ES2343595T3 - Comprimido multicapa que se disgrega por via oral. - Google Patents
Comprimido multicapa que se disgrega por via oral. Download PDFInfo
- Publication number
- ES2343595T3 ES2343595T3 ES07802442T ES07802442T ES2343595T3 ES 2343595 T3 ES2343595 T3 ES 2343595T3 ES 07802442 T ES07802442 T ES 07802442T ES 07802442 T ES07802442 T ES 07802442T ES 2343595 T3 ES2343595 T3 ES 2343595T3
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- Prior art keywords
- opioid
- tablet
- multilayer tablet
- coating
- agent
- Prior art date
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Classifications
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82145506P | 2006-08-04 | 2006-08-04 | |
| US821455P | 2006-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2343595T3 true ES2343595T3 (es) | 2010-08-04 |
Family
ID=38997507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07802442T Active ES2343595T3 (es) | 2006-08-04 | 2007-07-31 | Comprimido multicapa que se disgrega por via oral. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8603525B2 (OSRAM) |
| JP (1) | JP5497435B2 (OSRAM) |
| KR (1) | KR101408315B1 (OSRAM) |
| CN (1) | CN101563069B (OSRAM) |
| AT (1) | ATE462416T1 (OSRAM) |
| AU (1) | AU2007280471B2 (OSRAM) |
| CA (1) | CA2659523C (OSRAM) |
| DE (1) | DE602007005653D1 (OSRAM) |
| DK (1) | DK2046300T3 (OSRAM) |
| ES (1) | ES2343595T3 (OSRAM) |
| PT (1) | PT2046300E (OSRAM) |
| WO (1) | WO2008015221A2 (OSRAM) |
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| NZ574544A (en) * | 2006-08-04 | 2011-12-22 | Ethypharm Sa | Granule and orally disintegrating tablet comprising oxycodone |
| CN101842085B (zh) | 2007-10-31 | 2013-01-30 | 麦克内尔-Ppc股份有限公司 | 口腔崩解剂型 |
| US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| JP5607550B2 (ja) | 2008-03-11 | 2014-10-15 | ディポメド，インコーポレイティド | 非オピオイド鎮痛剤及びオピオイド鎮痛剤の組合せを含む胃保持性持続放出剤形 |
| EP2328561B1 (en) * | 2008-08-19 | 2015-11-25 | Adcock Ingram Intellectual Property (Pty) Limited | Rate Modulated Delivery of Drugs from a Three-Layer Tablet Comprising Tramadol, Diclofenac, Paracetamol |
| JP2012521393A (ja) * | 2009-03-26 | 2012-09-13 | ロイヤル カレッジ オブ サージェオンズ イン アイルランド | 口腔内分散性錠剤 |
| KR101752014B1 (ko) * | 2009-05-01 | 2017-06-28 | 아데어 파마슈티컬스 인코포레이티드 | 고용량 및 저용량 약물들의 조합을 포함하는 구강붕해정 조성물 |
| US8313768B2 (en) | 2009-09-24 | 2012-11-20 | Mcneil-Ppc, Inc. | Manufacture of tablet having immediate release region and sustained release region |
| US20110318411A1 (en) | 2010-06-24 | 2011-12-29 | Luber Joseph R | Multi-layered orally disintegrating tablet and the manufacture thereof |
| US8807979B2 (en) | 2009-09-24 | 2014-08-19 | Mcneil-Ppc, Inc. | Machine for the manufacture of dosage forms utilizing radiofrequency energy |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
| WO2011087765A2 (en) * | 2009-12-22 | 2011-07-21 | Mallinckrodt Inc. | Methods of producing stabilized solid pharmaceutical compositions containing morphinans |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| US9233491B2 (en) | 2012-05-01 | 2016-01-12 | Johnson & Johnson Consumer Inc. | Machine for production of solid dosage forms |
| US9445971B2 (en) | 2012-05-01 | 2016-09-20 | Johnson & Johnson Consumer Inc. | Method of manufacturing solid dosage form |
| US9511028B2 (en) | 2012-05-01 | 2016-12-06 | Johnson & Johnson Consumer Inc. | Orally disintegrating tablet |
