ES2724232T3 - Procedimientos de detección de células tumorales circulantes positivas para 5T4 y procedimientos de diagnóstico de cáncer positivo para 5T4 en un sujeto mamífero - Google Patents

Procedimientos de detección de células tumorales circulantes positivas para 5T4 y procedimientos de diagnóstico de cáncer positivo para 5T4 en un sujeto mamífero Download PDF

Info

Publication number
ES2724232T3
ES2724232T3 ES13708526T ES13708526T ES2724232T3 ES 2724232 T3 ES2724232 T3 ES 2724232T3 ES 13708526 T ES13708526 T ES 13708526T ES 13708526 T ES13708526 T ES 13708526T ES 2724232 T3 ES2724232 T3 ES 2724232T3
Authority
ES
Spain
Prior art keywords
marker
cells
blood sample
positive
circulating tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13708526T
Other languages
English (en)
Spanish (es)
Inventor
Hans-Peter Gerber
Dena Marrinucci
Steven Pirie-Shepherd
Eric Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Epic Sciences Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Epic Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL, Epic Sciences Inc filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2724232T3 publication Critical patent/ES2724232T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70589CD45

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
ES13708526T 2012-01-24 2013-01-22 Procedimientos de detección de células tumorales circulantes positivas para 5T4 y procedimientos de diagnóstico de cáncer positivo para 5T4 en un sujeto mamífero Active ES2724232T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261590066P 2012-01-24 2012-01-24
US201361753665P 2013-01-17 2013-01-17
PCT/IB2013/050547 WO2013111054A1 (en) 2012-01-24 2013-01-22 Methods for detecting 5t4-positive circulating tumor cells and methods of diagnosis of 5t4-positive cancer in a mammalian subject

Publications (1)

Publication Number Publication Date
ES2724232T3 true ES2724232T3 (es) 2019-09-09

Family

ID=47844410

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13708526T Active ES2724232T3 (es) 2012-01-24 2013-01-22 Procedimientos de detección de células tumorales circulantes positivas para 5T4 y procedimientos de diagnóstico de cáncer positivo para 5T4 en un sujeto mamífero

Country Status (14)

