FI102971B - Enantioselektiivinen polypeptidi, sen valmistus, sitä koodittava DNA j a geeni, sekä sitä ilmentävä mikro-organismi, ja menetelmä stereoisome erin valmistamiseksi - Google Patents

Enantioselektiivinen polypeptidi, sen valmistus, sitä koodittava DNA j a geeni, sekä sitä ilmentävä mikro-organismi, ja menetelmä stereoisome erin valmistamiseksi

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Publication number
FI102971B
FI102971B FI905660A FI905660A FI102971B FI 102971 B FI102971 B FI 102971B FI 905660 A FI905660 A FI 905660A FI 905660 A FI905660 A FI 905660A FI 102971 B FI102971 B FI 102971B
Authority
FI
Finland
Prior art keywords
polypeptide
enantioselective
dna
preparation
gene encoding
Prior art date
Application number
FI905660A
Other languages
English (en)
Swedish (sv)
Other versions
FI102971B1 (fi
FI905660A0 (fi
FI905660A (fi
Inventor
Dominique Petre
Edith Cerbelaud
Jean-Francois Mayaux
Patrice Yeh
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of FI905660A0 publication Critical patent/FI905660A0/fi
Publication of FI905660A publication Critical patent/FI905660A/fi
Application granted granted Critical
Publication of FI102971B1 publication Critical patent/FI102971B1/fi
Publication of FI102971B publication Critical patent/FI102971B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI905660A 1989-12-11 1990-11-15 Enantioselektiivinen polypeptidi, sen valmistus, sitä koodittava DNA j a geeni, sekä sitä ilmentävä mikro-organismi, ja menetelmä stereoisome erin valmistamiseksi FI102971B (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8916332A FR2655660B1 (fr) 1989-12-11 1989-12-11 Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Publications (4)

Publication Number Publication Date
FI905660A0 FI905660A0 (fi) 1990-11-15
FI905660A FI905660A (fi) 1991-06-12
FI102971B1 FI102971B1 (fi) 1999-03-31
FI102971B true FI102971B (fi) 1999-03-31

Family

ID=9388350

Family Applications (1)

Application Number Title Priority Date Filing Date
FI905660A FI102971B (fi) 1989-12-11 1990-11-15 Enantioselektiivinen polypeptidi, sen valmistus, sitä koodittava DNA j a geeni, sekä sitä ilmentävä mikro-organismi, ja menetelmä stereoisome erin valmistamiseksi

Country Status (20)

