ES2551744T3 - Nuevos compuestos de tiofeno para uso en terapia - Google Patents
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- ES2551744T3 ES2551744T3 ES09820849.9T ES09820849T ES2551744T3 ES 2551744 T3 ES2551744 T3 ES 2551744T3 ES 09820849 T ES09820849 T ES 09820849T ES 2551744 T3 ES2551744 T3 ES 2551744T3
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- YFXCNIVBAVFOBX-UHFFFAOYSA-N ethenylboronic acid Chemical compound OB(O)C=C YFXCNIVBAVFOBX-UHFFFAOYSA-N 0.000 description 1
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- 239000008103 glucose Substances 0.000 description 1
- 159000000011 group IA salts Chemical class 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 208000017105 hereditary amyloidosis Diseases 0.000 description 1
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- 239000003547 immunosorbent Substances 0.000 description 1
- 201000008319 inclusion body myositis Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
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- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
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- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 1
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- 239000000178 monomer Substances 0.000 description 1
- JHNLMNSDAFLKIB-RUDMXATFSA-N n,n-dimethyl-n'-(6-methyl-5-nitro-4-oxo-1h-pyrimidin-2-yl)methanimidamide Chemical compound CN(C)\C=N\C1=NC(C)=C([N+]([O-])=O)C(=O)N1 JHNLMNSDAFLKIB-RUDMXATFSA-N 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
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- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 125000002577 pseudohalo group Chemical group 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000008864 scrapie Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical class [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
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- 210000001103 thalamus Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- ARYHTUPFQTUBBG-UHFFFAOYSA-N thiophen-2-ylboronic acid Chemical compound OB(O)C1=CC=CS1 ARYHTUPFQTUBBG-UHFFFAOYSA-N 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 150000003606 tin compounds Chemical class 0.000 description 1
- 150000008648 triflates Chemical class 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
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- Epidemiology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0850043 | 2008-10-17 | ||
| SE0850043 | 2008-10-17 | ||
| SE0850050 | 2008-10-23 | ||
| SE0850050 | 2008-10-23 | ||
| PCT/SE2009/051187 WO2010044743A1 (en) | 2008-10-17 | 2009-10-19 | Novel thiophene compounds for use in theraphy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2551744T3 true ES2551744T3 (es) | 2015-11-23 |
Family
ID=42106726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09820849.9T Active ES2551744T3 (es) | 2008-10-17 | 2009-10-19 | Nuevos compuestos de tiofeno para uso en terapia |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8710246B2 (enExample) |
| EP (1) | EP2350042B1 (enExample) |
| JP (1) | JP5646495B2 (enExample) |
| KR (1) | KR101743049B1 (enExample) |
| CN (1) | CN102256959B (enExample) |
| BR (1) | BRPI0920850A2 (enExample) |
| CA (1) | CA2740969C (enExample) |
| ES (1) | ES2551744T3 (enExample) |
| WO (2) | WO2010044744A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012009484A2 (en) | 2010-07-13 | 2012-01-19 | Stc.Unm | Structure, synthesis, and applications for poly (phenylene) ethynylenes (ppes) |
| US9125415B2 (en) | 2011-07-08 | 2015-09-08 | Stc, Unm | Thiophene based oligomers as light activated biocides |
| US9359311B2 (en) | 2011-07-14 | 2016-06-07 | Neuroscios Gmbh | Substituted aromatic oligomers |
| US9549549B2 (en) | 2011-08-03 | 2017-01-24 | Stc.Unm | Antimicrobial materials and methods |
| WO2013036196A1 (en) * | 2011-09-07 | 2013-03-14 | Biochromix Ab | Novel thiophene compounds and method for in vivo imaging |
| SE536793C2 (sv) | 2012-07-02 | 2014-08-19 | Richter Life Science Dev Ab | Detektion av kolhydrater |
