ES2558087T3 - Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos - Google Patents
Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos Download PDFInfo
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- ES2558087T3 ES2558087T3 ES11707330.4T ES11707330T ES2558087T3 ES 2558087 T3 ES2558087 T3 ES 2558087T3 ES 11707330 T ES11707330 T ES 11707330T ES 2558087 T3 ES2558087 T3 ES 2558087T3
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- salt
- acid
- indole
- isopropoxy
- trifluoromethyl
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Landscapes
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| PCT/US2011/026806 WO2011109471A1 (en) | 2010-03-03 | 2011-03-02 | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
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| EP2342205B1 (en) | 2008-08-27 | 2016-04-20 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
| EP4148045A1 (en) | 2010-01-27 | 2023-03-15 | Arena Pharmaceuticals, Inc. | Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof |
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| AU2014414316B2 (en) * | 2014-10-27 | 2020-04-09 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| CA3002551A1 (en) | 2015-06-22 | 2016-12-29 | Arena Pharmaceuticals, Inc. | Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders |
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| CA3053418A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| CN119751336A (zh) | 2018-09-06 | 2025-04-04 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
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-
2011
- 2011-03-02 ES ES11707330.4T patent/ES2558087T3/es active Active
- 2011-03-02 JP JP2012556199A patent/JP2013521301A/ja not_active Abandoned
- 2011-03-02 SG SG10201501575VA patent/SG10201501575VA/en unknown
- 2011-03-02 SG SG2012061685A patent/SG183416A1/en unknown
- 2011-03-02 WO PCT/US2011/026806 patent/WO2011109471A1/en not_active Ceased
- 2011-03-02 US US13/581,846 patent/US9085581B2/en active Active
- 2011-03-02 CN CN201510932844.4A patent/CN105503882B/zh active Active
- 2011-03-02 CA CA2789480A patent/CA2789480A1/en not_active Withdrawn
- 2011-03-02 EP EP11707330.4A patent/EP2542554B1/en active Active
- 2011-03-02 CN CN201180022490.XA patent/CN102884064B/zh active Active
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- 2015-07-17 JP JP2015142650A patent/JP2015180706A/ja not_active Abandoned
Also Published As
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|---|---|
| SG10201501575VA (en) | 2015-04-29 |
| US20120329848A1 (en) | 2012-12-27 |
| WO2011109471A1 (en) | 2011-09-09 |
| US9085581B2 (en) | 2015-07-21 |
| SG183416A1 (en) | 2012-09-27 |
| CN102884064B (zh) | 2016-01-13 |
| JP2015180706A (ja) | 2015-10-15 |
| JP2013521301A (ja) | 2013-06-10 |
| US20150284399A1 (en) | 2015-10-08 |
| CN105503882A (zh) | 2016-04-20 |
| CA2789480A1 (en) | 2011-09-09 |
| EP2542554B1 (en) | 2015-11-04 |
| CN105503882B (zh) | 2019-07-05 |
| HK1179627A1 (zh) | 2013-10-04 |
| EP2542554A1 (en) | 2013-01-09 |
| CN102884064A (zh) | 2013-01-16 |
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