Country Link
US (2) US5260208A (fi)
EP (1) EP0433117B1 (fi)
JP (1) JP3150335B2 (fi)
KR (1) KR0164850B1 (fi)
CN (1) CN1052508A (fi)
AT (1) ATE152481T1 (fi)
AU (1) AU631696B2 (fi)
CA (1) CA2030073C (fi)
DE (1) DE69030615T2 (fi)
DK (1) DK0433117T3 (fi)
ES (1) ES2104596T3 (fi)
FI (1) FI102971B (fi)
FR (1) FR2655660B1 (fi)
GR (1) GR3024316T3 (fi)
HU (1) HUT56138A (fi)
IE (1) IE904115A1 (fi)
IL (1) IL96309A0 (fi)
NZ (1) NZ236087A (fi)
PT (1) PT95909B (fi)
ZA (1) ZA909071B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.
ES2124714T3 (es) * 1991-07-26 1999-02-16 Lonza Ag Procedimiento de ingenieria genetica para la preparacion de s-(+)-2,2-dimetilciclopropanocarboxamida mediante microorganismos.
US5258305A (en) * 1991-09-13 1993-11-02 Nitto Chemical Industry Co., Ltd. Manufacture of optically active 2-phenylpropionic acid and 2-phenylpropionamide from the nitrile using Rhodococcus equi
DE4244915C2 (de) * 1992-08-14 1998-12-03 Widmar Prof Dr Tanner DNA-Moleküle codierend Proteine, die an der O-Glykosylierung von Proteinen beteiligt sind
US6051431A (en) * 1994-07-22 2000-04-18 Dsm N.V. Selection marker gene free recombinant strains: a method for obtaining them and the use of these strains
JPH11513255A (ja) 1995-10-06 1999-11-16 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 立体特異的ニトリルヒドラターゼおよびアミダーゼ酵素をコードする核酸断片、ならびにキラルアミドおよび酸の生産に有用なそれら酵素を発現する組換え微生物
US6235516B1 (en) 1996-04-25 2001-05-22 Novartis Ag Biocatalysts with amine acylase activity
AU4113797A (en) 1996-07-10 1998-02-02 Lonza A.G. Method of preparing (s) - or (r) -3,3,3-trifluoro-2-hydroxy-2- methylpropionic acid
US6207647B1 (en) * 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
EP0905250A1 (en) * 1997-08-13 1999-03-31 Smithkline Beecham Corporation The Chlamydia trachomatis Glutamyl-tRNAGln amidotransferase subunit ratA
WO2000063354A1 (fr) * 1999-04-16 2000-10-26 Mitsubishi Rayon Co., Ltd. Nouveau gene amidase
CN1311197A (zh) * 2000-03-02 2001-09-05 上海博德基因开发有限公司 一种新的多肽——酰胺酶家族蛋白13和编码这种多肽的多核苷酸
EP1352964A4 (en) * 2000-12-22 2005-02-16 Nippon Soda Co PROCESS FOR PRODUCING A SUBSTANCE USING A MICROBIAL CATALYST
WO2003020929A1 (fr) * 2001-08-28 2003-03-13 Mitsubishi Rayon Co., Ltd. Nouveau gene d'amide hydrolase
EP2123767A1 (en) * 2008-05-20 2009-11-25 DSM IP Assets B.V. Preparation of epsilon-caprolactam via lysine cyclisation
TW201002823A (en) * 2008-05-20 2010-01-16 Dsm Ip Assets Bv Preparation of alpha-amino-epsilon-caprolactam via lysine cyclisation
CN111363736A (zh) * 2020-03-12 2020-07-03 东莞市东阳光生物合成药有限公司 制备右旋酮洛芬的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU74142A1 (fi) * 1976-01-08 1977-07-22
JPS5713000A (en) * 1980-06-24 1982-01-22 Ube Ind Ltd Preparation of optical active tryptophane
US4366250A (en) * 1980-09-24 1982-12-28 Anvar Preparation process of optically active α-aminated acids by biological hydrolysis of nitriles
JPS57186495A (en) * 1981-05-14 1982-11-16 Ube Ind Ltd Preparation of l-alpha-methylphenylalanine
JPS58192900A (ja) * 1982-05-04 1983-11-10 Ajinomoto Co Inc 複合プラスミド
US4925799A (en) * 1983-01-12 1990-05-15 The United States Of America As Represented By The Department Of Health And Human Services Plasmid cloning vector pAS1
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4921699A (en) * 1983-06-01 1990-05-01 Hoffman-La Roche Inc. Polypeptides having interferon activity
US4861722A (en) * 1983-08-24 1989-08-29 Ajinomoto Company, Inc. Coryneform bacteria carrying recombinant plasmids and their use in the fermentative production of L-lysine
NL8400312A (nl) * 1984-02-02 1985-09-02 Stamicarbon Optisch aktief gesubstitueerd boterzuuramide alsmede werkwijze voor de optische scheiding van gesubstitueerd boterzuuramide.
DE3435156A1 (de) * 1984-09-25 1986-04-03 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung der stereoisomeren von 1-amino-alkylphosphonsaeuren oder 1-aminoalkylphosphinsaeuren
NL8501093A (nl) * 1985-04-12 1986-11-03 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide.
US4920054A (en) * 1986-07-25 1990-04-24 Allelix, Inc. Shuttle vectors from rhodococcus equi
GB2195630B (en) * 1986-08-26 1990-07-18 Chuo Kaseihin Co Inc Method for producing carnitine, l-carnitineamide hydrolase and method for producing same
US4965197A (en) * 1987-06-12 1990-10-23 Massachusetts Institute Of Technology Coryneform expression and secretion system
AU613963B2 (en) * 1987-08-17 1991-08-15 Novo Industri A/S Process for preparation of organic chemicals
FR2626289B1 (fr) * 1988-01-27 1990-06-08 Rhone Poulenc Sante Procede de preparation d'acides aryl-2 alkanoiques optiquement actifs
FR2626288B1 (fi) * 1988-01-27 1990-05-18 Rhone Poulenc Sante
GB2218985A (en) * 1988-05-27 1989-11-29 Shell Int Research Producing optically active 2-aryloxypropionic acids
FR2655660B1 (fr) * 1989-12-11 1992-03-20 Rhone Poulenc Sante Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation.

Also Published As

Publication number Publication date
KR0164850B1 (ko) 1999-01-15
CN1052508A (zh) 1991-06-26
CA2030073A1 (en) 1991-06-12
ATE152481T1 (de) 1997-05-15
AU6661490A (en) 1991-06-13
IE904115A1 (en) 1991-06-19
US5766918A (en) 1998-06-16
DE69030615D1 (de) 1997-06-05
DE69030615T2 (de) 1997-11-06
EP0433117A1 (en) 1991-06-19
FI102971B1 (fi) 1999-03-31
IL96309A0 (en) 1991-08-16
ZA909071B (en) 1991-09-25
HU907151D0 (en) 1991-05-28
JPH04218379A (ja) 1992-08-07
FR2655660A1 (fr) 1991-06-14
KR910012245A (ko) 1991-08-07
DK0433117T3 (da) 1997-11-03
HUT56138A (en) 1991-07-29
EP0433117B1 (en) 1997-05-02
AU631696B2 (en) 1992-12-03
FI905660A0 (fi) 1990-11-15
PT95909B (pt) 1998-01-30
GR3024316T3 (en) 1997-10-31
CA2030073C (en) 2001-10-30
FI905660A (fi) 1991-06-12
PT95909A (pt) 1991-09-30
ES2104596T3 (es) 1997-10-16
JP3150335B2 (ja) 2001-03-26
FR2655660B1 (fr) 1992-03-20
NZ236087A (en) 1992-11-25
US5260208A (en) 1993-11-09

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Owner name: RHONE-POULENC SANTE