ES2332453T3 - Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. - Google Patents

Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. Download PDF

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Publication number
ES2332453T3
ES2332453T3 ES03783211T ES03783211T ES2332453T3 ES 2332453 T3 ES2332453 T3 ES 2332453T3 ES 03783211 T ES03783211 T ES 03783211T ES 03783211 T ES03783211 T ES 03783211T ES 2332453 T3 ES2332453 T3 ES 2332453T3
Authority
ES
Spain
Prior art keywords
quad
hydrocarbyl
quaternary
hydroxy
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03783211T
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English (en)
Spanish (es)
Inventor
Gary L. Cantrell
Robert E. Halvachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2332453T3 publication Critical patent/ES2332453T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ES03783211T 2002-11-08 2003-11-05 Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano. Expired - Lifetime ES2332453T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US424748P 2002-11-08
US42558002P 2002-11-12 2002-11-12
US425580P 2002-11-12

Publications (1)

Publication Number Publication Date
ES2332453T3 true ES2332453T3 (es) 2010-02-05

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03783211T Expired - Lifetime ES2332453T3 (es) 2002-11-08 2003-11-05 Proceso para la preparacion de sales de n-alquilo cuaternario de alcaloides de morfinano.

Country Status (11)

Country Link
US (1) US7285665B2 (https=)
EP (1) EP1562953B1 (https=)
JP (1) JP2006509745A (https=)
AT (1) ATE444295T1 (https=)
AU (1) AU2003290630B2 (https=)
CA (1) CA2504262C (https=)
DE (1) DE60329520D1 (https=)
ES (1) ES2332453T3 (https=)
MX (1) MXPA05004759A (https=)
PT (1) PT1562953E (https=)
WO (1) WO2004043964A2 (https=)

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US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
ES2714198T3 (es) 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
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TW200815451A (en) * 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
US8115002B2 (en) 2006-09-20 2012-02-14 Mallinckrodt Llc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
WO2008064150A1 (en) * 2006-11-22 2008-05-29 Progenics Pharmaceuticals, Inc. Processes for synthesizing quaternary 4,5-epoxy-morphinan analogs and isolating their n-stereoisomers
US20080176884A1 (en) * 2006-11-22 2008-07-24 Progenics Pharmaceuticals, Inc. 7,8-Saturated-4,5-Epoxy-Morphinanium Analogs
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US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
SI2565195T1 (sl) 2007-03-29 2015-09-30 Wyeth Llc Periferalni opioidni receptorji in antagonisti in njih uporaba
CL2008000905A1 (es) 2007-03-29 2008-08-22 Progenics Pharm Inc Compuestos derivados de morfina, antagonistas del receptor opioide periferico; metodo de preparacion; composicion farmaceutica; y uso para reducir los efectos de la actividad opioide endogena.
MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CN101827819B (zh) * 2007-08-09 2013-06-12 伦斯勒理工学院 阿片样物质酰胺季铵盐
US20110112129A2 (en) * 2007-11-26 2011-05-12 Pharmacofore, Inc. Peripheral Phenolic Opioid Antagonist
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
WO2009103004A1 (en) * 2008-02-14 2009-08-20 Alkermes, Inc. Selective opioid compounds
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
EP2285780B1 (en) 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398807A1 (en) 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325777B (zh) 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses

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Also Published As

Publication number Publication date
AU2003290630A1 (en) 2004-06-03
ATE444295T1 (de) 2009-10-15
JP2006509745A (ja) 2006-03-23
US7285665B2 (en) 2007-10-23
DE60329520D1 (de) 2009-11-12
WO2004043964A2 (en) 2004-05-27
CA2504262C (en) 2012-01-10
PT1562953E (pt) 2009-11-19
AU2003290630B2 (en) 2009-01-29
WO2004043964A3 (en) 2004-08-26
EP1562953A2 (en) 2005-08-17
US20060014771A1 (en) 2006-01-19
EP1562953B1 (en) 2009-09-30
CA2504262A1 (en) 2004-05-27
MXPA05004759A (es) 2005-08-02

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