PL1696812T3 - Ablacja tkanki nieodwracalną elektroporacją - Google Patents

Ablacja tkanki nieodwracalną elektroporacją

Info

Publication number
PL1696812T3
PL1696812T3 PL04815540T PL04815540T PL1696812T3 PL 1696812 T3 PL1696812 T3 PL 1696812T3 PL 04815540 T PL04815540 T PL 04815540T PL 04815540 T PL04815540 T PL 04815540T PL 1696812 T3 PL1696812 T3 PL 1696812T3
Authority
PL
Poland
Prior art keywords
tissue ablation
irreversible electroporation
electroporation
irreversible
ablation
Prior art date
Application number
PL04815540T
Other languages
English (en)
Inventor
Rafael Davalos
Boris Rubinsky
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of PL1696812T3 publication Critical patent/PL1696812T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B18/1233—Generators therefor with circuits for assuring patient safety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1477—Needle-like probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00714—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00761—Duration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00827—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
PL04815540T 2003-12-24 2004-12-21 Ablacja tkanki nieodwracalną elektroporacją PL1696812T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53258803P 2003-12-24 2003-12-24
PCT/US2004/043477 WO2005065284A2 (en) 2003-12-24 2004-12-21 Tissue ablation with irreversible electroporation
EP04815540.2A EP1696812B1 (en) 2003-12-24 2004-12-21 Tissue ablation with irreversible electroporation

Publications (1)

Publication Number Publication Date
PL1696812T3 true PL1696812T3 (pl) 2015-12-31

Family

ID=34748811

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04815540T PL1696812T3 (pl) 2003-12-24 2004-12-21 Ablacja tkanki nieodwracalną elektroporacją

Country Status (9)

Country Link
US (8) US20050171574A1 (pl)
EP (2) EP1696812B1 (pl)
JP (2) JP5138229B2 (pl)
AU (2) AU2004311842C1 (pl)
CA (1) CA2550846C (pl)
DK (1) DK1696812T3 (pl)
ES (2) ES2543832T3 (pl)
PL (1) PL1696812T3 (pl)
WO (1) WO2005065284A2 (pl)

Families Citing this family (343)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355425B1 (en) * 1999-03-26 2002-03-12 Billups-Rothenberg, Inc. Mutations associated with iron disorders
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US8251986B2 (en) * 2000-08-17 2012-08-28 Angiodynamics, Inc. Method of destroying tissue cells by eletroporation
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6697670B2 (en) 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US7130697B2 (en) * 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
USRE42016E1 (en) 2001-08-13 2010-12-28 Angiodynamics, Inc. Apparatus and method for the treatment of benign prostatic hyperplasia
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20050171574A1 (en) * 2003-12-24 2005-08-04 The Regents Of The University Of California Electroporation to interrupt blood flow
US8298222B2 (en) * 2003-12-24 2012-10-30 The Regents Of The University Of California Electroporation to deliver chemotherapeutics and enhance tumor regression
JP4443278B2 (ja) * 2004-03-26 2010-03-31 テルモ株式会社 拡張体付カテーテル
US9277955B2 (en) 2010-04-09 2016-03-08 Vessix Vascular, Inc. Power generating and control apparatus for the treatment of tissue
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US7601149B2 (en) 2005-03-07 2009-10-13 Boston Scientific Scimed, Inc. Apparatus for switching nominal and attenuated power between ablation probes
US20060264752A1 (en) * 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US20060293731A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating tumors using electroporation
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
WO2007004831A1 (en) * 2005-06-30 2007-01-11 Lg Electronics Inc. Method and apparatus for encoding and decoding an audio signal
US12433837B2 (en) 2005-07-22 2025-10-07 The Foundry, Llc Systems and methods for delivery of a therapeutic agent
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
CN101389280B (zh) * 2006-01-03 2011-02-16 爱尔康公司 用于离解和去除蛋白质组织的系统
US9168373B2 (en) * 2006-02-24 2015-10-27 Eastern Virginia Medical School Nanosecond pulsed electric fields cause melanomas to self-destruct
US8109926B2 (en) * 2006-09-14 2012-02-07 Lazure Scientific, Inc. Ablation probe with deployable electrodes
JP2010506657A (ja) 2006-10-16 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 組織の不可逆的エレクトロポレーションに使用される、所定の導電率を有するゲル
US20080132884A1 (en) * 2006-12-01 2008-06-05 Boris Rubinsky Systems for treating tissue sites using electroporation
DE602007006342D1 (de) * 2006-12-08 2010-06-17 Philips Intellectual Property System, verfahren und computerlesbares medium sowie verwendung zur programmierung einer kombinationstherapie
US7655004B2 (en) * 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US20080200911A1 (en) * 2007-02-15 2008-08-21 Long Gary L Electrical ablation apparatus, system, and method
US20080200762A1 (en) * 2007-02-16 2008-08-21 Stokes Michael J Flexible endoscope shapelock
US7815662B2 (en) 2007-03-08 2010-10-19 Ethicon Endo-Surgery, Inc. Surgical suture anchors and deployment device
DE602008002247D1 (de) * 2007-03-29 2010-09-30 Novozymes As Verfahren zur behandlung von pflanzlichem material mit einem enzym
US8075572B2 (en) 2007-04-26 2011-12-13 Ethicon Endo-Surgery, Inc. Surgical suturing apparatus
US8100922B2 (en) 2007-04-27 2012-01-24 Ethicon Endo-Surgery, Inc. Curved needle suturing tool
US8216217B2 (en) 2007-08-23 2012-07-10 Aegea Medical, Inc. Uterine therapy device and method
EP2170198B1 (en) 2007-07-06 2015-04-15 Tsunami Medtech, LLC Medical system
US20090054728A1 (en) * 2007-08-21 2009-02-26 Trusty Robert M Manipulatable guide system and methods for natural orifice translumenal endoscopic surgery
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US8579897B2 (en) 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8673623B2 (en) * 2007-08-31 2014-03-18 Board Of Regents, The University Of Texas System Apparatus for performing magnetic electroporation
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
