HK1140791A1 - Stem cell-derived retinal pigment epithelial cells - Google Patents
Stem cell-derived retinal pigment epithelial cellsInfo
- Publication number
- HK1140791A1 HK1140791A1 HK10107017A HK10107017A HK1140791A1 HK 1140791 A1 HK1140791 A1 HK 1140791A1 HK 10107017 A HK10107017 A HK 10107017A HK 10107017 A HK10107017 A HK 10107017A HK 1140791 A1 HK1140791 A1 HK 1140791A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- stem cell
- epithelial cells
- retinal pigment
- pigment epithelial
- derived retinal
- Prior art date
Links
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90781807P | 2007-04-18 | 2007-04-18 | |
PCT/IL2008/000556 WO2008129554A1 (en) | 2007-04-18 | 2008-04-27 | Stem cell-derived retinal pigment epithelial cells |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1140791A1 true HK1140791A1 (en) | 2010-10-22 |
Family
ID=39666210
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10107017A HK1140791A1 (en) | 2007-04-18 | 2010-07-20 | Stem cell-derived retinal pigment epithelial cells |
HK13106571.9A HK1179647A1 (en) | 2007-04-18 | 2013-06-04 | Stem cell-derived retinal pigment epithelial cells |
HK14104657.0A HK1191377A1 (zh) | 2007-04-18 | 2014-05-19 | 幹細胞衍生的視網膜色素上皮細胞 |
HK15112372.6A HK1211619A1 (en) | 2007-04-18 | 2015-12-16 | Stem cell-derived retinal pigment epithelial cells |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13106571.9A HK1179647A1 (en) | 2007-04-18 | 2013-06-04 | Stem cell-derived retinal pigment epithelial cells |
HK14104657.0A HK1191377A1 (zh) | 2007-04-18 | 2014-05-19 | 幹細胞衍生的視網膜色素上皮細胞 |
HK15112372.6A HK1211619A1 (en) | 2007-04-18 | 2015-12-16 | Stem cell-derived retinal pigment epithelial cells |
Country Status (10)
Country | Link |
---|---|
US (3) | US8956866B2 (es) |
EP (4) | EP2147094B2 (es) |
JP (1) | JP5395058B2 (es) |
CN (2) | CN103555654B (es) |
AU (1) | AU2008242106B2 (es) |
CA (1) | CA2684460C (es) |
ES (2) | ES2530370T5 (es) |
HK (4) | HK1140791A1 (es) |
IL (2) | IL225163B (es) |
WO (1) | WO2008129554A1 (es) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4248752A3 (en) | 2004-01-23 | 2024-01-03 | President And Fellows Of Harvard College | Improved modalities for the treatment of degenerative diseases of the retina |
US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
EP2410043A3 (en) * | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
ES2530370T5 (es) | 2007-04-18 | 2018-05-28 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
WO2009051671A1 (en) | 2007-10-12 | 2009-04-23 | Advanced Cell Technology, Inc. | Improved methods of producing rpe cells and compositions of rpe cells |
EP2955222B1 (en) * | 2008-03-17 | 2018-09-12 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
WO2009148170A1 (ja) | 2008-06-06 | 2009-12-10 | 独立行政法人理化学研究所 | 幹細胞の培養方法 |
CN101580816B (zh) * | 2009-04-23 | 2012-02-29 | 中国科学院广州生物医药与健康研究院 | 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法 |
EP2470645B1 (en) * | 2009-08-24 | 2019-06-26 | Wisconsin Alumni Research Foundation | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
ES2509567T3 (es) | 2009-08-28 | 2014-10-17 | Cellular Dynamics International, Inc. | Identificación de variación genética en tejidos afectados |
ES2619564T3 (es) | 2009-11-05 | 2017-06-26 | Riken | Un método de inducción de diferenciación de células madre cultivadas |
