JP6858560B2 - 置換チアゾールまたはオキサゾールp2x7受容体拮抗薬 - Google Patents
置換チアゾールまたはオキサゾールp2x7受容体拮抗薬 Download PDFInfo
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- JP6858560B2 JP6858560B2 JP2016550583A JP2016550583A JP6858560B2 JP 6858560 B2 JP6858560 B2 JP 6858560B2 JP 2016550583 A JP2016550583 A JP 2016550583A JP 2016550583 A JP2016550583 A JP 2016550583A JP 6858560 B2 JP6858560 B2 JP 6858560B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP14154038.5A EP2905282A1 (en) | 2014-02-05 | 2014-02-05 | Substituted thiazole or oxazole as P2X7 receptor antagonists |
| EP14154038.5 | 2014-02-05 | ||
| PCT/EP2015/052316 WO2015118019A1 (en) | 2014-02-05 | 2015-02-04 | Substituted thiazole or oxazole p2x7 receptor antagonists |
Publications (3)
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| JP2017508733A JP2017508733A (ja) | 2017-03-30 |
| JP2017508733A5 JP2017508733A5 (enExample) | 2021-01-21 |
| JP6858560B2 true JP6858560B2 (ja) | 2021-04-14 |
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| JP2016550583A Active JP6858560B2 (ja) | 2014-02-05 | 2015-02-04 | 置換チアゾールまたはオキサゾールp2x7受容体拮抗薬 |
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| SI (1) | SI3102573T1 (enExample) |
| TR (1) | TR201809769T4 (enExample) |
| WO (1) | WO2015118019A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2905282A1 (en) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
| EP3290416A1 (en) | 2016-08-31 | 2018-03-07 | AXXAM S.p.A. | Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist |
| EP3290417A1 (en) | 2016-08-31 | 2018-03-07 | AXXAM S.p.A. | 2-chloro-n-[2-(1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)-benzamides and their use as p2x7 receptor antagonists |
| CN106562947A (zh) * | 2016-11-03 | 2017-04-19 | 南昌大学 | 亮蓝g在制备人类免疫缺陷病毒糖蛋白120诱导神经病理痛药物中的应用 |
| CN111377867B (zh) * | 2018-12-28 | 2022-09-06 | 南京药石科技股份有限公司 | 一种合成2-(1-烷基-1h-吡唑-4-基)吗啉的中间体及其制备方法和应用 |
| CN113543852A (zh) | 2019-03-06 | 2021-10-22 | 第一三共株式会社 | 吡咯并吡唑衍生物 |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| EP4015039A1 (en) | 2020-12-18 | 2022-06-22 | AXXAM S.p.A. | Heterocyclic derivatives as p2x7 receptor antagonists |
| CN113968806A (zh) * | 2021-10-12 | 2022-01-25 | 北京科技大学 | 一种非对称硫代酰胺类萃取剂及其合成方法 |
| CN115305282A (zh) * | 2022-08-04 | 2022-11-08 | 烟台毓璜顶医院 | 一种用于AR-induced OD诊断和预后判别的靶点及治疗方法 |
| WO2025261412A1 (zh) * | 2024-06-18 | 2025-12-26 | 武汉人福创新药物研发中心有限公司 | 氨基酯类化合物及其作为p2x7拮抗剂的用途 |
| WO2026041663A1 (en) | 2024-08-22 | 2026-02-26 | Breye Therapeutics Aps | P2x7 receptor antagonists |
Family Cites Families (15)
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| JP2003128639A (ja) * | 2001-10-25 | 2003-05-08 | Sankyo Co Ltd | ベンツアミド誘導体 |
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| MXPA05012086A (es) | 2003-05-12 | 2006-02-22 | Pfizer Prod Inc | Inhibidores de benzamida del receptor p2x7. |
| KR101165936B1 (ko) * | 2006-11-09 | 2012-07-19 | 에프. 호프만-라 로슈 아게 | 티아졸 및 옥사졸-치환된 아릴아마이드 |
| ITMC20070152A1 (it) * | 2007-07-26 | 2009-01-27 | Faggiolati Pumps Spa | Miscelatore sommerso in particolare miscelatore sommerso per vasche di trattamento delle acque reflue. |
