ES2546465T3 - Inhibidores de N1/N2-lactama acetil-CoA carboxilasa - Google Patents

Inhibidores de N1/N2-lactama acetil-CoA carboxilasa Download PDF

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Publication number
ES2546465T3
ES2546465T3 ES11784783.0T ES11784783T ES2546465T3 ES 2546465 T3 ES2546465 T3 ES 2546465T3 ES 11784783 T ES11784783 T ES 11784783T ES 2546465 T3 ES2546465 T3 ES 2546465T3
Authority
ES
Spain
Prior art keywords
inhibitors
coa
compound
formula
acc2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11784783.0T
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English (en)
Spanish (es)
Inventor
Scott William Bagley
Robert Lee Dow
David Andrew Griffith
Aaron Christopher Smith
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Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2546465T3 publication Critical patent/ES2546465T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
ES11784783.0T 2010-10-29 2011-10-18 Inhibidores de N1/N2-lactama acetil-CoA carboxilasa Active ES2546465T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40812710P 2010-10-29 2010-10-29
US408127P 2010-10-29
US201161531744P 2011-09-07 2011-09-07
US201161531744P 2011-09-07
PCT/IB2011/054643 WO2012056372A1 (en) 2010-10-29 2011-10-18 N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS

Publications (1)

Publication Number Publication Date
ES2546465T3 true ES2546465T3 (es) 2015-09-23

Family

ID=44993633

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11784783.0T Active ES2546465T3 (es) 2010-10-29 2011-10-18 Inhibidores de N1/N2-lactama acetil-CoA carboxilasa

Country Status (26)

Country Link
US (3) US8859773B2 (https=)
EP (2) EP2952514A1 (https=)
JP (2) JP5647356B2 (https=)
KR (2) KR101529404B1 (https=)
CN (2) CN104774205A (https=)
AR (1) AR083578A1 (https=)
AU (1) AU2011322117B2 (https=)
BR (1) BR112013010310A2 (https=)
CA (1) CA2815169C (https=)
CY (1) CY1116405T1 (https=)
DK (1) DK2632925T3 (https=)
ES (1) ES2546465T3 (https=)
HK (1) HK1209733A1 (https=)
HU (1) HUE025078T2 (https=)
IL (1) IL225779A0 (https=)
MX (1) MX2013004733A (https=)
NZ (1) NZ609527A (https=)
PL (1) PL2632925T3 (https=)
PT (1) PT2632925E (https=)
RU (1) RU2540337C2 (https=)
SG (1) SG189883A1 (https=)
SI (1) SI2632925T1 (https=)
TW (3) TWI441823B (https=)
UY (1) UY33694A (https=)
WO (1) WO2012056372A1 (https=)
ZA (1) ZA201303882B (https=)

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CN104230922B (zh) 2013-06-19 2016-12-28 中国科学院上海药物研究所 一类五元杂环并吡啶类化合物及其制备方法和用途
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Also Published As

Publication number Publication date
CA2815169C (en) 2015-10-06
SG189883A1 (en) 2013-06-28
CN104774205A (zh) 2015-07-15
KR20140014078A (ko) 2014-02-05
SI2632925T1 (sl) 2015-07-31
US20120108619A1 (en) 2012-05-03
RU2013116924A (ru) 2014-12-10
JP5647356B2 (ja) 2014-12-24
CY1116405T1 (el) 2017-02-08
CN103189377B (zh) 2015-02-25
KR20150006899A (ko) 2015-01-19
WO2012056372A1 (en) 2012-05-03
EP2632925B1 (en) 2015-05-27
DK2632925T3 (en) 2015-06-29
CA2815169A1 (en) 2012-05-03
US9181252B2 (en) 2015-11-10
PT2632925E (pt) 2015-09-01
HUE025078T2 (en) 2016-01-28
BR112013010310A2 (pt) 2016-11-29
MX2013004733A (es) 2013-07-02
AU2011322117A1 (en) 2013-05-02
PL2632925T3 (pl) 2015-10-30
US20150152109A1 (en) 2015-06-04
TWI507406B (zh) 2015-11-11
UY33694A (es) 2012-05-31
NZ609527A (en) 2014-03-28
CN103189377A (zh) 2013-07-03
TW201418256A (zh) 2014-05-16
US20150025098A1 (en) 2015-01-22
JP2013542218A (ja) 2013-11-21
ZA201303882B (en) 2014-02-26
HK1209733A1 (en) 2016-04-08
RU2540337C2 (ru) 2015-02-10
US8993586B2 (en) 2015-03-31
JP2015057416A (ja) 2015-03-26
EP2952514A1 (en) 2015-12-09
AR083578A1 (es) 2013-03-06
US8859773B2 (en) 2014-10-14
IL225779A0 (en) 2013-06-27
EP2632925A1 (en) 2013-09-04
TW201531472A (zh) 2015-08-16
TWI441823B (zh) 2014-06-21
HK1186724A1 (en) 2014-03-21
KR101529404B1 (ko) 2015-06-26
AU2011322117B2 (en) 2015-01-22
TW201302751A (zh) 2013-01-16

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