KR102073730B1 (ko) * | 2009-11-17 | 2020-02-05 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 인간 rpe 세포의 생산 방법 및 인간 rpe 세포의 제약 제제 |
WO2012009377A2 (en) | 2010-07-12 | 2012-01-19 | University Of Southern California | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
WO2012149480A2 (en) * | 2011-04-29 | 2012-11-01 | University Of Southern California | Systems and methods for in vitro and in vivo imaging of cells on a substrate |
WO2012012803A2 (en) | 2010-07-23 | 2012-01-26 | Advanced Cell Technology, Inc. | Methods for detection of rare subpopulations of cells and highly purified compositions of cells |
FI20106354A0 (fi) * | 2010-12-20 | 2010-12-20 | Suomen Punainen Risti Veripalvelu | Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi |
JP6182456B2 (ja) | 2010-12-22 | 2017-08-23 | フェイト セラピューティクス,インコーポレイテッド | 単細胞選別のための細胞培養プラットホームおよびiPSCの再プログラミングの増強 |
US8349005B2 (en) | 2011-01-03 | 2013-01-08 | Masatoshi Murata | Method for burying implant to choroid |
US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
US10478206B2 (en) | 2011-04-29 | 2019-11-19 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
JP5985207B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜色素上皮細胞の製造方法 |
JP5985209B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 眼杯様構造体の製造方法 |
JP5985208B2 (ja) * | 2011-11-25 | 2016-09-06 | 住友化学株式会社 | 網膜組織の製造方法 |
JP6067232B2 (ja) * | 2011-11-25 | 2017-01-25 | 住友化学株式会社 | 網膜層特異的神経細胞を製造する方法 |
IN2014CN04599A (es) | 2011-11-25 | 2015-09-18 | Sumitomo Chemical Co | |
US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
CA2863172C (en) | 2012-01-31 | 2022-05-03 | Cell Cure Neurosciences Ltd. | Methods of selecting retinal pigmented epithelial cells |
RU2486603C1 (ru) * | 2012-04-11 | 2013-06-27 | Федеральное государственное бюджетное учреждение науки Институт биологии развития им. Н.К. Кольцова РАН (ИБР РАН) | Способ моделирования тканевой структуры сетчатки глаза человека |
CN103627669A (zh) * | 2012-08-22 | 2014-03-12 | 复旦大学 | 一种诱导人多能干细胞分化为视网膜前体细胞的方法 |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
AU2014212230B2 (en) | 2013-02-01 | 2019-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for generating retinal pigment epithelium (RPE) cells from induced pluripotent stem cells (iPSCs) |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
ES2604659T3 (es) * | 2013-04-03 | 2017-03-08 | Tampereen Yliopisto | Métodos y medios para la diferenciación de las células del ojo |
JP6546089B2 (ja) | 2013-08-06 | 2019-07-17 | 国立研究開発法人理化学研究所 | 前眼部組織の製造方法 |
EP3037524B8 (en) | 2013-08-23 | 2020-03-04 | Sumitomo Chemical Company, Limited | Method for producing retinal tissue and retina-related cells |
CN105849254A (zh) * | 2013-10-09 | 2016-08-10 | 希里欧斯株式会社 | 用于纯化视网膜色素上皮细胞的方法 |
CN105829527A (zh) * | 2013-11-11 | 2016-08-03 | 住友化学株式会社 | 用于制备视网膜色素上皮细胞的方法 |
US20150148383A1 (en) * | 2013-11-22 | 2015-05-28 | Regenerative Research Foundation | Methods for Inhibiting or Reversing Epiretinal Membrane Formation |
EP3080248A1 (en) | 2013-12-11 | 2016-10-19 | Pfizer Limited | Method for producing retinal pigment epithelial cells |
EP3604499A1 (en) | 2014-03-04 | 2020-02-05 | Fate Therapeutics, Inc. | Improved reprogramming methods and cell culture platforms |