| ES2553412T3 (es) * | 2007-10-31 | 2015-12-09 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| WO2009108551A2 (en) | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Heteroaryl amide analogues |
| CN104058999A (zh) * | 2008-02-29 | 2014-09-24 | 伊沃泰克股份公司 | 酰胺化合物、组合物及其应用 |
| CA2722035C (en) * | 2008-04-22 | 2016-10-11 | Janssen Pharmaceutica Nv | Quinoline or isoquinoline substituted p2x7 antagonists |
| EP2358371B1 (en) * | 2008-10-31 | 2015-02-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| AU2010229142A1 (en) * | 2009-03-23 | 2011-10-13 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| WO2010111059A1 (en) * | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| WO2010111060A1 (en) * | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
| US9718774B2 (en) * | 2012-12-12 | 2017-08-01 | Idorsia Pharmaceuticals Ltd | Indole carboxamide derivatives as P2X7 receptor antagonist |
| EP2905282A1 (en) * | 2014-02-05 | 2015-08-12 | AXXAM S.p.A. | Substituted thiazole or oxazole as P2X7 receptor antagonists |
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2014
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2015
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- 2015-02-04 CA CA2938703A patent/CA2938703C/en active Active
- 2015-02-04 EP EP15705523.7A patent/EP3102573B1/en active Active
- 2015-02-04 RS RS20180763A patent/RS57415B1/sr unknown
- 2015-02-04 TR TR2018/09769T patent/TR201809769T4/tr unknown
- 2015-02-04 PT PT157055237T patent/PT3102573T/pt unknown
- 2015-02-04 WO PCT/EP2015/052316 patent/WO2015118019A1/en not_active Ceased
- 2015-02-04 SI SI201530274T patent/SI3102573T1/en unknown
- 2015-02-04 HU HUE15705523A patent/HUE037545T2/hu unknown
- 2015-02-04 HR HRP20180973TT patent/HRP20180973T1/hr unknown
- 2015-02-04 ES ES15705523.7T patent/ES2670093T3/es active Active
- 2015-02-04 JP JP2016550583A patent/JP6858560B2/ja active Active
- 2015-02-04 PL PL15705523T patent/PL3102573T3/pl unknown
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2017
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015118019A9 (en) | 2016-04-21 |
| WO2015118019A1 (en) | 2015-08-13 |
| EP2905282A1 (en) | 2015-08-12 |
| HUE037545T2 (hu) | 2018-09-28 |
| SI3102573T1 (en) | 2018-07-31 |
| CA2938703C (en) | 2023-01-31 |
| CN106103432B (zh) | 2019-10-18 |
| IL247081B (en) | 2019-11-28 |
| LT3102573T (lt) | 2018-06-25 |
| DK3102573T3 (en) | 2018-06-18 |
| PL3102573T3 (pl) | 2018-11-30 |
| EP3102573A1 (en) | 2016-12-14 |
| CY1120295T1 (el) | 2019-07-10 |
| JP2017508733A (ja) | 2017-03-30 |
| RU2701858C1 (ru) | 2019-10-02 |
| CN106103432A (zh) | 2016-11-09 |
| RS57415B1 (sr) | 2018-09-28 |
| US20170008883A1 (en) | 2017-01-12 |
| HRP20180973T1 (hr) | 2018-08-10 |
| TR201809769T4 (tr) | 2018-07-23 |
| ES2670093T3 (es) | 2018-05-29 |
| US9718812B2 (en) | 2017-08-01 |
| IL247081A0 (en) | 2016-09-29 |
| US10167281B2 (en) | 2019-01-01 |
| US20170283409A1 (en) | 2017-10-05 |
| PT3102573T (pt) | 2018-05-22 |
| CA2938703A1 (en) | 2015-08-13 |
| EP3102573B1 (en) | 2018-04-11 |
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