ES2558124T3 - Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento - Google Patents
Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento Download PDFInfo
- Publication number
- ES2558124T3 ES2558124T3 ES14166884.8T ES14166884T ES2558124T3 ES 2558124 T3 ES2558124 T3 ES 2558124T3 ES 14166884 T ES14166884 T ES 14166884T ES 2558124 T3 ES2558124 T3 ES 2558124T3
- Authority
- ES
- Spain
- Prior art keywords
- restriction fragments
- sequencing
- aflp
- amplified adapter
- adapter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000005652 acute fatty liver of pregnancy Diseases 0.000 title abstract description 11
- 238000000034 method Methods 0.000 title abstract description 8
- 238000001514 detection method Methods 0.000 title description 8
- 239000012634 fragment Substances 0.000 abstract description 20
- 238000012163 sequencing technique Methods 0.000 abstract description 16
- 230000002068 genetic effect Effects 0.000 abstract description 8
- 238000003205 genotyping method Methods 0.000 abstract description 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 description 5
- 239000002773 nucleotide Substances 0.000 description 5
- 125000003729 nucleotide group Chemical group 0.000 description 5
- 238000002869 basic local alignment search tool Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 108700028369 Alleles Proteins 0.000 description 3
- 235000002566 Capsicum Nutrition 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000004005 microsphere Substances 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 239000006002 Pepper Substances 0.000 description 2
- 241000722363 Piper Species 0.000 description 2
- 235000016761 Piper aduncum Nutrition 0.000 description 2
- 235000017804 Piper guineense Nutrition 0.000 description 2
- 235000008184 Piper nigrum Nutrition 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 238000003505 heat denaturation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 101150044508 key gene Proteins 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000001303 quality assessment method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75259005P | 2005-12-22 | 2005-12-22 | |
US752590P | 2005-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2558124T3 true ES2558124T3 (es) | 2016-02-02 |
Family
ID=37834098
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06835670T Active ES2391837T3 (es) | 2005-12-22 | 2006-12-20 | Método para la detección de polimorfismos basados en AFLP de alto rendimiento |
ES14166884.8T Active ES2558124T3 (es) | 2005-12-22 | 2006-12-20 | Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento |
ES18174221T Active ES2882401T3 (es) | 2005-12-22 | 2006-12-20 | Método de detección de polimorfismos basado en AFLP de alto rendimiento |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES06835670T Active ES2391837T3 (es) | 2005-12-22 | 2006-12-20 | Método para la detección de polimorfismos basados en AFLP de alto rendimiento |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES18174221T Active ES2882401T3 (es) | 2005-12-22 | 2006-12-20 | Método de detección de polimorfismos basado en AFLP de alto rendimiento |
Country Status (8)
Country | Link |
---|---|
US (11) | US8481257B2 (pt-PT) |
EP (5) | EP1966393B1 (pt-PT) |
JP (1) | JP5452021B2 (pt-PT) |
CN (2) | CN101374963B (pt-PT) |
DK (3) | DK2789696T3 (pt-PT) |
ES (3) | ES2391837T3 (pt-PT) |
PL (1) | PL2789696T3 (pt-PT) |