US20170080030A1 (en) * | 2014-03-17 | 2017-03-23 | University Of Virginia Patent Foundation | Compositions and methods for treating retinopathy |
WO2015175504A1 (en) * | 2014-05-12 | 2015-11-19 | The Johns Hopkins University | Differentiation of human pluripotent stem cells into retinal pigment epithelium using hif1 inhibitors |
JP6682446B2 (ja) * | 2014-10-24 | 2020-04-15 | 大日本住友製薬株式会社 | 網膜組織の製造方法 |
AU2015336453B2 (en) | 2014-10-24 | 2021-05-20 | Riken | Production method for nerve tissue |
CA2970748C (en) * | 2014-12-18 | 2023-05-09 | Universite Pierre Et Marie Curie (Paris 6) | Transgenic rpe cells overexpressing otx2 for the treatment of retinal degeneration |
JP6882981B2 (ja) | 2014-12-30 | 2021-06-02 | セル キュア ニューロサイエンシズ リミテッド | Rpe細胞集団およびそれを作製する方法 |
JP2018502575A (ja) * | 2014-12-30 | 2018-02-01 | セル キュア ニューロサイエンシズ リミテッド | 網膜色素上皮細胞集団の評価法 |
EP3240612B1 (en) | 2014-12-30 | 2020-12-23 | Cell Cure Neurosciences Ltd. | Methods of treating retinal diseases |
WO2017017686A1 (en) | 2015-07-29 | 2017-02-02 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
EP4155391A1 (en) | 2015-08-05 | 2023-03-29 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
EP3331995A1 (en) * | 2015-08-05 | 2018-06-13 | Cell Cure Neurosciences Ltd. | Preparation of photoreceptors for the treatment of retinal diseases |
WO2017043604A1 (ja) * | 2015-09-08 | 2017-03-16 | 大日本住友製薬株式会社 | 網膜組織の製造方法 |
CN105112368B (zh) * | 2015-09-30 | 2018-09-21 | 奥思达干细胞有限公司 | 一种治疗视网膜变性的干细胞制剂及其使用方法 |
US11441126B2 (en) | 2015-10-16 | 2022-09-13 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
AU2016347652A1 (en) * | 2015-10-26 | 2018-05-24 | Cell Cure Neurosciences Ltd. | Preparation of retinal pigment epithelium cells |
CH711966A2 (it) * | 2015-12-23 | 2017-06-30 | Pinelli Roberto | Cellule staminali retinali. |
WO2017183732A1 (ja) | 2016-04-22 | 2017-10-26 | 大日本住友製薬株式会社 | 網膜組織の製造法 |
AU2017372468A1 (en) | 2016-12-07 | 2019-06-13 | Mayo Foundation For Medical Education And Research | Methods and materials for using fibrin supports for retinal pigment epithelium transplantation |
CN106754718A (zh) * | 2016-12-19 | 2017-05-31 | 胡其锐 | 一种人胚胎干细胞快速定向分化至视网膜色素上皮细胞的方法 |
WO2018146679A2 (en) * | 2017-02-08 | 2018-08-16 | Hadasit Medical Research Services And Development Ltd. | Photoreceptor cells for the treatment of retinal diseases |
IL269363B2 (en) | 2017-03-16 | 2024-02-01 | Lineage Cell Therapeutics Inc | Methods for measuring medical effects of treating retinal diseases |
CN108728413A (zh) * | 2017-06-13 | 2018-11-02 | 中山大学中山眼科中心 | 一种人多能干细胞来源人视网膜色素上皮细胞的制备和扩增培养方法 |
US11168301B2 (en) | 2017-10-05 | 2021-11-09 | Eyestem Research Private Limited | Method for producing photoreceptor cells, retinal pigmented epithelial cells, and retinal organoids |
WO2019182044A1 (ja) | 2018-03-22 | 2019-09-26 | オリエンタル酵母工業株式会社 | 多分化能性幹細胞分化促進剤 |
CN108531443A (zh) * | 2018-04-04 | 2018-09-14 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法 |
CN110205283B (zh) * | 2018-04-18 | 2021-04-23 | 浙江大学 | 一种诱导人羊膜上皮细胞向视网膜色素上皮细胞分化的方法及其应用 |
EP3754014A1 (en) | 2019-06-21 | 2020-12-23 | Centre d'Etude des Cellules Souches (CECS) | Automated method for preparing retinal pigment epithelium cells |
AU2021280260A1 (en) * | 2020-05-25 | 2023-02-02 | Hadasit Medical Research Services And Development Ltd. | Methods and compositions for treating retinal diseases and conditions |
