ES2270850T3 - Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. - Google Patents
Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. Download PDFInfo
- Publication number
- ES2270850T3 ES2270850T3 ES00947001T ES00947001T ES2270850T3 ES 2270850 T3 ES2270850 T3 ES 2270850T3 ES 00947001 T ES00947001 T ES 00947001T ES 00947001 T ES00947001 T ES 00947001T ES 2270850 T3 ES2270850 T3 ES 2270850T3
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 27
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 11
- 238000012360 testing method Methods 0.000 title claims description 22
- 238000003556 assay Methods 0.000 claims abstract description 7
- 239000000523 sample Substances 0.000 claims description 59
- 238000005259 measurement Methods 0.000 claims description 33
- 230000003287 optical effect Effects 0.000 claims description 25
- 238000005345 coagulation Methods 0.000 claims description 23
- 230000015271 coagulation Effects 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- 230000036962 time dependent Effects 0.000 claims description 19
- 230000001419 dependent effect Effects 0.000 claims description 10
- 230000035602 clotting Effects 0.000 claims description 9
- 230000023597 hemostasis Effects 0.000 claims description 7
- 206010053567 Coagulopathies Diseases 0.000 claims description 4
- 238000000149 argon plasma sintering Methods 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 2
- 239000003114 blood coagulation factor Substances 0.000 claims description 2
- 238000013168 hemostasis test Methods 0.000 claims description 2
- 230000031700 light absorption Effects 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 description 26
- 102000008946 Fibrinogen Human genes 0.000 description 26
- 229940012952 fibrinogen Drugs 0.000 description 26
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 15
- 229960002897 heparin Drugs 0.000 description 15
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- 230000007812 deficiency Effects 0.000 description 10
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- 230000002159 abnormal effect Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 229940127216 oral anticoagulant drug Drugs 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 102100026735 Coagulation factor VIII Human genes 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 108010076282 Factor IX Proteins 0.000 description 2
- 108010014172 Factor V Proteins 0.000 description 2
- 108010023321 Factor VII Proteins 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 108010014173 Factor X Proteins 0.000 description 2
- 108010074864 Factor XI Proteins 0.000 description 2
- 108010080865 Factor XII Proteins 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 2
- 101800004937 Protein C Proteins 0.000 description 2
- 102000017975 Protein C Human genes 0.000 description 2
- 229940096437 Protein S Drugs 0.000 description 2
- 102000029301 Protein S Human genes 0.000 description 2
- 108010066124 Protein S Proteins 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
- 101800001700 Saposin-D Proteins 0.000 description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
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- 230000006870 function Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 210000004205 output neuron Anatomy 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 229960000856 protein c Drugs 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 208000037919 acquired disease Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007820 coagulation assay Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000007395 thrombosis prophylaxis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/224—Haemostasis or coagulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US345080 | 1999-06-30 | ||
