BRPI0506474A - sistema de tecido com células tronco não diferenciadas derivadas no limbus da córnea - Google Patents
sistema de tecido com células tronco não diferenciadas derivadas no limbus da córneaInfo
- Publication number
- BRPI0506474A BRPI0506474A BRPI0506474-0A BRPI0506474A BRPI0506474A BR PI0506474 A BRPI0506474 A BR PI0506474A BR PI0506474 A BRPI0506474 A BR PI0506474A BR PI0506474 A BRPI0506474 A BR PI0506474A
- Authority
- BR
- Brazil
- Prior art keywords
- tissue system
- tissue
- stem cells
- limbic
- uscs
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"SISTEMA DE TECIDO COM CéLULAS TRONCO NãO DIFERENCIADAS DERIVADAS DO LIMBUS DA CóRNEA". A presente descrição apresenta um sistema de tecido com células tronco límbicas auto-regenerativas, em que as célula tronco límbicas são principalmente células tronco não diferenciadas (USCS). O sistema de tecido é derivado do tecido límbico da córnea isolado, e é apropriado para restaurar deteriorações da superfície ocular, particularmente aquelas que resultam das deficiências das células tronco límbicas. O sistema de tecido é gerado ao aumentar seletivamente o sistema de tecido para as USCS, por exemplo, mediante a seleção e a classificação das células que expressam marcadores de superfície específicos de células tronco, tal como o marcador 4 de antígeno embriónico específico de estágio (SSEA-4) . Depois do isolamento, as USCs são cultivadas em uma base de tecido na presença de um meio enriquecido para gerar o sistema de tecido, o qual é apropriado para o transplante, o implante, ou o enxerto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN74MU2004 | 2004-01-27 | ||
PCT/IB2005/000203 WO2005079145A2 (en) | 2004-01-27 | 2005-01-27 | Tissue system with undifferentiated stem cells derived from corneal limbus |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506474A true BRPI0506474A (pt) | 2007-02-06 |
Family
ID=34856876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506474-0A BRPI0506474A (pt) | 2004-01-27 | 2005-01-27 | sistema de tecido com células tronco não diferenciadas derivadas no limbus da córnea |
Country Status (10)
Country | Link |
---|---|
US (1) | US20050186672A1 (pt) |
EP (1) | EP1733026A4 (pt) |
JP (1) | JP2007524411A (pt) |
KR (1) | KR20070001108A (pt) |
CN (1) | CN100554411C (pt) |
BR (1) | BRPI0506474A (pt) |
CA (1) | CA2554691A1 (pt) |
SG (1) | SG151246A1 (pt) |
WO (1) | WO2005079145A2 (pt) |
ZA (1) | ZA200606102B (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2411101C (en) | 2000-06-05 | 2018-01-16 | Brigham And Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
WO2006088747A2 (en) * | 2005-02-14 | 2006-08-24 | Mercer University | Serum-free reagents for the isolation, cultivation, and cryopreservation of postnatal pluripotent epiblast-like stem cells |
WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
ZA200804718B (en) | 2005-12-29 | 2010-04-28 | Anthrogenesis Corp | Co-culture of placental stem cells and stem cells from a second source |
CN101432031A (zh) * | 2006-02-24 | 2009-05-13 | 利莱恩斯生命科学有限公司 | 结膜组织系统 |
KR100908481B1 (ko) * | 2006-04-24 | 2009-07-21 | 코아스템(주) | 중간엽 줄기세포 배양 배지 및 이를 이용한 중간엽줄기세포의 배양 방법 |
HUE059011T2 (hu) | 2006-05-31 | 2022-09-28 | Childrens Medical Center | Immunmodulátorként szolgáló ABC5-pozitív mezenchimális õssejtek |