WO (1) | WO2007073165A1 (pt-PT) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5220597B2 (ja) | 2005-06-23 | 2013-06-26 | キージーン ナムローゼ フェンノートシャップ | 1つ又は複数の多型性を同定する方法およびその使用方法 |
JP5237099B2 (ja) | 2005-09-29 | 2013-07-17 | キージーン ナムローゼ フェンノートシャップ | 変異させた集団のハイスループットスクリーニング |
EP1966393B1 (en) | 2005-12-22 | 2012-07-25 | Keygene N.V. | Method for high-throughput aflp-based polymorphism detection |
JP2009047956A (ja) * | 2007-08-21 | 2009-03-05 | Sony Corp | 撮像装置 |
CA2706801A1 (en) * | 2007-11-27 | 2009-06-04 | Vib Vzw | Genetic improvement of industrial microorganisms using marker-assisted directed evolution |
EP2172565A1 (en) * | 2008-09-24 | 2010-04-07 | Cyano Biotech GmbH | Method of identifying and/or differentiating cyanophyta |
CA2745853A1 (en) | 2008-12-05 | 2010-06-10 | Keygene N.V. | Farnesene synthase |
US20100227776A1 (en) * | 2009-03-05 | 2010-09-09 | The Ohio State University | Rapid Genotyping of SNPs |
WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
CN101886132B (zh) * | 2009-07-15 | 2013-09-18 | 北京百迈客生物科技有限公司 | 基于测序和bsa技术的性状相关的分子标记筛选方法 |
JP5799484B2 (ja) * | 2009-12-14 | 2015-10-28 | トヨタ自動車株式会社 | Dnaマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するdnaマイクロアレイ |
AU2010330936B2 (en) | 2009-12-17 | 2014-05-22 | Keygene N.V. | Restriction enzyme based whole genome sequencing |
EP2556171B1 (en) | 2010-04-05 | 2015-09-02 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
EP2599877B1 (en) * | 2010-06-30 | 2017-09-27 | BGI Genomics Co., Limited | New pcr sequencing method and use thereof in hla genotyping |
CN102061526B (zh) * | 2010-11-23 | 2014-04-30 | 深圳华大基因科技服务有限公司 | 一种DNA文库及其制备方法、以及一种检测SNPs的方法和装置 |
WO2012072705A1 (en) | 2010-12-01 | 2012-06-07 | Morphosys Ag | Simultaneous detection of biomolecules in single cells |
WO2012071685A1 (zh) * | 2010-12-02 | 2012-06-07 | 深圳华大基因科技有限公司 | Hpv精确分型的生物信息学分析的方法及系统 |
US20130331277A1 (en) * | 2011-01-14 | 2013-12-12 | Keygene N.V. | Paired end random sequence based genotyping |
CN102181943B (zh) * | 2011-03-02 | 2013-06-05 | 中山大学 | 一种配对双末端文库构建方法及用该文库进行基因组测序的方法 |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US9476095B2 (en) | 2011-04-15 | 2016-10-25 | The Johns Hopkins University | Safe sequencing system |
ES2556580T3 (es) * | 2011-07-08 | 2016-01-19 | Keygene N.V. | Genotipado a base de secuencias en base a ensayos de ligación a oligonucleótidos |
US20150120210A1 (en) * | 2011-12-29 | 2015-04-30 | Bgi Tech Solutions Co., Ltd. | Method and device for labelling single nucleotide polymorphism sites in genome |
EP3434789A1 (en) | 2012-01-13 | 2019-01-30 | Data2Bio | Genotyping by next-generation sequencing |
ES2665071T3 (es) | 2012-02-17 | 2018-04-24 | Fred Hutchinson Cancer Research Center | Composiciones y métodos para identificar mutaciones de manera precisa |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
CN104508141A (zh) * | 2012-08-23 | 2015-04-08 | 深圳华大基因科技有限公司 | 确定个体是否患有异常状态的方法及系统 |
CN102864498B (zh) * | 2012-09-24 | 2014-07-16 | 中国科学院天津工业生物技术研究所 | 一种长片段末端文库的构建方法 |
GB201217888D0 (en) * | 2012-10-05 | 2012-11-21 | Univ Leuven Kath | High-throughput genotyping by sequencing of single cell |
USRE50065E1 (en) | 2012-10-17 | 2024-07-30 | 10X Genomics Sweden Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
AU2013338393C1 (en) | 2012-10-29 | 2024-07-25 | The Johns Hopkins University | Papanicolaou test for ovarian and endometrial cancers |
US20140274738A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
