HK1140791A1 - 幹細胞衍生的視網膜色素上皮細胞 - Google Patents

幹細胞衍生的視網膜色素上皮細胞

Info

Publication number
HK1140791A1
HK1140791A1 HK10107017A HK10107017A HK1140791A1 HK 1140791 A1 HK1140791 A1 HK 1140791A1 HK 10107017 A HK10107017 A HK 10107017A HK 10107017 A HK10107017 A HK 10107017A HK 1140791 A1 HK1140791 A1 HK 1140791A1
Authority
HK
Hong Kong
Prior art keywords
stem cell
epithelial cells
retinal pigment
pigment epithelial
derived retinal
Prior art date
Application number
HK10107017A
Other languages
English (en)
Inventor
Masha Idelson
Ruslana Alper-Pinus
Alex Obolensky
Eyal Banin
Benjamin Reubinoff
Original Assignee
Hadasit Med Res Service
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39666210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1140791(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hadasit Med Res Service filed Critical Hadasit Med Res Service
Publication of HK1140791A1 publication Critical patent/HK1140791A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
HK10107017A 2007-04-18 2010-07-20 幹細胞衍生的視網膜色素上皮細胞 HK1140791A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90781807P 2007-04-18 2007-04-18
PCT/IL2008/000556 WO2008129554A1 (en) 2007-04-18 2008-04-27 Stem cell-derived retinal pigment epithelial cells

Publications (1)

Publication Number Publication Date
HK1140791A1 true HK1140791A1 (zh) 2010-10-22

Family

ID=39666210

Family Applications (4)

Application Number Title Priority Date Filing Date
HK10107017A HK1140791A1 (zh) 2007-04-18 2010-07-20 幹細胞衍生的視網膜色素上皮細胞
HK13106571.9A HK1179647A1 (zh) 2007-04-18 2013-06-04 幹細胞衍生的視網膜色素上皮細胞
HK14104657.0A HK1191377A1 (zh) 2007-04-18 2014-05-19 幹細胞衍生的視網膜色素上皮細胞
HK15112372.6A HK1211619A1 (zh) 2007-04-18 2015-12-16 幹細胞衍生的視網膜色素上皮細胞

Family Applications After (3)

Application Number Title Priority Date Filing Date
HK13106571.9A HK1179647A1 (zh) 2007-04-18 2013-06-04 幹細胞衍生的視網膜色素上皮細胞
HK14104657.0A HK1191377A1 (zh) 2007-04-18 2014-05-19 幹細胞衍生的視網膜色素上皮細胞
HK15112372.6A HK1211619A1 (zh) 2007-04-18 2015-12-16 幹細胞衍生的視網膜色素上皮細胞

Country Status (10)

