | 1998-01-27 | 1999-12-28 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6208893B1 (en) * | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
| US6440127B2 (en) | 1998-02-11 | 2002-08-27 | Cosman Company, Inc. | Method for performing intraurethral radio-frequency urethral enlargement |
| US6122599A (en) | 1998-02-13 | 2000-09-19 | Mehta; Shailesh | Apparatus and method for analyzing particles |
| SE513814C2 (sv) | 1998-03-31 | 2000-11-06 | Aditus Medical Ab | Anordning för behandling av sjukdomar med elektriska fält |
| US6219577B1 (en) | 1998-04-14 | 2001-04-17 | Global Vascular Concepts, Inc. | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| US6159163A (en) | 1998-05-07 | 2000-12-12 | Cedars-Sinai Medical Center | System for attenuating pain during bone marrow aspiration and method |
| AU3973599A (en) | 1998-05-08 | 1999-11-29 | Genetronics, Inc. | Electrically induced vessel vasodilation |
| US6697669B2 (en) | 1998-07-13 | 2004-02-24 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US6212433B1 (en) | 1998-07-28 | 2001-04-03 | Radiotherapeutics Corporation | Method for treating tumors near the surface of an organ |
| CA2346055C (en) | 1998-09-30 | 2004-06-29 | Animas Technologies Llc | Method and device for predicting physiological values |
| JP2002526103A (ja) | 1998-10-08 | 2002-08-20 | アストラゼネカ・アクチエボラーグ | 微細組み立てセル注入器 |
| US6611706B2 (en) | 1998-11-09 | 2003-08-26 | Transpharma Ltd. | Monopolar and bipolar current application for transdermal drug delivery and analyte extraction |
| DE69924750T2 (de) | 1998-11-16 | 2006-03-02 | United States Surgical Corp., Norwalk | Gerät zur thermischen behandlung von gewebe |
| US6090016A (en) * | 1998-11-18 | 2000-07-18 | Kuo; Hai Pin | Collapsible treader with enhanced stability |
| US6351674B2 (en) | 1998-11-23 | 2002-02-26 | Synaptic Corporation | Method for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation |
| US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
| US6261831B1 (en) | 1999-03-26 | 2001-07-17 | The United States Of America As Represented By The Secretary Of The Air Force | Ultra-wide band RF-enhanced chemotherapy for cancer treatmeat |
| US6738663B2 (en) | 1999-04-09 | 2004-05-18 | Oncostim, A Minnesota Corporation | Implantable device and method for the electrical treatment of cancer |
| US6627421B1 (en) | 1999-04-13 | 2003-09-30 | Imarx Therapeutics, Inc. | Methods and systems for applying multi-mode energy to biological samples |
| US7053063B2 (en) | 1999-07-21 | 2006-05-30 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes in tissue |
| US6300108B1 (en) | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6387671B1 (en) | 1999-07-21 | 2002-05-14 | The Regents Of The University Of California | Electrical impedance tomography to control electroporation |
| US6403348B1 (en) | 1999-07-21 | 2002-06-11 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6927049B2 (en) | 1999-07-21 | 2005-08-09 | The Regents Of The University Of California | Cell viability detection using electrical measurements |
| US20020010491A1 (en) | 1999-08-04 | 2002-01-24 | Schoenbach Karl H. | Method and apparatus for intracellular electro-manipulation |
| US6326177B1 (en) * | 1999-08-04 | 2001-12-04 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Method and apparatus for intracellular electro-manipulation |
| US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
| US6613211B1 (en) | 1999-08-27 | 2003-09-02 | Aclara Biosciences, Inc. | Capillary electrokinesis based cellular assays |
| JP4676042B2 (ja) * | 1999-10-01 | 2011-04-27 | 帝國製薬株式会社 | フェルビナク含有鎮痛・消炎外用貼付剤 |
| US6493592B1 (en) | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
| IT1320186B1 (it) | 2000-04-21 | 2003-11-26 | Igea Srl | Dispositivo e metodo di elettro-porazione in cui l'ampiezzadell'impulso o degli impulsi viene stabilita in modo automatico in |