US20100173344A1 (en) * | 2006-08-24 | 2010-07-08 | Cedars-Sinai Medical Center | Methods for isolating and using pituitary adenoma stem cells and pituitary adenoma cells |
US20100062477A1 (en) * | 2006-11-28 | 2010-03-11 | Cedars-Sinai Medical Center | Methods of isolating and propagating stem cells from benign tumors |
EP2150103A2 (en) * | 2007-04-26 | 2010-02-10 | Medinnova As | Transplant storage |
CN101889079B (zh) * | 2008-10-17 | 2012-08-08 | 宁夏医科大学附属医院 | 适于临床应用的人胎盘间质细胞库的建立方法 |
US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
WO2010104696A1 (en) * | 2009-03-11 | 2010-09-16 | Invitrx, Inc. | Method and composition for the treatment of moderate to severe keratoconjunctivitis sicca |
EP2309003A1 (en) * | 2009-09-18 | 2011-04-13 | Bioftalmik, S.L. | Method for the diagnosis of limbal stem cell deficiency |
CN102762720B (zh) | 2009-11-12 | 2015-03-11 | Vbi技术有限责任公司 | 类孢子细胞子群及其用途 |
KR101202836B1 (ko) * | 2010-08-27 | 2012-11-20 | 서울대학교산학협력단 | 세포응집을 이용한 인간 혈액 유래 혈구 세포괴의 유도와 이를 이용한 혈중 성체줄기세포 및 전구세포의 증폭방법 및 상기의 방법에 의해 제조된 줄기세포 |
CN103492555A (zh) * | 2011-04-20 | 2014-01-01 | 国立大学法人大阪大学 | 角膜上皮分化取向性iPS细胞 |
RU2475218C1 (ru) * | 2011-12-06 | 2013-02-20 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ выделения и органо-типической консервации аллогенного лимбального трансплантата |
WO2013184843A1 (en) * | 2012-06-05 | 2013-12-12 | The Regents Of The University Of California | Novel methods to regenerate human limbal stem cells |
US9308082B2 (en) | 2012-08-07 | 2016-04-12 | RegenEye, L.L.C. | Ocular collar stent for treating narrowing of the irideocorneal angle |
US10265161B2 (en) | 2012-08-07 | 2019-04-23 | Regeneye L. L. C. | Ocular collar stent for treating narrowing of the irideocorneal angle |
US9974645B2 (en) | 2012-08-07 | 2018-05-22 | RegenEye, L.L.C. | Method of reducing the occurrence of macular and neuroretinal degenerations by alleviating age related retinal stresses as a contributing factor in a mammalian eye |
CA2901931C (en) * | 2013-02-19 | 2023-03-07 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
CN107075469A (zh) * | 2014-06-27 | 2017-08-18 | 加利福尼亚大学董事会 | 培养的哺乳动物角膜缘干细胞、其产生方法和其用途 |
KR101645901B1 (ko) * | 2015-12-31 | 2016-08-04 | 가톨릭대학교 산학협력단 | 양막 슬라이드 지지체를 이용한 윤부줄기세포 배양방법 |
CN105797138A (zh) * | 2016-03-29 | 2016-07-27 | 深圳爱生再生医学科技有限公司 | 修复角膜的干细胞制剂及其制备方法和应用 |
CN106039289A (zh) * | 2016-05-26 | 2016-10-26 | 深圳爱生再生医学科技有限公司 | 干细胞制剂及其制备方法 |
WO2018106414A1 (en) | 2016-12-07 | 2018-06-14 | Mayo Foundation For Medical Education And Research | Methods and materials for using fibrin supports for retinal pigment epithelium transplantation |
CN110168076B (zh) * | 2017-01-13 | 2023-04-21 | 国立大学法人大阪大学 | 角膜上皮细胞群的制造方法 |
JP7311433B2 (ja) * | 2017-06-05 | 2023-07-19 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | 幹細胞を培養し、増殖させ、分化させるための方法及び材料 |
US20200129667A1 (en) * | 2017-06-30 | 2020-04-30 | Vascudyne Inc | Regenerative tissue and natural tissue implants |
WO2020018868A1 (en) | 2018-07-19 | 2020-01-23 | Texas Tech University System | Corneal epithelial cells and their products for treating corneal diseases |
CN109321527A (zh) * | 2018-10-10 | 2019-02-12 | 中国海洋大学 | 角膜缘干细胞稳定性的体外培养方法 |
CN111700912B (zh) * | 2020-06-03 | 2022-04-19 | 青岛海尔生物科技有限公司 | 一种适用于角膜缘干细胞缺乏症的滴眼液及制备 |
CN111657269B (zh) * | 2020-06-22 | 2022-02-08 | 镇江雷音再生医学科技有限公司 | 纤维蛋白胶用于smile来源人角膜透镜保存前的保护处理方法 |
CN113106057B (zh) * | 2020-12-23 | 2023-04-25 | 重庆医科大学附属儿童医院 | 一种用于肝细胞移植的自体干细胞制剂及制备方法 |