US20160184006A1 (en) * 2007-09-14 2016-06-30 Lazure Scientific, Inc. Ablation probe with deployable electrodes
US20090076500A1 (en) * 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-tine probe and treatment by activation of opposing tines
WO2009036457A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Multi-layer electrode ablation probe and related methods
WO2009036468A1 (en) 2007-09-14 2009-03-19 Lazure Technologies, Llc Transurethral systems and methods for ablation treatment of prostate tissue
US20090087900A1 (en) * 2007-09-28 2009-04-02 Kent Davey Apparatus for Performing Electrodistention on Algae Cells
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
US8480657B2 (en) 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US9707403B2 (en) 2007-12-12 2017-07-18 Neuro Code Tech Holdings, Llc Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics
US20090177219A1 (en) * 2008-01-03 2009-07-09 Conlon Sean P Flexible tissue-penetration instrument with blunt tip assembly and methods for penetrating tissue
WO2009089517A1 (en) 2008-01-10 2009-07-16 The Neuro-Signaling Foundation Method and system for processing cancer cell electrical signals for medical therapy
US8262680B2 (en) 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US20090247933A1 (en) * 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US20100004623A1 (en) * 2008-03-27 2010-01-07 Angiodynamics, Inc. Method for Treatment of Complications Associated with Arteriovenous Grafts and Fistulas Using Electroporation
EP2265326A4 (en) * 2008-04-17 2011-06-22 Neuro Signaling Foundation SYSTEM AND METHOD FOR TRIGGERING APOPTOSIS IN MALIGNANT TUMOR CELLS FOR MEDICAL TREATMENT
US10117707B2 (en) * 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US8992517B2 (en) * 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US20090281559A1 (en) * 2008-05-06 2009-11-12 Ethicon Endo-Surgery, Inc. Anastomosis patch
WO2009137609A2 (en) 2008-05-06 2009-11-12 Cellutions, Inc. Apparatus and systems for treating a human tissue condition
US20090281477A1 (en) 2008-05-09 2009-11-12 Angiodynamics, Inc. Electroporation device and method
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8114072B2 (en) 2008-05-30 2012-02-14 Ethicon Endo-Surgery, Inc. Electrical ablation device
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8070759B2 (en) 2008-05-30 2011-12-06 Ethicon Endo-Surgery, Inc. Surgical fastening device
US8652150B2 (en) * 2008-05-30 2014-02-18 Ethicon Endo-Surgery, Inc. Multifunction surgical device
US8317806B2 (en) 2008-05-30 2012-11-27 Ethicon Endo-Surgery, Inc. Endoscopic suturing tension controlling and indication devices
US8906035B2 (en) 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US9173704B2 (en) * 2008-06-20 2015-11-03 Angiodynamics, Inc. Device and method for the ablation of fibrin sheath formation on a venous catheter
WO2010008834A2 (en) * 2008-06-23 2010-01-21 Angiodynamics, Inc. Treatment devices and methods
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US20100010294A1 (en) * 2008-07-10 2010-01-14 Ethicon Endo-Surgery, Inc. Temporarily positionable medical devices
US20100010298A1 (en) * 2008-07-14 2010-01-14 Ethicon Endo-Surgery, Inc. Endoscopic translumenal flexible overtube
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8221411B2 (en) * 2008-07-28 2012-07-17 Medtronic, Inc. Systems and methods for cardiac tissue electroporation ablation
US8211125B2 (en) 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US8529563B2 (en) 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US20100056862A1 (en) * 2008-09-03 2010-03-04 Ethicon Endo-Surgery, Inc. Access needle for natural orifice translumenal endoscopic surgery
US8114119B2 (en) 2008-09-09 2012-02-14 Ethicon Endo-Surgery, Inc. Surgical grasping device
US20100100093A1 (en) * 2008-09-16 2010-04-22 Lazure Technologies, Llc. System and method for controlled tissue heating for destruction of cancerous cells
AU2009298436A1 (en) * 2008-10-01 2010-04-08 Chad Steelberg On-site barcode advertising
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
US8172772B2 (en) 2008-12-11 2012-05-08 Ethicon Endo-Surgery, Inc. Specimen retrieval device
US20100152725A1 (en) * 2008-12-12 2010-06-17 Angiodynamics, Inc. Method and system for tissue treatment utilizing irreversible electroporation and thermal track coagulation
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
US8361066B2 (en) * 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8828031B2 (en) 2009-01-12 2014-09-09 Ethicon Endo-Surgery, Inc. Apparatus for forming an anastomosis
WO2010085765A2 (en) * 2009-01-23 2010-07-29 Moshe Meir H Therapeutic energy delivery device with rotational mechanism
US9226772B2 (en) 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
US8037591B2 (en) 2009-02-02 2011-10-18 Ethicon Endo-Surgery, Inc. Surgical scissors
US20100198248A1 (en) * 2009-02-02 2010-08-05 Ethicon Endo-Surgery, Inc. Surgical dissector
US11284931B2 (en) 2009-02-03 2022-03-29 Tsunami Medtech, Llc Medical systems and methods for ablating and absorbing tissue
US8231603B2 (en) * 2009-02-10 2012-07-31 Angiodynamics, Inc. Irreversible electroporation and tissue regeneration
US20110004096A1 (en) * 2009-07-06 2011-01-06 California Institute Of Technology Electromagnetic cellular tomography
US9599591B2 (en) 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
US20100240995A1 (en) * 2009-03-17 2010-09-23 Bioelectromed Corp. System and method for treating tumors
US20100249700A1 (en) * 2009-03-27 2010-09-30 Ethicon Endo-Surgery, Inc. Surgical instruments for in vivo assembly
JP2012521863A (ja) * 2009-03-31 2012-09-20 アンジオダイナミツクス・インコーポレイテツド 治療装置の治療領域推定およびインタラクティブな患者治療計画のためのシステムおよび方法
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
WO2010118387A1 (en) * 2009-04-09 2010-10-14 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US8728139B2 (en) 2009-04-16 2014-05-20 Lazure Technologies, Llc System and method for energy delivery to a tissue using an electrode array
IT1394143B1 (it) * 2009-05-04 2012-05-25 Igea S P A Dispositivo per elettroporazione reversibile atto ad indurre apoptosi cellulare
