AU762047B2 - Insulin-like growth factor (IGF) I mutant variants - Google Patents
Insulin-like growth factor (IGF) I mutant variants Download PDFInfo
- Publication number
- AU762047B2 AU762047B2 AU27194/00A AU2719400A AU762047B2 AU 762047 B2 AU762047 B2 AU 762047B2 AU 27194/00 A AU27194/00 A AU 27194/00A AU 2719400 A AU2719400 A AU 2719400A AU 762047 B2 AU762047 B2 AU 762047B2
- Authority
- AU
- Australia
- Prior art keywords
- insulin
- igf
- replaced
- phenylalanine
- igfbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/16—Central respiratory analeptics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11501099P | 1999-01-06 | 1999-01-06 | |
| US60/115010 | 1999-01-06 | ||
| PCT/US2000/000151 WO2000040612A1 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (igf) i mutant variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2719400A AU2719400A (en) | 2000-07-24 |
| AU762047B2 true AU762047B2 (en) | 2003-06-19 |
Family
ID=22358799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU27194/00A Expired AU762047B2 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (IGF) I mutant variants |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6506874B1 (enExample) |
| EP (1) | EP1141015B1 (enExample) |
| JP (3) | JP2002535967A (enExample) |
| AU (1) | AU762047B2 (enExample) |
| CA (1) | CA2356257C (enExample) |
| CY (1) | CY1109452T1 (enExample) |
| DE (1) | DE60042550D1 (enExample) |
| DK (1) | DK1141015T3 (enExample) |
| ES (1) | ES2329220T3 (enExample) |
| IL (3) | IL143834A0 (enExample) |
| PT (1) | PT1141015E (enExample) |
| WO (1) | WO2000040612A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030069177A1 (en) * | 2000-05-16 | 2003-04-10 | Genentech, Inc. | Method for treating cartilage disorders |
| CA2356109C (en) * | 1999-01-06 | 2008-04-22 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
| AUPQ585500A0 (en) * | 2000-02-25 | 2000-03-16 | Gropep Pty Ltd | Treatment for peripheral sensory neuropathy |
| AUPR030900A0 (en) | 2000-09-22 | 2000-10-12 | Queensland University Of Technology | Growth factor complex |
| ES2207387B1 (es) * | 2002-02-28 | 2005-07-16 | Consejo Sup. Investig. Cientificas | Composicion quimica de igf-i para el tratamiento y prevencion de enfermedades neurodegenerativas. |
| US20060128615A1 (en) * | 2002-09-18 | 2006-06-15 | Pierrette Gaudreau | Ghrh analogues |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| DK2274978T3 (en) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
| US7355018B2 (en) * | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
| EP2385069A3 (en) | 2003-11-12 | 2012-05-30 | Biogen Idec MA Inc. | Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
| GB0426154D0 (en) * | 2004-11-29 | 2004-12-29 | European Molecular Biology Lab Embl | IGF-1 novel peptides |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| EP1674113A1 (en) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol) |
| AU2006203889A1 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | CRIPTO binding molecules |
| US20080103457A1 (en) * | 2005-01-11 | 2008-05-01 | Heart Failure Technologies, Inc. University Enterprise Laboratories (Uel) | Method and System for Treating Heart Failure |
| TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
| FR2892174B1 (fr) | 2005-10-14 | 2007-12-28 | Vallourec Mannesmann Oil Gas F | Element filete tubulaire muni d'un revetement protecteur sec |
| CN101484469B (zh) * | 2006-08-31 | 2012-12-12 | 弗·哈夫曼-拉罗切有限公司 | 生产胰岛素样生长因子-ⅰ的方法 |
| CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
| AU2009231394B2 (en) * | 2008-04-03 | 2013-09-05 | F. Hoffmann-La Roche Ag | Use of PEGylated IGF-I variants for the treatment of neuromuscular disorders |
| KR20100119899A (ko) * | 2008-04-03 | 2010-11-11 | 에프. 호프만-라 로슈 아게 | 폴리에틸렌글리콜화된 인슐린 유사 성장 인자 분석법 |
| EP2341940A1 (en) * | 2008-07-16 | 2011-07-13 | Arecor Limited | The stabilisation of proteins |
| EP2328607A1 (en) * | 2008-07-16 | 2011-06-08 | Arecor Limited | Stable formulation of a therapeutic protein |
| WO2010094906A1 (en) * | 2009-07-16 | 2010-08-26 | Arecor Limited | The stabilisation of proteins |
| US8759299B2 (en) * | 2009-07-22 | 2014-06-24 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59 |
| CA2773428A1 (en) * | 2009-09-10 | 2011-03-17 | Lonza Biologics Plc | Method and system for polypeptide purification |
| US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
| ES2674567T3 (es) | 2010-05-21 | 2018-07-02 | Merrimack Pharmaceuticals, Inc. | Proteínas de fusión biespecíficas |
| HRP20191305T1 (hr) | 2010-07-09 | 2019-10-18 | Bioverativ Therapeutics Inc. | Preradive jednolančane molekule i polipeptidi izrađeni koristeći iste |
| US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
| HUE039033T2 (hu) | 2012-01-10 | 2018-12-28 | Biogen Ma Inc | Terápiás molekulák transzportjának fokozása a vér-agy gáton keresztül |
