ES2647239T3 - Proceso para producir cristales de ácido polimórfico 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazolcarboxílico mediante método de adición de solvente pobre - Google Patents

Proceso para producir cristales de ácido polimórfico 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazolcarboxílico mediante método de adición de solvente pobre Download PDF

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Publication number
ES2647239T3
ES2647239T3 ES10799952.6T ES10799952T ES2647239T3 ES 2647239 T3 ES2647239 T3 ES 2647239T3 ES 10799952 T ES10799952 T ES 10799952T ES 2647239 T3 ES2647239 T3 ES 2647239T3
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ES
Spain
Prior art keywords
cyano
methyl
crystals
isobutyloxyphenyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10799952.6T
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English (en)
Spanish (es)
Inventor
Akihito Uemura
Tomoaki Nogata
Takumi Takeyasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Pharma Ltd
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Teijin Pharma Ltd
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Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
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Publication of ES2647239T3 publication Critical patent/ES2647239T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES10799952.6T 2009-07-15 2010-07-14 Proceso para producir cristales de ácido polimórfico 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazolcarboxílico mediante método de adición de solvente pobre Active ES2647239T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009166755 2009-07-15
JP2009166755 2009-07-15
PCT/JP2010/062291 WO2011007895A1 (ja) 2009-07-15 2010-07-14 貧溶媒添加法による２－（３－シアノ－４－イソブチルオキシフェニル）－４－メチル－５－チアゾールカルボン酸の結晶多形体の製造方法

Publications (1)

Publication Number Publication Date
ES2647239T3 true ES2647239T3 (es) 2017-12-20

Family

ID=43449505

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10799952.6T Active ES2647239T3 (es) 2009-07-15 2010-07-14 Proceso para producir cristales de ácido polimórfico 2-(3-ciano-4-isobutiloxifenil)-4-metil-5-tiazolcarboxílico mediante método de adición de solvente pobre

Country Status (15)

Country Link
US (1) US8735596B2 (ja)
EP (1) EP2455372B1 (ja)
JP (1) JP5654462B2 (ja)
KR (1) KR101645768B1 (ja)
CN (1) CN102471295B (ja)
AU (1) AU2010271717B2 (ja)
BR (1) BRPI1011671A2 (ja)
CA (1) CA2764603C (ja)
ES (1) ES2647239T3 (ja)
IL (1) IL217509A (ja)
MX (1) MX2011013946A (ja)
RU (1) RU2530895C2 (ja)
SG (1) SG177673A1 (ja)
TW (1) TWI516480B (ja)
WO (1) WO2011007895A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2502920A1 (en) 2011-03-25 2012-09-26 Sandoz Ag Crystallization process of Febuxostat from A
CN102267957B (zh) * 2011-08-24 2013-04-24 山东齐都药业有限公司 非布司他a晶型的制备方法
CN103936688A (zh) * 2013-01-21 2014-07-23 上海华拓医药科技发展股份有限公司 2-(3-氰基-4-(2-甲基丙氧基)苯基)-4-甲基-5-噻唑甲酸a晶的制备方法
CN103588723B (zh) * 2013-09-10 2015-05-20 杭州华东医药集团新药研究院有限公司 一种非布司他晶型a的制备方法
CN103739568B (zh) * 2014-02-07 2015-09-16 浙江普洛康裕制药有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基噻唑-5-甲酸a晶型的制备方法
TW201625580A (zh) * 2014-05-13 2016-07-16 Teijin Pharma Ltd 吡啶衍生物的新穎結晶多形體及其製造方法
KR20180013563A (ko) * 2016-07-29 2018-02-07 한미정밀화학주식회사 고순도 결정형 페북소스타트의 개선된 제조 방법
CN111499655B (zh) * 2019-01-31 2023-01-06 华东理工大学 一种制备球形晶体的三液乳化溶剂扩散法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1956014T (pt) * 1998-06-19 2019-04-24 Teijin Pharma Ltd Polimorfos de ácido 2-(3-ciano-4-isobutiloxifenil)-4-metil- 5-tiazolecarboxílico e método para a sua produção
JP2003261548A (ja) 2002-03-07 2003-09-19 Teijin Ltd ２−（３−シアノ−４−イソブチルオキシフェニル）−４−メチル−５−チアゾールカルボン酸の結晶多形体の製造方法
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
CN101139325B (zh) * 2006-09-07 2010-05-12 上海医药工业研究院 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸晶型及其制备方法
CN101684107A (zh) * 2008-09-26 2010-03-31 上海优拓医药科技有限公司 非布索坦的新晶型及其制备方法
CN101684108B (zh) * 2009-04-15 2012-01-11 天津市汉康医药生物技术有限公司 2-(3-氰基-4-异丁氧基苯基)-4-甲基-5-噻唑甲酸及其组合物
DE202010017868U1 (de) 2009-06-10 2012-11-28 Teva Pharmaceutical Industries Ltd. Kristalline Formen von Febuxostat

Also Published As

Publication number Publication date
TWI516480B (zh) 2016-01-11
CN102471295B (zh) 2014-07-16
AU2010271717B2 (en) 2014-11-27
BRPI1011671A2 (pt) 2016-03-22
EP2455372A4 (en) 2012-12-05
EP2455372B1 (en) 2017-10-11
SG177673A1 (en) 2012-02-28
IL217509A (en) 2016-04-21
RU2530895C2 (ru) 2014-10-20
US8735596B2 (en) 2014-05-27
TW201118076A (en) 2011-06-01
CA2764603C (en) 2017-03-14
AU2010271717A1 (en) 2011-01-20
IL217509A0 (en) 2012-03-01
CA2764603A1 (en) 2011-01-20
KR101645768B1 (ko) 2016-08-04
MX2011013946A (es) 2012-01-25
JP5654462B2 (ja) 2015-01-14
KR20120036363A (ko) 2012-04-17
RU2012105279A (ru) 2013-08-20
AU2010271717A8 (en) 2012-03-08
WO2011007895A1 (ja) 2011-01-20
JPWO2011007895A1 (ja) 2012-12-27
CN102471295A (zh) 2012-05-23
EP2455372A1 (en) 2012-05-23
US20120108821A1 (en) 2012-05-03

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