KR101529404B1 - N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 - Google Patents
N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 Download PDFInfo
- Publication number
- KR101529404B1 KR101529404B1 KR1020137013652A KR20137013652A KR101529404B1 KR 101529404 B1 KR101529404 B1 KR 101529404B1 KR 1020137013652 A KR1020137013652 A KR 1020137013652A KR 20137013652 A KR20137013652 A KR 20137013652A KR 101529404 B1 KR101529404 B1 KR 101529404B1
- Authority
- KR
- South Korea
- Prior art keywords
- leu
- mmol
- val
- ser
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *c1c(CC2(CCNCC2)NC2=O)c2n[n]1* Chemical compound *c1c(CC2(CCNCC2)NC2=O)c2n[n]1* 0.000 description 6
- QAFQLXQNVOFDDS-UHFFFAOYSA-N CC(C)(C)Nc1nccc(cc2)c1cc2C(N(CC1)CCC1(Cc1c[n](C(C)(C)C)nc11)NC1=O)=O Chemical compound CC(C)(C)Nc1nccc(cc2)c1cc2C(N(CC1)CCC1(Cc1c[n](C(C)(C)C)nc11)NC1=O)=O QAFQLXQNVOFDDS-UHFFFAOYSA-N 0.000 description 1
- MFLKGEABCKJOJW-UHFFFAOYSA-N CC(C)(C)[n](cc1CC(CC2)(CCN2C(c2cc(OC)c3[nH]ncc3c2)=O)N2)nc1C2=O Chemical compound CC(C)(C)[n](cc1CC(CC2)(CCN2C(c2cc(OC)c3[nH]ncc3c2)=O)N2)nc1C2=O MFLKGEABCKJOJW-UHFFFAOYSA-N 0.000 description 1
- DWDQVPVFBKEWSW-UHFFFAOYSA-N CC(C)(C)[n]1nc(C(O)=O)c(CC(CC2)(CCN2C(OC(C)(C)C)=O)C(N)=O)c1 Chemical compound CC(C)(C)[n]1nc(C(O)=O)c(CC(CC2)(CCN2C(OC(C)(C)C)=O)C(N)=O)c1 DWDQVPVFBKEWSW-UHFFFAOYSA-N 0.000 description 1
- DHEYDPOMUQCYIH-UHFFFAOYSA-N CC(C)(C)[n]1nc(C(O)=O)c(CC(CC2)(CCN2C(OC(C)(C)C)=O)N=O)c1 Chemical compound CC(C)(C)[n]1nc(C(O)=O)c(CC(CC2)(CCN2C(OC(C)(C)C)=O)N=O)c1 DHEYDPOMUQCYIH-UHFFFAOYSA-N 0.000 description 1
- DULVZDJHQKYNEW-UHFFFAOYSA-N CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(OC(C)(C)C)=O)N2)c1C2=O Chemical compound CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(OC(C)(C)C)=O)N2)c1C2=O DULVZDJHQKYNEW-UHFFFAOYSA-N 0.000 description 1
- UQCQMEQQIMBMSM-UHFFFAOYSA-N CCOC(c1c[n](C(C)(C)C)nc1I)=O Chemical compound CCOC(c1c[n](C(C)(C)C)nc1I)=O UQCQMEQQIMBMSM-UHFFFAOYSA-N 0.000 description 1
- GTMRDKCXGHWYDB-UHFFFAOYSA-N COC(c1cc(C(F)(F)F)c2[nH]ncc2c1)=O Chemical compound COC(c1cc(C(F)(F)F)c2[nH]ncc2c1)=O GTMRDKCXGHWYDB-UHFFFAOYSA-N 0.000 description 1
- AQDFNXASXNIENA-UHFFFAOYSA-N COC(c1cnc(cn[nH]2)c2c1)=O Chemical compound COC(c1cnc(cn[nH]2)c2c1)=O AQDFNXASXNIENA-UHFFFAOYSA-N 0.000 description 1
- JVMUEAIOOCTKKJ-UHFFFAOYSA-N COc1cc(cc(cc2)Br)c2cn1 Chemical compound COc1cc(cc(cc2)Br)c2cn1 JVMUEAIOOCTKKJ-UHFFFAOYSA-N 0.000 description 1
- DMKVADBRLQNYBM-UHFFFAOYSA-N C[n](c(cc1)c2cc1C(O)=O)nc2N Chemical compound C[n](c(cc1)c2cc1C(O)=O)nc2N DMKVADBRLQNYBM-UHFFFAOYSA-N 0.000 description 1
- BMHOAEQKRSPMLK-UHFFFAOYSA-N OC(c(cc1C=CN2)ccc1C2=O)=O Chemical compound OC(c(cc1C=CN2)ccc1C2=O)=O BMHOAEQKRSPMLK-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40812710P | 2010-10-29 | 2010-10-29 | |
| US61/408,127 | 2010-10-29 | ||
| US201161531744P | 2011-09-07 | 2011-09-07 | |
| US61/531,744 | 2011-09-07 | ||
| PCT/IB2011/054643 WO2012056372A1 (en) | 2010-10-29 | 2011-10-18 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20147036653A Division KR20150006899A (ko) | 2010-10-29 | 2011-10-18 | N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140014078A KR20140014078A (ko) | 2014-02-05 |
| KR101529404B1 true KR101529404B1 (ko) | 2015-06-26 |
Family
ID=44993633
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137013652A Expired - Fee Related KR101529404B1 (ko) | 2010-10-29 | 2011-10-18 | N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 |
| KR20147036653A Withdrawn KR20150006899A (ko) | 2010-10-29 | 2011-10-18 | N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20147036653A Withdrawn KR20150006899A (ko) | 2010-10-29 | 2011-10-18 | N1/N2-락탐 아세틸-CoA 카복실라아제 억제제 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8859773B2 (https=) |
| EP (2) | EP2952514A1 (https=) |
| JP (2) | JP5647356B2 (https=) |
| KR (2) | KR101529404B1 (https=) |
| CN (2) | CN104774205A (https=) |
