ES2384094T3 - Producción de liposomas multivesiculares - Google Patents
Producción de liposomas multivesiculares Download PDFInfo
- Publication number
- ES2384094T3 ES2384094T3 ES98957937T ES98957937T ES2384094T3 ES 2384094 T3 ES2384094 T3 ES 2384094T3 ES 98957937 T ES98957937 T ES 98957937T ES 98957937 T ES98957937 T ES 98957937T ES 2384094 T3 ES2384094 T3 ES 2384094T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G67/00—Loading or unloading vehicles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G2814/00—Indexing codes relating to loading or unloading articles or bulk materials
- B65G2814/03—Loading or unloading means
- B65G2814/0397—Loading or unloading means for ships
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mechanical Engineering (AREA)
- Aviation & Aerospace Engineering (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6585697P | 1997-11-14 | 1997-11-14 | |
| US65856P | 1997-11-14 | ||
| PCT/US1998/024261 WO1999025319A1 (en) | 1997-11-14 | 1998-11-13 | Production of multivesicular liposomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2384094T3 true ES2384094T3 (es) | 2012-06-29 |
Family
ID=22065597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98957937T Expired - Lifetime ES2384094T3 (es) | 1997-11-14 | 1998-11-13 | Producción de liposomas multivesiculares |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20020039596A1 (https=) |
| EP (1) | EP1030652B1 (https=) |
| JP (2) | JP4575592B2 (https=) |
| AT (1) | ATE554748T1 (https=) |
| AU (5) | AU752802C (https=) |
| CA (1) | CA2309548A1 (https=) |
| ES (1) | ES2384094T3 (https=) |
| IL (3) | IL135989A0 (https=) |
| NZ (1) | NZ504188A (https=) |
| WO (1) | WO1999025319A1 (https=) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0012624B1 (pt) * | 1999-07-15 | 2011-08-09 | métodos para a preparação de agentes terapêuticos envolvidos por lipìdeos. | |
| US6495166B1 (en) * | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
| US20050037086A1 (en) * | 1999-11-19 | 2005-02-17 | Zycos Inc., A Delaware Corporation | Continuous-flow method for preparing microparticles |
| AU783918B2 (en) * | 1999-11-19 | 2005-12-22 | Eisai Inc. | Continuous-flow method for preparing microparticles |
| AU2001252588A1 (en) | 2000-04-28 | 2001-11-12 | Tanabe Seiyaku Co., Ltd. | Method for preparing microsphere |
| EP1174497B1 (fr) * | 2000-07-19 | 2004-09-08 | Technodop Ltd. (Société de Droit Irlandais) | Chambre de culture cellulaire et bioréacteur pour la culture extracorporelle de cellules animales |
| US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
| JP4709367B2 (ja) * | 2000-10-19 | 2011-06-22 | テルモ株式会社 | 無菌的なリポソームの製造方法 |
| DE60132094T3 (de) † | 2001-10-26 | 2012-02-02 | Octoplus Polyactive Sciences B.V. | Verfahren zur Herstellung von gereinigten Partikeln |
| US20030180348A1 (en) * | 2002-03-22 | 2003-09-25 | Levinson R. Saul | Transcellular drug delivery system |
| US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| CA2497723A1 (en) * | 2002-09-11 | 2004-03-25 | Tanabe Seiyaku Co., Ltd. | Method for preparation of microspheres and apparatus therefor |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| ATE419846T1 (de) * | 2003-02-07 | 2009-01-15 | Prometic Biosciences Inc | Fettsäuren mittlerer kettenlänge, glyceride und analoga als stimulatoren der erythropoiese |
| BE1016051A5 (nl) | 2004-05-18 | 2006-02-07 | Utexbel Nv | Insectenwerende behandeling van textiel. |
| US9044733B2 (en) * | 2008-05-19 | 2015-06-02 | Otsuka America Pharmaceutical, Inc. | Method and apparatus for preparing a solution of a shear sensitive material |
| JP5371030B2 (ja) * | 2008-05-23 | 2013-12-18 | 国立大学法人 筑波大学 | ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのw/o/wエマルション |
| JP5107220B2 (ja) * | 2008-12-11 | 2012-12-26 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
| US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