USD630321S1 (en) 2009-05-08 2011-01-04 Angio Dynamics, Inc. Probe handle
US12514679B2 (en) 2009-05-11 2026-01-06 TriAgenics, Inc. Therapeutic tooth bud ablation
US10022202B2 (en) 2013-03-15 2018-07-17 Triagenics, Llc Therapeutic tooth bud ablation
WO2014143014A1 (en) 2013-03-15 2014-09-18 Triagenics, Llc Therapeutic tooth bud ablation
EP4338701B1 (en) 2009-05-11 2025-11-19 TriAgenics, Inc. Method of volume scanning
US8903488B2 (en) * 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2011028937A1 (en) * 2009-09-04 2011-03-10 The Regents Of The University Of California Extracellular matrix material created using non-thermal irreversible electroporation
US20110065161A1 (en) * 2009-09-14 2011-03-17 Board Of Regents, The University Of Texas System Bipolar solid state marx generator
US9750563B2 (en) 2009-09-22 2017-09-05 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US10386990B2 (en) 2009-09-22 2019-08-20 Mederi Rf, Llc Systems and methods for treating tissue with radiofrequency energy
US9474565B2 (en) 2009-09-22 2016-10-25 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US9775664B2 (en) 2009-09-22 2017-10-03 Mederi Therapeutics, Inc. Systems and methods for treating tissue with radiofrequency energy
US20110093009A1 (en) * 2009-10-16 2011-04-21 Ethicon Endo-Surgery, Inc. Otomy closure device
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8608652B2 (en) 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US20110118729A1 (en) * 2009-11-13 2011-05-19 Alcon Research, Ltd High-intensity pulsed electric field vitrectomy apparatus with load detection
US20110118734A1 (en) * 2009-11-16 2011-05-19 Alcon Research, Ltd. Capsularhexis device using pulsed electric fields
US20110118732A1 (en) * 2009-11-19 2011-05-19 The Regents Of The University Of California Controlled irreversible electroporation
US20110135626A1 (en) * 2009-12-08 2011-06-09 Alcon Research, Ltd. Localized Chemical Lysis of Ocular Tissue
US20110144562A1 (en) * 2009-12-14 2011-06-16 Alcon Research, Ltd. Localized Pharmacological Treatment of Ocular Tissue Using High-Intensity Pulsed Electrical Fields
WO2011081897A1 (en) * 2009-12-15 2011-07-07 Alcon Research, Ltd. High-intensity pulsed electric field vitrectomy apparatus
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US8353487B2 (en) 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9005198B2 (en) 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US20110202052A1 (en) * 2010-02-12 2011-08-18 Daniel Gelbart System for treating benign prostatic hyperplasia
GB201006841D0 (en) * 2010-04-26 2010-06-09 Thomsen Lars Method, device and system for targetted cell lysis
US9526911B1 (en) 2010-04-27 2016-12-27 Lazure Scientific, Inc. Immune mediated cancer cell destruction, systems and methods
US8546979B2 (en) 2010-08-11 2013-10-01 Alcon Research, Ltd. Self-matching pulse generator with adjustable pulse width and pulse frequency
US9943353B2 (en) 2013-03-15 2018-04-17 Tsunami Medtech, Llc Medical system and method of use
US8652130B2 (en) * 2010-08-18 2014-02-18 Invasix Ltd. Method and device for soft tissue ablation
EP2627274B1 (en) 2010-10-13 2022-12-14 AngioDynamics, Inc. System for electrically ablating tissue of a patient
CN103313671B (zh) 2010-10-25 2017-06-06 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
US9743974B2 (en) 2010-11-09 2017-08-29 Aegea Medical Inc. Positioning method and apparatus for delivering vapor to the uterus
JP2014501574A (ja) * 2010-11-23 2014-01-23 ヴァージニア テック インテレクチュアル プロパティーズ，インコーポレーテッド 異常な細胞集団を治療するか、組織スキャフォールドを生成するために組織の脈管構造を用いる不可逆的電気穿孔
EP2651505A4 (en) 2010-12-15 2014-06-11 Old Dominion Univ Res Found ELECTROPORATION-INDUCED ELECTROSENSIBILIZATION
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
US20240050143A1 (en) 2011-06-14 2024-02-15 Aerin Medical Inc. Methods and devices to treat nasal airways
US11304746B2 (en) 2011-06-14 2022-04-19 Aerin Medical Inc. Method of treating airway tissue to reduce mucus secretion
EP4233755A3 (en) 2011-06-14 2023-10-25 Aerin Medical, Inc. Device for treating nasal airways
US10314594B2 (en) 2012-12-14 2019-06-11 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US10813630B2 (en) 2011-08-09 2020-10-27 Corquest Medical, Inc. Closure system for atrial wall
US10307167B2 (en) 2012-12-14 2019-06-04 Corquest Medical, Inc. Assembly and method for left atrial appendage occlusion
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9662060B2 (en) 2011-10-07 2017-05-30 Aegea Medical Inc. Integrity testing method and apparatus for delivering vapor to the uterus
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
US9750568B2 (en) 2012-03-08 2017-09-05 Medtronic Ardian Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
JP6195856B2 (ja) 2012-03-08 2017-09-13 メドトロニック アーディアン ルクセンブルク ソシエテ ア レスポンサビリテ リミテ 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法
EP2847367B1 (en) * 2012-05-07 2017-03-29 The University of Ottawa Fabrication of nanopores using high electric fields
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
CA3158197A1 (en) 2012-05-29 2013-12-05 Autonomix Medical, Inc. Endoscopic sympathectomy systems and methods
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
CA2881462C (en) 2012-08-09 2020-07-14 University Of Iowa Research Foundation Catheters, catheter systems, and methods for puncturing through a tissue structure
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
US9113911B2 (en) * 2012-09-06 2015-08-25 Medtronic Ablation Frontiers Llc Ablation device and method for electroporating tissue cells
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
US10080907B1 (en) 2012-10-26 2018-09-25 University Of South Florida Systems and methods for controlling the spatial distribution of an electromagnetic field
US20140142689A1 (en) 2012-11-21 2014-05-22 Didier De Canniere Device and method of treating heart valve malfunction
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
US9438264B1 (en) 2015-09-10 2016-09-06 Realtek Semiconductor Corp. High-speed capacitive digital-to-analog converter and method thereof
US20140378963A1 (en) * 2013-06-20 2014-12-25 Gyrus Acmi, Inc., D.B.A. Olympus Surgical Technologies America Treatment of uterine fibroids by arterial ablation
