DE60042550D1 - Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i) - Google Patents

Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i)

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Publication number
DE60042550D1
DE60042550D1 DE60042550T DE60042550T DE60042550D1 DE 60042550 D1 DE60042550 D1 DE 60042550D1 DE 60042550 T DE60042550 T DE 60042550T DE 60042550 T DE60042550 T DE 60042550T DE 60042550 D1 DE60042550 D1 DE 60042550D1
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DE
Germany
Prior art keywords
muted
igf
insulin
variants
growth factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042550T
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German (de)
English (en)
Inventor
Yves Dubaquie
Henry Lowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
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Publication of DE60042550D1 publication Critical patent/DE60042550D1/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
DE60042550T 1999-01-06 2000-01-05 Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i) Expired - Lifetime DE60042550D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11501099P 1999-01-06 1999-01-06
PCT/US2000/000151 WO2000040612A1 (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Publications (1)

Publication Number Publication Date
DE60042550D1 true DE60042550D1 (de) 2009-08-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042550T Expired - Lifetime DE60042550D1 (de) 1999-01-06 2000-01-05 Mutierte varianten des insulin-ähnlichen wachstumsfaktor i (igf-i)

Country Status (12)

Country Link
US (6) US6509443B1 (enExample)
EP (1) EP1141015B1 (enExample)
JP (3) JP2002535967A (enExample)
AU (1) AU762047B2 (enExample)
CA (1) CA2356257C (enExample)
CY (1) CY1109452T1 (enExample)
DE (1) DE60042550D1 (enExample)
DK (1) DK1141015T3 (enExample)
ES (1) ES2329220T3 (enExample)
IL (3) IL143834A0 (enExample)
PT (1) PT1141015E (enExample)
WO (1) WO2000040612A1 (enExample)

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US20110152188A1 (en) * 2009-12-23 2011-06-23 Hanns-Christian Mahler Pharmaceutical compositions of igf/i proteins
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PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
CN104159922B (zh) 2012-01-10 2018-03-02 比奥根Ma公司 对转运治疗性分子穿过血脑屏障的增强
SG11201503782PA (en) * 2012-12-18 2015-06-29 Novartis Ag Stabilized insulin-like growth factor polypeptides
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DK1141015T3 (da) 2010-01-25
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CA2356257A1 (en) 2000-07-13
IL143834A (en) 2008-07-08
JP2002535967A (ja) 2002-10-29
EP1141015B1 (en) 2009-07-15
US6509443B1 (en) 2003-01-21
CA2356257C (en) 2012-10-16
EP1141015A1 (en) 2001-10-10
AU762047B2 (en) 2003-06-19
JP2007045829A (ja) 2007-02-22
US20040023883A1 (en) 2004-02-05
WO2000040612A1 (en) 2000-07-13
US20040033951A1 (en) 2004-02-19
ES2329220T3 (es) 2009-11-24
WO2000040612A9 (en) 2001-03-22
AU2719400A (en) 2000-07-24
IL186608A0 (en) 2008-01-20
PT1141015E (pt) 2009-10-13
IL186608A (en) 2014-06-30
US6506874B1 (en) 2003-01-14
US20040033952A1 (en) 2004-02-19
JP2005139203A (ja) 2005-06-02
JP4467549B2 (ja) 2010-05-26

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