CN112626019A (zh) * | 2020-12-28 | 2021-04-09 | 武汉爱尔眼科医院有限公司 | 一种眼角膜及角膜缘单细胞悬液的制备方法 |
Family Cites Families (17)
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US5703047A (en) * | 1992-09-21 | 1997-12-30 | Board Of Regents, The University Of Texas System | Methods and treatments for corneal healing with growth factors |
US5843780A (en) * | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US6152142A (en) * | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
US7410798B2 (en) * | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
US20030161817A1 (en) * | 2001-03-28 | 2003-08-28 | Young Henry E. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
US20020039788A1 (en) * | 2000-02-29 | 2002-04-04 | Isseroff Roslyn R. | Corneal epithelial graft composites |
US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
US20040015617A1 (en) * | 2001-01-25 | 2004-01-22 | Sangha Onkar S. | Flexible network interfaces and flexible data clocking |
US7347876B2 (en) * | 2001-04-25 | 2008-03-25 | Ray Jui-Fang Tsai | Method for expansion of epithelial stem cells |
ITRM20010476A1 (it) * | 2001-08-03 | 2003-02-03 | Idi Irccs | Lamine di epitelio corneale umano ricostruite e metodo per il loro ottenimento. |
US20050032207A1 (en) * | 2001-09-12 | 2005-02-10 | Anna Wobus | Method for isolating, culturing and differentiating intestinal stem cells for therapeutic use |
CA2483010A1 (en) * | 2002-04-19 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Placental derived stem cells and uses thereof |
ITUD20020092A1 (it) | 2002-04-30 | 2002-07-30 | Univ Degli Studi Udine | Metodo per l'identificazione e l'isolamento di cellule staminali di un tessuto umano |
US7422736B2 (en) * | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
US20050136536A1 (en) * | 2003-09-15 | 2005-06-23 | Anderson Daniel G. | Embryonic epithelial cells |
KR100931887B1 (ko) * | 2004-02-26 | 2009-12-15 | 리라이언스 라이프 사이언시스 프라이빗. 리미티드 | 각막 윤부에서 유도된 다능성 배아 유사 줄기 세포, 분리 방법 및 이들의 용도 |
MY165114A (en) * | 2006-09-01 | 2018-02-28 | Stempeutics Res Private Limited | Self-renewing master adult pluripotent stem cells |
-
2005
- 2005-01-25 US US11/043,019 patent/US20050186672A1/en not_active Abandoned
- 2005-01-27 JP JP2006550348A patent/JP2007524411A/ja active Pending
- 2005-01-27 WO PCT/IB2005/000203 patent/WO2005079145A2/en not_active Application Discontinuation
- 2005-01-27 CA CA002554691A patent/CA2554691A1/en not_active Abandoned
- 2005-01-27 EP EP05702360A patent/EP1733026A4/en not_active Withdrawn
- 2005-01-27 CN CNB2005800099478A patent/CN100554411C/zh not_active Expired - Fee Related
- 2005-01-27 SG SG200901427-5A patent/SG151246A1/en unknown
- 2005-01-27 BR BRPI0506474-0A patent/BRPI0506474A/pt not_active IP Right Cessation
- 2005-01-27 KR KR1020067015205A patent/KR20070001108A/ko active Search and Examination
-
2006
- 2006-07-24 ZA ZA200606102A patent/ZA200606102B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2007524411A (ja) | 2007-08-30 |
CN100554411C (zh) | 2009-10-28 |
ZA200606102B (en) | 2007-11-28 |
US20050186672A1 (en) | 2005-08-25 |
SG151246A1 (en) | 2009-04-30 |
WO2005079145A2 (en) | 2005-09-01 |
CA2554691A1 (en) | 2005-09-01 |
EP1733026A4 (en) | 2009-06-03 |
EP1733026A2 (en) | 2006-12-20 |
CN101052299A (zh) | 2007-10-10 |
WO2005079145A8 (en) | 2006-04-13 |
KR20070001108A (ko) | 2007-01-03 |
WO2005079145A3 (en) | 2007-05-03 |
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