US10154869B2 (en) 2013-08-02 2018-12-18 Gary M. Onik System and method for creating radio-frequency energy electrical membrane breakdown for tissue ablation
US10709491B2 (en) 2013-08-06 2020-07-14 Memorial Sloan-Kettering Cancer Center System, method and computer-accessible medium for in-vivo tissue ablation and/or damage
EP3981465A1 (en) 2013-11-14 2022-04-13 RM2 Technology LLC Systems and apparatuses for delivery of electrolysis products
US9566443B2 (en) 2013-11-26 2017-02-14 Corquest Medical, Inc. System for treating heart valve malfunction including mitral regurgitation
CN111167008A (zh) 2013-12-05 2020-05-19 免疫系统公司 利用射频电学膜击穿（rf-emb）的癌症免疫疗法
US10314648B2 (en) 2013-12-13 2019-06-11 The Trustees of the Universoty of Pennsylvania Coaxial ablation probe and method and system for real-time monitoring of ablation therapy
WO2015103574A1 (en) 2014-01-06 2015-07-09 Iowa Approach Inc. Apparatus and methods for renal denervation ablation
US10166321B2 (en) 2014-01-09 2019-01-01 Angiodynamics, Inc. High-flow port and infusion needle systems
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US20150289923A1 (en) * 2014-04-14 2015-10-15 Virginia Tech Intellectual Properties, Inc. Treatment planning for electrical-energy based therapies based on cell characteristics
EP3139997B1 (en) 2014-05-07 2018-09-19 Farapulse, Inc. Apparatus for selective tissue ablation
AU2015259303B2 (en) 2014-05-12 2021-10-28 Arena, Christopher B. Selective modulation of intracellular effects of cells using pulsed electric fields
EP3142584A1 (en) 2014-05-16 2017-03-22 Iowa Approach Inc. Methods and apparatus for multi-catheter tissue ablation
ES2942296T3 (es) 2014-05-22 2023-05-31 Aegea Medical Inc Método de prueba de integridad y aparato para administrar vapor al útero
EP3145425B1 (en) 2014-05-22 2024-10-23 CooperSurgical, Inc. Systems for performing endometrial ablation
EP3154464B1 (en) 2014-06-12 2025-03-12 Boston Scientific Scimed, Inc. Apparatus for rapid and selective tissue ablation with cooling
EP3154463B1 (en) 2014-06-12 2019-03-27 Farapulse, Inc. Apparatus for rapid and selective transurethral tissue ablation
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
WO2016060983A1 (en) 2014-10-14 2016-04-21 Iowa Approach Inc. Method and apparatus for rapid and safe pulmonary vein cardiac ablation
US10835311B2 (en) 2014-10-24 2020-11-17 Northwestern University Electroporation apparatus and method of using same for ablation of an arbitrary volume
US10842626B2 (en) 2014-12-09 2020-11-24 Didier De Canniere Intracardiac device to correct mitral regurgitation
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10271893B2 (en) 2014-12-15 2019-04-30 Medtronic Ablation Frontiers Llc Timed energy delivery
JP6723249B2 (ja) 2015-01-30 2020-07-15 アールエフイーエムビー ホールディングス リミテッド ライアビリティ カンパニー 軟部組織を切除するためのシステムおよび方法
US20180021084A1 (en) * 2015-02-04 2018-01-25 Rfemb Holdings, Llc Radio-frequency electrical membrane breakdown for reducing restenosis
WO2016130385A2 (en) * 2015-02-10 2016-08-18 George Mbella Ekema Tissue ablation by rapid and sustained alteration in membrane potential
CN108024803B (zh) * 2015-04-10 2021-10-19 安吉戴尼克公司 使用热控电极进行不可逆电穿孔的系统和方法
EP3288471A1 (en) 2015-05-01 2018-03-07 Inter Science GmbH Methods, systems, and apparatuses for tissue ablation using pulse shape designs
US12268433B2 (en) 2015-05-12 2025-04-08 National University Of Ireland, Galway Devices for therapeutic nasal neuromodulation and associated methods and systems
WO2016201264A1 (en) * 2015-06-11 2016-12-15 Massachusetts Institute Of Technology Methods for inducing electroporation and tissue ablation
US11154238B2 (en) 2015-08-07 2021-10-26 Electroceuticals, Llc Systems, methods and apparatuses for providing bioelectronic neurocode-based therapies to mammals
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
US10660702B2 (en) 2016-01-05 2020-05-26 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10130423B1 (en) 2017-07-06 2018-11-20 Farapulse, Inc. Systems, devices, and methods for focal ablation
US10172673B2 (en) 2016-01-05 2019-01-08 Farapulse, Inc. Systems devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
US12144541B2 (en) 2016-01-05 2024-11-19 Boston Scientific Scimed, Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
US20170189097A1 (en) 2016-01-05 2017-07-06 Iowa Approach Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
CA3011460A1 (en) 2016-01-15 2017-07-20 Rfemb Holdings, Llc Immunologic treatment of cancer
CN109069064B (zh) 2016-02-19 2022-05-13 埃杰亚医疗公司 用于确定体腔的完整性的方法和设备
WO2017152061A1 (en) 2016-03-04 2017-09-08 Aerin Medical, Inc. Eustachian tube modification
EP3471631A4 (en) 2016-06-16 2020-03-04 Farapulse, Inc. Systems, apparatuses, and methods for guide wire delivery
DK3474760T3 (da) 2016-06-27 2023-03-20 Galvanize Therapeutics Inc Generator og et kateter med en elektrode til at behandle en lungepassage
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
JP7158820B2 (ja) * 2016-10-26 2022-10-24 ロレアル エレクトロポレーションデバイスおよびエレクトロポレーションデバイスを制御するための方法
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11717337B2 (en) * 2016-11-29 2023-08-08 St. Jude Medical, Cardiology Division, Inc. Electroporation systems and catheters for electroporation systems
US11806071B2 (en) 2016-12-22 2023-11-07 Aerin Medical Inc. Soft palate treatment
WO2018191113A1 (en) 2017-04-10 2018-10-18 St. Jude Medical, Cardiology Division, Inc. Electroporation system and method of preconditioning tissue for electroporation therapy
US9987081B1 (en) 2017-04-27 2018-06-05 Iowa Approach, Inc. Systems, devices, and methods for signal generation
US10617867B2 (en) 2017-04-28 2020-04-14 Farapulse, Inc. Systems, devices, and methods for delivery of pulsed electric field ablative energy to esophageal tissue
SE541651C2 (en) 2017-07-28 2019-11-19 Scandinavian Chemotech Ab An electrode device and a needle electrode for use in delivery of electrical pulses to a desired tissue of a mammal
CN111065327B (zh) 2017-09-12 2023-01-06 波士顿科学医学有限公司 用于心室局灶性消融的系统、设备和方法
