ES2547336T3 - Composición tópica para su uso para el tratamiento de enrojecimiento inducido por rosácea - Google Patents
Composición tópica para su uso para el tratamiento de enrojecimiento inducido por rosácea Download PDFInfo
- Publication number
- ES2547336T3 ES2547336T3 ES11175578.1T ES11175578T ES2547336T3 ES 2547336 T3 ES2547336 T3 ES 2547336T3 ES 11175578 T ES11175578 T ES 11175578T ES 2547336 T3 ES2547336 T3 ES 2547336T3
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically acceptable
- treatment
- skin
- patient
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 241001303601 Rosacea Species 0.000 title abstract 2
- 201000004700 rosacea Diseases 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 2
- 210000002565 arteriole Anatomy 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
El uso de una composición que comprende: al menos uno de un agonista del receptor adrenérgico α2 y de una sal farmacéuticamente aceptable del mismo; y un portador farmacéuticamente aceptable para la preparación de un medicamento para tratar el enrojecimiento inducido por la rosácea, en el que dicha composición se aplica tópicamente directamente al área afectada de la piel de un paciente que necesita de tal tratamiento para reducir el flujo sanguíneo a través de las pequeñas arterias o arteriolas de la piel del paciente, y en la que dicha composición actúa localmente en la piel del paciente en la que el mencionado al menos uno de un agonista del receptor adrenérgico α2 y de una sal farmacéuticamente aceptable del mismo se selecciona del compuesto mostrado a continuación y sus sales farmacéuticamente aceptables:
Description
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47361103P | 2003-05-27 | 2003-05-27 | |
US473611P | 2003-05-27 | ||
US853585 | 2004-05-25 | ||
US10/853,585 US7439241B2 (en) | 2003-05-27 | 2004-05-25 | Compounds, formulations, and methods for treating or preventing rosacea |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2547336T3 true ES2547336T3 (es) | 2015-10-05 |
Family
ID=33457481
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14179642T Expired - Lifetime ES2812532T3 (es) | 2003-05-27 | 2004-05-26 | Compuestos, formulaciones y procedimientos para tratar o prevenir la rosácea |
ES11175578.1T Expired - Lifetime ES2547336T3 (es) | 2003-05-27 | 2004-05-26 | Composición tópica para su uso para el tratamiento de enrojecimiento inducido por rosácea |
ES04753601.6T Expired - Lifetime ES2376172T5 (es) | 2003-05-27 | 2004-05-26 | Compuestos, formulaciones y métodos para tratar o prevenir la rosácea |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14179642T Expired - Lifetime ES2812532T3 (es) | 2003-05-27 | 2004-05-26 | Compuestos, formulaciones y procedimientos para tratar o prevenir la rosácea |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04753601.6T Expired - Lifetime ES2376172T5 (es) | 2003-05-27 | 2004-05-26 | Compuestos, formulaciones y métodos para tratar o prevenir la rosácea |
Country Status (22)
Country | Link |
---|---|
US (13) | US7439241B2 (es) |
EP (3) | EP2388007B1 (es) |
CN (4) | CN101816793B (es) |
AT (1) | ATE530185T1 (es) |
AU (1) | AU2004242967C1 (es) |
CA (1) | CA2530938C (es) |
CY (3) | CY1112242T1 (es) |
DK (3) | DK2388007T3 (es) |
ES (3) | ES2812532T3 (es) |
HK (3) | HK1084591A1 (es) |
HR (1) | HRP20150957T1 (es) |
HU (3) | HUE051833T2 (es) |
IL (1) | IL172612A (es) |
LT (1) | LT2815748T (es) |
LU (1) | LU92462I2 (es) |
MX (1) | MXPA05014107A (es) |
NO (1) | NO333468B1 (es) |
NZ (1) | NZ544300A (es) |
PL (3) | PL1631293T5 (es) |
PT (3) | PT2815748T (es) |
SI (3) | SI2815748T1 (es) |
WO (1) | WO2004105703A2 (es) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
EP2481412B1 (en) * | 2004-05-25 | 2017-09-27 | Galderma Pharma S.A. | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
WO2006085840A1 (en) * | 2005-01-31 | 2006-08-17 | Kross Robert D | Skin-protective polymer for use in teat care compositions |
DE202005002183U1 (de) | 2005-02-04 | 2005-04-14 | Beiersdorf Ag | Hautverwöhnende Cremelotion |
BRPI0608951A2 (pt) * | 2005-03-30 | 2010-02-17 | Revance Therapeutics Inc | composições e método para o tratamento de acne |