| US20010044596A1 (en) * | 2000-05-10 | 2001-11-22 | Ali Jaafar | Apparatus and method for treatment of vascular restenosis by electroporation |
| US7141034B2 (en) | 2000-06-08 | 2006-11-28 | Altea Therapeutics Corporation | Transdermal drug delivery device, method of making same and method of using same |
| KR100375657B1 (ko) | 2000-06-21 | 2003-03-15 | 주식회사 몸앤맘 | 체지방 제거장치 및 방법 |
| US6669691B1 (en) | 2000-07-18 | 2003-12-30 | Scimed Life Systems, Inc. | Epicardial myocardial revascularization and denervation methods and apparatus |
| AU2001279026B2 (en) | 2000-07-25 | 2005-12-22 | Angiodynamics, Inc. | Apparatus for detecting and treating tumors using localized impedance measurement |
| US6697670B2 (en) | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6795728B2 (en) * | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US6892099B2 (en) * | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US6702808B1 (en) | 2000-09-28 | 2004-03-09 | Syneron Medical Ltd. | Device and method for treating skin |
| US20020133324A1 (en) * | 2000-11-03 | 2002-09-19 | Weaver James C. | Functional simulation method |
| US20050043726A1 (en) | 2001-03-07 | 2005-02-24 | Mchale Anthony Patrick | Device II |
| US20020177847A1 (en) * | 2001-03-30 | 2002-11-28 | Long Gary L. | Endoscopic ablation system with flexible coupling |
| CA2443968A1 (en) | 2001-04-12 | 2002-10-24 | Imperial College Innovations Limited | Diagnosis and treatment of cancer: i |
| WO2002087692A1 (en) | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | A method and apparatus for the treatment of cosmetic skin conditioins |
| EP1385439A1 (en) * | 2001-05-10 | 2004-02-04 | Rita Medical Systems, Inc. | Rf tissue ablation apparatus and method |
| JP2002360712A (ja) * | 2001-06-06 | 2002-12-17 | Komatsu Powertron Kk | 生体用誘導加熱方法及びその装置 |
| US7127284B2 (en) * | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
| US6832111B2 (en) | 2001-07-06 | 2004-12-14 | Hosheng Tu | Device for tumor diagnosis and methods thereof |
| US7130697B2 (en) | 2002-08-13 | 2006-10-31 | Minnesota Medical Physics Llc | Apparatus and method for the treatment of benign prostatic hyperplasia |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| DE60210111T2 (de) * | 2001-09-28 | 2007-03-29 | Rita Medical Systems, Inc., Mountain View | Impedanzgesteuerte vorrichtung zur ablation von gewebe |
| US20040243107A1 (en) | 2001-10-01 | 2004-12-02 | Macoviak John A | Methods and devices for treating atrial fibrilation |
| FR2830767B1 (fr) | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire |
| CN1606461B (zh) | 2001-10-24 | 2011-03-23 | 纸型电池有限公司 | 一种用制剂作皮肤治疗的装置、一种成套器具及皮肤贴片 |
| US6807444B2 (en) | 2001-11-05 | 2004-10-19 | Hosheng Tu | Apparatus and methods for monitoring tissue impedance |
| US20030170898A1 (en) | 2001-12-04 | 2003-09-11 | Gundersen Martin A. | Method for intracellular modifications within living cells using pulsed electric fields |
| US6912417B1 (en) | 2002-04-05 | 2005-06-28 | Ichor Medical Systmes, Inc. | Method and apparatus for delivery of therapeutic agents |
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US8150520B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods for catheter-based renal denervation |
| US6780178B2 (en) | 2002-05-03 | 2004-08-24 | The Board Of Trustees Of The Leland Stanford Junior University | Method and apparatus for plasma-mediated thermo-electrical ablation |
| US6801804B2 (en) | 2002-05-03 | 2004-10-05 | Aciont, Inc. | Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis |
| EP1501435B1 (en) * | 2002-05-06 | 2007-08-29 | Covidien AG | Blood detector for controlling an esu |
| AU2003299471A1 (en) | 2002-05-07 | 2004-05-13 | Kai Kroll | Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy |
