ES2620289T3 - Cebadores polinucleótidos para detectar mutaciones PIK3CA - Google Patents
Cebadores polinucleótidos para detectar mutaciones PIK3CA Download PDFInfo
- Publication number
- ES2620289T3 ES2620289T3 ES12169599.3T ES12169599T ES2620289T3 ES 2620289 T3 ES2620289 T3 ES 2620289T3 ES 12169599 T ES12169599 T ES 12169599T ES 2620289 T3 ES2620289 T3 ES 2620289T3
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- ES
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- Prior art keywords
- primer
- seq
- primers
- mutation
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 230000035772 mutation Effects 0.000 title abstract description 12
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 title abstract 2
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 230000000295 complement effect Effects 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 101150063858 Pik3ca gene Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 238000009396 hybridization Methods 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 241000239226 Scorpiones Species 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 13
- 238000003556 assay Methods 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 102200085788 rs121913279 Human genes 0.000 description 6
- 102200085789 rs121913279 Human genes 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- 101000829958 Homo sapiens N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Proteins 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 102100023315 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase Human genes 0.000 description 2
- 108010006785 Taq Polymerase Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- BZSALXKCVOJCJJ-IPEMHBBOSA-N (4s)-4-[[(2s)-2-acetamido-3-methylbutanoyl]amino]-5-[[(2s)-1-[[(2s)-1-[[(2s,3r)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy Chemical compound CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 BZSALXKCVOJCJJ-IPEMHBBOSA-N 0.000 description 1
- JTTIOYHBNXDJOD-UHFFFAOYSA-N 2,4,6-triaminopyrimidine Chemical compound NC1=CC(N)=NC(N)=N1 JTTIOYHBNXDJOD-UHFFFAOYSA-N 0.000 description 1
- 102100025230 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Human genes 0.000 description 1
- 108010087522 Aeromonas hydrophilia lipase-acyltransferase Proteins 0.000 description 1
- 108010039224 Amidophosphoribosyltransferase Proteins 0.000 description 1
- 239000004114 Ammonium polyphosphate Substances 0.000 description 1
- 101100098985 Caenorhabditis elegans cct-3 gene Proteins 0.000 description 1
- 101000724418 Homo sapiens Neutral amino acid transporter B(0) Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 108700010674 N-acetylVal-Nle(7,8)- allatotropin (5-13) Proteins 0.000 description 1
- 102100028267 Neutral amino acid transporter B(0) Human genes 0.000 description 1
- 108010025592 aminoadipoyl-cysteinyl-allylglycine Proteins 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0719034 | 2007-09-28 | ||
| GB0719034A GB2453173A (en) | 2007-09-28 | 2007-09-28 | Polynucleotide primers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2620289T3 true ES2620289T3 (es) | 2017-06-28 |
Family
ID=38701889
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12169594.4T Active ES2532225T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169599.3T Active ES2620289T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES12169604T Active ES2531055T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES10158523.0T Active ES2531994T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169586.0T Active ES2622885T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES10158519.8T Active ES2532141T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12169594.4T Active ES2532225T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12169604T Active ES2531055T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES10158523.0T Active ES2531994T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
| ES12169586.0T Active ES2622885T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores polinucleótidos para detectar mutaciones PIK3CA |
| ES10158519.8T Active ES2532141T3 (es) | 2007-09-28 | 2008-09-29 | Cebadores de polinucleótidos para detectar mutaciones de PIK3CA |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US8901285B2 (enExample) |
| EP (7) | EP2239341B1 (enExample) |
| JP (1) | JP5719593B2 (enExample) |
| KR (4) | KR101543214B1 (enExample) |
| CN (4) | CN103834724B (enExample) |
| AU (1) | AU2008303400B2 (enExample) |
| BR (1) | BRPI0817444A2 (enExample) |
| CA (2) | CA2700710C (enExample) |
| ES (6) | ES2532225T3 (enExample) |
| GB (1) | GB2453173A (enExample) |
| MX (1) | MX2010003486A (enExample) |
| RU (1) | RU2491289C2 (enExample) |
| WO (1) | WO2009040557A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2453173A (en) | 2007-09-28 | 2009-04-01 | Dxs Ltd | Polynucleotide primers |
| CA3113213A1 (en) | 2010-01-12 | 2011-07-21 | Siemens Healthcare Diagnostics Inc. | Oligonucleotides and methods for detecting kras mutations |
| JP2013081450A (ja) * | 2011-09-27 | 2013-05-09 | Arkray Inc | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット |
