ES2558087T3 - Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos - Google Patents
Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos Download PDFInfo
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- ES2558087T3 ES2558087T3 ES11707330.4T ES11707330T ES2558087T3 ES 2558087 T3 ES2558087 T3 ES 2558087T3 ES 11707330 T ES11707330 T ES 11707330T ES 2558087 T3 ES2558087 T3 ES 2558087T3
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- salt
- acid
- indole
- isopropoxy
- trifluoromethyl
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- QPILZZVXGUNELN-UHFFFAOYSA-M sodium;4-amino-5-hydroxynaphthalene-2,7-disulfonate;hydron Chemical compound [Na+].OS(=O)(=O)C1=CC(O)=C2C(N)=CC(S([O-])(=O)=O)=CC2=C1 QPILZZVXGUNELN-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33936210P | 2010-03-03 | 2010-03-03 | |
| US339362P | 2010-03-03 | ||
| PCT/US2011/026806 WO2011109471A1 (en) | 2010-03-03 | 2011-03-02 | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
Publications (1)
| Publication Number | Publication Date |
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| ES2558087T3 true ES2558087T3 (es) | 2016-02-01 |
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| ES11707330.4T Active ES2558087T3 (es) | 2010-03-03 | 2011-03-02 | Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos |
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| EP (1) | EP2542554B1 (enExample) |
| JP (2) | JP2013521301A (enExample) |
| CN (2) | CN102884064B (enExample) |
| CA (1) | CA2789480A1 (enExample) |
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| SG (2) | SG10201501575VA (enExample) |
| WO (1) | WO2011109471A1 (enExample) |
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| CN105816453B (zh) | 2008-08-27 | 2021-03-05 | 艾尼纳制药公司 | 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物 |
| US8853419B2 (en) | 2010-01-27 | 2014-10-07 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| CN102884064B (zh) * | 2010-03-03 | 2016-01-13 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| SG11201703369WA (en) * | 2014-10-27 | 2017-05-30 | Cellix Bio Private Ltd | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| DK3242666T5 (da) | 2015-01-06 | 2025-01-20 | Arena Pharm Inc | Forbindelsee til anvendelse i behandling af tilstande, der er forbundet med SIP1-receptoren |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩 |
| KR20190116416A (ko) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법 |
| MA47503A (fr) | 2017-02-16 | 2021-04-21 | Arena Pharm Inc | Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales |
| ES2987794T3 (es) | 2018-06-06 | 2024-11-18 | Arena Pharm Inc | Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1 |
| KR102836433B1 (ko) | 2018-09-06 | 2025-07-21 | 아레나 파마슈티칼스, 인크. | 자가면역 및 염증성 장애의 치료에 유용한 화합물 |
| WO2020086963A1 (en) * | 2018-10-26 | 2020-04-30 | Keros Therapeutics | Crystal forms of an alk2 inhibitor |
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-
2011
- 2011-03-02 CN CN201180022490.XA patent/CN102884064B/zh active Active
- 2011-03-02 JP JP2012556199A patent/JP2013521301A/ja not_active Abandoned
- 2011-03-02 CN CN201510932844.4A patent/CN105503882B/zh active Active
- 2011-03-02 US US13/581,846 patent/US9085581B2/en active Active
- 2011-03-02 SG SG10201501575VA patent/SG10201501575VA/en unknown
- 2011-03-02 WO PCT/US2011/026806 patent/WO2011109471A1/en not_active Ceased
- 2011-03-02 CA CA2789480A patent/CA2789480A1/en not_active Withdrawn
- 2011-03-02 ES ES11707330.4T patent/ES2558087T3/es active Active
- 2011-03-02 SG SG2012061685A patent/SG183416A1/en unknown
- 2011-03-02 EP EP11707330.4A patent/EP2542554B1/en active Active
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2015
- 2015-06-15 US US14/739,341 patent/US20150284399A1/en not_active Abandoned
- 2015-07-17 JP JP2015142650A patent/JP2015180706A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102884064A (zh) | 2013-01-16 |
| HK1179627A1 (zh) | 2013-10-04 |
| EP2542554A1 (en) | 2013-01-09 |
| CN102884064B (zh) | 2016-01-13 |
| JP2013521301A (ja) | 2013-06-10 |
| WO2011109471A1 (en) | 2011-09-09 |
| CN105503882B (zh) | 2019-07-05 |
| SG183416A1 (en) | 2012-09-27 |
| SG10201501575VA (en) | 2015-04-29 |
| US20120329848A1 (en) | 2012-12-27 |
| EP2542554B1 (en) | 2015-11-04 |
| US9085581B2 (en) | 2015-07-21 |
| CN105503882A (zh) | 2016-04-20 |
| US20150284399A1 (en) | 2015-10-08 |
| JP2015180706A (ja) | 2015-10-15 |
| CA2789480A1 (en) | 2011-09-09 |
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