| AU2003227960B2 (en) * | 2002-05-23 | 2008-10-30 | Gendel Limited | Ablation device |
| US7063698B2 (en) | 2002-06-14 | 2006-06-20 | Ncontact Surgical, Inc. | Vacuum coagulation probes |
| US6972014B2 (en) | 2003-01-04 | 2005-12-06 | Endocare, Inc. | Open system heat exchange catheters and methods of use |
| US7211083B2 (en) | 2003-03-17 | 2007-05-01 | Minnesota Medical Physics, Llc | Apparatus and method for hair removal by electroporation |
| EP1696812B1 (en) | 2003-12-24 | 2015-07-22 | The Regents of The University of California | Tissue ablation with irreversible electroporation |
| US20050261672A1 (en) | 2004-05-18 | 2005-11-24 | Mark Deem | Systems and methods for selective denervation of heart dysrhythmias |
| US7261710B2 (en) | 2004-10-13 | 2007-08-28 | Medtronic, Inc. | Transurethral needle ablation system |
| US20060264752A1 (en) | 2005-04-27 | 2006-11-23 | The Regents Of The University Of California | Electroporation controlled with real time imaging |
| US8114070B2 (en) * | 2005-06-24 | 2012-02-14 | Angiodynamics, Inc. | Methods and systems for treating BPH using electroporation |
| US20060293730A1 (en) | 2005-06-24 | 2006-12-28 | Boris Rubinsky | Methods and systems for treating restenosis sites using electroporation |
| US20070156135A1 (en) * | 2006-01-03 | 2007-07-05 | Boris Rubinsky | System and methods for treating atrial fibrillation using electroporation |
| US20080052786A1 (en) | 2006-08-24 | 2008-02-28 | Pei-Cheng Lin | Animal Model of Prostate Cancer and Use Thereof |
| JP5457183B2 (ja) * | 2006-09-14 | 2014-04-02 | ラジュール・テクノロジーズ・エルエルシイ | 癌細胞を破壊する装置及び方法 |
| US7655004B2 (en) * | 2007-02-15 | 2010-02-02 | Ethicon Endo-Surgery, Inc. | Electroporation ablation apparatus, system, and method |
| US20090248012A1 (en) * | 2008-03-27 | 2009-10-01 | The Regents Of The University Of California | Irreversible electroporation device and method for attenuating neointimal |
| US10702326B2 (en) * | 2011-07-15 | 2020-07-07 | Virginia Tech Intellectual Properties, Inc. | Device and method for electroporation based treatment of stenosis of a tubular body part |
-
2004
- 2004-12-21 EP EP04815540.2A patent/EP1696812B1/en not_active Expired - Lifetime
- 2004-12-21 AU AU2004311842A patent/AU2004311842C1/en not_active Expired
- 2004-12-21 DK DK04815540.2T patent/DK1696812T3/en active
- 2004-12-21 US US11/022,310 patent/US20050171574A1/en not_active Abandoned
- 2004-12-21 ES ES12002108T patent/ES2729378T3/es not_active Expired - Lifetime
- 2004-12-21 WO PCT/US2004/043477 patent/WO2005065284A2/en not_active Ceased
- 2004-12-21 PL PL04815540T patent/PL1696812T3/pl unknown
- 2004-12-21 ES ES04815540.2T patent/ES2543832T3/es not_active Expired - Lifetime
- 2004-12-21 US US11/022,309 patent/US20050171523A1/en not_active Abandoned
- 2004-12-21 CA CA2550846A patent/CA2550846C/en not_active Expired - Lifetime
- 2004-12-21 JP JP2006547425A patent/JP5138229B2/ja not_active Expired - Lifetime
- 2004-12-21 EP EP12002108.4A patent/EP2474281B1/en not_active Expired - Lifetime
- 2004-12-21 US US10/571,162 patent/US8048067B2/en active Active
-
2008
- 2008-06-27 US US12/163,727 patent/US20080269586A1/en not_active Abandoned
-
2010
- 2010-09-01 AU AU2010214761A patent/AU2010214761B2/en not_active Expired
-
2011
- 2011-09-20 US US13/237,199 patent/US8282631B2/en not_active Expired - Lifetime
-
2012
- 2012-07-11 US US13/546,339 patent/US9005189B2/en not_active Expired - Lifetime
- 2012-09-26 JP JP2012211929A patent/JP5766163B2/ja not_active Expired - Lifetime
-
2015
- 2015-03-05 US US14/639,632 patent/US10117701B2/en active Active
-
2018
- 2018-10-15 US US16/160,205 patent/US11033321B2/en not_active Expired - Lifetime
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