CY1109452T1 - Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i - Google Patents

Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i

Info

Publication number
CY1109452T1
CY1109452T1 CY20091101024T CY091101024T CY1109452T1 CY 1109452 T1 CY1109452 T1 CY 1109452T1 CY 20091101024 T CY20091101024 T CY 20091101024T CY 091101024 T CY091101024 T CY 091101024T CY 1109452 T1 CY1109452 T1 CY 1109452T1
Authority
CY
Cyprus
Prior art keywords
igf
methods
growth factor
insulin growth
insulin
Prior art date
Application number
CY20091101024T
Other languages
English (en)
Inventor
Yves Dubaquie
Henry Lowman
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1109452T1 publication Critical patent/CY1109452T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/16—Central respiratory analeptics
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Toxicology (AREA)

Abstract

Παρέχονται παραλλαγές IGF-I και ινσουλίνης που δεσμεύονται επιλεκτικά με IGFBP-1 και IGFBP-3. Αυτές οι αγωνιστικές παραλλαγές είναι χρήσιμες, για παράδειγμα, σε βελτίωση των ημιζωών του IGF-I και της ινσουλίνης, αντίστοιχα.
CY20091101024T 1999-01-06 2009-10-02 Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i CY1109452T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11501099P 1999-01-06 1999-01-06
EP00905535A EP1141015B1 (en) 1999-01-06 2000-01-05 Insulin-like growth factor (igf) i mutant variants

Publications (1)

Publication Number Publication Date
CY1109452T1 true CY1109452T1 (el) 2014-08-13

Family

ID=22358799

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101024T CY1109452T1 (el) 1999-01-06 2009-10-02 Μεταλλαγμενες παραλλαγες ινσουλινικου αυξητικου παραγοντα (igf)i

Country Status (12)

Country Link
US (6) US6506874B1 (el)
EP (1) EP1141015B1 (el)
JP (3) JP2002535967A (el)
AU (1) AU762047B2 (el)
CA (1) CA2356257C (el)
CY (1) CY1109452T1 (el)
DE (1) DE60042550D1 (el)
DK (1) DK1141015T3 (el)
ES (1) ES2329220T3 (el)
IL (3) IL143834A0 (el)
PT (1) PT1141015E (el)
WO (1) WO2000040612A1 (el)

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JP4467549B2 (ja) 2010-05-26
US6509443B1 (en) 2003-01-21
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US20040023883A1 (en) 2004-02-05
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JP2002535967A (ja) 2002-10-29
US20040033951A1 (en) 2004-02-19
PT1141015E (pt) 2009-10-13
US20030191065A1 (en) 2003-10-09
DE60042550D1 (de) 2009-08-27
WO2000040612A1 (en) 2000-07-13
IL143834A (en) 2008-07-08
EP1141015A1 (en) 2001-10-10
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CA2356257A1 (en) 2000-07-13
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