HK1191377A1 - 幹細胞衍生的視網膜色素上皮細胞 - Google Patents
幹細胞衍生的視網膜色素上皮細胞Info
- Publication number
- HK1191377A1 HK1191377A1 HK14104657.0A HK14104657A HK1191377A1 HK 1191377 A1 HK1191377 A1 HK 1191377A1 HK 14104657 A HK14104657 A HK 14104657A HK 1191377 A1 HK1191377 A1 HK 1191377A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cell
- epithelial cells
- retinal pigment
- pigment epithelial
- derived retinal
- Prior art date
Links
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/999—Small molecules not provided for elsewhere
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90781807P | 2007-04-18 | 2007-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1191377A1 true HK1191377A1 (zh) | 2014-07-25 |
Family
ID=39666210
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10107017A HK1140791A1 (zh) | 2007-04-18 | 2010-07-20 | 幹細胞衍生的視網膜色素上皮細胞 |
HK13106571.9A HK1179647A1 (zh) | 2007-04-18 | 2013-06-04 | 幹細胞衍生的視網膜色素上皮細胞 |
HK14104657.0A HK1191377A1 (zh) | 2007-04-18 | 2014-05-19 | 幹細胞衍生的視網膜色素上皮細胞 |
HK15112372.6A HK1211619A1 (zh) | 2007-04-18 | 2015-12-16 | 幹細胞衍生的視網膜色素上皮細胞 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10107017A HK1140791A1 (zh) | 2007-04-18 | 2010-07-20 | 幹細胞衍生的視網膜色素上皮細胞 |
HK13106571.9A HK1179647A1 (zh) | 2007-04-18 | 2013-06-04 | 幹細胞衍生的視網膜色素上皮細胞 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15112372.6A HK1211619A1 (zh) | 2007-04-18 | 2015-12-16 | 幹細胞衍生的視網膜色素上皮細胞 |
Country Status (10)
Country | Link |
---|---|
US (3) | US8956866B2 (zh) |
EP (4) | EP2886646B1 (zh) |
JP (1) | JP5395058B2 (zh) |
CN (2) | CN101688178B (zh) |
AU (1) | AU2008242106B2 (zh) |
CA (1) | CA2684460C (zh) |
ES (2) | ES2527444T5 (zh) |
HK (4) | HK1140791A1 (zh) |
IL (2) | IL225163B (zh) |
WO (1) | WO2008129554A1 (zh) |
Families Citing this family (75)
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CA2937099A1 (en) * | 2004-01-23 | 2005-08-04 | Astellas Institute For Regenerative Medicine | Improved modalities for the treatment of degenerative diseases of the retina |
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
US8597947B2 (en) * | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
ES2525684T3 (es) * | 2004-12-29 | 2014-12-29 | Hadasit Medical Research Services And Development Ltd. | Sistemas de cultivo de células madre |
CN101688178B (zh) | 2007-04-18 | 2013-12-04 | 哈达锡特医学研究服务及发展有限公司 | 干细胞衍生的视网膜色素上皮细胞 |
EP3636748A1 (en) | 2007-10-12 | 2020-04-15 | Astellas Institute for Regenerative Medicine | Improved methods of producing rpe cells and compositions of rpe cells |
WO2009117439A2 (en) | 2008-03-17 | 2009-09-24 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
JPWO2009148170A1 (ja) | 2008-06-06 | 2011-11-04 | 独立行政法人理化学研究所 | 幹細胞の培養方法 |
CN101580816B (zh) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法 |
JP6166900B2 (ja) * | 2009-08-24 | 2017-07-19 | ウイスコンシン アラムナイ リサーチ ファウンデーシヨンWisconsin Alumni Research Foundation | 実質的に純粋なヒト網膜前駆細胞培養物、前脳前駆細胞培養物、網膜色素上皮細胞培養物、及び、それらの製造方法 |
US9506114B2 (en) | 2009-08-28 | 2016-11-29 | Cellular Dynamics International, Inc. | Identifying genetic variation in affected tissues |
DK2496688T3 (en) * | 2009-11-05 | 2017-04-03 | Riken | Method of Inducing Differentiation in Cultured Stem Cells |
KR20120102709A (ko) | 2009-11-17 | 2012-09-18 | 어드밴스드 셀 테크놀로지, 인코포레이티드 | 인간 rpe 세포의 생산 방법 및 인간 rpe 세포의 제약 제제 |
ES2963295T3 (es) | 2010-07-12 | 2024-03-26 | Univ Southern California | Sustrato biocompatible para facilitar las interconexiones entre células madre y tejidos diana y métodos para implantarlo |