US11045648B2 (en) 2017-11-14 2021-06-29 Boston Scientific Scimed, Inc. Irreversible electroporation through a combination of substance injection and electrical field application
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
CA3087183A1 (en) 2017-12-26 2019-07-04 Galary, Inc. Optimization of energy delivery for various applications
US11364070B2 (en) 2018-01-23 2022-06-21 Boston Scientific Scimed, Inc. Enhanced needle array and therapies for tumor ablation
EP4275738B1 (en) 2018-02-08 2025-12-17 Boston Scientific Scimed, Inc. Apparatus for controlled delivery of pulsed electric field ablative energy to tissue
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
JP7043317B2 (ja) * 2018-03-29 2022-03-29 富士フイルムヘルスケア株式会社 医療システム
EP3787715B1 (en) 2018-05-02 2023-11-08 Cequr SA Devices and methods for providing a bolus dose in a microfluidic circuit of a pump
US20190336198A1 (en) 2018-05-03 2019-11-07 Farapulse, Inc. Systems, devices, and methods for ablation using surgical clamps
CN116327352A (zh) 2018-05-07 2023-06-27 波士顿科学医学有限公司 心外膜消融导管
WO2019217317A1 (en) 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses, and methods for filtering high voltage noise induced by pulsed electric field ablation
WO2019217433A1 (en) 2018-05-07 2019-11-14 Farapulse, Inc. Systems, apparatuses and methods for delivery of ablative energy to tissue
CN108830017B (zh) * 2018-07-05 2022-06-24 上海美杰医疗科技有限公司 基于个体阻抗的射频加热温度场预测系统
US12127779B2 (en) 2018-09-04 2024-10-29 Inter Science Gmbh Methods, systems, and apparatuses for tissue ablation using a modulated exponential decay pulse
US10687892B2 (en) 2018-09-20 2020-06-23 Farapulse, Inc. Systems, apparatuses, and methods for delivery of pulsed electric field ablative energy to endocardial tissue
WO2020094622A1 (en) * 2018-11-05 2020-05-14 Region Hovedstaden V/Herlev Hospital An electrode assembly for improved electric field distribution
US11419671B2 (en) 2018-12-11 2022-08-23 Neurent Medical Limited Systems and methods for therapeutic nasal neuromodulation
US11857240B2 (en) 2019-01-14 2024-01-02 Cryoelectric Science Ltd. Methods, systems, and apparatuses for cryosurgery, coldsurgery, and electrolysis
AU2020232595A1 (en) 2019-03-01 2021-09-16 Rampart Health, L.L.C. Pharmaceutical composition combining immunologic and chemotherapeutic method for the treatment of cancer
CN118948428A (zh) 2019-03-15 2024-11-15 波士顿科学国际有限公司 用于选择性细胞消融的时间多路复用波形
CN113573656B (zh) 2019-03-15 2025-05-30 波士顿科学国际有限公司 用于选择性细胞消融的波形发生器和控制
US20200289188A1 (en) 2019-03-15 2020-09-17 Boston Scientific Scimed, Inc. Spatially multiplexed waveform for selective cell ablation
MX2021014979A (es) 2019-06-06 2022-03-04 Triagenics Inc Sistemas de sonda de ablacion.
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
CA3147592A1 (en) 2019-07-16 2021-01-21 Galary, Inc. Treatment of the reproductive tract with pulsed electric fields
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
US10625080B1 (en) 2019-09-17 2020-04-21 Farapulse, Inc. Systems, apparatuses, and methods for detecting ectopic electrocardiogram signals during pulsed electric field ablation
CN114945338A (zh) 2019-10-15 2022-08-26 波士顿科学国际有限公司 用于消融系统的控制系统和用户界面
CN114786605A (zh) 2019-10-21 2022-07-22 英杜基奈克斯公司 用于十二指肠脉冲电场治疗的装置、系统和方法
US11065047B2 (en) 2019-11-20 2021-07-20 Farapulse, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US11497541B2 (en) 2019-11-20 2022-11-15 Boston Scientific Scimed, Inc. Systems, apparatuses, and methods for protecting electronic components from high power noise induced by high voltage pulses
US10842572B1 (en) 2019-11-25 2020-11-24 Farapulse, Inc. Methods, systems, and apparatuses for tracking ablation devices and generating lesion lines
US11540877B2 (en) 2019-12-03 2023-01-03 Biosense Webster (Israel) Ltd. Pulse generator for irreversible electroporation
US12102374B2 (en) 2019-12-03 2024-10-01 Biosense Webster (Israel) Ltd. Pulse generator for irreversible electroporation with switchable pulse application
US11660135B2 (en) 2019-12-05 2023-05-30 Biosense Webster (Israel) Ltd. Generating and interleaving of irreversible-electroporation and radiofrequnecy ablation (IRE/RFA) waveforms
US12042216B2 (en) 2019-12-09 2024-07-23 Biosense Webster (Israel) Ltd. Irreversible-electroporation (IRE) balloon catheter with membrane-insulated high-voltage balloon wires
US11903638B2 (en) 2019-12-11 2024-02-20 Biosense Webster (Israel) Ltd. Regulating delivery of irreversible electroporation pulses according to transferred energy
US11583332B2 (en) 2019-12-24 2023-02-21 Biosense Webster (Israel) Ltd. Combined cardiac pacing and irreversible electroporation (IRE) treatment
US11707320B2 (en) * 2019-12-24 2023-07-25 Biosense Webster (Israel) Ltd. Irreversible electroporation (IRE) based on field, contact force and time
US11992260B2 (en) 2020-03-31 2024-05-28 Boston Scientific Scimed, Inc. Smart probe identification for ablation modalities
WO2021205229A1 (en) 2020-04-09 2021-10-14 Neurent Medical Limited Systems and methods for improving sleep with therapeutic nasal treatment
US11896818B2 (en) 2020-04-09 2024-02-13 Neurent Medical Limited Systems and methods for therapeutic nasal treatment
US12285206B2 (en) 2020-06-01 2025-04-29 Biosense Webster (Israel) Ltd. Application of irreversible electroporation (IRE) ablation using catheter with electrode array
US11794004B2 (en) 2020-06-10 2023-10-24 Biosense Webster (Israel) Ltd. Electroporation with cooling
US12349962B2 (en) 2020-07-13 2025-07-08 Biosense Webster (Israel) Ltd. Sequential activation of electrode-pairs during irreversible electroporation (IRE)
US12310652B2 (en) 2020-07-24 2025-05-27 Boston Scientific Scimed, Inc. Hybrid electroporation ablation catheter
JP7536995B2 (ja) 2020-07-24 2024-08-20 ボストン サイエンティフィック サイムド，インコーポレイテッド 不可逆電気穿孔によるシングル・ショット心臓アブレーションのための電界印加
US11819265B2 (en) 2020-07-28 2023-11-21 Biosense Webster (Israel) Ltd. Cautious irreversible-electroporation (IRE) protocol for avoiding bubble generation
US12426944B2 (en) 2020-07-28 2025-09-30 Biosense Webster (Israel) Ltd. Automatically performing irreversible electroporation ablation during heart refractory period