| CA2888278A1 (en) * | 2012-10-15 | 2014-04-24 | Isa Odidi | Oral drug delivery formulations |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| BR112016015944A8 (pt) | 2014-01-10 | 2020-06-09 | Johnson & Johnson Consumer Inc | processo para produzir comprimido, que usa radiofrequência e partículas revestidas dissipadoras de energia |
| US20150209360A1 (en) * | 2014-01-30 | 2015-07-30 | Orbz, Llc | Oral caffeine delivery composition |
| DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
| CN104311447B (zh) * | 2014-10-09 | 2016-09-28 | 吉林省吴太感康药业有限公司 | 对乙酰氨基酚新晶型、其制备方法及复方氨酚烷胺制剂 |
| JP2017531026A (ja) | 2014-10-20 | 2017-10-19 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 徐放性乱用抑止性液体充填剤形 |
| BR112017009521A2 (pt) | 2014-11-11 | 2017-12-19 | Shionogi & Co | comprimido de múltiplas camadas que contém um fármaco instável à luz |
| CA2970065A1 (en) * | 2014-12-08 | 2016-06-16 | Cima Labs Inc. | Immediate release abuse-deterrent granulated dosage forms |
| WO2017017679A1 (en) * | 2015-07-29 | 2017-02-02 | Dexcel Pharma Technologies Ltd. | Compositions comprising atorvastatin or a pharmaceutically acceptable salt thereof |
| US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
| US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
| US10493026B2 (en) | 2017-03-20 | 2019-12-03 | Johnson & Johnson Consumer Inc. | Process for making tablet using radiofrequency and lossy coated particles |
| US11096894B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet for induced saliva generation |
| US11058641B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
| US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
| US11135157B2 (en) * | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
| US20190350858A1 (en) * | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
| US11096895B2 (en) * | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
| US11090263B2 (en) * | 2018-05-22 | 2021-08-17 | Fertin Pharma A/S | Tableted chewing gum suitable for active pharmaceutical ingredients |
| KR102697867B1 (ko) * | 2018-05-17 | 2024-08-23 | 페르틴 파르마 에이/에스 | 활성 약학적 성분에 적합한 정제형 츄잉 검 |
| US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
| US11058633B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
| JP7134048B2 (ja) * | 2018-09-28 | 2022-09-09 | ホソカワミクロン株式会社 | 測定評価装置及びそれによる評価方法 |
| CN109512796A (zh) * | 2018-12-26 | 2019-03-26 | 甘肃普安制药股份有限公司 | 一种氨酚羟考酮胶囊填充方法 |
| US10925853B2 (en) | 2019-04-17 | 2021-02-23 | Nordiccan A/S | Oral cannabinoid tablet |
| US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| WO2020225773A1 (en) | 2019-05-07 | 2020-11-12 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
| FR3099881B1 (fr) * | 2019-08-13 | 2022-08-26 | Ethypharm Sa | Comprimé orodispersible d’opioide à faible dosage et son procédé de préparation. |
| WO2021194253A1 (ko) * | 2020-03-25 | 2021-09-30 | 주식회사 삼양홀딩스 | 포말리도마이드의 경구용 정제 조성물 및 이의 제조 방법 |
| AU2021391823A1 (en) | 2020-12-03 | 2023-06-29 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| IL307454A (en) | 2021-04-07 | 2023-12-01 | Battelle Memorial Institute | Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors |
| CN117179292A (zh) * | 2023-09-21 | 2023-12-08 | 深圳天基权健康科技集团股份有限公司 | 一种富硒健脾营养片的制备方法及富硒健脾营养片 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| WO2025122954A1 (en) | 2023-12-08 | 2025-06-12 | Battelle Memorial Institute | Use of dna origami nanostructures for molecular information based data storage systems |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2679451B1 (fr) | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| CA2128820A1 (en) | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