| US9968698B2 (en) | 2013-11-08 | 2018-05-15 | Stc. Unm | Charged singlet-oxygen sensitizers and oppositely-charged surfactants |
| US10533991B2 (en) | 2014-03-14 | 2020-01-14 | Stc.Unm | P-phenylene ethynylene compounds as bioactive and detection agents |
| CA2973982C (en) | 2015-01-14 | 2018-04-03 | David G. Whitten | Conjugated polyelectrolytes and methods of using the same |
| JP6982319B2 (ja) | 2015-10-01 | 2021-12-17 | リヒター ライフ サイエンス ディヴェロップメント アクチエボラグRichter Life Science Development AB | 微生物ペプチドの検出 |
| US10772851B2 (en) | 2017-02-03 | 2020-09-15 | Aaron Kurt Neumann | Treatment and prevention of fungal infections |
| JP7545393B2 (ja) * | 2019-01-24 | 2024-09-04 | アルゼカ バイオサイエンシズ、エルエルシー | 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム |
| CN119264384A (zh) * | 2023-07-04 | 2025-01-07 | 宁德时代未来能源(上海)研究院有限公司 | 化合物、钙钛矿太阳能电池和用电装置 |
| CN118724890A (zh) * | 2024-06-05 | 2024-10-01 | 佛山大学 | 一种抗细菌生物膜剂的荧光示踪成像探针分子及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861692A (en) | 1986-12-22 | 1989-08-29 | Fuji Electric Company, Ltd. | Electrophotographic photosensitive material containing thiophene compound |
| JPS63158557A (ja) * | 1986-12-23 | 1988-07-01 | Fuji Electric Co Ltd | 電子写真用感光体 |
| US5747525A (en) | 1992-02-19 | 1998-05-05 | Industrial Technology Research Institute | Medicinal thiophene compounds |
| JP3885244B2 (ja) * | 1994-12-05 | 2007-02-21 | 松下電器産業株式会社 | オリゴチオフェン重合体、及びオリゴチオフェン化合物の製造方法 |
| CA2272275A1 (en) | 1996-11-26 | 1998-06-04 | Purdue Research Foundation | Polythiophene anti-tumor agents |
| US6730929B2 (en) * | 1999-12-24 | 2004-05-04 | Matsushita Electric Industrial Co., Ltd. | Organic electroluminescent device |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| WO2005002288A1 (ja) * | 2003-03-14 | 2005-01-06 | Semiconductor Energy Laboratory Co., Ltd. | 共役分子及びそれを用いた電界発光素子、並びに電界発光素子を用いた電子機器 |
| SE0401219D0 (sv) * | 2004-05-10 | 2004-05-10 | Biochromix Ab | Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter |
| JP4392499B2 (ja) * | 2004-12-07 | 2010-01-06 | 国立大学法人 筑波大学 | キラルポリマーの製造方法及びキラルポリマー並びにキラルポリマーの動的な電気化学的方法による光学活性制御 |
| JPWO2007063950A1 (ja) * | 2005-12-01 | 2009-05-07 | 国立大学法人東北大学 | コンフォーメーション病診断および治療用の長波長蛍光物質およびその使用 |
| EP1996951A1 (en) | 2006-02-09 | 2008-12-03 | BioChromix AB | Methods for detection of pathogenic prion proteins associated with prion diseases, using conjugated polyelectrolytes |
| WO2007109545A2 (en) * | 2006-03-16 | 2007-09-27 | The Regents Of The University Of California | Copolymers of alkoxythiophene |
| AU2008208091A1 (en) * | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| CA2721770A1 (en) * | 2007-04-18 | 2008-10-30 | Biochromix Ab | Medical use of conjugated polyelectrolytes |
-
2009
- 2009-10-19 WO PCT/SE2009/051188 patent/WO2010044744A1/en not_active Ceased
- 2009-10-19 KR KR1020117011029A patent/KR101743049B1/ko not_active Expired - Fee Related
- 2009-10-19 US US13/124,621 patent/US8710246B2/en not_active Expired - Fee Related
- 2009-10-19 BR BRPI0920850A patent/BRPI0920850A2/pt not_active IP Right Cessation
- 2009-10-19 JP JP2011532044A patent/JP5646495B2/ja not_active Expired - Fee Related
- 2009-10-19 CA CA2740969A patent/CA2740969C/en not_active Expired - Fee Related
- 2009-10-19 EP EP09820849.9A patent/EP2350042B1/en not_active Not-in-force
- 2009-10-19 ES ES09820849.9T patent/ES2551744T3/es active Active
- 2009-10-19 WO PCT/SE2009/051187 patent/WO2010044743A1/en not_active Ceased
- 2009-10-19 CN CN200980151290.7A patent/CN102256959B/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110099089A (ko) | 2011-09-06 |
| EP2350042A1 (en) | 2011-08-03 |
| US20120157516A1 (en) | 2012-06-21 |
| WO2010044743A1 (en) | 2010-04-22 |
| JP2012505879A (ja) | 2012-03-08 |
| KR101743049B1 (ko) | 2017-06-02 |
| JP5646495B2 (ja) | 2014-12-24 |
| BRPI0920850A2 (pt) | 2016-09-13 |
| US8710246B2 (en) | 2014-04-29 |
| CA2740969A1 (en) | 2010-04-22 |
| EP2350042B1 (en) | 2015-07-29 |
| EP2350042A4 (en) | 2013-07-31 |
| CA2740969C (en) | 2017-01-17 |
| WO2010044744A1 (en) | 2010-04-22 |
| CN102256959A (zh) | 2011-11-23 |
| CN102256959B (zh) | 2014-01-08 |
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