Country Link
US (1) US10254286B2 (enExample)
EP (1) EP2807485B1 (enExample)
JP (1) JP6254951B2 (enExample)
KR (1) KR101716555B1 (enExample)
CN (1) CN104094116B (enExample)
AU (2) AU2013213301A1 (enExample)
BR (1) BR112014018192A8 (enExample)
CA (1) CA2861437C (enExample)
ES (1) ES2724232T3 (enExample)
IL (1) IL233543B (enExample)
IN (1) IN2014DN07019A (enExample)
MX (1) MX361058B (enExample)
RU (1) RU2646498C2 (enExample)
WO (1) WO2013111054A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2803804B2 (ja) 1992-08-21 1998-09-24 株式会社長澤製作所 ボタン錠
JP6352588B2 (ja) 2009-10-21 2018-07-04 ザ スクリプス リサーチ インスティテュート 希少ではない細胞を用いて希少細胞を検出する方法
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EA201691352A1 (ru) * 2013-12-30 2016-11-30 Дзе Скриппс Рисерч Инститьют Диагностика рака легкого с помощью циркулирующих опухолевых клеток
EP3100047B1 (en) 2014-01-27 2021-08-11 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
EP3108246B1 (en) * 2014-02-21 2019-10-09 Epic Sciences, Inc. Methods for analyzing rare circulating cells
WO2015155345A1 (en) * 2014-04-11 2015-10-15 Medimmune Limited Antibodies and antibody-drug conjugates
EP3140656B1 (en) * 2014-05-09 2021-02-17 The Scripps Research Institute Compositions and methods for fluid biopsy of melanoma
AU2015306692B2 (en) * 2014-08-25 2021-07-22 Creatv Microtech, Inc. Use of circulating cell biomarkers in the blood for detection and diagnosis of diseases and methods of isolating them
EP3286565B1 (en) * 2015-04-21 2025-01-15 Genentech, Inc. Compositions and methods for prostate cancer analysis
IL290309B2 (en) * 2015-11-06 2024-04-01 Ventana Med Syst Inc Representative diagnostics
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
KR102478639B1 (ko) 2016-02-23 2022-12-19 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
KR102406596B1 (ko) * 2016-02-23 2022-06-10 노을 주식회사 패치를 이용하는 ctc 진단 방법 및 장치
KR20170099739A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
KR20170099787A (ko) * 2016-02-23 2017-09-01 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
AU2018247767B2 (en) 2017-04-03 2025-01-30 F. Hoffmann-La Roche Ag Antibodies binding to STEAP-1
EP3646010A4 (en) * 2017-06-27 2020-11-11 Qcdx, Llc QUANTITATIVE LIQUID BIOPSY DIAGNOSTIC SYSTEM AND METHOD
CN107918013A (zh) * 2017-09-25 2018-04-17 浙江天科高新技术发展有限公司 化学发光酶免测定循环肿瘤细胞中K‑Ras蛋白的方法及试剂盒
JP7678424B2 (ja) 2018-05-10 2025-05-16 学校法人順天堂 画像解析方法、装置、コンピュータプログラム、及び深層学習アルゴリズムの生成方法
WO2020086882A1 (en) * 2018-10-24 2020-04-30 Northwestern University Tumor cell aggregation inhibitors' for treating cancer
JP7381003B2 (ja) * 2019-04-26 2023-11-15 学校法人順天堂 疾患解析を支援する方法、装置、及びコンピュータプログラム、並びにコンピュータアルゴリズムを訓練する方法、装置、及びプログラム
US20230175073A1 (en) 2021-12-07 2023-06-08 Epic Sciences, Inc. Enhanced characterization of breast cancer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US5869053A (en) 1988-03-04 1999-02-09 Cancer Research Campaign Technology, Ltd. 5T4 antigen from human trophoblasts
ATE123652T1 (de) 1988-03-04 1995-06-15 Cancer Res Campaign Tech Antigene.
CN1224712C (zh) 1997-06-04 2005-10-26 牛津生物医学(英国)有限公司 载体
JP2003515323A (ja) 1999-11-18 2003-05-07 オックスフォード バイオメディカ(ユーケイ)リミテッド 抗 体
GB0126378D0 (en) 2001-11-02 2002-01-02 Oxford Biomedica Ltd Antigen
US7305112B2 (en) 2002-10-15 2007-12-04 The Scripps Research Institute Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media
WO2006031653A2 (en) * 2004-09-10 2006-03-23 Wyeth Humanized anti-5t4 antibodies and anti-5t4 antibody / calicheamicin conjugates
WO2007089911A2 (en) * 2006-01-30 2007-08-09 The Scripps Research Institute Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject
SG170091A1 (en) 2006-03-10 2011-04-29 Wyeth Corp Anti-5t4 antibodies and uses thereof
WO2008131048A2 (en) 2007-04-16 2008-10-30 Cellpoint Diagnotics, Inc. Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
CN110470835A (zh) 2009-03-24 2019-11-19 生物概念股份有限公司 细胞捕获和分析的装置和方法
CA2754610C (en) 2009-03-27 2015-05-05 Marc Isaac Damelin Tumor-initiating cells and methods for using same
CA2772623A1 (en) 2009-09-03 2011-03-10 The Scripps Research Institute Method for categorizing circulating tumor cells
JP6352588B2 (ja) 2009-10-21 2018-07-04 ザ スクリプス リサーチ インスティテュート 希少ではない細胞を用いて希少細胞を検出する方法
KR20130043104A (ko) * 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
BR112013000433A2 (pt) 2010-07-07 2016-05-17 Univ Michigan diagnóstico e tratamento de câncer de mama
KR101529810B1 (ko) 2011-04-01 2015-06-26 와이어쓰 엘엘씨 항체-약물 접합체

