TW200932229A - Quinoline derivatives 057 - Google Patents

Quinoline derivatives 057 Download PDF

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Publication number
TW200932229A
TW200932229A TW097146304A TW97146304A TW200932229A TW 200932229 A TW200932229 A TW 200932229A TW 097146304 A TW097146304 A TW 097146304A TW 97146304 A TW97146304 A TW 97146304A TW 200932229 A TW200932229 A TW 200932229A
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TW
Taiwan
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
formula
disease
Prior art date
Application number
TW097146304A
Other languages
English (en)
Chinese (zh)
Inventor
Simon David Guile
Toby Thompson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TW200932229A publication Critical patent/TW200932229A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
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TW097146304A 2007-11-30 2008-11-28 Quinoline derivatives 057 TW200932229A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99126507P 2007-11-30 2007-11-30

Publications (1)

Publication Number Publication Date
TW200932229A true TW200932229A (en) 2009-08-01

Family

ID=40676391

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097146304A TW200932229A (en) 2007-11-30 2008-11-28 Quinoline derivatives 057

Country Status (9)

Country Link
US (1) US8106073B2 (OSRAM)
EP (1) EP2225222B1 (OSRAM)
JP (1) JP2011505356A (OSRAM)
AR (1) AR069508A1 (OSRAM)
AT (1) ATE524458T1 (OSRAM)
ES (1) ES2370960T3 (OSRAM)
PE (1) PE20091036A1 (OSRAM)
TW (1) TW200932229A (OSRAM)
WO (1) WO2009070116A1 (OSRAM)

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PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
SG181719A1 (en) 2009-12-17 2012-07-30 Schering Corp Quinoline amide m1 receptor positive allosteric modulators
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
RU2014106611A (ru) 2011-07-22 2015-08-27 Актелион Фармасьютиклз Лтд Производные гетероциклических амидов в качестве антагонистов р2х7 рецептора
NZ628910A (en) 2012-01-20 2016-02-26 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
PL2931717T3 (pl) 2012-12-12 2017-05-31 Actelion Pharmaceuticals Ltd. Pochodne indolokarboksyamidu jako antagoniści receptora p2x7
AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
EP2956457B1 (en) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
ES2616114T3 (es) 2013-01-22 2017-06-09 Actelion Pharmaceuticals Ltd. Derivados de amida heterocíclica como antagonistas del receptor P2X7
US9399623B2 (en) * 2014-06-05 2016-07-26 Merck Patent Gmbh Quinoline derivatives and their use in neurodegenerative diseases
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire

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SE0302139D0 (sv) 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
SE0402925D0 (sv) 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
US20080058309A1 (en) 2006-07-27 2008-03-06 Astrazeneca Ab Novel Compounds 171
ES2388454T3 (es) * 2007-03-22 2012-10-15 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7

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PE20091036A1 (es) 2009-08-15
ATE524458T1 (de) 2011-09-15
ES2370960T3 (es) 2011-12-26
EP2225222A4 (en) 2010-12-01
JP2011505356A (ja) 2011-02-24
EP2225222B1 (en) 2011-09-14
EP2225222A1 (en) 2010-09-08
US8106073B2 (en) 2012-01-31
WO2009070116A1 (en) 2009-06-04
HK1148002A1 (en) 2011-08-26
US20090143428A1 (en) 2009-06-04

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