ES2638319T3 - Imidazopiridazinas sustituidas con amino - Google Patents
Imidazopiridazinas sustituidas con amino Download PDFInfo
- Publication number
- ES2638319T3 ES2638319T3 ES12761564.9T ES12761564T ES2638319T3 ES 2638319 T3 ES2638319 T3 ES 2638319T3 ES 12761564 T ES12761564 T ES 12761564T ES 2638319 T3 ES2638319 T3 ES 2638319T3
- Authority
- ES
- Spain
- Prior art keywords
- tumors
- alkyl
- inappropriate cellular
- group
- nhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 Amino substituted imidazopyridazines Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 125000005843 halogen group Chemical group 0.000 claims abstract description 11
- 239000012453 solvate Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 150000001204 N-oxides Chemical class 0.000 claims abstract description 7
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 230000024932 T cell mediated immunity Effects 0.000 claims 6
- 230000001413 cellular effect Effects 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 230000028709 inflammatory response Effects 0.000 claims 6
- 230000035755 proliferation Effects 0.000 claims 6
- 230000004083 survival effect Effects 0.000 claims 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 4
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 2
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 2
- 208000009849 Female Genital Neoplasms Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010059282 Metastases to central nervous system Diseases 0.000 claims 2
- 206010027540 Microcytosis Diseases 0.000 claims 2
- 210000000038 chest Anatomy 0.000 claims 2
- 201000011523 endocrine gland cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 208000037841 lung tumor Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 210000003932 urinary bladder Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 206010029098 Neoplasm skin Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 201000004477 skin sarcoma Diseases 0.000 claims 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical group OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 abstract description 21
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract description 16
- 125000000753 cycloalkyl group Chemical group 0.000 abstract description 13
- 125000003118 aryl group Chemical group 0.000 abstract description 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract description 9
- 125000000217 alkyl group Chemical group 0.000 abstract description 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract description 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract description 8
- 125000003003 spiro group Chemical group 0.000 abstract description 8
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract description 6
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 abstract description 6
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract description 5
- 125000004093 cyano group Chemical group *C#N 0.000 abstract description 4
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract description 2
- 101000573522 Homo sapiens MAP kinase-interacting serine/threonine-protein kinase 1 Proteins 0.000 description 4
- 102100026299 MAP kinase-interacting serine/threonine-protein kinase 1 Human genes 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 150000004677 hydrates Chemical class 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000001212 derivatisation Methods 0.000 description 2
- 238000003821 enantio-separation Methods 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004296 chiral HPLC Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid group Chemical group C(CCCCC)(=O)O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Fats And Perfumes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11180129 | 2011-09-06 | ||