| WO2010121307A1 (en) * | 2009-04-21 | 2010-10-28 | The University Of Queensland | Complex emulsions |
| US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
| US8173750B2 (en) * | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
| EP2450031B1 (en) * | 2009-07-02 | 2018-08-29 | Konica Minolta Holdings, Inc. | Method for producing liposomes by two-stage emulsification method using outer aqueous phase containing specific dispersing agent, method for producing liposome dispersion or dry powder thereof using the method for producing liposomes, and liposome dispersion or dry powder thereof produced thereby |
| US20120225117A1 (en) | 2009-11-20 | 2012-09-06 | Konica Minolta Holdings, Inc. | Process for production of w/o/w emulsion, process for production of liposome employing the process, and porous membrane for use in the processes |
| US20110250264A1 (en) | 2010-04-09 | 2011-10-13 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9770414B2 (en) * | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
| JP6194248B2 (ja) * | 2010-10-28 | 2017-09-06 | パシラ ファーマシューティカルズ インコーポレーテッド | 非ステロイド性抗炎症薬の徐放性処方物 |
| US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
| BR112013016365A2 (pt) | 2010-12-27 | 2018-06-26 | Terumo Corp | composição de lipossoma e processo para produção do mesmo |
| WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
| BR112013024663A2 (pt) | 2011-03-25 | 2016-12-20 | Terumo Corp | composição de lipossomas de liberação controlada de longa duração e método para produção da mesma |
| EP2846773A4 (en) | 2012-05-10 | 2015-12-30 | Painreform Ltd | DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF |
| JP5314794B2 (ja) * | 2012-08-27 | 2013-10-16 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
| CN105189643B (zh) | 2012-08-30 | 2019-01-15 | 派诺聚合物技术公司 | 用于水力压裂液的双重机制增稠剂 |
| JPWO2014046191A1 (ja) | 2012-09-21 | 2016-08-18 | テルモ株式会社 | 局所麻酔薬持続徐放性リポソーム製剤 |
| US10711238B2 (en) | 2012-10-02 | 2020-07-14 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
| US20140093952A1 (en) * | 2012-10-02 | 2014-04-03 | David Serway | Bioreactor Tangential Flow Perfusion Filter System |
| EP2951220B1 (en) | 2013-02-04 | 2020-11-25 | Pilot Polymer Technologies, Inc. | Salt-tolerant star macromolecules |
| WO2015036046A1 (en) * | 2013-09-13 | 2015-03-19 | N.V. Nutricia | Improved process for preparing infant formula using a static mixer |
| EP4218991A1 (en) | 2014-05-13 | 2023-08-02 | Amgen Inc. | Process control systems and methods for use with filters and filtration processes |
| LT3466432T (lt) | 2014-05-15 | 2020-12-28 | Insmed Incorporated | Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti |
| CN107075015B (zh) | 2014-07-03 | 2019-08-23 | 派诺聚合物技术公司 | 表面活性剂-相容性星形大分子 |
| US9439864B2 (en) | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
| CN106794141B (zh) * | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| US11633699B2 (en) | 2014-08-11 | 2023-04-25 | Osaka University | Dialyzer, liposome producing apparatus, and liposome producing method |
| PT3186281T (pt) | 2014-08-28 | 2019-07-10 | Halozyme Inc | Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica |
| JP6316182B2 (ja) * | 2014-12-19 | 2018-04-25 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
| EP3142656B1 (en) * | 2015-01-21 | 2018-10-17 | Pacira Pharmaceuticals, Inc. | Multivesicular liposome formulations of tranexamic acid |
| AU2016256979B2 (en) | 2015-05-04 | 2021-01-28 | Genfit | Method for preparing transmembrane pH-gradient vesicles |
| US10213284B2 (en) | 2015-06-30 | 2019-02-26 | Tela Bio, Inc. | Corner-lock stitch patterns |
| WO2017015421A1 (en) | 2015-07-21 | 2017-01-26 | Tela Bio, Inc. | Compliance control stitching in substrate materials |
| EP3448308B1 (en) | 2016-04-26 | 2024-08-14 | Tela Bio, Inc. | Hernia repair grafts having anti-adhesion barriers |
| EP3541815A4 (en) | 2016-11-18 | 2020-07-15 | Pacira Pharmaceuticals, Inc. | ZINC MELXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND METHODS OF MAKING THE SAME |