Country Link
US (3) US8956866B2 (zh)
EP (4) EP2554661B2 (zh)
JP (1) JP5395058B2 (zh)
CN (2) CN103555654B (zh)
AU (1) AU2008242106B2 (zh)
CA (1) CA2684460C (zh)
ES (2) ES2530370T5 (zh)
HK (4) HK1140791A1 (zh)
IL (2) IL225163B (zh)
WO (1) WO2008129554A1 (zh)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
EP4248751A3 (en) 2004-01-23 2023-11-01 President and Fellows of Harvard College Improved modalities for the treatment of degenerative diseases of the retina
US8597947B2 (en) 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
ES2525684T3 (es) * 2004-12-29 2014-12-29 Hadasit Medical Research Services And Development Ltd. Sistemas de cultivo de células madre
CA2684460C (en) 2007-04-18 2017-01-03 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
ES2764473T3 (es) 2007-10-12 2020-06-03 Astellas Inst For Regenerative Medicine Métodos mejorados para producir células RPE y composiciones de células RPE
SG10201607710UA (en) 2008-03-17 2016-11-29 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
WO2009148170A1 (ja) * 2008-06-06 2009-12-10 独立行政法人理化学研究所 幹細胞の培養方法
CN101580816B (zh) * 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法
EP3553170B1 (en) * 2009-08-24 2024-02-14 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
JP5885255B2 (ja) 2009-08-28 2016-03-15 セルラー ダイナミクス インターナショナル， インコーポレイテッド 罹患組織における遺伝的変異の同定
WO2011055855A1 (en) * 2009-11-05 2011-05-12 Riken A method for differentiation induction in cultured stem cells
IL281453B (en) 2009-11-17 2022-07-01 Astellas Inst For Regenerative Medicine Methods for preparing human rpe cells and pharmaceutical preparations of human rpe cells
US9089600B2 (en) * 2010-07-12 2015-07-28 University Of Southern California Systems and methods for in vitro and in vivo imaging of cells on a substrate
JP5876045B2 (ja) 2010-07-12 2016-03-02 ユニバーシティー オブ サザン カリフォルニア 幹細胞と標的組織の相互接続を促進する生体適合性基材およびそれを埋め込む方法
ES2874953T3 (es) * 2010-07-23 2021-11-05 Astellas Inst For Regenerative Medicine Métodos para la detección de subpoblaciones raras de células y composiciones muy purificadas de células
FI20106354A0 (fi) * 2010-12-20 2010-12-20 Suomen Punainen Risti Veripalvelu Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi
KR20140063501A (ko) 2010-12-22 2014-05-27 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
US8349005B2 (en) 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
US10478206B2 (en) 2011-04-29 2019-11-19 University Of Southern California Instruments and methods for the implantation of cell-seeded substrates
US8877489B2 (en) 2011-12-05 2014-11-04 California Institute Of Technology Ultrathin parylene-C semipermeable membranes for biomedical applications
JP6067232B2 (ja) * 2011-11-25 2017-01-25 住友化学株式会社 網膜層特異的神経細胞を製造する方法
EP2784152B1 (en) * 2011-11-25 2019-04-10 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
JP5985207B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
JP5985209B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 眼杯様構造体の製造方法
JP5985208B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜組織の製造方法
US9248013B2 (en) 2011-12-05 2016-02-02 California Institute Of Technology 3-Dimensional parylene scaffold cage
WO2013114360A1 (en) * 2012-01-31 2013-08-08 Cell Cure Neurosciences Ltd. Methods of selecting retinal pigmented epithelial cells
RU2486603C1 (ru) * 2012-04-11 2013-06-27 Федеральное государственное бюджетное учреждение науки Институт биологии развития им. Н.К. Кольцова РАН (ИБР РАН) Способ моделирования тканевой структуры сетчатки глаза человека
CN103627669A (zh) * 2012-08-22 2014-03-12 复旦大学 一种诱导人多能干细胞分化为视网膜前体细胞的方法
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US20150368713A1 (en) 2013-02-01 2015-12-24 THE UNITED STATES OF AMERICAN, as represented by the Secretary, Department of Health and Human Serv METHOD FOR GENERATING RETINAL PIGMENT EPITHELIUM (RPE) CELLS FROM INDUCED PLURIPOTENT STEM CELLS (IPSCs)
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
AU2014246962A1 (en) * 2013-04-03 2015-11-19 Tampereen Yliopisto Methods and media for differentiating eye cells
AU2014303443B2 (en) * 2013-08-06 2020-11-12 Riken Method for producing anterior eye segment tissue
KR102278978B1 (ko) 2013-08-23 2021-07-19 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
EP3056564B1 (en) * 2013-10-09 2021-07-21 Healios K.K. Method for purification of retinal pigment epithelial cells
US10760050B2 (en) 2013-11-11 2020-09-01 Sumitomo Chemical Company, Limited Method for producing retinal pigment epithelial cells
US20150148383A1 (en) * 2013-11-22 2015-05-28 Regenerative Research Foundation Methods for Inhibiting or Reversing Epiretinal Membrane Formation
MX2016007671A (es) 2013-12-11 2016-10-14 Pfizer Ltd Metodo para producir celulas del epitelio pigmentario retiniano.
EP3604499A1 (en) 2014-03-04 2020-02-05 Fate Therapeutics, Inc. Improved reprogramming methods and cell culture platforms
US20170080030A1 (en) * 2014-03-17 2017-03-23 University Of Virginia Patent Foundation Compositions and methods for treating retinopathy
WO2015175504A1 (en) * 2014-05-12 2015-11-19 The Johns Hopkins University Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors
US11214772B2 (en) 2014-10-24 2022-01-04 Sumitomo Dainippon Pharma Co., Ltd. Production method for retinal tissue
WO2016063985A1 (ja) 2014-10-24 2016-04-28 大日本住友製薬株式会社 神経組織の製造方法
US11865189B2 (en) 2014-12-18 2024-01-09 Sorbonne Universite Transgenic RPE cells overexpressing OTX2 for the treatment of retinal degeneration
