CA2356257C - Insulin-like growth factor (igf) i mutant variants - Google Patents

Insulin-like growth factor (igf) i mutant variants Download PDF

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Publication number
CA2356257C
CA2356257C CA2356257A CA2356257A CA2356257C CA 2356257 C CA2356257 C CA 2356257C CA 2356257 A CA2356257 A CA 2356257A CA 2356257 A CA2356257 A CA 2356257A CA 2356257 C CA2356257 C CA 2356257C
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Canada
Prior art keywords
igf
igfbp
insulin
replaced
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2356257A
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English (en)
French (fr)
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CA2356257A1 (en
Inventor
Yves Dubaquie
Henry Lowman
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Genentech Inc
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Genentech Inc
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Publication date
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Priority to CA2702760A priority Critical patent/CA2702760C/en
Publication of CA2356257A1 publication Critical patent/CA2356257A1/en
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Publication of CA2356257C publication Critical patent/CA2356257C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/16—Central respiratory analeptics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
CA2356257A 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants Expired - Lifetime CA2356257C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2702760A CA2702760C (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11501099P 1999-01-06 1999-01-06
US60/115,010 1999-12-09
PCT/US2000/000151 WO2000040612A1 (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2702760A Division CA2702760C (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Publications (2)

Publication Number Publication Date
CA2356257A1 CA2356257A1 (en) 2000-07-13
CA2356257C true CA2356257C (en) 2012-10-16

Family

ID=22358799

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2356257A Expired - Lifetime CA2356257C (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Country Status (12)

Country Link
US (6) US6509443B1 (enExample)
EP (1) EP1141015B1 (enExample)
JP (3) JP2002535967A (enExample)
AU (1) AU762047B2 (enExample)
CA (1) CA2356257C (enExample)
CY (1) CY1109452T1 (enExample)
DE (1) DE60042550D1 (enExample)
DK (1) DK1141015T3 (enExample)
ES (1) ES2329220T3 (enExample)
IL (3) IL143834A0 (enExample)
PT (1) PT1141015E (enExample)
WO (1) WO2000040612A1 (enExample)

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WO2009121759A2 (en) * 2008-04-03 2009-10-08 F. Hoffmann-La Roche Ag Use of pegylated igf-i variants for the treatment of neuromuscular disorders
EP2328607A1 (en) * 2008-07-16 2011-06-08 Arecor Limited Stable formulation of a therapeutic protein
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UA103104C2 (ru) * 2009-07-22 2013-09-10 Ипсен Фарма С.А.С. Аналоги инсулиноподобного фактора роста-1 (igf-1), содержащие аминокислотную замену в положении 59
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US20110152188A1 (en) * 2009-12-23 2011-06-23 Hanns-Christian Mahler Pharmaceutical compositions of igf/i proteins
US8691771B2 (en) 2010-05-21 2014-04-08 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins for tissue repair
PT2591006T (pt) 2010-07-09 2019-07-29 Bioverativ Therapeutics Inc Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas
WO2013012733A1 (en) 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
CN104159922B (zh) 2012-01-10 2018-03-02 比奥根Ma公司 对转运治疗性分子穿过血脑屏障的增强
SG11201503782PA (en) * 2012-12-18 2015-06-29 Novartis Ag Stabilized insulin-like growth factor polypeptides
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DK1141015T3 (da) 2010-01-25
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CA2356257A1 (en) 2000-07-13
IL143834A (en) 2008-07-08
JP2002535967A (ja) 2002-10-29
EP1141015B1 (en) 2009-07-15
DE60042550D1 (de) 2009-08-27
US6509443B1 (en) 2003-01-21
EP1141015A1 (en) 2001-10-10
AU762047B2 (en) 2003-06-19
JP2007045829A (ja) 2007-02-22
US20040023883A1 (en) 2004-02-05
WO2000040612A1 (en) 2000-07-13
US20040033951A1 (en) 2004-02-19
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WO2000040612A9 (en) 2001-03-22
AU2719400A (en) 2000-07-24
IL186608A0 (en) 2008-01-20
PT1141015E (pt) 2009-10-13
IL186608A (en) 2014-06-30
US6506874B1 (en) 2003-01-14
US20040033952A1 (en) 2004-02-19
JP2005139203A (ja) 2005-06-02
JP4467549B2 (ja) 2010-05-26

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