| EP11180129 | 2011-09-06 | ||
| EP11182440 | 2011-09-23 | ||
| EP11182440 | 2011-09-23 | ||
| EP12179902 | 2012-08-09 | ||
| EP12179902 | 2012-08-09 | ||
| PCT/EP2012/067264 WO2013034570A1 (en) | 2011-09-06 | 2012-09-05 | Amino-substituted imidazopyridazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2638319T3 true ES2638319T3 (es) | 2017-10-19 |
Family
ID=47831558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12761564.9T Active ES2638319T3 (es) | 2011-09-06 | 2012-09-05 | Imidazopiridazinas sustituidas con amino |
Country Status (36)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103717604B (zh) | 2011-06-01 | 2016-06-01 | 拜耳知识产权有限责任公司 | 取代的氨基咪唑并哒嗪 |
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| WO2013041634A1 (en) * | 2011-09-23 | 2013-03-28 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| JP6147761B2 (ja) | 2011-12-12 | 2017-06-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | アミノ置換イミダゾピリダジン |
| EP2858993B1 (en) * | 2012-03-29 | 2018-01-10 | Bayer Intellectual Property GmbH | Amino-substituted imidazopyridazines |
| CN104321326B (zh) | 2012-04-04 | 2017-05-31 | 拜耳医药股份有限公司 | 氨基取代的咪唑并哒嗪 |
| HK1208025A1 (en) | 2012-11-19 | 2016-02-19 | 拜耳医药股份公司 | Aminoimidazopyridazines |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| RS60244B1 (sr) | 2013-01-15 | 2020-06-30 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| HK1211578A1 (en) | 2013-01-30 | 2016-05-27 | 拜耳医药股份公司 | Amidoimidazopyridazines as mknk-1 kinase inhibitors |
| HK1212699A1 (zh) * | 2013-02-20 | 2016-06-17 | 拜耳医药股份公司 | 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物 |
| CN105658653A (zh) | 2013-08-23 | 2016-06-08 | 因赛特公司 | 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 |
| EP3092242A1 (en) | 2014-01-09 | 2016-11-16 | Bayer Pharma Aktiengesellschaft | Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US20180022750A1 (en) * | 2014-12-23 | 2018-01-25 | Bayer Pharma Aktiengesellschaft | 6-hydroxybenzofuranyl- and 6-alkoxybenzofuranyl-substituted imidazopyridazines |
| EP3285809B1 (en) | 2015-04-20 | 2019-09-11 | eFFECTOR Therapeutics, Inc. | Inhibitors of immune checkpoint modulators for use in treating cancer and infections |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
| WO2017117052A1 (en) * | 2015-12-31 | 2017-07-06 | Effector Therapeutics, Inc. | Mnk biomarkers and uses thereof |
| WO2017157418A1 (en) | 2016-03-15 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Combination of mknk1-inhibitors |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4408047A (en) | 1980-03-28 | 1983-10-04 | Merck & Co., Inc. | Imidazodiazines |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| FR2619818B1 (fr) | 1987-09-01 | 1990-01-12 | Sanofi Sa | Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| WO2003018020A1 (fr) | 2001-08-23 | 2003-03-06 | Takeda Chemical Industries, Ltd. | Inhibiteurs de jnk |
| US20100216798A1 (en) | 2005-07-29 | 2010-08-26 | Astellas Pharma Inc | Fused heterocycles as lck inhibitors |
| US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
| US7750000B2 (en) * | 2005-09-02 | 2010-07-06 | Bayer Schering Pharma Ag | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments |
| DE102005042742A1 (de) | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| WO2007033080A2 (en) | 2005-09-12 | 2007-03-22 | Emory University | Alzheimer's disease imaging agents |
| DE102006029447A1 (de) | 2006-06-21 | 2007-12-27 | Bayer Schering Pharma Ag | Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel |
| ES2340093T3 (es) | 2006-06-22 | 2010-05-28 | Biovitrum Ab (Publ) | Derivados pirazina y piridina como inhibidores de cinasa mnk. |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| EP1900739A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Diazolodiazine derivatives as kinase inhibitors |
| CA2663091A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Modulators of interleukin-1 receptor-associated kinase |
| RU2009120389A (ru) | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
| WO2008058126A2 (en) | 2006-11-06 | 2008-05-15 | Supergen, Inc. | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
| WO2008072682A1 (ja) | 2006-12-15 | 2008-06-19 | Daiichi Sankyo Company, Limited | イミダゾ［１，２－ｂ］ピリダジン誘導体 |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| PA8792501A1 (es) | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
| EP2217601A1 (en) | 2007-11-08 | 2010-08-18 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyridazines for use as protein kinase inhibitors |
| JP2011507902A (ja) | 2007-12-21 | 2011-03-10 | ワイス・エルエルシー | 肝臓Ｘ受容体のモジュレーターとしてのイミダゾ［１，２−ｂ］ピリダジン化合物 |
| JP6121991B2 (ja) * | 2011-05-17 | 2017-04-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｍｋｎｋ１キナーゼ阻害剤としてのアミノ置換イミダゾピリダジン |
| CN103717604B (zh) | 2011-06-01 | 2016-06-01 | 拜耳知识产权有限责任公司 | 取代的氨基咪唑并哒嗪 |
| ES2610366T3 (es) | 2011-06-22 | 2017-04-27 | Bayer Intellectual Property Gmbh | Heterociclil-aminoimidazopiridazinas |
| AR087701A1 (es) | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| US9353081B2 (en) | 2011-09-23 | 2016-05-31 | Hoffmann-La Roche Inc. | Bicyclic dihydroquinoline-2-one derivatives |
| WO2013041634A1 (en) | 2011-09-23 | 2013-03-28 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| JP6147761B2 (ja) | 2011-12-12 | 2017-06-14 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | アミノ置換イミダゾピリダジン |
| EP2858993B1 (en) | 2012-03-29 | 2018-01-10 | Bayer Intellectual Property GmbH | Amino-substituted imidazopyridazines |
| CN104321326B (zh) | 2012-04-04 | 2017-05-31 | 拜耳医药股份有限公司 | 氨基取代的咪唑并哒嗪 |
| HK1208025A1 (en) | 2012-11-19 | 2016-02-19 | 拜耳医药股份公司 | Aminoimidazopyridazines |
| HK1211578A1 (en) | 2013-01-30 | 2016-05-27 | 拜耳医药股份公司 | Amidoimidazopyridazines as mknk-1 kinase inhibitors |
| HK1212699A1 (zh) | 2013-02-20 | 2016-06-17 | 拜耳医药股份公司 | 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物 |
| EP3092242A1 (en) | 2014-01-09 | 2016-11-16 | Bayer Pharma Aktiengesellschaft | Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders |
-
2012
- 2012-05-09 UA UAA201403426A patent/UA117092C2/uk unknown
- 2012-09-05 HR HRP20171248TT patent/HRP20171248T1/hr unknown
- 2012-09-05 PT PT127615649T patent/PT2758401T/pt unknown
- 2012-09-05 JP JP2014528955A patent/JP6174583B2/ja not_active Expired - Fee Related
- 2012-09-05 KR KR1020147008395A patent/KR20140059268A/ko not_active Ceased
- 2012-09-05 AP AP2014007496A patent/AP2014007496A0/xx unknown
- 2012-09-05 RS RS20170812A patent/RS56179B1/sr unknown
- 2012-09-05 AU AU2012306422A patent/AU2012306422B2/en not_active Ceased
- 2012-09-05 SI SI201231035T patent/SI2758401T1/sl unknown
- 2012-09-05 CA CA2847514A patent/CA2847514A1/en not_active Abandoned
- 2012-09-05 ME MEP-2017-191A patent/ME02951B/me unknown
- 2012-09-05 WO PCT/EP2012/067264 patent/WO2013034570A1/en active Application Filing
- 2012-09-05 MY MYPI2014700492A patent/MY168413A/en unknown
- 2012-09-05 LT LTEP12761564.9T patent/LT2758401T/lt unknown
- 2012-09-05 PL PL12761564T patent/PL2758401T3/pl unknown
- 2012-09-05 CN CN201280047525.XA patent/CN103958515B/zh not_active Expired - Fee Related
- 2012-09-05 BR BR112014004687A patent/BR112014004687A2/pt not_active IP Right Cessation