EP3013983B1 (en) | 2013-06-25 | 2023-02-15 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
CN104630202A (zh) * | 2013-11-13 | 2015-05-20 | 北京大学 | 一种能够减小微量核酸物质整体扩增时产生偏倚的扩增方法 |
CN105849264B (zh) | 2013-11-13 | 2019-09-27 | 纽亘技术公司 | 用于鉴别重复测序读数的组合物和方法 |
ES2693217T3 (es) | 2013-12-02 | 2018-12-10 | Personal Genome Diagnostics Inc. | Método para evaluar variantes minoritarias en una muestra |
SG11201707515SA (en) | 2015-04-10 | 2017-10-30 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
CN106676095A (zh) * | 2015-11-09 | 2017-05-17 | 中国科学院植物研究所 | 用于开发遗传标记的成套试剂和高通量测序开发遗传标记的方法 |
EP3187040A1 (en) | 2015-12-30 | 2017-07-05 | Vilmorin et Cie | Resistance to tolcndv in melons |
CN105695572B (zh) * | 2016-02-02 | 2021-02-23 | 中国水产科学研究院南海水产研究所 | 一种基于Indel和SSR位点技术大批量且高效开发分子标记的方法 |
ITUA20162640A1 (it) * | 2016-04-15 | 2017-10-15 | Menarini Silicon Biosystems Spa | Metodo e kit per la generazione di librerie di dna per sequenziamento massivo parallelo |
US10190155B2 (en) * | 2016-10-14 | 2019-01-29 | Nugen Technologies, Inc. | Molecular tag attachment and transfer |
CN106701949B (zh) * | 2016-12-30 | 2019-09-17 | 人和未来生物科技(长沙)有限公司 | 一种减少扩增偏倚的基因突变检测方法和试剂 |
CA3198931A1 (en) | 2017-01-20 | 2018-07-26 | Sequenom, Inc. | Methods for non-invasive assessment of genetic alterations |
WO2018183942A1 (en) | 2017-03-31 | 2018-10-04 | Grail, Inc. | Improved library preparation and use thereof for sequencing-based error correction and/or variant identification |
KR102775704B1 (ko) | 2017-08-07 | 2025-02-28 | 더 존스 홉킨스 유니버시티 | 암을 평가하고 치료하기 위한 방법 및 재료 |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
WO2019121603A1 (en) | 2017-12-18 | 2019-06-27 | Keygene N.V. | Chemical mutagenesis of cassava |
DE202019005627U1 (de) | 2018-04-02 | 2021-05-31 | Grail, Inc. | Methylierungsmarker und gezielte Methylierungssondenpanels |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
WO2020069350A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
AU2019390691A1 (en) | 2018-11-28 | 2021-05-13 | Keygene N.V. | Targeted enrichment by endonuclease protection |
WO2020123318A1 (en) | 2018-12-10 | 2020-06-18 | 10X Genomics, Inc. | Resolving spatial arrays using deconvolution |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
CN113474466A (zh) | 2019-02-21 | 2021-10-01 | 主基因有限公司 | 多倍体基因分型 |
US20220205017A1 (en) * | 2019-05-20 | 2022-06-30 | Arima Genomics, Inc. | Methods and compositions for enhanced genome coverage and preservation of spatial proximal contiguity |
EP3976820A1 (en) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
US20220243267A1 (en) * | 2019-05-31 | 2022-08-04 | North Carolina State University | Compositions and methods related to quantitative reduced representation sequencing |
WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
EP4073245A1 (en) | 2019-12-12 | 2022-10-19 | Keygene N.V. | Semi-solid state nucleic acid manipulation |
CA3161280A1 (en) | 2019-12-20 | 2021-06-24 | Rene Cornelis Josephus Hogers | Next-generation sequencing library preparation using covalently closed nucleic acid molecule ends |
ES2946357T3 (es) | 2019-12-23 | 2023-07-17 | 10X Genomics Inc | Métodos para el análisis espacial usando ligación con molde de ARN |
EP4081656A1 (en) | 2019-12-23 | 2022-11-02 | 10X Genomics, Inc. | Compositions and methods for using fixed biological samples in partition-based assays |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
