ES2558087T3 - Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos - Google Patents
Procesos para la preparación de moduladores del receptor S1P1 y formas cristalinas de los mismos Download PDFInfo
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- ES2558087T3 ES2558087T3 ES11707330.4T ES11707330T ES2558087T3 ES 2558087 T3 ES2558087 T3 ES 2558087T3 ES 11707330 T ES11707330 T ES 11707330T ES 2558087 T3 ES2558087 T3 ES 2558087T3
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- salt
- acid
- indole
- isopropoxy
- trifluoromethyl
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
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| US339362P | 2010-03-03 | ||
| PCT/US2011/026806 WO2011109471A1 (en) | 2010-03-03 | 2011-03-02 | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
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| ES (1) | ES2558087T3 (OSRAM) |
| SG (2) | SG10201501575VA (OSRAM) |
| WO (1) | WO2011109471A1 (OSRAM) |
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| US8580841B2 (en) | 2008-07-23 | 2013-11-12 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
| CN105816453B (zh) * | 2008-08-27 | 2021-03-05 | 艾尼纳制药公司 | 用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物 |
| SG182610A1 (en) | 2010-01-27 | 2012-08-30 | Arena Pharm Inc | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
| CA2789480A1 (en) * | 2010-03-03 | 2011-09-09 | Arena Pharmaceuticals, Inc. | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
| EP3212626B1 (en) * | 2014-10-27 | 2018-11-07 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| CA3053418A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| JP2020507610A (ja) | 2017-02-16 | 2020-03-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法 |
| BR112020024762A2 (pt) | 2018-06-06 | 2021-03-23 | Arena Pharmaceuticals, Inc. | métodos de tratamento de condições relacionadas ao receptor s1p1 |
| CN119751336A (zh) | 2018-09-06 | 2025-04-04 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
| JP7504880B2 (ja) * | 2018-10-26 | 2024-06-24 | ケロス セラピューティクス インコーポレイテッド | Ａｌｋ２阻害剤の結晶形 |
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-
2011
- 2011-03-02 CA CA2789480A patent/CA2789480A1/en not_active Withdrawn
- 2011-03-02 JP JP2012556199A patent/JP2013521301A/ja not_active Abandoned
- 2011-03-02 CN CN201180022490.XA patent/CN102884064B/zh active Active
- 2011-03-02 SG SG10201501575VA patent/SG10201501575VA/en unknown
- 2011-03-02 WO PCT/US2011/026806 patent/WO2011109471A1/en not_active Ceased
- 2011-03-02 ES ES11707330.4T patent/ES2558087T3/es active Active
- 2011-03-02 SG SG2012061685A patent/SG183416A1/en unknown
- 2011-03-02 CN CN201510932844.4A patent/CN105503882B/zh active Active
- 2011-03-02 US US13/581,846 patent/US9085581B2/en active Active
- 2011-03-02 EP EP11707330.4A patent/EP2542554B1/en active Active
-
2015
- 2015-06-15 US US14/739,341 patent/US20150284399A1/en not_active Abandoned
- 2015-07-17 JP JP2015142650A patent/JP2015180706A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011109471A1 (en) | 2011-09-09 |
| CN102884064A (zh) | 2013-01-16 |
| SG183416A1 (en) | 2012-09-27 |
| EP2542554B1 (en) | 2015-11-04 |
| CN105503882B (zh) | 2019-07-05 |
| HK1179627A1 (zh) | 2013-10-04 |
| CN102884064B (zh) | 2016-01-13 |
| US9085581B2 (en) | 2015-07-21 |
| CA2789480A1 (en) | 2011-09-09 |
| EP2542554A1 (en) | 2013-01-09 |
| JP2015180706A (ja) | 2015-10-15 |
| US20120329848A1 (en) | 2012-12-27 |
| JP2013521301A (ja) | 2013-06-10 |
| US20150284399A1 (en) | 2015-10-08 |
| SG10201501575VA (en) | 2015-04-29 |
| CN105503882A (zh) | 2016-04-20 |
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