ES2329220T3 - Variantes mutantes del factor de crecimiento similar a insulina (igf) i. - Google Patents

Variantes mutantes del factor de crecimiento similar a insulina (igf) i. Download PDF

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Publication number
ES2329220T3
ES2329220T3 ES00905535T ES00905535T ES2329220T3 ES 2329220 T3 ES2329220 T3 ES 2329220T3 ES 00905535 T ES00905535 T ES 00905535T ES 00905535 T ES00905535 T ES 00905535T ES 2329220 T3 ES2329220 T3 ES 2329220T3
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Spain
Prior art keywords
igf
igfbp
insulin
peptide
binding
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Expired - Lifetime
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ES00905535T
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English (en)
Spanish (es)
Inventor
Yves Dubaquie
Henry Lowman
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/16—Central respiratory analeptics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A—HUMAN NECESSITIES
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
ES00905535T 1999-01-06 2000-01-05 Variantes mutantes del factor de crecimiento similar a insulina (igf) i. Expired - Lifetime ES2329220T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11501099P 1999-01-06 1999-01-06
US115010P 1999-01-06

Publications (1)

Publication Number Publication Date
ES2329220T3 true ES2329220T3 (es) 2009-11-24

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ES00905535T Expired - Lifetime ES2329220T3 (es) 1999-01-06 2000-01-05 Variantes mutantes del factor de crecimiento similar a insulina (igf) i.

Country Status (12)

Country Link
US (6) US6509443B1 (enExample)
EP (1) EP1141015B1 (enExample)
JP (3) JP2002535967A (enExample)
AU (1) AU762047B2 (enExample)
CA (1) CA2356257C (enExample)
CY (1) CY1109452T1 (enExample)
DE (1) DE60042550D1 (enExample)
DK (1) DK1141015T3 (enExample)
ES (1) ES2329220T3 (enExample)
IL (3) IL143834A0 (enExample)
PT (1) PT1141015E (enExample)
WO (1) WO2000040612A1 (enExample)

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WO2009121759A2 (en) * 2008-04-03 2009-10-08 F. Hoffmann-La Roche Ag Use of pegylated igf-i variants for the treatment of neuromuscular disorders
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
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UA103104C2 (ru) * 2009-07-22 2013-09-10 Ипсен Фарма С.А.С. Аналоги инсулиноподобного фактора роста-1 (igf-1), содержащие аминокислотную замену в положении 59
MX2012002901A (es) * 2009-09-10 2012-06-27 Lonza Biologics Plc Metodo y sistema para purificacion de polipeptidos.
US20110152188A1 (en) * 2009-12-23 2011-06-23 Hanns-Christian Mahler Pharmaceutical compositions of igf/i proteins
US8691771B2 (en) 2010-05-21 2014-04-08 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins for tissue repair
PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
CN104159922B (zh) 2012-01-10 2018-03-02 比奥根Ma公司 对转运治疗性分子穿过血脑屏障的增强
SG11201503782PA (en) * 2012-12-18 2015-06-29 Novartis Ag Stabilized insulin-like growth factor polypeptides
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CA2356257A1 (en) 2000-07-13
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EP1141015B1 (en) 2009-07-15
DE60042550D1 (de) 2009-08-27
US6509443B1 (en) 2003-01-21
CA2356257C (en) 2012-10-16
EP1141015A1 (en) 2001-10-10
AU762047B2 (en) 2003-06-19
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US20040023883A1 (en) 2004-02-05
WO2000040612A1 (en) 2000-07-13
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IL186608A0 (en) 2008-01-20
PT1141015E (pt) 2009-10-13
IL186608A (en) 2014-06-30
US6506874B1 (en) 2003-01-14
US20040033952A1 (en) 2004-02-19
JP2005139203A (ja) 2005-06-02
JP4467549B2 (ja) 2010-05-26

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