- 2012-09-05 EP EP12761564.9A patent/EP2758401B1/en active Active
- 2012-09-05 MX MX2014002697A patent/MX348064B/es active IP Right Grant
- 2012-09-05 DK DK12761564.9T patent/DK2758401T3/en active
- 2012-09-05 EA EA201400311A patent/EA025688B1/ru not_active IP Right Cessation
- 2012-09-05 ES ES12761564.9T patent/ES2638319T3/es active Active
- 2012-09-05 SG SG11201400219PA patent/SG11201400219PA/en unknown
- 2012-09-05 US US14/342,977 patent/US9499547B2/en not_active Expired - Fee Related
- 2012-09-05 PH PH1/2014/500501A patent/PH12014500501A1/en unknown
- 2012-09-05 PE PE2014000307A patent/PE20141593A1/es not_active Application Discontinuation
-
2014
- 2014-03-05 MA MA36793A patent/MA35422B1/fr unknown
- 2014-03-06 GT GT201400043A patent/GT201400043A/es unknown
- 2014-03-06 EC ECSP14013231 patent/ECSP14013231A/es unknown
- 2014-03-06 IL IL231351A patent/IL231351A/en not_active IP Right Cessation
- 2014-03-06 CO CO14048372A patent/CO6900146A2/es unknown
- 2014-03-06 CR CR20140113A patent/CR20140113A/es unknown
- 2014-03-06 DO DO2014000051A patent/DOP2014000051A/es unknown
- 2014-03-06 CL CL2014000543A patent/CL2014000543A1/es unknown
- 2014-04-04 ZA ZA2014/02498A patent/ZA201402498B/en unknown
-
2017
- 2017-08-23 CY CY20171100892T patent/CY1119433T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2638319T3 (es) | Imidazopiridazinas sustituidas con amino | |
| ES2924193T3 (es) | Procesos e intermedios para preparar un medicamento | |
| ES2632430T3 (es) | Compuestos de imidazopirrolidinona | |
| AR126701A1 (es) | Derivados de n-ciclopropilpirido[4,3-d]pirimidin-4-amina y usos de los mismos | |
| PE20230249A1 (es) | Compuestos de heteroarilo biciclicos y usos de estos | |
| ES2650915T3 (es) | Imidazopiridazinas amino-sustituidas | |
| ES2512491T3 (es) | Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa | |
| ES2600028T3 (es) | Inhibidores selectivos de la glucosidasa y sus usos | |
| ES2657121T3 (es) | Derivados de diazacarbazol como ligandos tau-pet | |
| ES2632914T3 (es) | Derivados de 1,3-dihidro-2H-bencimidazol-2-ona sustituidos con heterociclos como agentes antivirales para el virus respiratorio sincicial | |
| AR066130A1 (es) | Formas cristalinas de saxagliptina y procesos para preparar las mismas | |
| AR070531A1 (es) | Inhibidores de cinasa pim y metodos para su uso | |
| AU2016254700A1 (en) | RSV antiviral pyrazolo- and triazolo-pyrimidine compounds | |
| CL2012000953A1 (es) | Procedimientos de preparacion de derivados espiro[furo[2,3-f][1,3]benzodioxol-7,3`-indol]-2`(1`h)-onas. | |
| RU2015148006A (ru) | Дейтерированные нуклеозидные пролекарства, применимые для лечения hcv | |
| AR041184A1 (es) | Derivados de benzopiranonas, inhibidores de las cinasas dependientes de ciclinas y su uso | |
| AR105522A1 (es) | Derivados de amida sustituida que tienen actividad multimodal contra el dolor | |
| AR051754A1 (es) | Metodos para preparar compuestos de indazol | |
| AR071274A1 (es) | Derivados de pregabalina , composiciones farmaceuticas que los contienen y proceso de preparacion de los mismos | |
| ES2608359T3 (es) | Compuestos de pirazolo[3,4-d]pirimidina sustituidos, su preparación y uso como ligandos de receptores sigma | |
| ES2993277T3 (en) | 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza | |
| DE60300986D1 (de) | Verfahren zur herstellung einer pharmazeutisch aktiven verbindung (granisetron) | |
| ES2957316T3 (es) | Compuestos heteroaromáticos que tienen actividad contra VSR | |
| AR044567A1 (es) | Derivados de imidazol, su preparacion y su utilizacion como medicamento | |
| ES2524712T3 (es) | Derivados de oxazolopirimidina 2,5-sustituidos en calidad de agonistas de EDG-1 |