US12076071B2 (en) 2020-08-14 2024-09-03 Kardium Inc. Systems and methods for treating tissue with pulsed field ablation
US11532082B2 (en) 2020-08-31 2022-12-20 Biosense Webster (Israel) Ltd. Real-time correction of anatomical maps
WO2022055961A2 (en) 2020-09-08 2022-03-17 Farapulse, Inc. Contoured electrodes for pulsed electric field ablation, and systems, devices, and methods thereof
WO2022072385A2 (en) 2020-09-30 2022-04-07 Boston Scientific Scimed Inc Pretreatment waveform for irreversible electroporation
US12290306B2 (en) 2020-10-19 2025-05-06 Biosense Webster (Israel) Ltd. Using unipolar configuration for irreversible-electroporation (IRE)
AU2020475251C1 (en) 2020-10-26 2024-09-19 TriAgenics, Inc. Ablation probe systems
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
US11911096B2 (en) 2020-12-17 2024-02-27 Biosense Webster (Israel) Ltd. Detecting contact and proximity between ablation electrodes by sensing changes in voltage morphology of non-activated electrodes
JP7764483B2 (ja) 2021-01-27 2025-11-05 ボストン サイエンティフィック サイムド，インコーポレイテッド 不可逆的エレクトロポレーションアブレーションのための電圧制御パルスシーケンス
AU2022220325A1 (en) 2021-02-12 2023-09-07 Rampart Health, L.L.C. Therapeutic composition and method combining multiplex immunotherapy with cancer vaccine for the treatment of cancer
US12357817B2 (en) 2021-04-06 2025-07-15 Aerin Medical Inc. Nasal neuromodulation devices and methods
JP7688153B2 (ja) 2021-04-07 2025-06-03 ビーティーエル メディカル デベロップメント エー．エス． パルス場アブレーション装置および方法
WO2022245793A1 (en) 2021-05-17 2022-11-24 Boston Scientific Scimed, Inc. Energy delivery system and device
EP4595912A3 (en) 2021-07-06 2025-10-22 BTL Medical Development A.S. Pulsed field ablation device
US20230165629A1 (en) 2021-11-29 2023-06-01 Boston Scientific Scimed, Inc. Bipolar needle with adjustable electrode for geometrically controlled thermal ablation of biological tissue
US12514633B2 (en) 2021-11-30 2026-01-06 Medtronic Vascular, Inc. Vessel modification using heat therapy
WO2023161796A1 (en) * 2022-02-23 2023-08-31 Cochlear Limited Adaptive electroporation
WO2023250370A1 (en) 2022-06-21 2023-12-28 Squirrel Corporation Apparatus and methods for renal denervation
IT202200019635A1 (it) 2022-09-23 2024-03-23 Igea S P A Dispositivo per l'elettroporazione migliorato
CN120091798A (zh) 2022-09-30 2025-06-03 阿尔普发医疗股份有限公司 用于组织消融的设备和方法
AU2023358001B2 (en) 2022-10-05 2025-05-22 Btl Medical Development A.S. Pulsed field ablation device and method
WO2025212782A1 (en) 2024-04-03 2025-10-09 Field Medical, Inc. Systems and methods for affecting a target tissue via a pulsed field

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1653819A (en) 1926-08-07 1927-12-27 Northcott Ephraim Electrotherapeutical apparatus
DE863111C (de) 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US4016886A (en) 1974-11-26 1977-04-12 The United States Of America As Represented By The United States Energy Research And Development Administration Method for localizing heating in tumor tissue
US4407943A (en) 1976-12-16 1983-10-04 Millipore Corporation Immobilized antibody or antigen for immunoassay
CH617590A5 (pl) 1977-05-27 1980-06-13 Carba Ag
DE2800039C2 (de) 1978-01-02 1984-06-20 Horst Dr.Med. 6700 Ludwigshafen Kief Akupunkturgerät
US5370675A (en) 1992-08-12 1994-12-06 Vidamed, Inc. Medical probe device and method
US5385544A (en) 1992-08-12 1995-01-31 Vidamed, Inc. BPH ablation method and apparatus
GB8408529D0 (en) 1984-04-03 1984-05-16 Health Lab Service Board Concentration of biological particles
US4946793A (en) 1986-05-09 1990-08-07 Electropore, Inc. Impedance matching for instrumentation which electrically alters vesicle membranes
US5098843A (en) 1987-06-04 1992-03-24 Calvin Noel M Apparatus for the high efficiency transformation of living cells
US5749847A (en) 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5389069A (en) 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
WO1989006555A1 (en) 1988-01-21 1989-07-27 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
EP0346513A1 (de) 1988-06-15 1989-12-20 Etama Ag Anordnung zur Elektrotherapie
ES2012944A6 (es) 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
DE4000893A1 (de) 1990-01-15 1991-07-18 Bosch Gmbh Robert Mehrkanaliges geraet zur elektrostimulation
US5134070A (en) 1990-06-04 1992-07-28 Casnig Dael R Method and device for cell cultivation on electrodes
US5193537A (en) 1990-06-12 1993-03-16 Zmd Corporation Method and apparatus for transcutaneous electrical cardiac pacing
US5052391A (en) 1990-10-22 1991-10-01 R.F.P., Inc. High frequency high intensity transcutaneous electrical nerve stimulator and method of treatment
US5990095A (en) 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5173158A (en) 1991-07-22 1992-12-22 Schmukler Robert E Apparatus and methods for electroporation and electrofusion
US5328451A (en) 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
US5425752A (en) 1991-11-25 1995-06-20 Vu'nguyen; Dung D. Method of direct electrical myostimulation using acupuncture needles
US6210402B1 (en) 1995-11-22 2001-04-03 Arthrocare Corporation Methods for electrosurgical dermatological treatment
US6500173B2 (en) * 1992-01-07 2002-12-31 Ronald A. Underwood Methods for electrosurgical spine surgery
US6132419A (en) 1992-05-22 2000-10-17 Genetronics, Inc. Electroporetic gene and drug therapy
US5318563A (en) 1992-06-04 1994-06-07 Valley Forge Scientific Corporation Bipolar RF generator
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5634899A (en) 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5807306A (en) 1992-11-09 1998-09-15 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus
GB9226376D0 (en) 1992-12-18 1993-02-10 British Tech Group Tomography
JPH08506259A (ja) 1993-02-02 1996-07-09 ヴィーダメッド インコーポレイテッド 経尿道ニードル切除装置および方法
US5792187A (en) 1993-02-22 1998-08-11 Angeion Corporation Neuro-stimulation to control pain during cardioversion defibrillation
US5403311A (en) 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US6832996B2 (en) 1995-06-07 2004-12-21 Arthrocare Corporation Electrosurgical systems and methods for treating tissue
