ES2328159T3 - Inmunoglobulinas anti-epcam. - Google Patents
Inmunoglobulinas anti-epcam. Download PDFInfo
- Publication number
- ES2328159T3 ES2328159T3 ES05707293T ES05707293T ES2328159T3 ES 2328159 T3 ES2328159 T3 ES 2328159T3 ES 05707293 T ES05707293 T ES 05707293T ES 05707293 T ES05707293 T ES 05707293T ES 2328159 T3 ES2328159 T3 ES 2328159T3
- Authority
- ES
- Spain
- Prior art keywords
- cancer
- immunoglobulin
- epcam
- administration
- human immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/778,915 US20050180979A1 (en) | 2004-02-13 | 2004-02-13 | Anti-EpCAM immunoglobulins |
| US778915 | 2004-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2328159T3 true ES2328159T3 (es) | 2009-11-10 |
Family
ID=34838270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05707293T Expired - Lifetime ES2328159T3 (es) | 2004-02-13 | 2005-02-09 | Inmunoglobulinas anti-epcam. |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20050180979A1 (enExample) |
| EP (2) | EP1713830B1 (enExample) |
| JP (1) | JP5220315B2 (enExample) |
| KR (1) | KR101236224B1 (enExample) |
| CN (1) | CN1976951B (enExample) |
| AT (1) | ATE437186T1 (enExample) |
| AU (1) | AU2005215874B2 (enExample) |
| BR (1) | BRPI0507660A (enExample) |
| CA (1) | CA2555694C (enExample) |
| DE (1) | DE602005015544D1 (enExample) |
| DK (1) | DK1713830T3 (enExample) |
| EA (1) | EA011951B1 (enExample) |
| ES (1) | ES2328159T3 (enExample) |
| IL (1) | IL177069A (enExample) |
| MX (1) | MXPA06008942A (enExample) |
| NO (1) | NO339364B1 (enExample) |
| NZ (1) | NZ549125A (enExample) |
| PL (1) | PL1713830T3 (enExample) |
| PT (1) | PT1713830E (enExample) |
| SI (1) | SI1713830T1 (enExample) |
| UA (1) | UA87128C2 (enExample) |
| WO (1) | WO2005080428A2 (enExample) |
| ZA (1) | ZA200606083B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070122406A1 (en) | 2005-07-08 | 2007-05-31 | Xencor, Inc. | Optimized proteins that target Ep-CAM |
| EP2474822A1 (en) | 2003-01-24 | 2012-07-11 | University of Utah | Methods of predicting mortality risk by determining telomere length |
| AU2007213920B2 (en) * | 2006-02-09 | 2013-08-29 | Amgen Research (Munich) Gmbh | Treatment of metastatic breast cancer |
| DK2041181T3 (da) * | 2006-06-08 | 2011-08-29 | Helmholtz Zentrum Muenchen | Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi |
| EP1865001A1 (en) * | 2006-06-08 | 2007-12-12 | Gsf-Forschungszentrum Für Umwelt Und Gesundheit, Gmbh | Specific protease inhibitors and their use in cancer therapy |
| EP2142570B1 (en) * | 2007-04-04 | 2011-06-15 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Anti-epcam antibody and uses thereof |
| CA2748265C (en) | 2008-12-22 | 2018-04-03 | University Of Utah Research Foundation | Monochrome multiplex quantitative pcr |
| EP2480687B1 (en) * | 2009-09-21 | 2015-01-28 | Paul Walfish | Methods and compositions for the diagnosis and treatment of thyroid cancer |
| EP2819695B1 (en) * | 2012-03-02 | 2018-06-27 | Academia Sinica | ANTI-EPITHELIAL CELL ADHESION MOLECULE (EpCAM) ANTIBODIES AND METHODS OF USE THEREOF |
| CN103387988B (zh) * | 2012-09-24 | 2016-01-06 | 厦门大学 | 上皮细胞粘附分子的核酸适体EpCAM Ccut及其制备方法 |
| EP2999800B1 (en) | 2013-05-22 | 2019-09-25 | Telomere Diagnostics Inc. | Measures of short telomere abundance |
| CN103275226B (zh) * | 2013-06-09 | 2017-08-29 | 中国科学技术大学 | 特异性抗人上皮细胞粘附分子（EpCAM）的单克隆抗体的制备、鉴定及应用 |
| ES2728668T3 (es) * | 2014-01-08 | 2019-10-28 | Univ Leland Stanford Junior | Terapia dirigida para el cáncer de pulmón de células pequeñas |
| CA2971169A1 (en) | 2014-12-30 | 2016-07-07 | Telomere Diagnostics, Inc. | Multiplex quantitative pcr |
| AU2016358296B2 (en) * | 2015-11-19 | 2020-05-21 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| KR20190038567A (ko) | 2016-07-26 | 2019-04-08 | 테사 테라퓨틱스 피티이. 엘티디. | 키메라 항원 수용체 |
| WO2020018964A1 (en) | 2018-07-20 | 2020-01-23 | Fred Hutchinson Cancer Research Center | Compositions and methods for controlled expression of antigen-specific receptors |
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| US5853697A (en) * | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
| BRPI9809391B8 (pt) * | 1997-04-14 | 2021-05-25 | Amgen Res Munich Gmbh | processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica |
| US6855544B1 (en) * | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
| US7605238B2 (en) * | 1999-08-24 | 2009-10-20 | Medarex, Inc. | Human CTLA-4 antibodies and their uses |
| DK1383785T3 (da) * | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| US20030175268A1 (en) * | 2002-01-11 | 2003-09-18 | Saint-Remy Jean-Marie R. | Method and pharmaceutical composition for preventing and/or treating systemic inflammatory response syndrome |
| PL375064A1 (en) * | 2002-05-20 | 2005-11-14 | Abgenix, Inc. | Treatment of renal carcinoma using antibodies against the egfr |
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- 2005-02-09 CA CA2555694A patent/CA2555694C/en not_active Expired - Fee Related
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