| WO2018160026A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| KR102069680B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| WO2018160027A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
| EP3761963B1 (en) | 2018-03-09 | 2025-01-22 | Tela Bio, Inc. | Surgical repair graft |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| JP7449275B2 (ja) | 2018-05-02 | 2024-03-13 | インスメッド インコーポレイテッド | リポソーム薬物製剤の製造方法 |
| CN108636122B (zh) * | 2018-06-22 | 2023-05-23 | 南京航空航天大学 | 一种多膜蒸馏组件与压缩机等压降排布系统及工作方法 |
| JP7219344B2 (ja) * | 2019-01-07 | 2023-02-07 | プサン ナショナル ユニバーシティ インダストリー-ユニバーシティ コーポレーション ファウンデーション | 血液脳関門の透過性を増進させるw/o/w型トリオレインエマルジョンを利用した薬物伝達プラットホーム |
| US11446130B2 (en) | 2019-03-08 | 2022-09-20 | Tela Bio, Inc. | Textured medical textiles |
| CN110179752B (zh) * | 2019-05-31 | 2024-02-20 | 常州吾合生物医药有限责任公司 | 高浓度布比卡因多囊脂质体及其制备工艺、配液系统 |
| EP3821972B1 (de) | 2019-11-12 | 2024-07-10 | Fresenius Medical Care Deutschland GmbH | Verwendung eines filtermoduls zur filtration einer biotechnologischen flüssigkeit und filtermodul zur filtration einer biotechnologischen flüssigkeit |
| US20230052318A1 (en) * | 2020-01-06 | 2023-02-16 | Pacira Pharmaceuticals, Inc. | Treatment of pain associated with cesarean section surgery with sustained-release liposomal anesthetic compositions |
| CN115515581A (zh) | 2020-01-10 | 2022-12-23 | 帕西拉制药股份有限公司 | 通过给予缓释脂质体麻醉组合物治疗疼痛 |
| US20230080593A1 (en) * | 2020-01-10 | 2023-03-16 | Pacira Pharmaceuticals, Inc. | Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions |
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
| CN121774830A (zh) * | 2020-03-27 | 2026-04-03 | 阿拉斯廷护肤品股份有限公司 | 与色素沉着有关的组合物和方法 |
| US11918688B2 (en) | 2021-01-11 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of hip pain with sustained-release liposomal anesthetic compositions |
| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12151024B2 (en) * | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| WO2022159564A1 (en) * | 2021-01-22 | 2022-07-28 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| EP4308084A4 (en) | 2021-03-19 | 2025-04-23 | Pacira Pharmaceuticals, Inc. | Treatment of pain in pediatric patients by administration of delayed-release liposomal anesthetic compositions |
| CN116887912A (zh) * | 2021-05-18 | 2023-10-13 | 花王株式会社 | 水包油型乳化物的制造方法 |
| CN113616524B (zh) * | 2021-06-07 | 2024-05-14 | 浙江圣兆药物科技股份有限公司 | 一种用于制备储库泡沫脂质体的装置及工艺 |
| EP4415713A4 (en) | 2021-10-14 | 2025-08-06 | Pacira Pharmaceuticals Inc | MULTIVESICULAR LIPOSOME FORMULATIONS OF BUPIVACAINE AND THEIR USES |
| GB2626483A (en) * | 2021-10-14 | 2024-07-24 | Pacira Pharmaceuticals Inc | Multivesicular liposome formulations of dexamethasone |
| EP4482493A4 (en) | 2022-02-24 | 2025-12-17 | Pacira Pharmaceuticals Inc | USE OF BUPIVACAIN MULTI-SICULAR LIPOSOMES AS A ANGLI BLOCK IN STARS |
| US12226610B2 (en) | 2022-11-03 | 2025-02-18 | Pacira Pharmaceuticals, Inc. | Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions |
| US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
| CN116370413A (zh) * | 2023-03-14 | 2023-07-04 | 常州吾合生物医药有限责任公司 | 一种制备布比卡因脂质体过程中去除有机溶剂的方法 |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12156940B1 (en) | 2024-05-20 | 2024-12-03 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| KR20250169170A (ko) | 2024-05-20 | 2025-12-02 | 파씨라 파마슈티칼스, 인코포레이티드 | 부피바카인 다중소포성 리포솜의 제조 |
| US12280149B1 (en) | 2024-05-20 | 2025-04-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12514756B1 (en) | 2024-10-08 | 2026-01-06 | Covidien Lp | Dermal patch and systems, kits, and methods associated therewith |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684251A (en) | 1970-09-08 | 1972-08-15 | Us Army | Apparatus for continuous emulsification |
| US3946994A (en) | 1974-04-10 | 1976-03-30 | Petrolite Corporation | System for producing emulsions |
