ATE109828T1 - Sekretion eines dem insulin ähnlichen wachstumsfaktors in e. coli. - Google Patents
Sekretion eines dem insulin ähnlichen wachstumsfaktors in e. coli.Info
- Publication number
- ATE109828T1 ATE109828T1 AT88870067T AT88870067T ATE109828T1 AT E109828 T1 ATE109828 T1 AT E109828T1 AT 88870067 T AT88870067 T AT 88870067T AT 88870067 T AT88870067 T AT 88870067T AT E109828 T1 ATE109828 T1 AT E109828T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- secretion
- coli
- growth factor
- igf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4189687A | 1987-04-23 | 1987-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE109828T1 true ATE109828T1 (de) | 1994-08-15 |
Family
ID=21918925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88870067T ATE109828T1 (de) | 1987-04-23 | 1988-04-22 | Sekretion eines dem insulin ähnlichen wachstumsfaktors in e. coli. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0288451B1 (de) |
AT (1) | ATE109828T1 (de) |
AU (1) | AU607209B2 (de) |
CA (1) | CA1314507C (de) |
DE (1) | DE3850995T2 (de) |
ES (1) | ES2007309T3 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4963665A (en) * | 1986-01-07 | 1990-10-16 | Washington University | Human preproinsulin-like growth factor I |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
DE3901681A1 (de) * | 1989-01-21 | 1990-07-26 | Behringwerke Ag | Signalpeptid fuer die sekretion von peptiden in escherichia coli, verfahren zu seiner gewinnung und seine verwendung |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
EP0546049B1 (de) * | 1990-08-28 | 1995-07-19 | E.I. Du Pont De Nemours And Company | Eine methode für die schnelle selektion von effizienten sekretionsvektoren |
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
WO1998011913A1 (en) * | 1996-09-16 | 1998-03-26 | Dalhousie University | Use of igf-i for the treatment of polycystic kidney disease and related indications |
US6156728A (en) | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
ES2329220T3 (es) | 1999-01-06 | 2009-11-24 | Genentech, Inc. | Variantes mutantes del factor de crecimiento similar a insulina (igf) i. |
EP1141014B1 (de) | 1999-01-06 | 2004-12-08 | Genentech, Inc. | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
DE60005806T2 (de) | 1999-04-08 | 2004-08-05 | Genentech, Inc., South San Francisco | Zusammensetzung auf basis gegensätzlich geladener polypeptide |
EP1282437B1 (de) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Behandlung von knorpelerkrankungen |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
NZ545940A (en) | 2003-09-12 | 2009-12-24 | Tercica Inc | Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency |
MXPA06005705A (es) | 2003-11-21 | 2006-08-23 | Dow Global Technologies Inc | Sistemas de expresion mejorada con secrecion de sistema de sec. |
KR20130019457A (ko) | 2004-07-26 | 2013-02-26 | 다우 글로벌 테크놀로지스 엘엘씨 | 균주 조작에 의한 개선된 단백질 발현 방법 |
WO2007094842A2 (en) | 2005-12-02 | 2007-08-23 | Genentech, Inc. | Binding polypeptides and uses thereof |
ES2577292T3 (es) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Polipéptidos de unión con secuencias hipervariables de VH/VL diversificadas y consenso |
KR101491867B1 (ko) | 2007-01-31 | 2015-02-10 | 피페넥스 인크. | 증가된 발현을 위한 박테리아 리더 서열 |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
CN101688213A (zh) | 2007-04-27 | 2010-03-31 | 陶氏环球技术公司 | 用于快速筛选微生物宿主以鉴定某些在表达异源蛋白质方面具有改善的产量和/或质量的菌株的方法 |
WO2009076196A1 (en) | 2007-12-07 | 2009-06-18 | Dow Global Technologies Inc. | High copy number self-replicating plasmids in pseudomonas |
CA3002965A1 (en) * | 2015-10-30 | 2017-05-04 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4336336A (en) * | 1979-01-12 | 1982-06-22 | President And Fellows Of Harvard College | Fused gene and method of making and using same |
DE3484950D1 (de) * | 1983-08-23 | 1991-09-26 | Mitsubishi Chem Ind | Plasmidvektoren. |
-
1988
- 1988-04-22 AT AT88870067T patent/ATE109828T1/de not_active IP Right Cessation
- 1988-04-22 AU AU15091/88A patent/AU607209B2/en not_active Expired
- 1988-04-22 CA CA000564937A patent/CA1314507C/en not_active Expired - Lifetime
- 1988-04-22 EP EP88870067A patent/EP0288451B1/de not_active Expired - Lifetime
- 1988-04-22 DE DE3850995T patent/DE3850995T2/de not_active Expired - Lifetime
- 1988-04-22 ES ES88870067T patent/ES2007309T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0288451A3 (en) | 1989-04-19 |
DE3850995D1 (de) | 1994-09-15 |
ES2007309T3 (es) | 1994-11-01 |
DE3850995T2 (de) | 1995-03-16 |
ES2007309A4 (es) | 1989-06-16 |
CA1314507C (en) | 1993-03-16 |
AU607209B2 (en) | 1991-02-28 |
EP0288451B1 (de) | 1994-08-10 |
EP0288451A2 (de) | 1988-10-26 |
AU1509188A (en) | 1988-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EEIH | Change in the person of patent owner | ||
EELA | Cancelled due to lapse of time |