ES2527444T3 - Células del epitelio pigmentario de la retina derivadas de células madre - Google Patents

Células del epitelio pigmentario de la retina derivadas de células madre Download PDF

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Publication number
ES2527444T3
ES2527444T3 ES08738258.6T ES08738258T ES2527444T3 ES 2527444 T3 ES2527444 T3 ES 2527444T3 ES 08738258 T ES08738258 T ES 08738258T ES 2527444 T3 ES2527444 T3 ES 2527444T3
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cells
stem cells
retinal pigment
pigment epithelial
pluripotent stem
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ES2527444T5 (es
ES2527444T8 (es
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Masha Idelson
Ruslana Alper-Pinus
Alex Obolensky
Eyal Banin
Benjamin Reubinoff
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Hadasit Medical Research Services and Development Co
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Hadasit Medical Research Services and Development Co
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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Abstract

Un método de inducción de la diferenciación dirigida de células madre pluripotentes humanas en células del epitelio pigmentario de la retina, método que comprende: a. cultivar células madre pluripotentes humanas en un sistema de cultivo que comprende un medio básico suplementado con nicotinamida (NA) para generar células en diferenciación; y b. cultivar dichas células en diferenciación en un sistema de cultivo que comprende un medio básico suplementado con uno o más miembros de la superfamilia de factores de crecimiento de transformación TGFβ, mediante lo que dichas células madre pluripotentes humanas son inducidas a la diferenciación en células RPE.

Description

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Claims (1)

  1. imagen1
ES08738258.6T 2007-04-18 2008-04-27 Células del epitelio pigmentario de la retina derivadas de células madre Active ES2527444T5 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90781807P 2007-04-18 2007-04-18
US907818P 2007-04-18
PCT/IL2008/000556 WO2008129554A1 (en) 2007-04-18 2008-04-27 Stem cell-derived retinal pigment epithelial cells

Publications (3)

Publication Number Publication Date
ES2527444T3 true ES2527444T3 (es) 2015-01-23
ES2527444T8 ES2527444T8 (es) 2016-06-22
ES2527444T5 ES2527444T5 (es) 2018-05-17

Family

ID=39666210

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Application Number Title Priority Date Filing Date
ES08738258.6T Active ES2527444T5 (es) 2007-04-18 2008-04-27 Células del epitelio pigmentario de la retina derivadas de células madre
ES12181140.0T Active ES2530370T5 (es) 2007-04-18 2008-04-27 Células del epitelio pigmentario de la retina derivadas de células madre

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES12181140.0T Active ES2530370T5 (es) 2007-04-18 2008-04-27 Células del epitelio pigmentario de la retina derivadas de células madre

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US (3) US8956866B2 (es)
EP (4) EP2886646B1 (es)
JP (1) JP5395058B2 (es)
CN (2) CN101688178B (es)
AU (1) AU2008242106B2 (es)
CA (1) CA2684460C (es)
ES (2) ES2527444T5 (es)
HK (4) HK1140791A1 (es)
IL (2) IL225163B (es)
WO (1) WO2008129554A1 (es)

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