Also Published As

Publication number Publication date
CN104094116A (zh) 2014-10-08
JP2015507190A (ja) 2015-03-05
KR20140100580A (ko) 2014-08-14
RU2014127474A (ru) 2016-03-20
US20150017661A1 (en) 2015-01-15
RU2646498C2 (ru) 2018-03-05
IL233543A0 (en) 2014-08-31
JP6254951B2 (ja) 2017-12-27
CA2861437C (en) 2018-08-21
CA2861437A1 (en) 2013-08-01
EP2807485A1 (en) 2014-12-03
IN2014DN07019A (enExample) 2015-04-10
KR101716555B1 (ko) 2017-03-14
AU2013213301A1 (en) 2014-07-17
BR112014018192A8 (pt) 2021-03-02
US10254286B2 (en) 2019-04-09
HK1202923A1 (en) 2015-10-09
CN104094116B (zh) 2017-05-31
EP2807485B1 (en) 2019-03-13
IL233543B (en) 2018-02-28
AU2018220154A1 (en) 2018-09-13
MX361058B (es) 2018-11-23
MX2014008928A (es) 2014-10-24
WO2013111054A1 (en) 2013-08-01

Similar Documents

Publication Publication Date Title
ES2724232T3 (es) Procedimientos de detección de células tumorales circulantes positivas para 5T4 y procedimientos de diagnóstico de cáncer positivo para 5T4 en un sujeto mamífero
Marrinucci et al. Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers
ES2661735T3 (es) Método para usar células no raras para detectar células raras
ES2420834T3 (es) Métodos de detección de células tumorales circulantes y métodos de diagnóstico del cáncer en un sujeto mamífero
ES2397971T3 (es) Ensayo de células tumorales circulantes
KR101604649B1 (ko) 혈액 내 순환 흑색종 세포의 자동화된 계산 및 특징화
US10823736B2 (en) Method of assessing disease condition of cancer
MX2014006884A (es) Aparato, sistema y metodo para identificar celulas tumorales circulantes.
Tura et al. Identification of circulating melanoma cells in uveal melanoma patients by dual-marker immunoenrichment
CN101606060A (zh) 细胞图像的归类方法
CN103792364A (zh) 用于检测外周血中循环肿瘤细胞ror1蛋白的试剂及其应用
CN108572255B (zh) 检测pd-l1+循环肿瘤细胞的试剂在筛选癌症风险个体以及在癌症患者预后中的应用
Hong et al. Phenotype of circulating tumor cell: face-off between epithelial and mesenchymal masks
Yin et al. Cytokeratin 20 and Ki-67 to distinguish carcinoma in situ from flat non-neoplastic urothelium
ES2939298T3 (es) Combinación de marcadores para el diagnóstico del cáncer
RU2571821C2 (ru) Способ выявления циркулирующих опухолевых клеток, микроэмбол и апоптотических телец в крови больных раком легкого человека
US20250208138A1 (en) Method of isolating and analyzing circulating tumor cells
US20240058334A1 (en) Methods for treating small cell lung cancer and other neuroendocrine cancers
ES2356738T3 (es) Células tumorales circulantes (ctc): evaluación temprana del tiempo de evolución, de la supervivencia y la respuesta a la terapia en pacientes con cáncer metastásico.
HK1202923B (en) Methods for detecting 5t4-positive circulating tumor cells and methods of diagnosis of 5t4-positive cancer in a mammalian subject
Cheema Pancreatic Tumor Cell Capture via Dendrimer-Mediated Multivalent Binding and Antibody Cocktail
WO2025137394A1 (en) Using extracellular vesicles to assess treatment efficacy of antibody-drug conjugate (adc) therapies
Smerage et al. SECTION II: MOLECULAR AND CELLULAR MARKERS OF PROGNOSIS