| IT1015665B (it) | 1974-07-04 | 1977-05-20 | Snam Progetti | Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo |
| CH588887A5 (https=) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4113765A (en) | 1975-03-21 | 1978-09-12 | Standard Oil Company (Indiana) | Continuous process for sulfonating alkyl aromatics |
| US4897308A (en) * | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
| US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
| CH624011A5 (https=) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| DE2909906A1 (de) | 1979-03-14 | 1980-10-02 | Bayer Ag | Verfahren zur kontinuierlichen herstellung von mikrokapseln |
| US4235587A (en) * | 1979-04-09 | 1980-11-25 | Honeywell Inc. | Flame responsive control circuit |
| JPS55153713A (en) | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| JPS6127918Y2 (https=) | 1979-11-07 | 1986-08-19 | ||
| US4394372A (en) * | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
| US4420398A (en) | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
| US4454083A (en) | 1981-12-21 | 1984-06-12 | Appleton Papers Inc. | Continuous microencapsulation |
| US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
| US5387410A (en) * | 1983-03-18 | 1995-02-07 | Mallinckrodt, Inc. | Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US4588578A (en) | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| JPH0768117B2 (ja) | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | 薬剤放出調整用小胞製剤 |
| US5186941A (en) | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
| FR2548043A1 (fr) | 1983-06-14 | 1985-01-04 | Saint Gobain Vitrage | Procede et dispositif pour la fabrication par coulee d'une couche optiquement homogene transparente a partir d'un melange de composants |
| US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| US4478824A (en) * | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
| US4888115A (en) | 1983-12-29 | 1989-12-19 | Cuno, Incorporated | Cross-flow filtration |
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5141674A (en) | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| JPH0753661B2 (ja) | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| US4610868A (en) | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| DE3421865A1 (de) | 1984-06-13 | 1985-12-19 | Bayer Ag, 5090 Leverkusen | Kontinuierliche herstellung von mikrokapseldispersionen |
| US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| DE3432718C1 (de) | 1984-09-06 | 1986-05-22 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen |
| US4761288A (en) | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| US4788001A (en) * | 1985-04-02 | 1988-11-29 | Dow Corning Corporation | Oil-in-water emulsion |
| GB2176715A (en) | 1985-06-27 | 1987-01-07 | Apv Int Ltd | Beer filtration |
| US5292701A (en) * | 1985-08-29 | 1994-03-08 | W. R. Grace & Co.-Conn. | High pore volume and pore diameter aluminum phosphate and method of making the same |
| IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
| EP0225130B1 (en) | 1985-11-22 | 1991-10-30 | Takeda Chemical Industries, Ltd. | Liposome composition |
| US5244678A (en) | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US4861597A (en) | 1986-05-20 | 1989-08-29 | Wako Pure Chemical Industries, Ltd. | Novel functionallized liposomes and a process for production thereof |
| US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US5147134A (en) | 1986-08-21 | 1992-09-15 | Petrolite Corporation | Process for the continuous production of high-internal-phase-ratio emulsions |
| US4877619A (en) | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
| US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
| US4781871A (en) * | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
| US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
| US4844620A (en) | 1986-11-24 | 1989-07-04 | Petrolite Corporation | System for producing high-internal-phase-ratio emulsion products on a continuous basis |
