PT1562953E - Processo para a preparação de sais quaternários de n -alquilmorfinano - Google Patents

Processo para a preparação de sais quaternários de n -alquilmorfinano Download PDF

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Publication number
PT1562953E
PT1562953E PT03783211T PT03783211T PT1562953E PT 1562953 E PT1562953 E PT 1562953E PT 03783211 T PT03783211 T PT 03783211T PT 03783211 T PT03783211 T PT 03783211T PT 1562953 E PT1562953 E PT 1562953E
Authority
PT
Portugal
Prior art keywords
preparation
morphinan alkaloid
quaternary
alkaloid salts
alkyl morphinan
Prior art date
Application number
PT03783211T
Other languages
English (en)
Portuguese (pt)
Inventor
Gary L Cantrell
Robert E Halvachs
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of PT1562953E publication Critical patent/PT1562953E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
PT03783211T 2002-11-08 2003-11-05 Processo para a preparação de sais quaternários de n -alquilmorfinano PT1562953E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US42558002P 2002-11-12 2002-11-12

Publications (1)

Publication Number Publication Date
PT1562953E true PT1562953E (pt) 2009-11-19

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03783211T PT1562953E (pt) 2002-11-08 2003-11-05 Processo para a preparação de sais quaternários de n -alquilmorfinano

Country Status (11)

Country Link
US (1) US7285665B2 (https=)
EP (1) EP1562953B1 (https=)
JP (1) JP2006509745A (https=)
AT (1) ATE444295T1 (https=)
AU (1) AU2003290630B2 (https=)
CA (1) CA2504262C (https=)
DE (1) DE60329520D1 (https=)
ES (1) ES2332453T3 (https=)
MX (1) MXPA05004759A (https=)
PT (1) PT1562953E (https=)
WO (1) WO2004043964A2 (https=)

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US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
ES2714198T3 (es) 2005-03-07 2019-05-27 Univ Chicago Uso de antagonistas opioideos para atenuar la proliferación y la migración de células endoteliales
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AU2013200437B2 (en) * 2005-05-25 2015-01-15 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone, process for its synthesis and its pharmaceutical use
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200815451A (en) 2006-08-04 2008-04-01 Wyeth Corp 6-carboxy-normorphinan derivatives, synthesis and uses thereof
EP2099764B1 (en) 2006-09-20 2011-07-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
FR2906252B1 (fr) * 2006-09-21 2008-11-28 Sanofi Aventis Sa Procede de preparation d'halogenures de n-aklyl naltrexone
MX2009005463A (es) * 2006-11-22 2009-08-28 Progenics Pharm Inc Proceso para sintetizar analogos cuaternarios de 4,5-epoxi-morfinano y aislar sus n-estereoisomeros.
EP2101774A2 (en) * 2006-11-22 2009-09-23 Progenics Pharmaceuticals, Inc. 7,8-saturated-4,5-epoxy-morphinanium analogs
EP2137189B1 (en) 2007-03-06 2015-05-06 Mallinckrodt LLC Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
EP2565195B1 (en) 2007-03-29 2015-05-06 Wyeth LLC Peripheral opioid receptor and antagonists and uses thereof
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
AU2008286979B2 (en) * 2007-08-09 2013-03-28 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
WO2009070733A1 (en) * 2007-11-26 2009-06-04 Pharmacofore, Inc. Peripheral phenolic opioid antagonist
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
ES2671897T3 (es) * 2008-02-14 2018-06-11 Alkermes, Inc. Compuestos opioides selectivos
CA2719134C (en) 2008-03-21 2015-06-30 The University Of Chicago Treatment with opioid antagonists and mtor inhibitors
US8148528B2 (en) 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
EP2331508B1 (en) 2008-09-03 2014-11-12 Mallinckrodt LLC Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
EP2398806A1 (en) 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-morphinanium n-oxides and processes for their production
US8563724B2 (en) 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CA2802294C (en) 2010-06-11 2016-05-10 Rhodes Technologies Process for n-dealkylation of tertiary amines
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos

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Also Published As

Publication number Publication date
ATE444295T1 (de) 2009-10-15
US20060014771A1 (en) 2006-01-19
AU2003290630A1 (en) 2004-06-03
AU2003290630B2 (en) 2009-01-29
ES2332453T3 (es) 2010-02-05
EP1562953A2 (en) 2005-08-17
MXPA05004759A (es) 2005-08-02
CA2504262C (en) 2012-01-10
JP2006509745A (ja) 2006-03-23
EP1562953B1 (en) 2009-09-30
US7285665B2 (en) 2007-10-23
WO2004043964A2 (en) 2004-05-27
DE60329520D1 (de) 2009-11-12
WO2004043964A3 (en) 2004-08-26
CA2504262A1 (en) 2004-05-27

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