US5464437A (en) 1993-07-08 1995-11-07 Urologix, Inc. Benign prostatic hyperplasia treatment catheter with urethral cooling
US5533999A (en) 1993-08-23 1996-07-09 Refractec, Inc. Method and apparatus for modifications of visual acuity by thermal means
JP3054319B2 (ja) * 1994-03-04 2000-06-19 矢崎総業株式会社 防水ゴム栓およびその製造方法
US5458625A (en) 1994-05-04 1995-10-17 Kendall; Donald E. Transcutaneous nerve stimulation device and method for using same
US5836905A (en) 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
US5947889A (en) 1995-01-17 1999-09-07 Hehrlein; Christoph Balloon catheter used to prevent re-stenosis after angioplasty and process for producing a balloon catheter
US5720921A (en) 1995-03-10 1998-02-24 Entremed, Inc. Flow electroporation chamber and method
US5810762A (en) 1995-04-10 1998-09-22 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6607529B1 (en) 1995-06-19 2003-08-19 Medtronic Vidamed, Inc. Electrosurgical device
US5919142A (en) 1995-06-22 1999-07-06 Btg International Limited Electrical impedance tomography method and apparatus
US5983131A (en) 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
EP0776678A1 (en) 1995-11-30 1997-06-04 Hewlett-Packard Company System for administering transcutaneous cardiac pacing with transcutaneous electrical nerve stimuli
US6010613A (en) * 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
US5718246A (en) 1996-01-03 1998-02-17 Preferential, Inc. Preferential induction of electrically mediated cell death from applied pulses
US6090106A (en) 1996-01-09 2000-07-18 Gyrus Medical Limited Electrosurgical instrument
US6016452A (en) 1996-03-19 2000-01-18 Kasevich; Raymond S. Dynamic heating method and radio frequency thermal treatment
US5778894A (en) 1996-04-18 1998-07-14 Elizabeth Arden Co. Method for reducing human body cellulite by treatment with pulsed electromagnetic energy
SE509241C2 (sv) 1996-07-18 1998-12-21 Radinvent Ab Anordningar för elektrodynamisk strålterapi av tumörsjukdomar
US6102885A (en) 1996-08-08 2000-08-15 Bass; Lawrence S. Device for suction-assisted lipectomy and method of using same
US6106521A (en) 1996-08-16 2000-08-22 United States Surgical Corporation Apparatus for thermal treatment of tissue
US5991697A (en) 1996-12-31 1999-11-23 The Regents Of The University Of California Method and apparatus for optical Doppler tomographic imaging of fluid flow velocity in highly scattering media
AU6262698A (en) 1997-02-04 1998-08-25 National Aeronautics And Space Administration - Nasa Multimodality instrument for tissue characterization
JPH10243947A (ja) * 1997-03-04 1998-09-14 Olympus Optical Co Ltd 高周波装置
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6085115A (en) 1997-05-22 2000-07-04 Massachusetts Institite Of Technology Biopotential measurement including electroporation of tissue surface
US5978704A (en) 1997-06-03 1999-11-02 Uab Research Foundation Method and apparatus for treating cardiac arrhythmia
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
AU9472998A (en) 1997-09-04 1999-03-22 Science Research Laboratory, Inc. Cell separation using electric fields
US5999847A (en) 1997-10-21 1999-12-07 Elstrom; John A. Apparatus and method for delivery of surgical and therapeutic agents
WO1999021584A1 (en) 1997-10-24 1999-05-06 Children's Medical Center Corporation METHODS FOR PROMOTING CELL TRANSFECTION $i(IN VIVO)
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6009347A (en) 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6440127B2 (en) 1998-02-11 2002-08-27 Cosman Company, Inc. Method for performing intraurethral radio-frequency urethral enlargement
US6122599A (en) 1998-02-13 2000-09-19 Mehta; Shailesh Apparatus and method for analyzing particles
SE513814C2 (sv) 1998-03-31 2000-11-06 Aditus Medical Ab Anordning för behandling av sjukdomar med elektriska fält
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6159163A (en) 1998-05-07 2000-12-12 Cedars-Sinai Medical Center System for attenuating pain during bone marrow aspiration and method
EP1079890A4 (en) 1998-05-08 2008-12-03 Genetronics Inc VASODILATION OF AN ELECTRICALLY INDUCED VESSEL
US6697669B2 (en) 1998-07-13 2004-02-24 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6212433B1 (en) 1998-07-28 2001-04-03 Radiotherapeutics Corporation Method for treating tumors near the surface of an organ
DK1102559T3 (da) 1998-09-30 2003-09-29 Cygnus Therapeutic Systems Fremgangsmåde og anordning til forudsigelse af fysiologiske værdier
EP1124939B1 (en) 1998-10-08 2003-04-23 AstraZeneca AB Microfabricated cell injector
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
WO2000028909A1 (en) 1998-11-16 2000-05-25 United States Surgical Corporation Apparatus for thermal treatment of tissue
US6090016A (en) * 1998-11-18 2000-07-18 Kuo; Hai Pin Collapsible treader with enhanced stability
US6351674B2 (en) 1998-11-23 2002-02-26 Synaptic Corporation Method for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6261831B1 (en) 1999-03-26 2001-07-17 The United States Of America As Represented By The Secretary Of The Air Force Ultra-wide band RF-enhanced chemotherapy for cancer treatmeat
US6738663B2 (en) 1999-04-09 2004-05-18 Oncostim, A Minnesota Corporation Implantable device and method for the electrical treatment of cancer
US7412285B2 (en) 1999-04-09 2008-08-12 Oncostim, Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US6627421B1 (en) 1999-04-13 2003-09-30 Imarx Therapeutics, Inc. Methods and systems for applying multi-mode energy to biological samples
US6300108B1 (en) * 1999-07-21 2001-10-09 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US6927049B2 (en) 1999-07-21 2005-08-09 The Regents Of The University Of California Cell viability detection using electrical measurements
US6387671B1 (en) 1999-07-21 2002-05-14 The Regents Of The University Of California Electrical impedance tomography to control electroporation
US6403348B1 (en) 1999-07-21 2002-06-11 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes
US7053063B2 (en) 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
US20020010491A1 (en) 1999-08-04 2002-01-24 Schoenbach Karl H. Method and apparatus for intracellular electro-manipulation