CN113275053A (zh) | 2020-02-03 | 2021-08-20 | 帝肯基因组学公司 | 试剂存储系统 |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US12129516B2 (en) | 2020-02-07 | 2024-10-29 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
EP4242325B1 (en) | 2020-04-22 | 2025-01-29 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
EP4414459A3 (en) | 2020-05-22 | 2024-09-18 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
AU2021283184A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
US12265079B1 (en) | 2020-06-02 | 2025-04-01 | 10X Genomics, Inc. | Systems and methods for detecting analytes from captured single biological particles |
US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
WO2021252591A1 (en) | 2020-06-10 | 2021-12-16 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
EP4450639A3 (en) | 2020-06-25 | 2025-01-22 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
EP4491742A3 (en) | 2020-09-18 | 2025-05-21 | 10x Genomics, Inc. | Sample handling apparatus and image registration methods |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
EP4225914A1 (en) | 2020-10-06 | 2023-08-16 | Keygene N.V. | Targeted sequence addition |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
EP4251761A1 (en) | 2020-11-24 | 2023-10-04 | Keygene N.V. | Targeted enrichment using nanopore selective sequencing |
US20240093288A1 (en) | 2020-11-25 | 2024-03-21 | Koninklijke Nederlandse Akademie Van Wetenschappen | Ribosomal profiling in single cells |
AU2021409136A1 (en) | 2020-12-21 | 2023-06-29 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
US20240076653A1 (en) * | 2020-12-31 | 2024-03-07 | Mokobio Life Science Corporation Beijing | Method for constructing multiplex pcr library for high-throughput targeted sequencing |
EP4421491A3 (en) | 2021-02-19 | 2024-11-27 | 10X Genomics, Inc. | Method of using a modular assay support device |
EP4524261A3 (en) | 2021-03-18 | 2025-05-14 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
WO2022221425A1 (en) | 2021-04-14 | 2022-10-20 | 10X Genomics, Inc. | Methods of measuring mislocalization of an analyte |
EP4582555A2 (en) | 2021-06-03 | 2025-07-09 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
EP4509614A3 (en) | 2021-09-01 | 2025-05-14 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
EP4305195A2 (en) | 2021-12-01 | 2024-01-17 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
EP4441711A1 (en) | 2021-12-20 | 2024-10-09 | 10X Genomics, Inc. | Self-test for pathology/histology slide imaging device |
CN115131784B (zh) * | 2022-04-26 | 2023-04-18 | 东莞博奥木华基因科技有限公司 | 一种图像处理方法、装置、电子设备及存储介质 |
WO2024121354A1 (en) | 2022-12-08 | 2024-06-13 | Keygene N.V. | Duplex sequencing with covalently closed dna ends |
WO2024209000A1 (en) | 2023-04-04 | 2024-10-10 | Keygene N.V. | Linkers for duplex sequencing |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US24939A (en) | 1859-08-02 | Improvement in sewing-machines | ||
EP0124990B1 (en) | 1983-04-28 | 1987-08-19 | Flexible Steel Lacing Company | Method and apparatus for riveting fasteners to a belt |
EP0456721A4 (en) | 1989-01-31 | 1992-06-03 | University Of Miami | Microdissection and amplification of chromosomal dna |
US20100267023A1 (en) | 1992-09-24 | 2010-10-21 | Keygene N.V. | Selective restriction fragment amplification: fingerprinting |
HU223760B1 (hu) | 1991-09-24 | 2005-01-28 | Keygene N.V. | Szelektív restrikciós fragmentumsokszorosítás, általános módszer DNS-fingerprint analízisére |
