TW201018484A - Anti-Notch2 antibodies and methods of use - Google Patents
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- TW201018484A TW201018484A TW98133312A TW98133312A TW201018484A TW 201018484 A TW201018484 A TW 201018484A TW 98133312 A TW98133312 A TW 98133312A TW 98133312 A TW98133312 A TW 98133312A TW 201018484 A TW201018484 A TW 201018484A
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| ES2413087T3 (es) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el diagnóstico y tratamiento del cáncer |
| JP5618544B2 (ja) | 2007-01-24 | 2014-11-05 | オンコメッドファーマシューティカルズ インコーポレイテッド | 癌の診断および処置のための組成物および方法 |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| ME02069B (me) | 2008-07-08 | 2015-05-20 | Oncomed Pharm Inc | Vezujuci agensi notch1 receptora i postupci njihove primene |
| CN102170909B (zh) * | 2008-10-01 | 2015-11-25 | 霍夫曼-拉罗奇有限公司 | 抗-notch2抗体和使用方法 |
| US8906649B2 (en) | 2010-09-27 | 2014-12-09 | Janssen Biotech, Inc. | Antibodies binding human collagen II |
| ES2757857T3 (es) * | 2010-09-27 | 2020-04-30 | Janssen Biotech Inc | Anticuerpos de unión a colágeno II humano |
| MX2014004074A (es) * | 2011-10-05 | 2014-06-05 | Genentech Inc | Metodo de tratamiento de condiciones del higado utilizando antagonistas de notch2. |
| US20130323266A1 (en) * | 2012-05-16 | 2013-12-05 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancer with notch2/3 antibodies |
| RU2666990C2 (ru) | 2012-08-13 | 2018-09-13 | Дженентек, Инк. | Антитела к jagged и способы их применения |
| EP2970468B1 (en) | 2013-03-13 | 2021-07-07 | Novartis AG | Notch2 binding molecules for treating respiratory diseases |
| AU2014236815B2 (en) | 2013-03-15 | 2019-04-04 | Genentech, Inc. | Compositions and methods for diagnosis and treatment of hepatic cancers |
| JP6571115B2 (ja) | 2014-02-12 | 2019-09-04 | ジェネンテック, インコーポレイテッド | 抗jagged1抗体及び使用方法 |
| WO2016007775A1 (en) | 2014-07-11 | 2016-01-14 | Genentech, Inc. | Notch pathway inhibition |
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| KR20110061600A (ko) | 2011-06-09 |
| US20150104461A1 (en) | 2015-04-16 |
| JP2015145379A (ja) | 2015-08-13 |
| PE20120080A1 (es) | 2012-02-17 |
| RU2011117237A (ru) | 2012-11-10 |
| BRPI0913827A2 (pt) | 2020-12-29 |
| US20180057589A1 (en) | 2018-03-01 |
| US20140037643A1 (en) | 2014-02-06 |
| WO2010039832A1 (en) | 2010-04-08 |
| US20170204175A9 (en) | 2017-07-20 |
| IL211623A0 (en) | 2011-05-31 |
| AU2009298569A1 (en) | 2010-04-08 |
| CN102170909A (zh) | 2011-08-31 |
| US20140314782A1 (en) | 2014-10-23 |
| CL2011000711A1 (es) | 2012-07-20 |
| MX2011002928A (es) | 2011-04-11 |
| US8404239B2 (en) | 2013-03-26 |
| AR073717A1 (es) | 2010-11-24 |
| JP2012504634A (ja) | 2012-02-23 |
| EP2334331A1 (en) | 2011-06-22 |
| CA2736429A1 (en) | 2010-04-08 |
| EP2334331B1 (en) | 2015-04-29 |
| RU2580029C2 (ru) | 2016-04-10 |
| ZA201101651B (en) | 2012-06-27 |
| CN102170909B (zh) | 2015-11-25 |
| KR101712214B1 (ko) | 2017-03-03 |
| US20100080808A1 (en) | 2010-04-01 |
| JP5710487B2 (ja) | 2015-04-30 |
| ES2541726T3 (es) | 2015-07-23 |
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