ES2670093T3 - Antagonistas del receptor de P2X7 de tiazol u oxazol sustituidos - Google Patents

Antagonistas del receptor de P2X7 de tiazol u oxazol sustituidos Download PDF

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Publication number
ES2670093T3
ES2670093T3 ES15705523.7T ES15705523T ES2670093T3 ES 2670093 T3 ES2670093 T3 ES 2670093T3 ES 15705523 T ES15705523 T ES 15705523T ES 2670093 T3 ES2670093 T3 ES 2670093T3
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ethyl
thiazol
benzamide
chloro
methyl
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Spanish (es)
Inventor
Paolo Pevarello
Stefan Lohmer
Chiara Liberati
Pierfausto Seneci
Cristina PESENTI
Adolfo Prandi
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AXXAM SpA
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AXXAM SpA
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EP2905282A1 (en) * 2014-02-05 2015-08-12 AXXAM S.p.A. Substituted thiazole or oxazole as P2X7 receptor antagonists
EP3290417A1 (en) 2016-08-31 2018-03-07 AXXAM S.p.A. 2-chloro-n-[2-(1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)-benzamides and their use as p2x7 receptor antagonists
EP3290416A1 (en) * 2016-08-31 2018-03-07 AXXAM S.p.A. Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist
CN106562947A (zh) * 2016-11-03 2017-04-19 南昌大学 亮蓝g在制备人类免疫缺陷病毒糖蛋白120诱导神经病理痛药物中的应用
CN111377867B (zh) * 2018-12-28 2022-09-06 南京药石科技股份有限公司 一种合成2-(1-烷基-1h-吡唑-4-基)吗啉的中间体及其制备方法和应用
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EP4015039A1 (en) 2020-12-18 2022-06-22 AXXAM S.p.A. Heterocyclic derivatives as p2x7 receptor antagonists
US20240368092A1 (en) * 2021-09-03 2024-11-07 Breye Therapeutics Aps 2,4-Dihydro-3H-1,2,4-Triazol-3-One P2X7 Antagonists
CN113968806A (zh) * 2021-10-12 2022-01-25 北京科技大学 一种非对称硫代酰胺类萃取剂及其合成方法
CN115305282A (zh) * 2022-08-04 2022-11-08 烟台毓璜顶医院 一种用于AR-induced OD诊断和预后判别的靶点及治疗方法
CN121159455A (zh) * 2024-06-18 2025-12-19 武汉人福创新药物研发中心有限公司 氨基酯类化合物及其作为p2x7拮抗剂的用途
WO2026041663A1 (en) 2024-08-22 2026-02-26 Breye Therapeutics Aps P2x7 receptor antagonists
CN121248499B (zh) * 2025-09-22 2026-07-17 广州国家实验室 四氢异喹啉类木瓜蛋白酶样蛋白酶抑制剂及其用途

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