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6613211B1 (en) 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
JP4676042B2 (ja) * 1999-10-01 2011-04-27 帝國製薬株式会社 フェルビナク含有鎮痛・消炎外用貼付剤
US6493592B1 (en) 1999-12-01 2002-12-10 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode position maintenance
IT1320186B1 (it) 2000-04-21 2003-11-26 Igea Srl Dispositivo e metodo di elettro-porazione in cui l'ampiezzadell'impulso o degli impulsi viene stabilita in modo automatico in
US20010044596A1 (en) * 2000-05-10 2001-11-22 Ali Jaafar Apparatus and method for treatment of vascular restenosis by electroporation
KR100375657B1 (ko) 2000-06-21 2003-03-15 주식회사 몸앤맘 체지방 제거장치 및 방법
US6669691B1 (en) 2000-07-18 2003-12-30 Scimed Life Systems, Inc. Epicardial myocardial revascularization and denervation methods and apparatus
EP1304971A1 (en) 2000-07-25 2003-05-02 Rita Medical Systems, Inc. Apparatus for detecting and treating tumors using localized impedance measurement
US6697670B2 (en) * 2001-08-17 2004-02-24 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients
US6795728B2 (en) 2001-08-17 2004-09-21 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits by electroporation
US6892099B2 (en) * 2001-02-08 2005-05-10 Minnesota Medical Physics, Llc Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation
US6702808B1 (en) 2000-09-28 2004-03-09 Syneron Medical Ltd. Device and method for treating skin
US20020133324A1 (en) * 2000-11-03 2002-09-19 Weaver James C. Functional simulation method
US20050043726A1 (en) 2001-03-07 2005-02-24 Mchale Anthony Patrick Device II
US20020177847A1 (en) * 2001-03-30 2002-11-28 Long Gary L. Endoscopic ablation system with flexible coupling
WO2002083945A2 (en) 2001-04-12 2002-10-24 Imperial College Innovations Limited Diagnosis and treatment of cancer: i
WO2002087692A1 (en) 2001-04-26 2002-11-07 The Procter & Gamble Company A method and apparatus for the treatment of cosmetic skin conditioins
CN100518685C (zh) * 2001-05-10 2009-07-29 脉管动力股份有限公司 组织消融设备
JP2002360712A (ja) * 2001-06-06 2002-12-17 Komatsu Powertron Kk 生体用誘導加熱方法及びその装置
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US6832111B2 (en) 2001-07-06 2004-12-14 Hosheng Tu Device for tumor diagnosis and methods thereof
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US7130697B2 (en) 2002-08-13 2006-10-31 Minnesota Medical Physics Llc Apparatus and method for the treatment of benign prostatic hyperplasia
ATE320767T1 (de) * 2001-09-28 2006-04-15 Rita Medical Systems Inc Impedanzgesteuerte vorrichtung zur ablation von gewebe
US20040243107A1 (en) 2001-10-01 2004-12-02 Macoviak John A Methods and devices for treating atrial fibrilation
FR2830767B1 (fr) 2001-10-12 2004-03-12 Optis France Sa Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire
JP4394444B2 (ja) 2001-10-24 2010-01-06 パワー ペーパー リミティド 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法
US6807444B2 (en) 2001-11-05 2004-10-19 Hosheng Tu Apparatus and methods for monitoring tissue impedance
WO2003047684A2 (en) * 2001-12-04 2003-06-12 University Of Southern California Method for intracellular modifications within living cells using pulsed electric fields
EP1483019A4 (en) 2002-03-11 2007-07-04 Altea Therapeutics Corp TRANSDERMALES MEDICAMENT PAVING SYSTEM, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE APPLICATION THEREOF
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US6780178B2 (en) 2002-05-03 2004-08-24 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus for plasma-mediated thermo-electrical ablation
US6801804B2 (en) 2002-05-03 2004-10-05 Aciont, Inc. Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis
DE60315970T2 (de) * 2002-05-06 2008-05-21 Covidien Ag Blutdetektor zur kontrolle einer elektrochirurgischen einheit
EP1506039B1 (en) * 2002-05-23 2008-10-29 Gendel Limited Ablation device
US7063698B2 (en) 2002-06-14 2006-06-20 Ncontact Surgical, Inc. Vacuum coagulation probes
US6972014B2 (en) 2003-01-04 2005-12-06 Endocare, Inc. Open system heat exchange catheters and methods of use
US7211083B2 (en) 2003-03-17 2007-05-01 Minnesota Medical Physics, Llc Apparatus and method for hair removal by electroporation
US20050171574A1 (en) 2003-12-24 2005-08-04 The Regents Of The University Of California Electroporation to interrupt blood flow
US20050261672A1 (en) 2004-05-18 2005-11-24 Mark Deem Systems and methods for selective denervation of heart dysrhythmias
US7261710B2 (en) 2004-10-13 2007-08-28 Medtronic, Inc. Transurethral needle ablation system
US20060264752A1 (en) 2005-04-27 2006-11-23 The Regents Of The University Of California Electroporation controlled with real time imaging
US8114070B2 (en) * 2005-06-24 2012-02-14 Angiodynamics, Inc. Methods and systems for treating BPH using electroporation
US20060293730A1 (en) 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating restenosis sites using electroporation
US20070156135A1 (en) * 2006-01-03 2007-07-05 Boris Rubinsky System and methods for treating atrial fibrillation using electroporation
US20080052786A1 (en) 2006-08-24 2008-02-28 Pei-Cheng Lin Animal Model of Prostate Cancer and Use Thereof
US8109926B2 (en) * 2006-09-14 2012-02-07 Lazure Scientific, Inc. Ablation probe with deployable electrodes
US7655004B2 (en) * 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
US20090247933A1 (en) * 2008-03-27 2009-10-01 The Regents Of The University Of California; Angiodynamics, Inc. Balloon catheter method for reducing restenosis via irreversible electroporation
US10702326B2 (en) * 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part

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US20120071874A1 (en) 2012-03-22
US20050171523A1 (en) 2005-08-04
CA2550846A1 (en) 2005-07-21
US8048067B2 (en) 2011-11-01
JP5138229B2 (ja) 2013-02-06
EP1696812A2 (en) 2006-09-06
US20120277741A1 (en) 2012-11-01
US20080269586A1 (en) 2008-10-30
JP2007516792A (ja) 2007-06-28
CA2550846C (en) 2018-01-23
US20070043345A1 (en) 2007-02-22
AU2004311842A1 (en) 2005-07-21
JP5766163B2 (ja) 2015-08-19
US10117701B2 (en) 2018-11-06

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