WO2022261320A1 (en) | 2021-06-09 | 2022-12-15 | Lineage Cell Therapeutics, Inc. | Methods and compositions for treating retinal diseases and conditions |
JP2024527986A (ja) | 2021-07-28 | 2024-07-26 | リネージ セル セラピューティクス インコーポレイテッド | 網膜色素上皮細胞の増殖 |
US20230377685A1 (en) | 2022-04-15 | 2023-11-23 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
CN115840045B (zh) * | 2023-02-23 | 2023-04-28 | 中国农业大学 | 一种猪胚胎期毛囊基板前体细胞的鉴定方法及其应用 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG49267A1 (en) | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
US5750342A (en) * | 1990-06-11 | 1998-05-12 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands of tissue target |
TW209224B (es) * | 1991-05-27 | 1993-07-11 | Yoshitomi Pharmaceutical | |
US6045791A (en) * | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
DE4219250A1 (de) * | 1992-06-12 | 1993-12-16 | Behringwerke Ag | Serum-freies Zellkulturmedium |
DE69329556D1 (de) | 1993-04-30 | 2000-11-16 | Photogenesis Inc | Transplantation des retinalen pigmentepithels |
US5755785A (en) | 1994-08-12 | 1998-05-26 | The University Of South Florida | Sutureless corneal transplantation method |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5941250A (en) | 1996-11-21 | 1999-08-24 | University Of Louisville Research Foundation Inc. | Retinal tissue implantation method |
GB9715584D0 (en) | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
JP3663990B2 (ja) | 1999-08-31 | 2005-06-22 | 不二製油株式会社 | 含気チョコレート及びその製造法 |
GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
IL153095A0 (en) | 2000-06-20 | 2003-06-24 | Es Cell Int Pte Ltd | Embryonic stem cells, methods for culturing the same and methods utilizing the same |
NZ526453A (en) | 2001-01-31 | 2005-01-28 | Pfizer Prod Inc | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes |
CA2473503C (en) * | 2002-01-14 | 2010-01-05 | The Board Of Trustees Of The University Of Illinois | Use of modified pyrimidine compounds to promote stem cell migration and proliferation |
AU2003201745A1 (en) | 2002-02-11 | 2003-09-04 | Pfizer Limited | Nicotinamide derivatives and a tiotropium salt in combination for the treatment of e.g. inflammatory, allergic and respiratory diseases |
US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
US20050019718A1 (en) | 2003-07-22 | 2005-01-27 | Hanson G. Herbert | Orthodontic devices for use with arch wires |
US7794704B2 (en) * | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
EP4248752A3 (en) * | 2004-01-23 | 2024-01-03 | President And Fellows Of Harvard College | Improved modalities for the treatment of degenerative diseases of the retina |
DE102004048640A1 (de) * | 2004-10-04 | 2006-04-06 | Otmar Fahrion | Kette |
JP2006113175A (ja) * | 2004-10-13 | 2006-04-27 | Konica Minolta Opto Inc | 光学フィルム、偏光板及び表示装置 |
EP2410043A3 (en) | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
ES2530370T5 (es) | 2007-04-18 | 2018-05-28 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
JP5658691B2 (ja) | 2009-02-25 | 2015-01-28 | コーニンクレッカ フィリップス エヌ ヴェ | フォトン冷却依存レーザー電圧を使用するレーザーダイオードのための出力パワーの安定化 |
US10220117B2 (en) * | 2013-10-09 | 2019-03-05 | The Regents Of The University Of California | Methods of mammalian retinal stem cell production and applications |
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