WO1995019697A1 (en) * | 1994-01-21 | 1995-07-27 | North Carolina State University | Methods for within family selection in woody perennials using genetic markers |
EG23907A (en) | 1994-08-01 | 2007-12-30 | Delta & Pine Land Co | Control of plant gene expression |
US6013445A (en) * | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
NZ298236A (en) * | 1994-11-28 | 1999-01-28 | Du Pont | Primers for detecting genetic polymorphisms |
US5565340A (en) * | 1995-01-27 | 1996-10-15 | Clontech Laboratories, Inc. | Method for suppressing DNA fragment amplification during PCR |
US6100030A (en) * | 1997-01-10 | 2000-08-08 | Pioneer Hi-Bred International, Inc. | Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening |
US6090556A (en) * | 1997-04-07 | 2000-07-18 | Japan Science & Technology Corporation | Method for quantitatively determining the expression of a gene |
JP2001515362A (ja) | 1997-05-13 | 2001-09-18 | ディスプレイ・システムズ・バイオテック・アクティーゼルスカブ | mRNAをクローニングする方法および差次的に発現された転写物のディスプレイ(DODET) |
ATE369439T1 (de) | 1997-12-15 | 2007-08-15 | Csl Behring Gmbh | Markierter primer, geeignet für die detektion von nukleinsäuren |
CA2273616A1 (en) | 1998-06-08 | 1999-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for parallel screening of allelic variation |
US6124201A (en) | 1998-06-12 | 2000-09-26 | Advanced Micro Devices, Inc. | Method for manufacturing semiconductors with self-aligning vias |
ATE244771T1 (de) | 1998-07-29 | 2003-07-15 | Keygene Nv | Verfahren zur erkennung von nukleinsäuremethylierungen durch aflp |
US6232067B1 (en) | 1998-08-17 | 2001-05-15 | The Perkin-Elmer Corporation | Adapter directed expression analysis |
US6703228B1 (en) | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
EP1001037A3 (en) | 1998-09-28 | 2003-10-01 | Whitehead Institute For Biomedical Research | Pre-selection and isolation of single nucleotide polymorphisms |
WO2000023620A1 (en) | 1998-10-16 | 2000-04-27 | Keygene N.V. | Method for the generation of dna fingerprints |
EP1124990B1 (en) | 1998-10-27 | 2006-01-18 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
US6480791B1 (en) | 1998-10-28 | 2002-11-12 | Michael P. Strathmann | Parallel methods for genomic analysis |
EP1141384A2 (en) | 1999-01-06 | 2001-10-10 | Cornell Research Foundation, Inc. | Method for accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing |
US20040029155A1 (en) * | 1999-01-08 | 2004-02-12 | Curagen Corporation | Method for identifying a biomolecule |
DE60004630T2 (de) | 1999-01-12 | 2004-06-17 | Quanam Medical Corp., Santa Clara | Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten |
DE19911130A1 (de) * | 1999-03-12 | 2000-09-21 | Hager Joerg | Verfahren zur Identifikation chromosomaler Regionen und Gene |
JP2002540802A (ja) | 1999-04-06 | 2002-12-03 | イェール ユニバーシティ | 配列標識の固定されたアドレス分析 |
ES2298139T3 (es) * | 1999-04-09 | 2008-05-16 | Keygene N.V. | Metodo para el analisis de mezclas de reaccion de aflp utilizando tecnicas de extension del iniciador. |
US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
US20020119448A1 (en) | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
US20030204075A9 (en) * | 1999-08-09 | 2003-10-30 | The Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
WO2001021840A2 (en) * | 1999-09-23 | 2001-03-29 | Gene Logic, Inc. | Indexing populations |