| US4781831A (en) * | 1986-12-19 | 1988-11-01 | Goldsmith Robert L | Cross-flow filtration device with filtrate flow conduits and method of forming same |
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US5723147A (en) * | 1987-02-23 | 1998-03-03 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| GB8704171D0 (en) | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
| DK86988A (da) | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | Liposompraeparat og anvendelse deraf |
| JP2666345B2 (ja) | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| US5069936A (en) | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| CA1337273C (en) | 1987-07-29 | 1995-10-10 | Robert P. Lenk | Method for size separation of particles |
| ATE113468T1 (de) * | 1987-07-29 | 1994-11-15 | Liposome Co Inc | Verfahren zur trennung von teilchen nach grösse. |
| IE63518B1 (en) | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| US5807572A (en) | 1988-02-18 | 1998-09-15 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| DE68901733T2 (de) * | 1988-03-04 | 1993-03-25 | Takeda Chemical Industries Ltd | Liposom-zusammensetzung. |
| US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5261903A (en) * | 1988-04-11 | 1993-11-16 | M.D. Inc. | Composite anesthetic article and method of use |
| MX9203504A (es) * | 1988-04-20 | 1992-07-01 | Liposome Co Inc | Complejo agente: lipido activo de alta proporcion. |
| US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| US5576017A (en) | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
| US4937078A (en) | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
| US4921853A (en) * | 1988-11-14 | 1990-05-01 | Michigan State University | Method for producing analgesia in mammals |
| US4908463A (en) | 1988-12-05 | 1990-03-13 | Ethyl Corporation | Aluminoxane process |
| US5049392A (en) | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| US4956290A (en) * | 1989-03-27 | 1990-09-11 | Phillips Petroleum Company | Large scale process for the purification of alcohol oxidase |
| US5364632A (en) | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5227170A (en) * | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
| FR2651680B1 (fr) | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5227165A (en) | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
| US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
| US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5169934A (en) * | 1990-05-14 | 1992-12-08 | Anergen, Inc. | Intracellularly cleavable compounds |
| USRE35192E (en) * | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
| IS1685B (is) | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
| SE506930C2 (sv) * | 1991-03-25 | 1998-03-02 | Svedala Pumps & Process Ab | Förfarande och anordning för förtjockning av finpartikulära suspensioner |
| US5885260A (en) | 1991-05-30 | 1999-03-23 | Mehl, Sr.; Thomas L. | Freeze-dried liposome delivery system for application of skin treatment agents |
| JPH06511470A (ja) | 1991-07-03 | 1994-12-22 | ネクスター・フアーマシユーテイカルズ・インコーポレイテツド | 薬剤を含むリポソームの調製における充填技術 |
| US5977326A (en) | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| SE9200952D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| JPH08505312A (ja) * | 1992-10-16 | 1996-06-11 | ザックセ,アンドレアス | 液状分散系を製造する方法及び装置 |
| US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| JPH06247842A (ja) | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
| ATE166573T1 (de) * | 1993-03-24 | 1998-06-15 | Ciba Geigy Ag | Verfahren zur herstellung einer liposomendispersion im hochdruckbereich |
| EP0692961A1 (en) * | 1993-04-02 | 1996-01-24 | The Liposome Company, Inc. | Method of producing liposomes |
| US5891842A (en) | 1993-04-09 | 1999-04-06 | Trustees Of Tufts College | Methodology for eliciting an analgesic response in a living subject |
