HUE037545T2 - Helyettesített tiazolok vagy oxazolok mint P2X7 receptor antagonisták - Google Patents

Helyettesített tiazolok vagy oxazolok mint P2X7 receptor antagonisták

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Publication number
HUE037545T2
HUE037545T2 HUE15705523A HUE15705523A HUE037545T2 HU E037545 T2 HUE037545 T2 HU E037545T2 HU E15705523 A HUE15705523 A HU E15705523A HU E15705523 A HUE15705523 A HU E15705523A HU E037545 T2 HUE037545 T2 HU E037545T2
Authority
HU
Hungary
Prior art keywords
oxazole
receptor antagonists
substituted thiazole
thiazole
substituted
Prior art date
Application number
HUE15705523A
Other languages
English (en)
Hungarian (hu)
Inventor
Paolo Pevarello
Stefan Lohmer
Chiara Liberati
Pierfausto Seneci
Cristina Pesenti
Adolfo Prandi
Original Assignee
Axxam Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axxam Spa filed Critical Axxam Spa
Publication of HUE037545T2 publication Critical patent/HUE037545T2/hu

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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HUE15705523A 2014-02-05 2015-02-04 Helyettesített tiazolok vagy oxazolok mint P2X7 receptor antagonisták HUE037545T2 (hu)

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EP3290417A1 (en) 2016-08-31 2018-03-07 AXXAM S.p.A. 2-chloro-n-[2-(1,3-thiazol-5-yl)ethyl]-5-(5-fluoropyrimidin-2-yl)-benzamides and their use as p2x7 receptor antagonists
EP3290416A1 (en) * 2016-08-31 2018-03-07 AXXAM S.p.A. Substituted n-[2-(4-phenoxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide and n-[2-(4-benzyloxypiperidin-1-yl)-2-(1,3-thiazol-5-yl)ethyl]benzamide derivatives and their use as p2x7 receptor antagonist
CN106562947A (zh) * 2016-11-03 2017-04-19 南昌大学 亮蓝g在制备人类免疫缺陷病毒糖蛋白120诱导神经病理痛药物中的应用
CN111377867B (zh) * 2018-12-28 2022-09-06 南京药石科技股份有限公司 一种合成2-(1-烷基-1h-吡唑-4-基)吗啉的中间体及其制备方法和应用
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US20240368092A1 (en) * 2021-09-03 2024-11-07 Breye Therapeutics Aps 2,4-Dihydro-3H-1,2,4-Triazol-3-One P2X7 Antagonists
CN113968806A (zh) * 2021-10-12 2022-01-25 北京科技大学 一种非对称硫代酰胺类萃取剂及其合成方法
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