US6287778B1 (en) | 1999-10-19 | 2001-09-11 | Affymetrix, Inc. | Allele detection using primer extension with sequence-coded identity tags |
US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
WO2001038572A1 (fr) | 1999-11-19 | 2001-05-31 | Takara Bio Inc. | Methode d'amplification d'acides nucleiques |
WO2001075167A1 (en) | 2000-03-31 | 2001-10-11 | Fred Hutchinson Cancer Research Center | Reverse genetic strategy for identifying functional mutations in genes of known sequence |
US20110131679A2 (en) | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
EP1282729A2 (en) | 2000-05-15 | 2003-02-12 | Keygene N.V. | Microsatellite-aflp |
US7300751B2 (en) * | 2000-06-30 | 2007-11-27 | Syngenta Participations Ag | Method for identification of genetic markers |
AU2002246612B2 (en) | 2000-10-24 | 2007-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic DNA |
US7141364B1 (en) * | 2001-03-29 | 2006-11-28 | Council Of Scientific And Industrial Research | Universal primers for wildlife identification |
US20040053236A1 (en) | 2001-03-30 | 2004-03-18 | Mccallum Claire M. | Reverse genetic strategy for identifying functional mutations in genes of known sequences |
WO2002083911A1 (en) | 2001-04-12 | 2002-10-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Production of plants with increased tolerance to drought stress or with increased transpiration |
US20050064406A1 (en) | 2001-04-20 | 2005-03-24 | Eugene Zabarovsky | Methods for high throughput genome analysis using restriction site tagged microarrays |
EP1417475A4 (en) | 2001-07-06 | 2006-06-28 | 454 Corp | METHOD FOR ISOLATING INDEPENDENT, PARALLEL CHEMICAL MICRORE ACTIONS USING A POROUS FILTER |
AU2002323509A1 (en) | 2001-08-30 | 2003-03-18 | Purdue Research Foundation | Methods to produce transgenic plants resistant to osmotic stress |
EP1288301A1 (en) | 2001-08-31 | 2003-03-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | Plant-derived resistance gene |
US6902921B2 (en) | 2001-10-30 | 2005-06-07 | 454 Corporation | Sulfurylase-luciferase fusion proteins and thermostable sulfurylase |
US7504222B2 (en) | 2001-10-31 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
US7655791B2 (en) * | 2001-11-13 | 2010-02-02 | Rubicon Genomics, Inc. | DNA amplification and sequencing using DNA molecules generated by random fragmentation |
US7432416B2 (en) | 2002-03-27 | 2008-10-07 | Agrigenetics, Inc. | Generation of plants with improved drought tolerance |
US6815167B2 (en) | 2002-04-25 | 2004-11-09 | Geneohm Sciences | Amplification of DNA to produce single-stranded product of defined sequence and length |
EP1362929A3 (en) * | 2002-05-17 | 2004-05-19 | Affymetrix, Inc. | Methods for genotyping |
US7108976B2 (en) * | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
WO2004001074A1 (en) | 2002-06-21 | 2003-12-31 | Lynx Therapeutics, Inc. | Method for detecting foreign dna in a host genome |
WO2004022758A1 (en) | 2002-09-05 | 2004-03-18 | Plant Bioscience Limited | Genome partitioning |
US20040157238A1 (en) | 2002-09-20 | 2004-08-12 | Quinn John J. | Method for detection of multiple nucleic acid sequence variations |
AU2003298095A1 (en) | 2002-10-18 | 2004-05-04 | Cropdesign N.V. | Identification of e2f target genes and uses thereof |
MXPA05006633A (es) | 2002-12-18 | 2006-05-25 | Third Wave Tech Inc | Deteccion de pequenos acidos nucleicos. |
JP2004208586A (ja) | 2002-12-27 | 2004-07-29 | Wakunaga Pharmaceut Co Ltd | Hlaの検出 |