| CN102453765B (zh) * | 2011-11-03 | 2013-07-24 | 厦门艾德生物医药科技有限公司 | Pik3ca基因驱动突变的检测探针、引物及试剂盒 |
| BR112014023530A2 (pt) | 2012-03-29 | 2017-07-18 | Novartis Ag | diagnóstico farmacêutico |
| CN102816839A (zh) * | 2012-07-06 | 2012-12-12 | 杭州艾迪康医学检验中心有限公司 | 用于检测结直肠癌pik3ca基因热点突变位点的试剂盒 |
| EP2711432A1 (en) * | 2012-09-21 | 2014-03-26 | Genomica S.A.U. | Method for detection of BRAF and PI3K mutations |
| CN108130373A (zh) * | 2013-03-13 | 2018-06-08 | 豪夫迈·罗氏有限公司 | 在人pi3kca (pik3ca)基因中检测突变的方法和组合物 |
| CN103773837A (zh) * | 2013-06-25 | 2014-05-07 | 宁波有成生物医药科技有限公司 | 一种pik3ca基因突变荧光定量pcr检测试剂盒及检测方法 |
| RU2549682C1 (ru) * | 2013-10-21 | 2015-04-27 | Общество с ограниченной ответственностью "БИОЧИП-ИМБ" | Способ анализа соматических мутаций в гене pi3k с использованием lna-блокирующей мультиплексной пцр и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом) |
| WO2015161274A1 (en) * | 2014-04-18 | 2015-10-22 | Blueprint Medicines Corporation | Pik3ca fusions |
| CN105274188A (zh) * | 2014-05-29 | 2016-01-27 | 北京雅康博生物科技有限公司 | Pik3ca基因突变检测试剂盒 |
| RS59710B1 (sr) * | 2014-08-07 | 2020-01-31 | Pharmassist Ltd | Metod određivanja mutacionog statusa pik3ca u uzorku |
| US12391985B2 (en) | 2014-08-07 | 2025-08-19 | Pharmassist Ltd | Method of determining PIK3CA mutational status in a sample |
| US10276072B2 (en) * | 2014-09-03 | 2019-04-30 | Washme Properties, Llc | Illuminated sign |
| CN105441533B (zh) * | 2014-11-29 | 2019-07-05 | 上海赛安生物医药科技有限公司 | Pik3ca基因突变检测体系及其试剂盒 |
| CN104531875A (zh) * | 2014-12-30 | 2015-04-22 | 宁波有成生物医药科技有限公司 | 一种MyD88基因突变荧光定量PCR检测试剂盒及检测方法 |
| WO2025110738A1 (ko) * | 2023-11-24 | 2025-05-30 | 주식회사 캐니캐티케어 | 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법 |
| KR20250078789A (ko) | 2023-11-24 | 2025-06-04 | 주식회사 캐니캐티케어 | 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| GB9208135D0 (en) * | 1992-04-13 | 1992-05-27 | Ludwig Inst Cancer Res | Polypeptides having kinase activity,their preparation and use |
| US5846824A (en) * | 1994-02-07 | 1998-12-08 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US6274327B1 (en) | 1992-04-13 | 2001-08-14 | Ludwig Institute For Cancer Research | Polypeptides having kinase activity, their preparation and use |
| US20030225013A1 (en) * | 2002-05-31 | 2003-12-04 | Isis Pharmaceuticals Inc. | Antisense modulation of phosphoinositide-3-kinase, regulatory subunit 4, p150 expression |
| US5847972A (en) | 1993-09-24 | 1998-12-08 | Eick; Stephen Gregory | Method and apparatus for graphically analzying a log-file |
| US6043062A (en) * | 1995-02-17 | 2000-03-28 | The Regents Of The University Of California | Constitutively active phosphatidylinositol 3-kinase and uses thereof |
| US5948664A (en) * | 1996-02-29 | 1999-09-07 | The Regents Of The University Of California | PI 3-kinase polypeptides |
| JP2000506396A (ja) * | 1996-11-01 | 2000-05-30 | オニックス ファーマシューティカルズ，インコーポレイティド | ホスファチジルイノシトール―３′―キナーゼ関連タンパク質をコードするヌクレオチド配列及びその利用 |
| US6277563B1 (en) * | 1997-01-16 | 2001-08-21 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| US5955277A (en) * | 1997-05-05 | 1999-09-21 | Novo Nordisk A/S | Mutant cDNA encoding the p85α subunit of phosphatidylinositol 3-kinase |
| US5994076A (en) * | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
| US8101349B2 (en) * | 1997-12-23 | 2012-01-24 | Novartis Vaccines And Diagnostics, Inc. | Gene products differentially expressed in cancerous cells and their methods of use II |
| US6537751B1 (en) | 1998-04-21 | 2003-03-25 | Genset S.A. | Biallelic markers for use in constructing a high density disequilibrium map of the human genome |
| AU4187499A (en) * | 1998-05-14 | 1999-11-29 | Chiron Corporation | Human genes and gene expression products v |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| US6274237B1 (en) * | 1999-05-21 | 2001-08-14 | Chisso Corporation | Potentially crimpable composite fiber and a non-woven fabric using the same |
| AU781151B2 (en) * | 1999-10-26 | 2005-05-12 | Immusol Incorporated | Ribozyme therapy for the treatment of proliferative skin and eye diseases |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| AU2001294842A1 (en) * | 2000-09-28 | 2002-04-08 | Atairgin Technologies, Inc. | A method of determining tumor characteristics by determining abnormal copy number or expression level of lipid-associated genes |
| USH2191H1 (en) * | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| CN1358850A (zh) * | 2000-12-13 | 2002-07-17 | 上海博德基因开发有限公司 | 一种新的多肽——人磷脂酰肌醇3(PtdIns 3)－激酶17.6和编码这种多肽的多核苷酸 |
| CA2372542A1 (en) | 2001-02-20 | 2002-08-20 | Pfizer Products Inc. | Transgenic animals containing a dominant negative mutant form of the p85 subunit of pi-3 kinase |
| US20030162174A1 (en) * | 2001-06-11 | 2003-08-28 | Sutherland John W. | Detecting nucleic acid deletion sequences |
| WO2003025175A2 (fr) * | 2001-09-17 | 2003-03-27 | Molecular Engines Laboratories | Sequences impliquees dans les phenomenes de suppression tumorale, reversion tumorale, apoptose et/ou resistance aux virus et leur utilisation comme medicaments |
| US20030182669A1 (en) * | 2002-03-19 | 2003-09-25 | Rockman Howard A. | Phosphoinositide 3-kinase mediated inhibition of GPCRs |
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