| US09/345,080 US6502040B2 (en) | 1997-12-31 | 1999-06-30 | Method for presenting thrombosis and hemostasis assay data |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2270850T3 true ES2270850T3 (es) | 2007-04-16 |
Family
ID=23353417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00947001T Expired - Lifetime ES2270850T3 (es) | 1999-06-30 | 2000-06-30 | Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6502040B2 (https=) |
| EP (1) | EP1188060B1 (https=) |
| JP (1) | JP2003529046A (https=) |
| KR (1) | KR20020042539A (https=) |
| AT (1) | ATE328327T1 (https=) |
| AU (1) | AU768436B2 (https=) |
| CA (1) | CA2377528C (https=) |
| DE (1) | DE60028374T2 (https=) |
| ES (1) | ES2270850T3 (https=) |
| WO (1) | WO2001001152A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005520170A (ja) * | 2001-06-29 | 2005-07-07 | バイオメリュー・インコーポレイテッド | 患者における抗リン脂質抗体症候群の可能性の上昇を予測するための方法 |
| WO2003063929A1 (en) * | 2002-01-28 | 2003-08-07 | Debiotech S.A. | Peritoneal dialysis system |
| US9125989B2 (en) | 2003-01-23 | 2015-09-08 | Debiotech S.A. | Device for determining the characteristics of peritoneal membrane |
| ES1063877Y (es) | 2006-10-02 | 2007-03-16 | Lafuente Flo Rosa | Funda perfeccionada para cascos de motocicleta |
| JP5602027B2 (ja) * | 2008-02-14 | 2014-10-08 | オリオン ディアグノスティカ オサケ ユキチュア | 未来の性質を予測する方法 |
| US20110104725A1 (en) * | 2008-05-02 | 2011-05-05 | Advanced Liquid Logic, Inc. | Method of Effecting Coagulation in a Droplet |
| US20090298103A1 (en) * | 2008-05-20 | 2009-12-03 | The University Of Vermont And State Agriculture College | Predicting hemostatic risk; dependence on plasma composition |
| JP5982976B2 (ja) * | 2012-04-13 | 2016-08-31 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析方法及びそのプログラム |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3307392A (en) | 1964-05-04 | 1967-03-07 | Research Corp | Automatic prothrombin timer apparatus and method |
| US3458287A (en) | 1965-04-29 | 1969-07-29 | Medical Laboratory Automation | Method and means of determining endpoint times in blood clotting tests |
| US3658480A (en) | 1970-04-13 | 1972-04-25 | Bio Data Corp | Coagulation timing apparatus, and method |
| US4047890A (en) | 1973-11-01 | 1977-09-13 | Bio/Data Corporation | Method and apparatus for determining deficiencies in enzymatic reactors particularly clotting factor levels in blood plasmas |
| SU590665A1 (ru) | 1976-02-11 | 1978-01-30 | Новосибирский государственный медицинский институт | Способ исследовани процесса свертывани крови |
| US4040788A (en) | 1976-04-05 | 1977-08-09 | Sanford L. Simons | Apparatus, instrumentation, and method for comparing samples |
| DE2635081C3 (de) | 1976-08-04 | 1980-08-07 | Bio/Data Corp., Willow Grove, Pa. (V.St.A.) | Verfahren und Vorrichtung zur Bestimmung von Blutplasma-Gerinnungsfaktorpegeln |
| FR2364453A1 (fr) | 1976-09-08 | 1978-04-07 | Lacombe Pierre | Dispositif electronique apportant un perfectionnement aux appareils destines a analyser la coagulation sanguine : prothrombinometre citrate-oxalate |
| US4199748A (en) | 1976-11-01 | 1980-04-22 | Rush-Presbyterian-St. Luke's Medical Center | Automated method and apparatus for classification of cells with application to the diagnosis of anemia |
| JPS5451893A (en) | 1977-09-30 | 1979-04-24 | Sankyo Co | Measuring of blood coagulating time |
| JPS5822703B2 (ja) | 1978-08-30 | 1983-05-10 | 三共株式会社 | 血液凝固測定方法 |
| US4289498A (en) | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
| US4766083A (en) | 1982-04-04 | 1988-08-23 | Wako Pure Chemical Industries, Ltd. | Method for the photometric determination of biological agglutination |
| SU1076086A1 (ru) | 1982-12-28 | 1984-02-29 | Всесоюзный Научно-Исследовательский И Конструкторский Институт Медицинской Лабораторной Техники | Гемокоагулограф |
| EP0115459A3 (en) | 1983-01-26 | 1986-11-20 | University Of Medicine And Dentistry Of New Jersey | Hematological prediction of sepsis and other disease states |