EP1581661B1 (en) * | 2003-01-10 | 2012-09-12 | Keygene N.V. | Aflp-based method for integrating physical and genetic maps |
ES2342665T3 (es) | 2003-01-29 | 2010-07-12 | 454 Corporation | Secuenciacion desde dos extremos. |
EP2365095A1 (en) * | 2003-02-26 | 2011-09-14 | Callida Genomics, Inc. | Random array DNA analysis by hybridization |
JP4888876B2 (ja) | 2003-06-13 | 2012-02-29 | 田平 武 | アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター |
US7754945B2 (en) | 2003-06-24 | 2010-07-13 | Agrigenetics Inc. | Generation of plants with improved drought tolerance |
EP1685242B1 (en) | 2003-06-24 | 2011-04-20 | Agrigenetics, Inc. | Generation of plants with improved drought tolerance |
US7051935B2 (en) | 2003-07-28 | 2006-05-30 | Imageid Ltd. | Color calibration for color bar codes |
US7365179B2 (en) | 2003-09-09 | 2008-04-29 | Compass Genetics, Llc | Multiplexed analytical platform |
WO2005040400A2 (en) * | 2003-10-24 | 2005-05-06 | Mmi Genomics, Inc. | Methods and systems for inferring traits to manage non-beef livestock |
EP2789383B1 (en) | 2004-01-07 | 2023-05-03 | Illumina Cambridge Limited | Molecular arrays |
US20050233354A1 (en) | 2004-01-22 | 2005-10-20 | Affymetrix, Inc. | Genotyping degraded or mitochandrial DNA samples |
DE602005018166D1 (de) | 2004-02-12 | 2010-01-21 | Population Genetics Technologi | Genetische analyse mittels sequenzspezifischem sortieren |
CA2556981C (en) | 2004-02-18 | 2015-10-13 | The Trustees Of Boston University | Method for detecting and quantifying rare mutations or polymorphisms |
EP1574585A1 (en) | 2004-03-12 | 2005-09-14 | Plant Research International B.V. | Method for selective amplification of DNA fragments for genetic fingerprinting |
JP4809594B2 (ja) | 2004-08-02 | 2011-11-09 | 東京エレクトロン株式会社 | 検査装置 |
FR2876479B1 (fr) | 2004-10-11 | 2006-12-15 | Parkeon | Machine a pieces a receptacle de pieces de monnaie amovible |
US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
US7393665B2 (en) | 2005-02-10 | 2008-07-01 | Population Genetics Technologies Ltd | Methods and compositions for tagging and identifying polynucleotides |
US7407757B2 (en) | 2005-02-10 | 2008-08-05 | Population Genetics Technologies | Genetic analysis by sequence-specific sorting |
WO2006122215A2 (en) * | 2005-05-10 | 2006-11-16 | State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Methods of mapping polymorphisms and polymorphism microarrays |
WO2006138284A2 (en) | 2005-06-15 | 2006-12-28 | Callida Genomics, Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
JP5220597B2 (ja) | 2005-06-23 | 2013-06-26 | キージーン ナムローゼ フェンノートシャップ | 1つ又は複数の多型性を同定する方法およびその使用方法 |
CN101278058A (zh) * | 2005-06-23 | 2008-10-01 | 科因股份有限公司 | 使用高通量测序技术对复杂基因组测序的改良策略 |
US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
US10316364B2 (en) | 2005-09-29 | 2019-06-11 | Keygene N.V. | Method for identifying the source of an amplicon |
JP5237099B2 (ja) | 2005-09-29 | 2013-07-17 | キージーン ナムローゼ フェンノートシャップ | 変異させた集団のハイスループットスクリーニング |
EP1960541B1 (en) * | 2005-11-14 | 2013-04-24 | Keygene N.V. | Method for high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites |
EP1966393B1 (en) | 2005-12-22 | 2012-07-25 | Keygene N.V. | Method for high-throughput aflp-based polymorphism detection |
WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
DK2002017T3 (en) | 2006-04-04 | 2015-09-07 | Keygene Nv | High-capacity detection of molecular markers based on restriction fragments |