| AR (1) | AR083578A1 (https=) |
| AU (1) | AU2011322117B2 (https=) |
| BR (1) | BR112013010310A2 (https=) |
| CA (1) | CA2815169C (https=) |
| CY (1) | CY1116405T1 (https=) |
| DK (1) | DK2632925T3 (https=) |
| ES (1) | ES2546465T3 (https=) |
| HK (1) | HK1209733A1 (https=) |
| HU (1) | HUE025078T2 (https=) |
| IL (1) | IL225779A0 (https=) |
| MX (1) | MX2013004733A (https=) |
| NZ (1) | NZ609527A (https=) |
| PL (1) | PL2632925T3 (https=) |
| PT (1) | PT2632925E (https=) |
| RU (1) | RU2540337C2 (https=) |
| SG (1) | SG189883A1 (https=) |
| SI (1) | SI2632925T1 (https=) |
| TW (3) | TWI441823B (https=) |
| UY (1) | UY33694A (https=) |
| WO (1) | WO2012056372A1 (https=) |
| ZA (1) | ZA201303882B (https=) |
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| ES2546465T3 (es) * | 2010-10-29 | 2015-09-23 | Pfizer Inc | Inhibidores de N1/N2-lactama acetil-CoA carboxilasa |
| PL2953942T3 (pl) | 2013-02-06 | 2018-03-30 | Bayer Cropscience Aktiengesellschaft | Podstawione halogenem pochodne pirazolu jako środki do zwalczania szkodników |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN103214327A (zh) * | 2013-03-22 | 2013-07-24 | 郑州泰基鸿诺药物科技有限公司 | 一种芳香环或芳杂环三氟甲基酮化合物及其制备方法 |
| CN104230922B (zh) | 2013-06-19 | 2016-12-28 | 中国科学院上海药物研究所 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| US20160220557A1 (en) | 2013-09-12 | 2016-08-04 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
| MX2016008653A (es) | 2014-01-03 | 2016-09-26 | Bayer Animal Health Gmbh | Nuevas pirazolil-heteroarilamidas como agentes plaguicidas. |
| CN104844509A (zh) * | 2014-02-14 | 2015-08-19 | 河南工业大学 | 一种条件温和无金属参与的胺基喹啉衍生物的制备方法 |
| KR101731624B1 (ko) * | 2014-07-01 | 2017-05-04 | 광주과학기술원 | 세포 리프로그래밍 유도용 조성물 |
| CN106749002A (zh) * | 2015-02-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一种含硝基喹啉结构的葡萄糖激酶活化剂及其用途 |
| BR112017019266B1 (pt) | 2015-03-10 | 2022-05-10 | Bayer Animal Health Gmbh | Compostos derivados de pirazolila e composição farmacêutica compreendendo o referido composto |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| WO2018170203A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Mk2 inhibitors, synthesis thereof, and intermediates thereto |
| WO2018170200A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Heteroaryl compounds useful as mk2 inhibitors |
| AU2018233367B2 (en) | 2017-03-16 | 2021-08-12 | Jiangsu Hengrui Medicine Co., Ltd. | Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof |
| EP3601259B1 (en) | 2017-03-30 | 2022-02-23 | F. Hoffmann-La Roche AG | Isoquinolines as inhibitors of hpk1 |
| CN111406056B (zh) | 2017-11-21 | 2023-02-28 | 辉瑞公司 | 选择性acc抑制剂的结晶2-氨基-2-(羟甲基)丙烷-1,3-二醇盐 |
| TW202019905A (zh) | 2018-07-24 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 異喹啉化合物及其用途 |
| TW202024053A (zh) | 2018-10-02 | 2020-07-01 | 美商建南德克公司 | 異喹啉化合物及其用途 |
| US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
| CN109824669A (zh) * | 2018-12-21 | 2019-05-31 | 西南大学 | 哌啶螺环酒石酸类化合物制备及应用 |
| EP4149917B1 (en) * | 2020-05-12 | 2025-07-30 | Merck Sharp & Dohme LLC | Factor xi activation inhibitors |
| EP4154880A4 (en) * | 2020-05-21 | 2024-06-05 | Shionogi & Co., Ltd | Pharmaceutical for treating fatty liver diseases |
| CN116670142A (zh) | 2021-02-01 | 2023-08-29 | 细胞基因公司 | Mk2抑制剂、其合成和其中间体 |
| TW202317104A (zh) * | 2021-06-25 | 2023-05-01 | 美商賽迪拉治療股份有限公司 | Ｔｅａｄ抑制劑及其用途 |
| MA71611A (fr) * | 2022-07-29 | 2025-05-30 | Pfizer Inc. | Nouveaux inhibiteurs de l'acc |
| CN121241054A (zh) * | 2023-04-14 | 2025-12-30 | 北京双鹤润创科技有限公司 | 氮杂环羰基稠环衍生物及其用途 |
| CN121909191A (zh) * | 2023-08-16 | 2026-04-21 | 智擎生技制药股份有限公司 | Mta协同性的prmt5抑制剂 |
| TW202602453A (zh) * | 2024-03-14 | 2026-01-16 | 智擎生技製藥股份有限公司 | Mta協同性的prmt5抑制劑 |
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| WO2009144555A1 (en) * | 2008-05-28 | 2009-12-03 | Pfizer Inc. | Pyrazolospiroketone acetyl-coa carboxylase inhibitors |
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