ES2370960T3 - Un derivado de quinolina que actúa como antagonista del receptor p2x7. - Google Patents

Un derivado de quinolina que actúa como antagonista del receptor p2x7. Download PDF

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Publication number
ES2370960T3
ES2370960T3 ES08855156T ES08855156T ES2370960T3 ES 2370960 T3 ES2370960 T3 ES 2370960T3 ES 08855156 T ES08855156 T ES 08855156T ES 08855156 T ES08855156 T ES 08855156T ES 2370960 T3 ES2370960 T3 ES 2370960T3
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compound
pharmaceutically acceptable
acceptable salt
formula
inhibitor
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Spanish (es)
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Simon David Guile
Toby Thompson
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AstraZeneca AB
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AstraZeneca AB
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Diabetes (AREA)
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  • Virology (AREA)
  • Reproductive Health (AREA)
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ES08855156T 2007-11-30 2008-11-28 Un derivado de quinolina que actúa como antagonista del receptor p2x7. Active ES2370960T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99126507P 2007-11-30 2007-11-30
US991265P 2007-11-30

Publications (1)

Publication Number Publication Date
ES2370960T3 true ES2370960T3 (es) 2011-12-26

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ES08855156T Active ES2370960T3 (es) 2007-11-30 2008-11-28 Un derivado de quinolina que actúa como antagonista del receptor p2x7.

Country Status (9)

Country Link
US (1) US8106073B2 (OSRAM)
EP (1) EP2225222B1 (OSRAM)
JP (1) JP2011505356A (OSRAM)
AR (1) AR069508A1 (OSRAM)
AT (1) ATE524458T1 (OSRAM)
ES (1) ES2370960T3 (OSRAM)
PE (1) PE20091036A1 (OSRAM)
TW (1) TW200932229A (OSRAM)
WO (1) WO2009070116A1 (OSRAM)

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KR20090122396A (ko) * 2007-03-22 2009-11-27 아스트라제네카 아베 염증성 질환 치료용 퀴놀린 유도체
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
ME02421B (me) * 2009-12-17 2016-09-20 Merck Sharp & Dohme Pozitivni alosterni modulatori m1 receptora na bazi hinolin amida
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2013014587A1 (en) 2011-07-22 2013-01-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
TWI576347B (zh) 2012-01-20 2017-04-01 艾克泰聯製藥有限公司 作為ｐ２ｘ受體拮抗劑之雜環醯胺衍生物
PL2931717T3 (pl) 2012-12-12 2017-05-31 Actelion Pharmaceuticals Ltd. Pochodne indolokarboksyamidu jako antagoniści receptora p2x7
CN104854087B (zh) 2012-12-18 2017-03-22 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的吲哚羧酰胺衍生物
CN104918617B (zh) 2013-01-22 2017-05-10 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
WO2014115078A1 (en) 2013-01-22 2014-07-31 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
EP3152192A1 (en) * 2014-06-05 2017-04-12 Merck Patent GmbH Novel quinoline derivatives and their use in neurodegenerative diseases
EP3962493A2 (en) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor

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US8106073B2 (en) 2012-01-31
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WO2009070116A1 (en) 2009-06-04
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