CN101772888B (zh) | 2007-08-06 | 2013-05-29 | 日本电波工业株式会社 | 音叉型晶体振子及其频率调整方法 |
US8362325B2 (en) | 2007-10-03 | 2013-01-29 | Ceres, Inc. | Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics |
US20090124758A1 (en) | 2007-11-09 | 2009-05-14 | Bridgestone Sports Co., Ltd. | Golf ball |
US20140051585A1 (en) | 2012-08-15 | 2014-02-20 | Natera, Inc. | Methods and compositions for reducing genetic library contamination |
EP3004381A1 (en) | 2013-06-07 | 2016-04-13 | Keygene N.V. | Method for targeted sequencing |
-
2006
- 2006-12-20 EP EP06835670A patent/EP1966393B1/en active Active
- 2006-12-20 EP EP14166884.8A patent/EP2789696B1/en active Active
- 2006-12-20 WO PCT/NL2006/000648 patent/WO2007073165A1/en active Application Filing
- 2006-12-20 DK DK14166884.8T patent/DK2789696T3/en active
- 2006-12-20 DK DK06835670.8T patent/DK1966393T3/da active
- 2006-12-20 EP EP10186841A patent/EP2363504A1/en not_active Ceased
- 2006-12-20 CN CN200680051561.8A patent/CN101374963B/zh active Active
- 2006-12-20 DK DK18174221.4T patent/DK3404114T3/da active
- 2006-12-20 CN CN201410177894.1A patent/CN103937899B/zh active Active
- 2006-12-20 US US12/158,040 patent/US8481257B2/en active Active
- 2006-12-20 EP EP15199849.9A patent/EP3045544A1/en not_active Withdrawn
- 2006-12-20 ES ES06835670T patent/ES2391837T3/es active Active
- 2006-12-20 ES ES14166884.8T patent/ES2558124T3/es active Active
- 2006-12-20 ES ES18174221T patent/ES2882401T3/es active Active
- 2006-12-20 JP JP2008547127A patent/JP5452021B2/ja active Active
- 2006-12-20 EP EP18174221.4A patent/EP3404114B1/en active Active
- 2006-12-20 PL PL14166884T patent/PL2789696T3/pl unknown
-
2012
- 2012-11-01 US US13/666,385 patent/US8815512B2/en active Active
-
2014
- 2014-05-09 US US14/274,591 patent/US9334536B2/en active Active
- 2014-06-27 US US14/318,352 patent/US8911945B2/en active Active
- 2014-11-21 US US14/550,805 patent/US9062348B1/en active Active
-
2015
- 2015-04-29 US US14/699,891 patent/US9328383B2/en active Active
-
2016
- 2016-04-22 US US15/136,224 patent/US9777324B2/en active Active
- 2016-12-01 US US15/366,417 patent/US9702004B2/en active Active
-
2017
- 2017-08-22 US US15/683,252 patent/US10106850B2/en active Active
-
2018
- 2018-10-19 US US16/165,645 patent/US20190144938A1/en not_active Abandoned
-
2019
- 2019-07-19 US US16/517,502 patent/US11008615B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2558124T3 (es) | Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento | |
Kadri | Polymerase chain reaction (PCR): Principle and applications | |
JP6946292B2 (ja) | ゲノム分析のためのシステムおよび方法 | |
RU2752700C2 (ru) | Способы и композиции для днк-профилирования | |
Teneva | Molecular markers in animal genome analysis. | |
WO2004061124A2 (en) | Compositions, methods, and systems for inferring bovine breed | |
Singh et al. | DNA sequencing and rapid DNA tests | |
Li et al. | Typing of 67 SNP loci on X chromosome by PCR and MALDI-TOF MS | |
Sinha et al. | Molecular basis of identification through DNA fingerprinting in humans | |
CN111485024A (zh) | 用于个体特征确认的引物组合、及其应用 | |
Nakahara et al. | Automated SNPs typing system based on the invader assay | |
Yadav et al. | DNA FINGERPRINT G | |
HK1263018A1 (en) | Method for high-throughput aflp-based polymorphism detection | |
HK1263018B (en) | Method for high-throughput aflp-based polymorphism detection | |
HK1200497B (en) | Method for high-throughput aflp-based polymorphism detection |