CY1109452T1 - Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i - Google Patents
Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)iInfo
- Publication number
- CY1109452T1 CY1109452T1 CY20091101024T CY091101024T CY1109452T1 CY 1109452 T1 CY1109452 T1 CY 1109452T1 CY 20091101024 T CY20091101024 T CY 20091101024T CY 091101024 T CY091101024 T CY 091101024T CY 1109452 T1 CY1109452 T1 CY 1109452T1
- Authority
- CY
- Cyprus
- Prior art keywords
- igf
- methods
- growth factor
- insulin growth
- insulin
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
- 102000004877 Insulin Human genes 0.000 title abstract 3
- 108090001061 Insulin Proteins 0.000 title abstract 3
- 229940125396 insulin Drugs 0.000 title abstract 3
- 239000003102 growth factor Substances 0.000 title 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 2
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 abstract 1
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 abstract 1
- 102000004375 Insulin-like growth factor-binding protein 1 Human genes 0.000 abstract 1
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11501099P | 1999-01-06 | 1999-01-06 | |
| EP00905535A EP1141015B1 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (igf) i mutant variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109452T1 true CY1109452T1 (el) | 2014-08-13 |
Family
ID=22358799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101024T CY1109452T1 (el) | 1999-01-06 | 2009-10-02 | Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6509443B1 (enExample) |
| EP (1) | EP1141015B1 (enExample) |
| JP (3) | JP2002535967A (enExample) |
| AU (1) | AU762047B2 (enExample) |
| CA (1) | CA2356257C (enExample) |
| CY (1) | CY1109452T1 (enExample) |
| DE (1) | DE60042550D1 (enExample) |
| DK (1) | DK1141015T3 (enExample) |
| ES (1) | ES2329220T3 (enExample) |
| IL (3) | IL143834A0 (enExample) |
| PT (1) | PT1141015E (enExample) |
| WO (1) | WO2000040612A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1141014T3 (da) | 1999-01-06 | 2005-04-11 | Genentech Inc | Insulinlignende vækstfaktor (IGF) i mutantvariant |
| AUPQ585500A0 (en) * | 2000-02-25 | 2000-03-16 | Gropep Pty Ltd | Treatment for peripheral sensory neuropathy |
| AU2001263215A1 (en) | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
| AUPR030900A0 (en) | 2000-09-22 | 2000-10-12 | Queensland University Of Technology | Growth factor complex |
| ES2207387B1 (es) * | 2002-02-28 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas. |
| WO2004027064A2 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| CN1870893A (zh) | 2003-09-12 | 2006-11-29 | 特西卡股份有限公司 | 胰岛素样生长因子-1(igf-1)缺陷的治疗方法 |
| WO2005033134A2 (en) * | 2003-09-30 | 2005-04-14 | Regeneron Pharmaceuticals, Inc. | Secreted protein therapeutics and uses thereof |
| CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
| GB0426154D0 (en) * | 2004-11-29 | 2004-12-29 | European Molecular Biology Lab Embl | IGF-1 novel peptides |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| EP1674113A1 (en) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
| EP2311880A3 (en) | 2005-01-05 | 2011-07-27 | Biogen Idec MA Inc. | Cripto binding molecules |
| EP1841443A4 (en) * | 2005-01-11 | 2012-05-02 | Heart Failure Technologies Inc | METHOD AND SYSTEM FOR TREATING HEART ERRORS |
| TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
| FR2892174B1 (fr) | 2005-10-14 | 2007-12-28 | Vallourec Mannesmann Oil Gas F | Element filete tubulaire muni d'un revetement protecteur sec |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| KR101106795B1 (ko) * | 2006-08-31 | 2012-01-18 | 에프. 호프만-라 로슈 아게 | 인슐린-유사 성장 인자-i의 제조 방법 |
| MX2010010495A (es) * | 2008-04-03 | 2010-10-15 | Hoffmann La Roche | Uso de variantes del factor de crecimiento similar a la insulina (igf-i) pegiladas para el tratamiento de trastornos neuromusculares. |
| CN101965516A (zh) * | 2008-04-03 | 2011-02-02 | 弗·哈夫曼-拉罗切有限公司 | 聚乙二醇化胰岛素样生长因子测定 |
