ES2301991T3 - Derivados de benzotiazol como ligandos del receptor de adenosina. - Google Patents
Derivados de benzotiazol como ligandos del receptor de adenosina. Download PDFInfo
- Publication number
- ES2301991T3 ES2301991T3 ES04732950T ES04732950T ES2301991T3 ES 2301991 T3 ES2301991 T3 ES 2301991T3 ES 04732950 T ES04732950 T ES 04732950T ES 04732950 T ES04732950 T ES 04732950T ES 2301991 T3 ES2301991 T3 ES 2301991T3
- Authority
- ES
- Spain
- Prior art keywords
- methoxy
- benzothiazol
- tetrahydro
- dioxepan
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title claims description 52
- 239000002126 C01EB10 - Adenosine Substances 0.000 title claims description 26
- 229960005305 adenosine Drugs 0.000 title claims description 26
- 150000001875 compounds Chemical class 0.000 claims abstract description 145
- -1 1,4-dioxepanyl Chemical group 0.000 claims abstract description 28
- 125000003118 aryl group Chemical group 0.000 claims abstract description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 7
- 150000002367 halogens Chemical group 0.000 claims abstract description 7
- 125000001424 substituent group Chemical group 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 3
- 239000002253 acid Substances 0.000 claims description 78
- OXTDIRWZIDDHBO-UHFFFAOYSA-N 7-(1,4-dioxepan-6-yl)-4-methoxy-1,3-benzothiazol-2-amine Chemical compound C1=2SC(N)=NC=2C(OC)=CC=C1C1COCCOC1 OXTDIRWZIDDHBO-UHFFFAOYSA-N 0.000 claims description 71
- IROSJWQNPFYKIH-UHFFFAOYSA-N 4-methoxy-7-(oxan-4-yl)-1,3-benzothiazol-2-amine Chemical compound C1=2SC(N)=NC=2C(OC)=CC=C1C1CCOCC1 IROSJWQNPFYKIH-UHFFFAOYSA-N 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 31
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- IUTFBJMDMPOCAW-UHFFFAOYSA-N 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylic acid Chemical compound C1CN(C(=O)O)CCC21OCCO2 IUTFBJMDMPOCAW-UHFFFAOYSA-N 0.000 claims description 6
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- XIOAQYYOSOUUDD-UHFFFAOYSA-N 3-[4-methoxy-7-(oxan-4-yl)-1,3-benzothiazol-2-yl]-1-methyl-1-(oxolan-3-ylmethyl)urea Chemical compound C1=2SC(NC(=O)N(C)CC3COCC3)=NC=2C(OC)=CC=C1C1CCOCC1 XIOAQYYOSOUUDD-UHFFFAOYSA-N 0.000 claims description 3
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- PHZRXWPHDKNIPH-SHTZXODSSA-N COc1ccc(C2CCOCC2)c2sc(NC(=O)N(C)[C@H]3CC[C@H](O)CC3)nc12 Chemical compound COc1ccc(C2CCOCC2)c2sc(NC(=O)N(C)[C@H]3CC[C@H](O)CC3)nc12 PHZRXWPHDKNIPH-SHTZXODSSA-N 0.000 claims description 3
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- 206010013663 drug dependence Diseases 0.000 claims description 3
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Classifications
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
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- Hospice & Palliative Care (AREA)
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- Rheumatology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03011039 | 2003-05-19 | ||
| EP03011039 | 2003-05-19 |
Publications (1)
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|---|---|
| ES2301991T3 true ES2301991T3 (es) | 2008-07-01 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| ES04732950T Expired - Lifetime ES2301991T3 (es) | 2003-05-19 | 2004-05-14 | Derivados de benzotiazol como ligandos del receptor de adenosina. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7371748B2 (zh) |
| EP (1) | EP1636223B1 (zh) |
| JP (1) | JP4444290B2 (zh) |
| KR (1) | KR100859886B1 (zh) |
| CN (1) | CN100528871C (zh) |
| AR (1) | AR044362A1 (zh) |
| AT (1) | ATE389652T1 (zh) |
| AU (1) | AU2004251814B2 (zh) |
| BR (1) | BRPI0410440A (zh) |
| CA (1) | CA2524366C (zh) |
| CL (1) | CL2004001067A1 (zh) |
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| HK (1) | HK1092469A1 (zh) |
| HR (1) | HRP20080207T3 (zh) |
| IL (1) | IL171686A (zh) |
| MX (1) | MXPA05012360A (zh) |
| NO (1) | NO20055150L (zh) |
| NZ (1) | NZ543074A (zh) |
| PL (1) | PL1636223T3 (zh) |
| PT (1) | PT1636223E (zh) |
| RU (1) | RU2351597C2 (zh) |
| SI (1) | SI1636223T1 (zh) |
| TW (1) | TW200505882A (zh) |
| WO (1) | WO2005000842A1 (zh) |
| ZA (1) | ZA200509294B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008052930A2 (en) * | 2006-11-03 | 2008-05-08 | F. Hoffmann-La Roche Ag | Preparation of 4-alk0xy-7- (tetrahydropyran-4-yl) benzothiazol-2-amine derivatives |
| DK3661941T3 (da) | 2017-08-01 | 2023-03-13 | Merck Patent Gmbh | Thiazolopyridinderivater som adenosinreceptor-antagonister |
| TW201920123A (zh) * | 2017-08-21 | 2019-06-01 | 德商馬克專利公司 | 作為腺苷受體拮抗劑之喹㗁啉衍生物 |
| SG11202001337XA (en) | 2017-08-21 | 2020-03-30 | Merck Patent Gmbh | Bezimidazole derivatives as adenosine receptor antagonists |
| WO2019141096A1 (zh) * | 2018-01-19 | 2019-07-25 | 四川科伦博泰生物医药股份有限公司 | 取代脲类化合物及其制备方法和用途 |
| CN112867715B (zh) | 2018-10-25 | 2024-03-05 | 默克专利股份公司 | 作为腺苷受体拮抗剂的5-氮杂吲唑衍生物 |
| BR112021007727A2 (pt) | 2018-10-25 | 2021-07-27 | Merck Patent Gmbh | derivados de 5-azaindazol como antagonistas receptores de adenosina |
| AR117844A1 (es) * | 2019-01-22 | 2021-09-01 | Merck Patent Gmbh | Derivados de tiazolopiridina como antagonistas del receptor de adenosina |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE385794T1 (de) * | 2000-06-21 | 2008-03-15 | Hoffmann La Roche | Benzothiazolderivate zur behandlung von alzheimer und parkinson |
| BR0214455A (pt) * | 2001-11-27 | 2004-11-03 | Hoffmann La Roche | Derivados benzotiazol |
| US6727247B2 (en) * | 2001-12-10 | 2004-04-27 | Hoffman-La Roche Inc. | Substituted benzothiazole amide derivatives |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| BRPI0406747A (pt) * | 2003-01-13 | 2005-12-20 | Hoffmann La Roche | Derivados de benzoxazol e seu uso como ligandos de receptor de adenosina |
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2006
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2008
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