| EP3626735A1 (en) * | 2012-12-18 | 2020-03-25 | Novartis AG | Stabilized insulin-like growth factor polypeptides |
| TWI828269B (zh) | 2013-03-15 | 2024-01-01 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
| EP3254104B1 (en) | 2015-02-04 | 2021-08-25 | Bristol-Myers Squibb Company | Methods of selecting therapeutic molecules |
| SG11201706293XA (en) | 2015-02-04 | 2017-09-28 | Hoffmann La Roche | Tau antisense oligomers and uses thereof |
| CA3000742A1 (en) | 2015-10-02 | 2017-04-06 | Silver Creek Pharmaceuticals, Inc. | Bi-specific therapeutic proteins for tissue repair |
| EP3453722A1 (en) * | 2017-09-06 | 2019-03-13 | Julius-Maximilians-Universität Würzburg | Pharmaceuticals and devices for the covalent immobilization to the extracellular matrix by transglutaminase |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989005822A1 (en) * | 1987-12-24 | 1989-06-29 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| ATE81779T1 (de) | 1985-08-22 | 1992-11-15 | Gropep Pty Ltd | Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren. |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| AU627423B2 (en) | 1987-04-06 | 1992-08-27 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them |
| DE3850995T2 (de) | 1987-04-23 | 1995-03-16 | Monsanto Co | Sekretion eines dem Insulin ähnlichen Wachstumsfaktors in E. coli. |
| US5470828A (en) | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
| ATE86496T1 (de) * | 1988-02-05 | 1993-03-15 | Ciba Geigy Ag | Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten. |
| DK131988A (da) | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
| US5258287A (en) | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| DE3854842T2 (de) | 1988-04-12 | 1996-06-13 | Amgen Boulder Inc | Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| GB8826451D0 (en) | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
| IL92816A0 (en) | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
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| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
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2000
- 2000-01-05 DE DE60042550T patent/DE60042550D1/de not_active Expired - Lifetime
- 2000-01-05 JP JP2000592320A patent/JP2002535967A/ja not_active Withdrawn
- 2000-01-05 CA CA2356257A patent/CA2356257C/en not_active Expired - Lifetime
- 2000-01-05 ES ES00905535T patent/ES2329220T3/es not_active Expired - Lifetime
- 2000-01-05 EP EP00905535A patent/EP1141015B1/en not_active Expired - Lifetime
- 2000-01-05 IL IL14383400A patent/IL143834A0/xx unknown
- 2000-01-05 DK DK00905535.1T patent/DK1141015T3/da active
- 2000-01-05 WO PCT/US2000/000151 patent/WO2000040612A1/en not_active Ceased
- 2000-01-05 AU AU27194/00A patent/AU762047B2/en not_active Expired
- 2000-01-05 PT PT00905535T patent/PT1141015E/pt unknown
- 2000-11-28 US US09/723,981 patent/US6506874B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/723,896 patent/US6509443B1/en not_active Expired - Lifetime
-
2001
- 2001-06-19 IL IL143834A patent/IL143834A/en not_active IP Right Cessation
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2003
- 2003-05-22 US US10/444,326 patent/US20030191065A1/en not_active Abandoned
- 2003-05-22 US US10/444,649 patent/US20040033951A1/en not_active Abandoned
- 2003-05-22 US US10/444,262 patent/US20040023883A1/en not_active Abandoned
- 2003-05-22 US US10/444,701 patent/US20040033952A1/en not_active Abandoned
-
2005
- 2005-02-16 JP JP2005038688A patent/JP2005139203A/ja not_active Withdrawn
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2006
- 2006-08-25 JP JP2006229517A patent/JP4467549B2/ja not_active Expired - Lifetime
-
2007
- 2007-10-11 IL IL186608A patent/IL186608A/en not_active IP Right Cessation
-
2009
- 2009-10-02 CY CY20091101024T patent/CY1109452T1/el unknown
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| WO1989005822A1 (en) * | 1987-12-24 | 1989-06-29 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1141015A1 (en) | 2001-10-10 |
| IL186608A0 (en) | 2008-01-20 |
| US6506874B1 (en) | 2003-01-14 |
| WO2000040612A9 (en) | 2001-03-22 |
| US20040023883A1 (en) | 2004-02-05 |
| IL186608A (en) | 2014-06-30 |
| CA2356257A1 (en) | 2000-07-13 |
| CA2356257C (en) | 2012-10-16 |
| JP2005139203A (ja) | 2005-06-02 |
| JP2002535967A (ja) | 2002-10-29 |
| AU2719400A (en) | 2000-07-24 |
| WO2000040612A1 (en) | 2000-07-13 |
| CY1109452T1 (el) | 2014-08-13 |
| PT1141015E (pt) | 2009-10-13 |
| DK1141015T3 (da) | 2010-01-25 |
| US20030191065A1 (en) | 2003-10-09 |
| JP4467549B2 (ja) | 2010-05-26 |
| JP2007045829A (ja) | 2007-02-22 |
| IL143834A0 (en) | 2002-04-21 |
| US20040033952A1 (en) | 2004-02-19 |
| EP1141015B1 (en) | 2009-07-15 |
| IL143834A (en) | 2008-07-08 |
| DE60042550D1 (de) | 2009-08-27 |
| US20040033951A1 (en) | 2004-02-19 |
| ES2329220T3 (es) | 2009-11-24 |
| US6509443B1 (en) | 2003-01-21 |
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