| EP2341940A1 (en) * | 2008-07-16 | 2011-07-13 | Arecor Limited | The stabilisation of proteins |
| WO2010094906A1 (en) * | 2009-07-16 | 2010-08-26 | Arecor Limited | The stabilisation of proteins |
| EP2328607A1 (en) * | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
| JP5571186B2 (ja) * | 2009-07-22 | 2014-08-13 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 59位にアミノ酸置換を有するインスリン様増殖因子−1(igf−1)の類似体 |
| CN102906104B (zh) * | 2009-09-10 | 2015-04-22 | 朗萨生物制剂有限公司 | 用于多肽纯化的方法和系统 |
| US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
| JP6200806B2 (ja) | 2010-05-21 | 2017-09-20 | メリマック ファーマシューティカルズ インコーポレーティッド | 二重特異的融合タンパク質 |
| WO2012006635A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Processable single chain molecules and polypeptides made using same |
| WO2013012733A1 (en) | 2011-07-15 | 2013-01-24 | Biogen Idec Ma Inc. | Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto |
| DK2802606T3 (en) | 2012-01-10 | 2018-06-25 | Biogen Ma Inc | INCREASE TRANSPORT OF THERAPEUTIC MOLECULES OVER THE BLOOD-BRAIN BARRIER |
| EP3626735A1 (en) * | 2012-12-18 | 2020-03-25 | Novartis AG | Stabilized insulin-like growth factor polypeptides |
| EA037906B1 (ru) | 2013-03-15 | 2021-06-04 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора ix |
| PE20171766A1 (es) | 2015-02-04 | 2017-12-21 | Hoffmann La Roche | Oligomeros antisentido de tau y usos de estos |
| WO2016127000A1 (en) | 2015-02-04 | 2016-08-11 | Bristol-Myers Squibb Company | Methods of selecting therapeutic molecules |
| US10040840B2 (en) | 2015-10-02 | 2018-08-07 | Silver Creek Pharmaceuticals, Inc. | Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue |
| EP3453722A1 (en) * | 2017-09-06 | 2019-03-13 | Julius-Maximilians-Universität Würzburg | Pharmaceuticals and devices for the covalent immobilization to the extracellular matrix by transglutaminase |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| WO1987001038A1 (en) | 1985-08-22 | 1987-02-26 | Commonwealth Scientific And Industrial Research Or | Peptide analogues of mammalian insulin-like growth factor-1 |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| WO1988007863A1 (en) | 1987-04-06 | 1988-10-20 | Biogrowth, Inc. | Human somatomedin carrier protein subunits and process for producing them |
| AU607209B2 (en) | 1987-04-23 | 1991-02-28 | Monsanto Technology Llc | Secretion of insulin-like growth factor-i in e. coli |
| US5470828A (en) | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
| US5164370A (en) | 1987-12-24 | 1992-11-17 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
| EP0327503B1 (en) * | 1988-02-05 | 1993-03-10 | Ciba-Geigy Ag | Use of igf i in the manufacture of a medicament for the treatment of renal diseases |
| DK131988A (da) | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
| US5258287A (en) | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| EP0418230B1 (en) | 1988-04-12 | 1995-12-27 | Amgen Boulder Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| GB8826451D0 (en) | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
| IL92816A0 (en) | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| DE69218948T2 (de) | 1991-08-01 | 1997-07-31 | Auckland Uniservices Ltd | IGF-I zur Verbesserung der neuronale Lage |
| GB9217696D0 (en) | 1992-08-20 | 1992-09-30 | Agricultural & Food Res | Use of specific binding molecules |
| US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
| US5342763A (en) | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
| SG46612A1 (en) * | 1992-12-02 | 1998-02-20 | Hoechst Ag | Process for obtaining proinsulin in processing correctly linked cystine bridges |
| US5597700A (en) | 1994-04-28 | 1997-01-28 | California Research, Llc | Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method |
| SE9402331D0 (sv) * | 1994-07-01 | 1994-07-01 | Pharmacia Ab | New use |
