ES2541726T3 - Anticuerpos anti-Notch2 y métodos de uso - Google Patents

Anticuerpos anti-Notch2 y métodos de uso Download PDF

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Publication number
ES2541726T3
ES2541726T3 ES09793181.0T ES09793181T ES2541726T3 ES 2541726 T3 ES2541726 T3 ES 2541726T3 ES 09793181 T ES09793181 T ES 09793181T ES 2541726 T3 ES2541726 T3 ES 2541726T3
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ES
Spain
Prior art keywords
antibody
amino acid
region
human
binding
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Active
Application number
ES09793181.0T
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English (en)
Spanish (es)
Inventor
Christian W. Siebel
Yan Wu
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41349057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2541726(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2541726T3 publication Critical patent/ES2541726T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES09793181.0T 2008-10-01 2009-09-30 Anticuerpos anti-Notch2 y métodos de uso Active ES2541726T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10191708P 2008-10-01 2008-10-01
US101917P 2008-10-01
PCT/US2009/059028 WO2010039832A1 (en) 2008-10-01 2009-09-30 Anti-notch2 antibodies and methods of use

Publications (1)

Publication Number Publication Date
ES2541726T3 true ES2541726T3 (es) 2015-07-23

Family

ID=41349057

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09793181.0T Active ES2541726T3 (es) 2008-10-01 2009-09-30 Anticuerpos anti-Notch2 y métodos de uso

Country Status (18)

Country Link
US (5) US8404239B2 (enExample)
EP (1) EP2334331B1 (enExample)
JP (2) JP5710487B2 (enExample)
KR (1) KR101712214B1 (enExample)
CN (1) CN102170909B (enExample)
AR (1) AR073717A1 (enExample)
AU (1) AU2009298569A1 (enExample)
BR (1) BRPI0913827A2 (enExample)
CA (1) CA2736429A1 (enExample)
CL (1) CL2011000711A1 (enExample)
ES (1) ES2541726T3 (enExample)
IL (1) IL211623A0 (enExample)
MX (1) MX2011002928A (enExample)
PE (1) PE20120080A1 (enExample)
RU (1) RU2580029C2 (enExample)
TW (1) TW201018484A (enExample)
WO (1) WO2010039832A1 (enExample)
ZA (1) ZA201101651B (enExample)

Families Citing this family (21)

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US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
MX2011002928A (es) * 2008-10-01 2011-04-11 Genentech Inc Anticuerpos anti-notch2 y metodos de uso.
EP2621950A4 (en) * 2010-09-27 2015-09-02 Janssen Biotech Inc ANTIBODIES FOR BINDING HUMAN COLLAGEN II
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
US20130089562A1 (en) * 2011-10-05 2013-04-11 Genenthech, Inc. Methods of treating liver conditions using notch2 antagonists
WO2013173542A1 (en) * 2012-05-16 2013-11-21 Oncomed Pharmaceuticals, Inc. Methods for treating cancer with notch2/3 antibodies
RU2666990C2 (ru) 2012-08-13 2018-09-13 Дженентек, Инк. Антитела к jagged и способы их применения
EP2970468B1 (en) 2013-03-13 2021-07-07 Novartis AG Notch2 binding molecules for treating respiratory diseases
MX2015011444A (es) 2013-03-15 2015-12-16 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento del cancer hepatico.
SI3105253T1 (sl) 2014-02-12 2018-10-30 F. Hoffmann-La Roche Ag Protitelesa anti-Jagged1 in načini njihove uporabe
EP3166627A1 (en) 2014-07-11 2017-05-17 Genentech, Inc. Notch pathway inhibition
WO2017053939A1 (en) * 2015-09-26 2017-03-30 Kung, Hsing-Jien Method and composition for treatment of hair loss
GB201521447D0 (en) 2015-12-04 2016-01-20 Ucb Biopharma Sprl De novo antibody design
WO2018222880A1 (en) 2017-05-31 2018-12-06 Trustees Of Boston University Mechano-activated control of gene expression
CA3185122A1 (en) * 2020-07-17 2022-01-20 Cecilia Pui Chi Chiu Anti-notch2 antibodies and methods of use
CN121057747A (zh) * 2023-04-18 2025-12-02 上海洛启生物医药技术有限公司 抗Notch2纳米抗体及其应用
CN120441700B (zh) * 2023-11-21 2026-02-10 兰州大学第二医院 一种抗人notch2单链抗体、编码基因、试剂盒及其用途
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
MX2011002928A (es) 2011-04-11
JP2012504634A (ja) 2012-02-23
AU2009298569A1 (en) 2010-04-08
US20170204175A9 (en) 2017-07-20
TW201018484A (en) 2010-05-16
RU2580029C2 (ru) 2016-04-10
AR073717A1 (es) 2010-11-24
WO2010039832A1 (en) 2010-04-08
EP2334331A1 (en) 2011-06-22
CA2736429A1 (en) 2010-04-08
US20180057589A1 (en) 2018-03-01
BRPI0913827A2 (pt) 2020-12-29
US20140037643A1 (en) 2014-02-06
RU2011117237A (ru) 2012-11-10
JP2015145379A (ja) 2015-08-13
US8404239B2 (en) 2013-03-26
PE20120080A1 (es) 2012-02-17
US20100080808A1 (en) 2010-04-01
KR20110061600A (ko) 2011-06-09
IL211623A0 (en) 2011-05-31
CN102170909B (zh) 2015-11-25
KR101712214B1 (ko) 2017-03-03
CL2011000711A1 (es) 2012-07-20
EP2334331B1 (en) 2015-04-29
US20150104461A1 (en) 2015-04-16
JP5710487B2 (ja) 2015-04-30
ZA201101651B (en) 2012-06-27
US20140314782A1 (en) 2014-10-23
CN102170909A (zh) 2011-08-31

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