WO2012149480A2 (en) | 2011-04-29 | 2012-11-01 | University Of Southern California | Systems and methods for in vitro and in vivo imaging of cells on a substrate |
AU2011280878B2 (en) | 2010-07-23 | 2016-06-16 | Astellas Institute For Regenerative Medicine | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
FI20106354A0 (fi) * | 2010-12-20 | 2010-12-20 | Suomen Punainen Risti Veripalvelu | Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi |
KR102703637B1 (ko) | 2010-12-22 | 2024-09-05 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
US10478206B2 (en) | 2011-04-29 | 2019-11-19 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
JP5985209B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 眼杯様構造体の製造方法 |
AU2012341417B2 (en) | 2011-11-25 | 2018-06-28 | Riken | Methods for producing retinal tissue and retina-related cell |
JP5985207B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜色素上皮細胞の製造方法 |
JP6067232B2 (ja) * | 2011-11-25 | 2017-01-25 | 住友化学株式会社 | 網膜層特異的神経細胞を製造する方法 |
JP5985208B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜組織の製造方法 |
US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
WO2013114360A1 (en) * | 2012-01-31 | 2013-08-08 | Cell Cure Neurosciences Ltd. | Methods of selecting retinal pigmented epithelial cells |
RU2486603C1 (ru) * | 2012-04-11 | 2013-06-27 | Федеральное государственное бюджетное учреждение науки Институт биологии развития им. Н.К. Кольцова РАН (ИБР РАН) | Способ моделирования тканевой структуры сетчатки глаза человека |
CN103627669A (zh) * | 2012-08-22 | 2014-03-12 | 复旦大学 | 一种诱导人多能干细胞分化为视网膜前体细胞的方法 |
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US20150368713A1 (en) | 2013-02-01 | 2015-12-24 | THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv | METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs) |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
EP2828380B1 (en) * | 2013-04-03 | 2016-09-21 | Tampereen Yliopisto | Methods and media for differentiating eye cells |
WO2015020091A1 (ja) * | 2013-08-06 | 2015-02-12 | 独立行政法人理化学研究所 | 前眼部組織の製造方法 |
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JP2017504311A (ja) * | 2013-12-11 | 2017-02-09 | ファイザー・リミテッドPfizer Limited | 網膜色素上皮細胞を生成する方法 |
EP3114214B1 (en) | 2014-03-04 | 2023-11-01 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
WO2015142855A1 (en) * | 2014-03-17 | 2015-09-24 | University Of Virginia Patent Foundation | Compositions and methods for treating retinopathy |
WO2015175504A1 (en) * | 2014-05-12 | 2015-11-19 | The Johns Hopkins University | Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors |
AU2015336454B2 (en) | 2014-10-24 | 2021-04-29 | Riken | Production method for retinal tissue |
TWI810142B (zh) | 2014-10-24 | 2023-08-01 | 日商住友製藥股份有限公司 | 神經組織的製造方法 |
JP6734853B2 (ja) * | 2014-12-18 | 2020-08-05 | ソルボンヌ・ユニヴェルシテSorbonne Universite | 網膜変性処置のためのotx2過剰発現トランスジェニック網膜色素上皮細胞 |
IL305070A (en) | 2014-12-30 | 2023-10-01 | Cell Cure Neurosciences Ltd | RPE cell populations and methods for their production |
WO2016108219A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Methods of treating retinal diseases |
EP3916085A1 (en) * | 2014-12-30 | 2021-12-01 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
US11230696B2 (en) | 2015-07-29 | 2022-01-25 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
JP6868608B2 (ja) * | 2015-08-05 | 2021-05-12 | セル キュア ニューロサイエンシズ リミテッド | 網膜疾患の処置のための光受容体の調製 |
EP3331994B1 (en) | 2015-08-05 | 2022-09-14 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
JP6884354B2 (ja) * | 2015-09-08 | 2021-06-09 | 大日本住友製薬株式会社 | 網膜組織の製造方法 |
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