ES2676351T3 - Método de análisis de una célula u otro material biológico que contiene un ácido nucleico - Google Patents

Método de análisis de una célula u otro material biológico que contiene un ácido nucleico Download PDF

Info

Publication number
ES2676351T3
ES2676351T3 ES11720571.6T ES11720571T ES2676351T3 ES 2676351 T3 ES2676351 T3 ES 2676351T3 ES 11720571 T ES11720571 T ES 11720571T ES 2676351 T3 ES2676351 T3 ES 2676351T3
Authority
ES
Spain
Prior art keywords
compound
cells
cell
formula
fluorochrome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11720571.6T
Other languages
English (en)
Spanish (es)
Inventor
Paul James Smith
Rachel J. Errington
Laurence Hylton Patterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biostatus Ltd
Original Assignee
Biostatus Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biostatus Ltd filed Critical Biostatus Ltd
Application granted granted Critical
Publication of ES2676351T3 publication Critical patent/ES2676351T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/16—Amino-anthraquinones
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/16—Amino-anthraquinones
    • C09B1/20—Preparation from starting materials already containing the anthracene nucleus
    • C09B1/207—Dyes with amino groups and with onium groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1003—Carbocyclic compounds
    • C09K2211/1011—Condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/302—Stain compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ES11720571.6T 2010-04-09 2011-04-08 Método de análisis de una célula u otro material biológico que contiene un ácido nucleico Active ES2676351T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201005939 2010-04-09
GBGB1005939.2A GB201005939D0 (en) 2010-04-09 2010-04-09 Method of analysing a cell or other biological material containing nucleic acid
PCT/GB2011/050702 WO2011124927A1 (en) 2010-04-09 2011-04-08 Method of analysing a cell or other biological material containing a nucleic acid

Publications (1)

Publication Number Publication Date
ES2676351T3 true ES2676351T3 (es) 2018-07-18

Family

ID=42236073

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11720571.6T Active ES2676351T3 (es) 2010-04-09 2011-04-08 Método de análisis de una célula u otro material biológico que contiene un ácido nucleico

Country Status (16)

Country Link
US (2) US9051467B2 (enExample)
EP (2) EP3366667B1 (enExample)
JP (2) JP6033767B2 (enExample)
KR (2) KR101846491B1 (enExample)
CN (1) CN102947266B (enExample)
AU (2) AU2011236610B2 (enExample)
BR (1) BR112012025820B1 (enExample)
CA (1) CA2797440C (enExample)
DK (2) DK2556047T3 (enExample)
ES (1) ES2676351T3 (enExample)
GB (1) GB201005939D0 (enExample)
HU (1) HUE038706T2 (enExample)
NO (1) NO2556047T3 (enExample)
PL (1) PL2556047T3 (enExample)
PT (1) PT2556047T (enExample)
WO (1) WO2011124927A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201005939D0 (en) * 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid
US8790892B2 (en) 2011-04-04 2014-07-29 Biotium, Inc. Substituted anthraquinone dyes for cellular stains and enzyme detection
JP2013094135A (ja) * 2011-11-02 2013-05-20 Waseda Univ 人工ナノ材料の安全性を評価する方法
US9933341B2 (en) 2012-04-05 2018-04-03 Becton, Dickinson And Company Sample preparation for flow cytometry
CN104379760B (zh) * 2012-04-05 2018-03-16 Bd公司 用于流式细胞术的样品制备
US9709500B2 (en) 2012-05-02 2017-07-18 Charles River Laboratories, Inc. Optical method for detecting viable microorganisms in a cell sample
EP2769204B1 (en) 2012-05-02 2016-02-17 Charles River Laboratories, Inc. Cell capture system and use thereof
US8993260B2 (en) 2012-05-02 2015-03-31 Charles River Laboratories, Inc. Fluorescence-based viability staining method using a membrane permeable flourescent dye and membrane impermeable fluorescence quencher
GB201214169D0 (en) 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof
WO2015095152A1 (en) * 2013-12-17 2015-06-25 The Penn State Research Foundation Manipulation of light spectral quality to reduce parasitism by cuscuta and other plant parasites
GB201610971D0 (en) 2016-06-23 2016-08-10 Biostatus Ltd Compounds
CN113667323B (zh) * 2019-11-21 2023-07-14 苏州优逸兰迪生物科技有限公司 一种染料化合物的制备方法
CN112679543B (zh) * 2020-12-29 2022-07-22 天津全和诚科技有限责任公司 一种亲脂性荧光素探针及其制备方法
CN113072937B (zh) * 2021-04-12 2022-06-07 郑州大学 一种脂滴靶向碳点、制备方法及应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123605A (en) * 1960-01-08 1964-03-03 Basic anthraquinone dyestuffs
FR1379649A (fr) * 1963-06-20 1964-11-27 Oreal Nouveaux colorants anthraquinoniques et leur utilisation pour la teinture des cheveux
GB1053536A (enExample) * 1962-10-29
NL299891A (enExample) * 1962-10-29
JPS503337B1 (enExample) * 1964-08-06 1975-02-03
US3646072A (en) * 1970-07-27 1972-02-29 Du Pont Turquoise biscationic anthraquinone dyes
JPS503337A (enExample) 1973-05-11 1975-01-14
US4123222A (en) 1976-03-23 1978-10-31 Ciba-Geigy Corporation Process for the dyeing or printing of polyacrylonitrile material
FR2431128A1 (fr) * 1978-07-13 1980-02-08 Oreal Procede d'evaluation de l'etat ionique des cheveux
US4353708A (en) * 1978-07-13 1982-10-12 L'oreal Evaluation of the state of change of keratin fibers
US5057413A (en) 1988-06-13 1991-10-15 Becton, Dickinson And Company Method for discriminating between intact and damaged cells in a sample
GB8923075D0 (en) 1989-10-13 1989-11-29 Patterson Laurence H Anti-cancer compounds
JPH04136802A (ja) * 1990-09-28 1992-05-11 Nippon Kayaku Co Ltd 着色フィルター
US5520707A (en) * 1995-08-07 1996-05-28 Clairol, Inc. Methods for dyeing hair with anthraquinone hair dyes having a quaternary ammonium side chain
GB9813062D0 (en) * 1998-06-18 1998-08-19 Univ Wales Medicine An anthraquinone and its derivatives
EP1147147A1 (en) * 1998-12-07 2001-10-24 Eastman Chemical Company A colorant composition, a polymer nanocomposite comprising the colorant composition and articles produced therefrom
US6562785B1 (en) * 1999-03-23 2003-05-13 Howard M. Shapiro Method for overcoming bacterial antibiotic resistance
KR20030010585A (ko) * 2000-02-28 2003-02-05 다이이치 가가쿠 야쿠힝 가부시키가이샤 아연 형광탐침
US6949250B2 (en) 2002-12-16 2005-09-27 The United States Of America As Represented By The Secretary Of Agriculture Selective algaecides for control of cyanochloronta
US20070082377A1 (en) 2005-10-07 2007-04-12 Olin Michael R Cytotoxicity assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
GB201005939D0 (en) * 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid

Also Published As

Publication number Publication date
KR101957288B1 (ko) 2019-03-12
BR112012025820B1 (pt) 2020-05-12
HUE038706T2 (hu) 2018-11-28
CN102947266A (zh) 2013-02-27
DK3366667T3 (da) 2021-05-10
WO2011124927A1 (en) 2011-10-13
US11255761B2 (en) 2022-02-22
EP3366667A1 (en) 2018-08-29
US20130101994A1 (en) 2013-04-25
CA2797440A1 (en) 2011-10-13
GB201005939D0 (en) 2010-05-26
KR20130083836A (ko) 2013-07-23
JP2013528571A (ja) 2013-07-11
PL2556047T3 (pl) 2018-10-31
BR112012025820A2 (pt) 2016-06-28
CA2797440C (en) 2020-01-28
EP2556047B1 (en) 2018-06-06
JP6033767B2 (ja) 2016-11-30
DK2556047T3 (en) 2018-07-16
AU2016250384B2 (en) 2018-05-10
US20150268142A1 (en) 2015-09-24
AU2011236610B2 (en) 2016-07-28
AU2016250384A1 (en) 2016-11-17
PT2556047T (pt) 2018-07-11
EP3366667B1 (en) 2021-02-17
JP6586070B2 (ja) 2019-10-02
EP2556047A1 (en) 2013-02-13
KR20180037318A (ko) 2018-04-11
JP2017112988A (ja) 2017-06-29
CN102947266B (zh) 2016-02-03
US9051467B2 (en) 2015-06-09
NO2556047T3 (enExample) 2018-11-03
KR101846491B1 (ko) 2018-04-06

Similar Documents

Publication Publication Date Title
ES2676351T3 (es) Método de análisis de una célula u otro material biológico que contiene un ácido nucleico
AU2011236610A1 (en) Method of analysing a cell or other biological material containing a nucleic acid
Shivalingam et al. The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy
Song et al. Low molecular weight fluorescent probes with good photostability for imaging RNA-rich nucleolus and RNA in cytoplasm in living cells
CN108069902A (zh) 一类标记和/或检测细胞中脂滴的荧光探针及其制备和应用
CA3004831C (en) Fluorochromes for organelle tracing and multi-color imaging
CN111100476B (zh) 一种pH荧光探针的合成及应用
Li et al. A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode
Liu et al. Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane
Zeng et al. A novel and photostable pH probe for selectively staining nuclei in living cells
Gupta et al. A luminescent pH-sensitive lysosome targeting Eu (iii) probe
Krčová et al. Highly selective mitochondrial probes based on fluorinated pentamethinium salts: On two-photon properties and microscopic applications
US11591476B2 (en) In-vivo probe for real time longitudinal monitoring of inducible nitric-oxide synthase in living cells and animals
Class et al. Patent application title: Method of Analysing a Cell or Other Biological Material Containing a Nucleic Acid Inventors: Paul James Smith (Vale Of Glamorgan, GB) Rachel J. Errington (Vale Of Glamorgan, GB) Laurence Hylton Patterson (North Yorkshire, GB) Assignees: BIOSTATUS LIMITED
Adair et al. Correlative multimodal optical and X-ray fluorescence imaging of brominated fluorophores
Papkovsky et al. Luminescent Probes
Thiel From Imaging to Proteomics–Using Photoactivatable Probes to Study Enzymes
Pandey et al. Acridine-Based Fluorescent Probes: Synthesis, Biological, and Nonbiological Applications
Bolze et al. Two-photon dyes and nucleic acid detection
변규원 Studies on synthesis and properties of novel fluorescent molecules and their applications to super-resolution bioimaging
CN115368307A (zh) 肼类化合物及其制备方法和用途
WO2013075285A1 (zh) 一类双苄基五甲川菁荧光染料、其制备方法及应用
Kapteyn Towards the Development of a Novel DNA Binding Fluorescent Cell Stain; An Analysis of Common DNA Dyes and Their Applications