| SE9501472D0 (sv) | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
| US5622932A (en) | 1995-05-05 | 1997-04-22 | Eli Lilly And Company | IGF-1 superagonists |
| US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
| US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
| CA2224859A1 (en) | 1996-04-17 | 1997-10-23 | Amitabh Gaur | Ligand inhibitors of insulin-like growth factor binding proteins and methods of use therefor |
| ZA978334B (en) * | 1996-09-16 | 1999-03-16 | Univ Dalhousie | Use of IFG-I for the treatment of kidney disorders renal insufficiencies steriod toxicity and related indications |
| WO1998029451A1 (en) | 1996-12-27 | 1998-07-09 | Daiichi Pharmaceutical Co., Ltd. | Method for elevating the concentration of free insulin-like growth factor |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| AR012894A1 (es) | 1997-06-13 | 2000-11-22 | Lilly Co Eli | Formulacion de insulina en solucion estable, su uso para preparar un medicamento y proceso para la preparacion de la misma. |
| DE19757250A1 (de) | 1997-12-22 | 1999-07-01 | Forssmann Wolf Georg Prof Dr | Insulin-like growth factor binding protein und seine Verwendung |
| AU6515499A (en) | 1998-10-16 | 2000-05-08 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
| JP2003518917A (ja) | 1999-05-19 | 2003-06-17 | ゼンコー | 糖尿病の処置に有用なインシュリン様活性を有する新規タンパク質 |
-
2000
- 2000-01-05 PT PT00905535T patent/PT1141015E/pt unknown
- 2000-01-05 CA CA2356257A patent/CA2356257C/en not_active Expired - Lifetime
- 2000-01-05 JP JP2000592320A patent/JP2002535967A/ja not_active Withdrawn
- 2000-01-05 WO PCT/US2000/000151 patent/WO2000040612A1/en not_active Ceased
- 2000-01-05 DK DK00905535.1T patent/DK1141015T3/da active
- 2000-01-05 ES ES00905535T patent/ES2329220T3/es not_active Expired - Lifetime
- 2000-01-05 EP EP00905535A patent/EP1141015B1/en not_active Expired - Lifetime
- 2000-01-05 DE DE60042550T patent/DE60042550D1/de not_active Expired - Lifetime
- 2000-01-05 IL IL14383400A patent/IL143834A0/xx unknown
- 2000-01-05 AU AU27194/00A patent/AU762047B2/en not_active Expired
- 2000-11-28 US US09/723,896 patent/US6509443B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/723,981 patent/US6506874B1/en not_active Expired - Lifetime
-
2001
- 2001-06-19 IL IL143834A patent/IL143834A/en not_active IP Right Cessation
-
2003
- 2003-05-22 US US10/444,649 patent/US20040033951A1/en not_active Abandoned
- 2003-05-22 US US10/444,701 patent/US20040033952A1/en not_active Abandoned
- 2003-05-22 US US10/444,326 patent/US20030191065A1/en not_active Abandoned
- 2003-05-22 US US10/444,262 patent/US20040023883A1/en not_active Abandoned
-
2005
- 2005-02-16 JP JP2005038688A patent/JP2005139203A/ja not_active Withdrawn
-
2006
- 2006-08-25 JP JP2006229517A patent/JP4467549B2/ja not_active Expired - Lifetime
-
2007
- 2007-10-11 IL IL186608A patent/IL186608A/en not_active IP Right Cessation
-
2009
- 2009-10-02 CY CY20091101024T patent/CY1109452T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2329220T3 (es) | 2009-11-24 |
| US20030191065A1 (en) | 2003-10-09 |
| JP2007045829A (ja) | 2007-02-22 |
| US20040033952A1 (en) | 2004-02-19 |
| IL186608A (en) | 2014-06-30 |
| WO2000040612A9 (en) | 2001-03-22 |
| AU2719400A (en) | 2000-07-24 |
| CA2356257A1 (en) | 2000-07-13 |
| JP2005139203A (ja) | 2005-06-02 |
| US6506874B1 (en) | 2003-01-14 |
| IL186608A0 (en) | 2008-01-20 |
| PT1141015E (pt) | 2009-10-13 |
| JP4467549B2 (ja) | 2010-05-26 |
| JP2002535967A (ja) | 2002-10-29 |
| US6509443B1 (en) | 2003-01-21 |
| DK1141015T3 (da) | 2010-01-25 |
| IL143834A0 (en) | 2002-04-21 |
| DE60042550D1 (de) | 2009-08-27 |
| AU762047B2 (en) | 2003-06-19 |
| WO2000040612A1 (en) | 2000-07-13 |
| US20040023883A1 (en) | 2004-02-05 |
| IL143834A (en) | 2008-07-08 |
| CA2356257C (en) | 2012-10-16 |
| US20040033951A1 (en) | 2004-02-19 |
| EP1141015A1 (en) | 2001-10-10 |
| EP1141015B1 (en) | 2009-07-15 |
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