ES2414706T3 - Métodos para aumentar la eritropoyetina endógena - Google Patents

Métodos para aumentar la eritropoyetina endógena Download PDF

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Publication number
ES2414706T3
ES2414706T3 ES02805548T ES02805548T ES2414706T3 ES 2414706 T3 ES2414706 T3 ES 2414706T3 ES 02805548 T ES02805548 T ES 02805548T ES 02805548 T ES02805548 T ES 02805548T ES 2414706 T3 ES2414706 T3 ES 2414706T3
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Spain
Prior art keywords
alkyl
alkoxy
carbonyl
alkylamino
carbamoyl
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Expired - Lifetime
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ES02805548T
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English (en)
Spanish (es)
Inventor
Stephen J. Klaus
Al Y. Lin
Thomas B. Neff
Qingjian Wang
Volkmar Guenzler-Pukall
Michael P. Arend
Lee A. Flippin
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Fibrogen Inc
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Fibrogen Inc
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    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/746Erythropoetin

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
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ES02805548T 2001-12-06 2002-12-06 Métodos para aumentar la eritropoyetina endógena Expired - Lifetime ES2414706T3 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US33708201P 2001-12-06 2001-12-06
US337082P 2001-12-06
US34965902P 2002-01-16 2002-01-16
US349659P 2002-01-16
US35968302P 2002-02-25 2002-02-25
US359683P 2002-02-25
US38648802P 2002-06-05 2002-06-05
US386488P 2002-06-05
PCT/US2002/039163 WO2003053997A2 (en) 2001-12-06 2002-12-06 Methods of increasing endogenous erythropoietin (epo)

Publications (1)

Publication Number Publication Date
ES2414706T3 true ES2414706T3 (es) 2013-07-22

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ID=27502557

Family Applications (3)

Application Number Title Priority Date Filing Date
ES02805548T Expired - Lifetime ES2414706T3 (es) 2001-12-06 2002-12-06 Métodos para aumentar la eritropoyetina endógena
ES10181796.3T Expired - Lifetime ES2686626T3 (es) 2001-12-06 2002-12-06 Medicamentos para tratar anemia asociada con enfermedad renal
ES10181768.2T Expired - Lifetime ES2686625T3 (es) 2001-12-06 2002-12-06 Métodos para el tratamiento o prevención de la anemia

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES10181796.3T Expired - Lifetime ES2686626T3 (es) 2001-12-06 2002-12-06 Medicamentos para tratar anemia asociada con enfermedad renal
ES10181768.2T Expired - Lifetime ES2686625T3 (es) 2001-12-06 2002-12-06 Métodos para el tratamiento o prevención de la anemia

Country Status (12)

Country Link
US (15) US20030153503A1 (enExample)
EP (7) EP2289531B1 (enExample)
JP (5) JP2005524612A (enExample)
CN (7) CN102526045A (enExample)
AU (3) AU2002357096B2 (enExample)
CA (4) CA2916093C (enExample)
DK (3) DK2289531T3 (enExample)
ES (3) ES2414706T3 (enExample)
HU (1) HU229475B1 (enExample)
IL (2) IL162085A0 (enExample)
NO (1) NO343732B1 (enExample)
WO (2) WO2003053997A2 (enExample)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855510B2 (en) * 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
AU2002241154A1 (en) * 2001-03-21 2002-10-03 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
JP2005524612A (ja) 2001-12-06 2005-08-18 ファイブローゲン、インコーポレーテッド 内因性エリスロポエチン(epo)を増加させる方法
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
US8318703B2 (en) 2001-12-06 2012-11-27 Fibrogen, Inc. Methods for improving kidney function
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
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