HUE054887T2 (hu) | 2005-06-17 | 2021-10-28 | Wisconsin Alumni Res Found | Topikális érösszehúzó készítmények és eljárások sejtek védelmére rák kemoterápia és radioterápia alatt |
WO2007002447A2 (en) * | 2005-06-23 | 2007-01-04 | Bioform Medical, Inc. | Compositions for treating rosacea |
FR2894474B1 (fr) * | 2005-12-12 | 2008-04-11 | Galderma Res & Dev | Gel depigmentant hydroalcoolique |
US20080293728A1 (en) * | 2007-05-18 | 2008-11-27 | Mcintire Gregory L | Complexes Comprising alpha2-Adrenergic Receptor Agonists and Compositions |
SI2182960T1 (sl) * | 2007-07-27 | 2014-07-31 | Galderma Laboratories Inc. | Spojine, formulacije in postopki za zmanjĺ anje koĺ˝nih gub, meäśkanja in poveĺ anja |
US20090061020A1 (en) * | 2007-08-31 | 2009-03-05 | Theobald Klaus P | Brimonidine Compositions for Treating Erythema |
BRPI0819075A2 (pt) | 2007-11-16 | 2014-10-07 | Vicept Therapeutics Inc | Método para tratar púrpura em um indivíduo e método para diminuir a púrpura em um indivíduo antes de um procedimento cirúrgico |
IE20070935A1 (en) * | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Guanidine based compounds and their use in the treatment of mental and neurological disorders. |
US20110224215A1 (en) * | 2007-12-21 | 2011-09-15 | Galderma Laboratories, Inc. | Pre-surgical treatment |
EP2320911B1 (en) | 2008-08-01 | 2014-10-08 | Eye Therapies LLC | Vasoconstriction compositions and methods of use |
US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
WO2010085753A1 (en) * | 2009-01-23 | 2010-07-29 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
FR2942138A1 (fr) | 2009-02-16 | 2010-08-20 | Galderma Res & Dev | Association de composes pour le traitement ou la prevention des affections dermatologiques |
CN106511273A (zh) * | 2009-05-15 | 2017-03-22 | 瑞克欧制药有限公司 | 舌下右美托咪定组合物及其使用方法 |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
KR101453601B1 (ko) * | 2009-05-29 | 2014-10-22 | 갈데르마 리써어치 앤드 디벨로프먼트 | 주입으로 인한 피부 반응 감소를 위한 필러와 아드레날린 수용체 작용제의 주사가능한 조합 |
JP2013508454A (ja) * | 2009-10-26 | 2013-03-07 | ガルデルマ ファルマ ソシエテ アノニム | 急性紅斑の治療又は予防法 |
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US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
AU2011231544B2 (en) * | 2010-03-26 | 2015-01-15 | Galderma Research & Development | Improved methods and compositions for safe and effective treatment of telangiectasia |
CN106038476B (zh) * | 2010-03-26 | 2020-04-17 | 盖尔德马研究及发展公司 | 安全和有效治疗红斑的改进的方法和组合物 |
AU2011273510B2 (en) * | 2010-06-30 | 2015-04-16 | Galderma Research & Development | Use of alpha-adrenergic receptor agonist for preventing or treating skin tumor |
CA2810746A1 (en) | 2010-06-30 | 2012-01-05 | Galderma Research & Development | Method for preventing or treating skin tumor |
CN103140217B (zh) * | 2010-08-06 | 2015-08-19 | 盖尔德马研究及发展公司 | 用于治疗或预防皮肤病的化合物的组合 |
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US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
US20120082625A1 (en) * | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
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FR2966365B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel topique |
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FR2966366B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel de brimonidine |
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WO2012087280A2 (en) | 2010-12-20 | 2012-06-28 | Colgate-Palmolive Company | Gelatin encapsulated oral care composition containing hydrophilic active, hydrophobic structuring agent and oil carrier |
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WO2013016072A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
CA2850964C (en) | 2011-10-05 | 2021-02-02 | Jennifer L. Sanders | Methods and compositions for treating foot or hand pain |
WO2013057579A2 (en) | 2011-10-19 | 2013-04-25 | Galderma Pharma S.A. | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
JP2014530847A (ja) | 2011-10-19 | 2014-11-20 | ガルデルマ ソシエテ アノニム | 毛細血管腫の治療方法 |
UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
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