| PT695169E (pt) | 1993-04-22 | 2003-04-30 | Skyepharma Inc | Lipossomas multivesiculares de ciclodextrina encapsulando compostos farmacologicos e metodos para a sua utilizacao |
| WO1994026250A1 (en) | 1993-05-14 | 1994-11-24 | Depotech Corporation | Method for treating neurological disorders |
| US5455044A (en) | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
| US5776486A (en) * | 1993-05-28 | 1998-07-07 | Aphios Corporation | Methods and apparatus for making liposomes containing hydrophobic drugs |
| US5554382A (en) | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
| CA2163860A1 (en) | 1993-06-30 | 1995-01-12 | Chung C. Hsu | Method for preparing liposomes |
| SE503277C2 (sv) * | 1993-07-20 | 1996-05-13 | Alfa Laval Brewery Syst Ab | Filter avsett för tvärströmsfiltrering |
| US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5853755A (en) | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| US5387387A (en) * | 1993-09-30 | 1995-02-07 | Alex James & Associates, Inc. | Method and apparatus for dry spinning spandex |
| GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| EP0727210B1 (en) * | 1993-10-13 | 2001-12-19 | Darwin Discovery Limited | Analgesic agent and its use |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| ATE164515T1 (de) * | 1993-11-05 | 1998-04-15 | Amgen Inc | Herstellung von liposomen und verfahren zur substanzverkapselung |
| US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| AU686277B2 (en) | 1993-11-16 | 1998-02-05 | Pacira Pharmaceuticals, Inc. | Vesicles with controlled release of actives |
| US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
| US5451408A (en) | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
| SE518578C2 (sv) | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6048545A (en) | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
| US6066331A (en) | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| SE9402453D0 (sv) | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| DE4430592A1 (de) | 1994-08-20 | 1996-02-22 | Max Delbrueck Centrum | Liposomale Zubereitung, ihre Herstellung und ihre Verwendung |
| US5993850A (en) * | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| US5589189A (en) * | 1994-09-14 | 1996-12-31 | Nexstar Pharmaceuticals, Inc. | Liposome dispersion |
| US5702722A (en) | 1994-09-30 | 1997-12-30 | Bracco Research S.A. | Liposomes with enhanced entrapment capacity, method and use |
| IL115849A0 (en) * | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
| DE69603577T2 (de) | 1995-02-10 | 1999-11-25 | Medtronic, Inc. | Verfahren und vorrichtung zur verabreichung von analgetika |
| JP3958360B2 (ja) * | 1995-02-24 | 2007-08-15 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 免疫治療剤として役立つポリペプチド及びポリペプチド調製の方法 |
| US6007838A (en) * | 1995-06-07 | 1999-12-28 | The United States Of America As Represented By The Secretary Of The Army | Process for making liposome preparation |
| EP0752245B1 (en) | 1995-07-05 | 2002-05-22 | European Community | Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery |
| US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| WO1997006784A1 (en) * | 1995-08-15 | 1997-02-27 | Universite Libre De Bruxelles | Liposomes preparation method and plant |
| US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| GB9605915D0 (en) | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
| EP0914094A4 (en) | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
| GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
| US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5997899A (en) | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
| HUP0000522A3 (en) | 1996-10-15 | 2000-10-30 | Transave Inc Monmouth Junction | N-acyl phoshpatidylethanolamine-mediated liposomal drug delivery |
| US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| WO1998024415A1 (en) | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
