ES2300257T3 - Terapia antisentido contra trpm-2. - Google Patents

Terapia antisentido contra trpm-2. Download PDF

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Publication number
ES2300257T3
ES2300257T3 ES00914710T ES00914710T ES2300257T3 ES 2300257 T3 ES2300257 T3 ES 2300257T3 ES 00914710 T ES00914710 T ES 00914710T ES 00914710 T ES00914710 T ES 00914710T ES 2300257 T3 ES2300257 T3 ES 2300257T3
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Spain
Prior art keywords
trpm
baselineskip
antisense
odn
composition
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Expired - Lifetime
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ES00914710T
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English (en)
Spanish (es)
Inventor
Martin Gleave
Paul S. Rennie
Hideaki Miyake
Colleen Nelson
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University of British Columbia
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University of British Columbia
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61P5/00Drugs for disorders of the endocrine system
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    • A61P5/28Antiandrogens
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    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/315Phosphorothioates
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    • C12N2310/33415-Methylcytosine
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    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES00914710T 1999-02-26 2000-02-25 Terapia antisentido contra trpm-2. Expired - Lifetime ES2300257T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12172699P 1999-02-26 1999-02-26
US121726P 1999-02-26

Publications (1)

Publication Number Publication Date
ES2300257T3 true ES2300257T3 (es) 2008-06-16

Family

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Application Number Title Priority Date Filing Date
ES00914710T Expired - Lifetime ES2300257T3 (es) 1999-02-26 2000-02-25 Terapia antisentido contra trpm-2.

Country Status (15)

Country Link
US (7) US7534773B1 (de)
EP (1) EP1163254B1 (de)
JP (1) JP4785252B2 (de)
KR (2) KR100820266B1 (de)
AT (1) ATE385237T1 (de)
AU (1) AU767133B2 (de)
CA (2) CA2371814C (de)
DE (1) DE60037938T2 (de)
DK (1) DK1163254T3 (de)
ES (1) ES2300257T3 (de)
HU (1) HU227190B1 (de)
IL (2) IL144975A0 (de)
NO (1) NO330799B1 (de)
NZ (1) NZ513757A (de)
WO (1) WO2000049937A2 (de)

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