| US4705756A (en) | 1983-01-26 | 1987-11-10 | University Of Medicine And Dentistry Of New Jersey | Method of determining the existence and/or the monitoring of a pathological condition in a mammal |
| JPS59203959A (ja) | 1983-05-04 | 1984-11-19 | Toa Medical Electronics Co Ltd | 血液凝固時間測定装置 |
| JPH0695095B2 (ja) | 1983-11-25 | 1994-11-24 | 株式会社島津製作所 | 全自動血液分析装置 |
| DE3502878A1 (de) | 1985-01-29 | 1986-07-31 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung des fibrinolytischen zustands von plasma |
| JPS61272655A (ja) | 1985-05-28 | 1986-12-02 | Iryo Kogaku Kenkyusho:Kk | 血小板凝集能の定量的判定方法 |
| GB8516081D0 (en) | 1985-06-25 | 1985-07-31 | Ciba Geigy Ag | Assay & purification of amyloid components |
| US4902630A (en) | 1985-07-22 | 1990-02-20 | Abbott Laboratories | Fluorescence polarization immunoassy and reagents for measurement of c-reactive protein |
| ATE134880T1 (de) | 1988-04-04 | 1996-03-15 | Lawrence A Potempa | Bindung von immunkomplexen durch modifizierte formen von c-reaktiven proteinen |
| US5593897A (en) | 1988-04-04 | 1997-01-14 | Northwestern University | Binding of immune complexes by modified forms of C-reactive protein |
| US4965725B1 (en) | 1988-04-08 | 1996-05-07 | Neuromedical Systems Inc | Neural network based automated cytological specimen classification system and method |
| US5156974A (en) | 1988-05-27 | 1992-10-20 | Biodata Corporation | Method for determining the fibrinogen level of a blood sample |
| US5003065A (en) | 1988-06-14 | 1991-03-26 | Carey Merritt | Compounds and process for measuring c-reactive protein |
| US5697369A (en) * | 1988-12-22 | 1997-12-16 | Biofield Corp. | Method and apparatus for disease, injury and bodily condition screening or sensing |
| US5055412A (en) | 1989-03-21 | 1991-10-08 | Proksch Gary J | Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same |
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| WO1991001383A1 (en) | 1989-07-14 | 1991-02-07 | Michigan State University | Method for diagnosing blood clotting disorders |
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| SU1691741A1 (ru) | 1989-08-25 | 1991-11-15 | Донецкий государственный медицинский институт | Способ прогнозировани геморрагических осложнений при травматической болезни |
| US4998535A (en) | 1989-09-05 | 1991-03-12 | Univ. of Washington New England Medical Center Hospitals, Inc. | Thrombolysis predictive instrument |
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2000
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- 2000-06-30 WO PCT/US2000/018310 patent/WO2001001152A1/en not_active Ceased
- 2000-06-30 AT AT00947001T patent/ATE328327T1/de not_active IP Right Cessation
- 2000-06-30 CA CA002377528A patent/CA2377528C/en not_active Expired - Lifetime
- 2000-06-30 DE DE60028374T patent/DE60028374T2/de not_active Expired - Lifetime
- 2000-06-30 AU AU60676/00A patent/AU768436B2/en not_active Expired
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- 2000-06-30 EP EP00947001A patent/EP1188060B1/en not_active Expired - Lifetime
- 2000-06-30 JP JP2001507105A patent/JP2003529046A/ja active Pending
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| AU768436B2 (en) | 2003-12-11 |
| WO2001001152A9 (en) | 2002-05-02 |
| ATE328327T1 (de) | 2006-06-15 |
| EP1188060A4 (en) | 2005-04-13 |
| EP1188060A1 (en) | 2002-03-20 |
| KR20020042539A (ko) | 2002-06-05 |
| CA2377528A1 (en) | 2001-01-04 |
| DE60028374T2 (de) | 2007-06-06 |
| CA2377528C (en) | 2008-02-05 |
| WO2001001152A1 (en) | 2001-01-04 |
| DE60028374D1 (de) | 2006-07-06 |
| EP1188060B1 (en) | 2006-05-31 |
| AU6067600A (en) | 2001-01-31 |
| JP2003529046A (ja) | 2003-09-30 |
| US20020010553A1 (en) | 2002-01-24 |
| US6502040B2 (en) | 2002-12-31 |
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