| US5865184A (en) | 1997-01-13 | 1999-02-02 | Takiguchi; Tetsuo | Combined spinal and epidural anesthesia |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| GB9704351D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| GB9704352D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
| ATE481970T1 (de) | 1997-03-13 | 2010-10-15 | James N Campbell | Zusammensetzungen enthaltend capsaicin oder capsaicin analoge und ein anästhetikum |
| US5947689A (en) | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
| JP2002503254A (ja) | 1997-06-05 | 2002-01-29 | ヘモスフィア,インコーポレイテッド | フィブリノゲンをコーティングしたミクロスフィア |
| US6287587B2 (en) | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
| WO1999004771A2 (en) | 1997-07-21 | 1999-02-04 | Darwin Discovery Limited | Use of levobupivacaine |
| WO1999004772A2 (en) | 1997-07-22 | 1999-02-04 | Darwin Discovery Limited | Use of levobupivacaine |
| US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
| US6106858A (en) | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| US6306432B1 (en) | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| CA2304096C (en) | 1997-09-18 | 2003-09-09 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| US6033708A (en) | 1997-09-30 | 2000-03-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for producing sterile filterable liposome dispersion |
| IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
| US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
| US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
-
1998
- 1998-11-13 AU AU14075/99A patent/AU752802C/en not_active Expired
- 1998-11-13 WO PCT/US1998/024261 patent/WO1999025319A1/en not_active Ceased
- 1998-11-13 US US09/192,064 patent/US20020039596A1/en not_active Abandoned
- 1998-11-13 EP EP98957937A patent/EP1030652B1/en not_active Expired - Lifetime
- 1998-11-13 AT AT98957937T patent/ATE554748T1/de active
- 1998-11-13 JP JP2000520753A patent/JP4575592B2/ja not_active Expired - Lifetime
- 1998-11-13 CA CA002309548A patent/CA2309548A1/en not_active Abandoned
- 1998-11-13 ES ES98957937T patent/ES2384094T3/es not_active Expired - Lifetime
- 1998-11-13 IL IL13598998A patent/IL135989A0/xx active IP Right Grant
- 1998-11-13 NZ NZ504188A patent/NZ504188A/en not_active IP Right Cessation
-
2000
- 2000-05-05 IL IL135989A patent/IL135989A/en not_active IP Right Cessation
-
2002
- 2002-10-01 AU AU2002301268A patent/AU2002301268B2/en not_active Expired
-
2006
- 2006-01-06 AU AU2006200044A patent/AU2006200044A1/en not_active Abandoned
-
2007
- 2007-02-25 US US11/678,615 patent/US9585838B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 AU AU2008203032A patent/AU2008203032B2/en not_active Expired
- 2008-08-31 IL IL193778A patent/IL193778A0/en unknown
-
2010
- 2010-07-20 JP JP2010162514A patent/JP2010285438A/ja active Pending
- 2010-08-13 AU AU2010212347A patent/AU2010212347B2/en not_active Expired
-
2013
- 2013-03-08 US US13/791,302 patent/US20140004173A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4575592B2 (ja) | 2010-11-04 |
| AU2008203032A1 (en) | 2008-07-31 |
| AU2010212347A1 (en) | 2010-09-09 |
| AU1407599A (en) | 1999-06-07 |
| AU2008203032B2 (en) | 2010-05-13 |
| US20020039596A1 (en) | 2002-04-04 |
| US20070235889A1 (en) | 2007-10-11 |
| EP1030652A4 (en) | 2006-05-24 |
| IL135989A (en) | 2009-02-11 |
| AU752802C (en) | 2006-04-13 |
| ATE554748T1 (de) | 2012-05-15 |
| US20140004173A1 (en) | 2014-01-02 |
| AU2006200044A1 (en) | 2006-02-02 |
| IL135989A0 (en) | 2001-05-20 |
| JP2010285438A (ja) | 2010-12-24 |
| WO1999025319A1 (en) | 1999-05-27 |
| IL193778A0 (en) | 2009-05-04 |
| US9585838B2 (en) | 2017-03-07 |
| EP1030652A1 (en) | 2000-08-30 |
| AU2002301268B2 (en) | 2005-10-06 |
| CA2309548A1 (en) | 1999-05-27 |
| AU2010212347B2 (en) | 2012-03-22 |
| JP2001522870A (ja) | 2001-11-20 |
| EP1030652B1 (en) | 2012-04-25 |
| NZ504188A (en) | 2001-10-26 |
| AU752802B2 (en) | 2002-10-03 |
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