AU2002357096B2 - Methods of increasing endogenous erythropoietin (EPO) - Google Patents

Methods of increasing endogenous erythropoietin (EPO) Download PDF

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Publication number
AU2002357096B2
AU2002357096B2 AU2002357096A AU2002357096A AU2002357096B2 AU 2002357096 B2 AU2002357096 B2 AU 2002357096B2 AU 2002357096 A AU2002357096 A AU 2002357096A AU 2002357096 A AU2002357096 A AU 2002357096A AU 2002357096 B2 AU2002357096 B2 AU 2002357096B2
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Australia
Prior art keywords
alkyl
compound
alkoxy
subject
epo
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AU2002357096A
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AU2002357096A1 (en
Inventor
Michael P. Arend
Lee A. Flippin
Volkmar Guenzler-Pukall
Stephen J. Klaus
Al Y. Lin
Thomas B. Neff
Qingjian Wang
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Fibrogen Inc
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Fibrogen Inc
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    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/746Erythropoetin

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AU2002357096A 2001-12-06 2002-12-06 Methods of increasing endogenous erythropoietin (EPO) Expired AU2002357096B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009200018A AU2009200018C1 (en) 2001-12-06 2009-01-02 Methods of increasing endogenous erythropoietin (EPO)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US33708201P 2001-12-06 2001-12-06
US60/337,082 2001-12-06
US34965902P 2002-01-16 2002-01-16
US60/349,659 2002-01-16
US35968302P 2002-02-25 2002-02-25
US60/359,683 2002-02-25
US38648802P 2002-06-05 2002-06-05
US60/386,488 2002-06-05
PCT/US2002/039163 WO2003053997A2 (en) 2001-12-06 2002-12-06 Methods of increasing endogenous erythropoietin (epo)

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AU2009200018A Division AU2009200018C1 (en) 2001-12-06 2009-01-02 Methods of increasing endogenous erythropoietin (EPO)

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AU2002357096A1 AU2002357096A1 (en) 2003-07-09
AU2002357096B2 true AU2002357096B2 (en) 2008-10-16

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AU2002362065A Expired AU2002362065B2 (en) 2001-12-06 2002-12-06 Stabilization of hypoxia inducible factor (HIF) alpha
AU2002357096A Expired AU2002357096B2 (en) 2001-12-06 2002-12-06 Methods of increasing endogenous erythropoietin (EPO)
AU2009200018A Expired AU2009200018C1 (en) 2001-12-06 2009-01-02 Methods of increasing endogenous erythropoietin (EPO)

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AU2002362065A Expired AU2002362065B2 (en) 2001-12-06 2002-12-06 Stabilization of hypoxia inducible factor (HIF) alpha

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AU2009200018A Expired AU2009200018C1 (en) 2001-12-06 2009-01-02 Methods of increasing endogenous erythropoietin (EPO)

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US (15) US20030153503A1 (enExample)
EP (7) EP2289531B1 (enExample)
JP (5) JP2005524612A (enExample)
CN (7) CN100522946C (enExample)
AU (3) AU2002362065B2 (enExample)
CA (4) CA2916093C (enExample)
DK (3) DK2289531T3 (enExample)
ES (3) ES2414706T3 (enExample)
HU (1) HU229475B1 (enExample)
IL (2) IL162085A0 (enExample)
NO (1) NO343732B1 (enExample)
WO (2) WO2003049686A2 (enExample)

Families Citing this family (135)

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US6855510B2 (en) * 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
EP1379630B1 (en) * 2001-03-21 2012-09-26 Isis Innovation Limited Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
US8318703B2 (en) 2001-12-06 2012-11-27 Fibrogen, Inc. Methods for improving kidney function
CN100522946C (zh) * 2001-12-06 2009-08-05 法布罗根股份有限公司 低氧诱导因子(HIF)α的稳定化
EP2295060B1 (en) 2001-12-06 2018-10-31 Fibrogen, Inc. Treatment or prevention of ischemic or hypoxic conditions
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