ES2774456T3 (es) 2014-12-30 2020-07-21 Cell Cure Neurosciences Ltd Poblaciones de células del RPE y métodos de generación de las mismas
IL253244B2 (en) 2014-12-30 2023-09-01 Cell Cure Neurosciences Ltd Methods for treating retinal diseases
EP3240890B1 (en) 2014-12-30 2021-06-16 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
WO2017017686A1 (en) 2015-07-29 2017-02-02 Hadasit Medical Research Services And Development Ltd. Large scale production of retinal pigment epithelial cells
ES2932823T3 (es) * 2015-08-05 2023-01-26 Cell Cure Neurosciences Ltd Preparación de células del epitelio pigmentario de la retina
CA2993910A1 (en) 2015-08-05 2017-02-09 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
ES2971677T3 (es) * 2015-09-08 2024-06-06 Sumitomo Pharma Co Ltd Método para la producción de tejido retiniano
CN105112368B (zh) * 2015-09-30 2018-09-21 奥思达干细胞有限公司 一种治疗视网膜变性的干细胞制剂及其使用方法
SG10202111851YA (en) 2015-10-16 2021-12-30 Fate Therapeutics Inc Platform for the Induction & Maintenance of Ground State Pluripotency
WO2017072763A1 (en) * 2015-10-26 2017-05-04 Cell Cure Neurosciences Ltd. Preparation of retinal pigment epithelium cells
CH711966A2 (it) * 2015-12-23 2017-06-30 Pinelli Roberto Cellule staminali retinali.
SG11201809201UA (en) 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
MX2019006576A (es) 2016-12-07 2019-08-21 Mayo Found Medical Education & Res Metodos y materiales para usar soportes de fibrina para trasplante de epitelio de pigmento retiniano.
CN106754718A (zh) * 2016-12-19 2017-05-31 胡其锐 一种人胚胎干细胞快速定向分化至视网膜色素上皮细胞的方法
CA3052872A1 (en) * 2017-02-08 2018-08-16 Hadasit Medical Research Services And Development Ltd. Photoreceptor cells for the treatment of retinal diseases
IL269363B2 (en) 2017-03-16 2024-02-01 Lineage Cell Therapeutics Inc Methods for measuring medical effects of treating retinal diseases
CN108728413A (zh) * 2017-06-13 2018-11-02 中山大学中山眼科中心 一种人多能干细胞来源人视网膜色素上皮细胞的制备和扩增培养方法
WO2019069327A1 (en) 2017-10-05 2019-04-11 Eyestem Research Private Limited UNIFIED CELL DIFFERENTIATION PROTOCOL
EP3770250A4 (en) 2018-03-22 2021-11-24 Oriental Yeast Co., Ltd. DIFFERENTIATION PROMOTER FOR PLURIPOTENT STEM CELLS
CN108531443A (zh) * 2018-04-04 2018-09-14 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法
CN110205283B (zh) * 2018-04-18 2021-04-23 浙江大学 一种诱导人羊膜上皮细胞向视网膜色素上皮细胞分化的方法及其应用
EP3969570A1 (en) * 2019-05-15 2022-03-23 Novo Nordisk A/S Methods for obtaining eye field progenitor cells from human pluripotent stem cells
EP3754014A1 (en) 2019-06-21 2020-12-23 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing retinal pigment epithelium cells
CA3184790A1 (en) * 2020-05-25 2021-12-02 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
WO2022261320A1 (en) 2021-06-09 2022-12-15 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
EP4377445A1 (en) 2021-07-28 2024-06-05 Lineage Cell Therapeutics, Inc. Expansion of retinal pigment epithelium cells
US20230377685A1 (en) 2022-04-15 2023-11-23 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
CN115840045B (zh) * 2023-02-23 2023-04-28 中国农业大学 一种猪胚胎期毛囊基板前体细胞的鉴定方法及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5750342A (en) * 1990-06-11 1998-05-12 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands of tissue target
TW209224B (zh) * 1991-05-27 1993-07-11 Yoshitomi Pharmaceutical
US6045791A (en) 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
DE4219250A1 (de) * 1992-06-12 1993-12-16 Behringwerke Ag Serum-freies Zellkulturmedium
ATE196923T1 (de) 1993-04-30 2000-10-15 Photogenesis Inc Transplantation des retinalen pigmentepithels
US5755785A (en) 1994-08-12 1998-05-26 The University Of South Florida Sutureless corneal transplantation method
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
GB9715584D0 (en) 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
JP3663990B2 (ja) 1999-08-31 2005-06-22 不二製油株式会社 含気チョコレート及びその製造法
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
US7112437B2 (en) 2000-06-20 2006-09-26 Es Cell International Pte Ltd. Methods of culturing embryonic stem cells and controlled differentiation
IL156413A0 (en) 2001-01-31 2004-01-04 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
WO2003060085A2 (en) * 2002-01-14 2003-07-24 The Board Of Trustees Of The University Of Illinois Mammalian neural stem cells, compositions and uses thereof
WO2003068233A1 (en) 2002-02-11 2003-08-21 Pfizer Limited Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
US20050019718A1 (en) 2003-07-22 2005-01-27 Hanson G. Herbert Orthodontic devices for use with arch wires
EP4248751A3 (en) * 2004-01-23 2023-11-01 President and Fellows of Harvard College Improved modalities for the treatment of degenerative diseases of the retina
US7794704B2 (en) * 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
DE102004048640A1 (de) * 2004-10-04 2006-04-06 Otmar Fahrion Kette
JP2006113175A (ja) * 2004-10-13 2006-04-27 Konica Minolta Opto Inc 光学フィルム、偏光板及び表示装置
ES2525684T3 (es) * 2004-12-29 2014-12-29 Hadasit Medical Research Services And Development Ltd. Sistemas de cultivo de células madre
CA2684460C (en) 2007-04-18 2017-01-03 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
CN102334251B (zh) 2009-02-25 2013-05-29 皇家飞利浦电子股份有限公司 利用光子冷却依存激光器电压用于激光二极管的输出功率稳定
WO2015054526A2 (en) * 2013-10-09 2015-04-16 The Regents Of The University Of California Methods of mammalian retinal stem cell production and applications

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