| JP3557654B2 (ja) * | 1994-08-01 | 2004-08-25 | 大正製薬株式会社 | 安定なマスキング処理顆粒 |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| FR2766089B1 (fr) | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| CA2322315C (en) | 1998-03-06 | 2008-09-16 | Eurand International S.P.A. | Fast disintegrating tablets |
| TW585786B (en) | 1998-07-28 | 2004-05-01 | Takeda Chemical Industries Ltd | Lansoprazole-containing rapidly disintegrable solid pharmaceutical composition |
| FR2785538B1 (fr) | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
| WO2000030617A1 (en) * | 1998-11-25 | 2000-06-02 | Cima Labs Inc. | Taste masking rapid release coating system |
| FR2790387B1 (fr) | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
| US20030092724A1 (en) * | 2001-09-18 | 2003-05-15 | Huaihung Kao | Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic |
| US8329217B2 (en) * | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
| US7326387B2 (en) * | 2002-05-20 | 2008-02-05 | Theodore A. M. Arts | Air decontamination devices |
| IL165361A0 (en) * | 2002-05-31 | 2006-01-15 | Alza Corp | Dosage forms and compositions for osmotic deliveryof variable dosages of oxycodone |
| CA2495564A1 (en) * | 2002-08-15 | 2005-01-27 | Euro-Celtique S.A. | Pharmaceutical compositions |
| DE10239999A1 (de) * | 2002-08-27 | 2004-03-04 | Röhm GmbH & Co. KG | Granulat oder Pulver zur Herstellung von Überzugs- und Bindemitteln für Arzneiformen |
| MXPA05013202A (es) * | 2003-06-06 | 2006-03-09 | Ethypharm Sa | Tableta de multiples capas oralmente dispersable. |
| NZ574544A (en) * | 2006-08-04 | 2011-12-22 | Ethypharm Sa | Granule and orally disintegrating tablet comprising oxycodone |
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2007
- 2007-07-31 AU AU2007280471A patent/AU2007280471B2/en active Active
- 2007-07-31 DK DK07802442.9T patent/DK2046300T3/da active
- 2007-07-31 PT PT07802442T patent/PT2046300E/pt unknown
- 2007-07-31 ES ES07802442T patent/ES2343595T3/es active Active
- 2007-07-31 KR KR1020097002332A patent/KR101408315B1/ko active Active
- 2007-07-31 CN CN2007800365780A patent/CN101563069B/zh active Active
- 2007-07-31 DE DE602007005653T patent/DE602007005653D1/de active Active
- 2007-07-31 WO PCT/EP2007/057913 patent/WO2008015221A2/en not_active Ceased
- 2007-07-31 JP JP2009522248A patent/JP5497435B2/ja active Active
- 2007-07-31 CA CA2659523A patent/CA2659523C/en active Active
- 2007-07-31 AT AT07802442T patent/ATE462416T1/de active
- 2007-07-31 US US12/376,065 patent/US8603525B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR101408315B1 (ko) | 2014-06-20 |
| AU2007280471B2 (en) | 2012-10-18 |
| JP5497435B2 (ja) | 2014-05-21 |
| CN101563069A (zh) | 2009-10-21 |
| CN101563069B (zh) | 2012-07-11 |
| DK2046300T3 (da) | 2010-07-26 |
| ATE462416T1 (de) | 2010-04-15 |
| CA2659523C (en) | 2014-01-28 |
| DE602007005653D1 (de) | 2010-05-12 |
| KR20090038447A (ko) | 2009-04-20 |
| WO2008015221A3 (en) | 2008-07-31 |
| PT2046300E (pt) | 2010-07-01 |
| HK1128881A1 (en) | 2009-11-13 |
| US8603525B2 (en) | 2013-12-10 |
| CA2659523A1 (en) | 2008-02-07 |
| US20090311320A1 (en) | 2009-12-17 |
| AU2007280471A1 (en) | 2008-02-07 |
| JP2009545561A (ja) | 2009-12-24 |
| WO2008015221A2 (en) | 2008-02-07 |
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