CA2504262C - Process for the preparation of quaternary n-alkyl morphinan alkaloid salts - Google Patents

Process for the preparation of quaternary n-alkyl morphinan alkaloid salts Download PDF

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Publication number
CA2504262C
CA2504262C CA2504262A CA2504262A CA2504262C CA 2504262 C CA2504262 C CA 2504262C CA 2504262 A CA2504262 A CA 2504262A CA 2504262 A CA2504262 A CA 2504262A CA 2504262 C CA2504262 C CA 2504262C
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CA
Canada
Prior art keywords
hydroxy
hydrocarbyl
alpha
acyloxy
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2504262A
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English (en)
French (fr)
Other versions
CA2504262A1 (en
Inventor
Gary L. Cantrell
Robert E. Halvachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Specgx LLC
Original Assignee
Mallinckrodt LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt LLC filed Critical Mallinckrodt LLC
Publication of CA2504262A1 publication Critical patent/CA2504262A1/en
Application granted granted Critical
Publication of CA2504262C publication Critical patent/CA2504262C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA2504262A 2002-11-08 2003-11-05 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts Expired - Lifetime CA2504262C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42474802P 2002-11-08 2002-11-08
US60/424,748 2002-11-08
US42558002P 2002-11-12 2002-11-12
US60/425,580 2002-11-12
PCT/US2003/035463 WO2004043964A2 (en) 2002-11-08 2003-11-05 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Publications (2)

Publication Number Publication Date
CA2504262A1 CA2504262A1 (en) 2004-05-27
CA2504262C true CA2504262C (en) 2012-01-10

Family

ID=32314554

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2504262A Expired - Lifetime CA2504262C (en) 2002-11-08 2003-11-05 Process for the preparation of quaternary n-alkyl morphinan alkaloid salts

Country Status (11)

Country Link
US (1) US7285665B2 (https=)
EP (1) EP1562953B1 (https=)
JP (1) JP2006509745A (https=)
AT (1) ATE444295T1 (https=)
AU (1) AU2003290630B2 (https=)
CA (1) CA2504262C (https=)
DE (1) DE60329520D1 (https=)
ES (1) ES2332453T3 (https=)
MX (1) MXPA05004759A (https=)
PT (1) PT1562953E (https=)
WO (1) WO2004043964A2 (https=)

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US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
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US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
SI2565195T1 (sl) 2007-03-29 2015-09-30 Wyeth Llc Periferalni opioidni receptorji in antagonisti in njih uporaba
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MX2009010550A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
WO2008138383A1 (de) * 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CN101827819B (zh) * 2007-08-09 2013-06-12 伦斯勒理工学院 阿片样物质酰胺季铵盐
US20110112129A2 (en) * 2007-11-26 2011-05-12 Pharmacofore, Inc. Peripheral Phenolic Opioid Antagonist
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WO2009103004A1 (en) * 2008-02-14 2009-08-20 Alkermes, Inc. Selective opioid compounds
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
EP2285780B1 (en) 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
CN101607963B (zh) 2008-06-20 2013-04-03 重庆医药工业研究院有限责任公司 吗啡喃衍生物及其制备方法
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2398807A1 (en) 2009-02-23 2011-12-28 Mallinckrodt LLC (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
CN102325777B (zh) 2009-02-23 2015-08-12 马林克罗特公司 (+)-吗啡喃*n-氧化物及其制备方法
KR20120088537A (ko) 2009-04-24 2012-08-08 브럭 유니버시티 모르피난 및 모르피논 화합물의 제조방법
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses

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Also Published As

Publication number Publication date
AU2003290630A1 (en) 2004-06-03
ATE444295T1 (de) 2009-10-15
JP2006509745A (ja) 2006-03-23
US7285665B2 (en) 2007-10-23
DE60329520D1 (de) 2009-11-12
WO2004043964A2 (en) 2004-05-27
PT1562953E (pt) 2009-11-19
AU2003290630B2 (en) 2009-01-29
WO2004043964A3 (en) 2004-08-26
EP1562953A2 (en) 2005-08-17
US20060014771A1 (en) 2006-01-19
EP1562953B1 (en) 2009-09-30
ES2332453T3 (es) 2010-02-05
CA2504262A1 (en) 2004-05-27
MXPA05004759A (es) 2005-08-02

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Effective date: 20231106