ES2270850T3 - Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. - Google Patents
Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. Download PDFInfo
- Publication number
- ES2270850T3 ES2270850T3 ES00947001T ES00947001T ES2270850T3 ES 2270850 T3 ES2270850 T3 ES 2270850T3 ES 00947001 T ES00947001 T ES 00947001T ES 00947001 T ES00947001 T ES 00947001T ES 2270850 T3 ES2270850 T3 ES 2270850T3
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 27
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 11
- 238000012360 testing method Methods 0.000 title claims description 22
- 238000003556 assay Methods 0.000 claims abstract description 7
- 239000000523 sample Substances 0.000 claims description 59
- 238000005259 measurement Methods 0.000 claims description 33
- 230000003287 optical effect Effects 0.000 claims description 25
- 238000005345 coagulation Methods 0.000 claims description 23
- 230000015271 coagulation Effects 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 20
- 239000008280 blood Substances 0.000 claims description 20
- 230000036962 time dependent Effects 0.000 claims description 19
- 230000001419 dependent effect Effects 0.000 claims description 10
- 230000035602 clotting Effects 0.000 claims description 9
- 230000023597 hemostasis Effects 0.000 claims description 7
- 206010053567 Coagulopathies Diseases 0.000 claims description 4
- 238000000149 argon plasma sintering Methods 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims description 2
- 239000003114 blood coagulation factor Substances 0.000 claims description 2
- 238000013168 hemostasis test Methods 0.000 claims description 2
- 230000031700 light absorption Effects 0.000 claims description 2
- 230000000977 initiatory effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 description 26
- 102000008946 Fibrinogen Human genes 0.000 description 26
- 229940012952 fibrinogen Drugs 0.000 description 26
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 15
- 229960002897 heparin Drugs 0.000 description 15
- 229920000669 heparin Polymers 0.000 description 15
- 230000007812 deficiency Effects 0.000 description 10
- 239000003146 anticoagulant agent Substances 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 210000002569 neuron Anatomy 0.000 description 4
- 229940127216 oral anticoagulant drug Drugs 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 102100026735 Coagulation factor VIII Human genes 0.000 description 2
- 206010010356 Congenital anomaly Diseases 0.000 description 2
- 108010076282 Factor IX Proteins 0.000 description 2
- 108010014172 Factor V Proteins 0.000 description 2
- 108010023321 Factor VII Proteins 0.000 description 2
- 108010054218 Factor VIII Proteins 0.000 description 2
- 108010014173 Factor X Proteins 0.000 description 2
- 108010074864 Factor XI Proteins 0.000 description 2
- 108010080865 Factor XII Proteins 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 2
- 101800004937 Protein C Proteins 0.000 description 2
- 102000017975 Protein C Human genes 0.000 description 2
- 229940096437 Protein S Drugs 0.000 description 2
- 102000029301 Protein S Human genes 0.000 description 2
- 108010066124 Protein S Proteins 0.000 description 2
- 108010094028 Prothrombin Proteins 0.000 description 2
- 101800001700 Saposin-D Proteins 0.000 description 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
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- 230000006870 function Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 210000004205 output neuron Anatomy 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 229960000856 protein c Drugs 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 208000027205 Congenital disease Diseases 0.000 description 1
- 208000029767 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 208000037919 acquired disease Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007820 coagulation assay Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 238000007395 thrombosis prophylaxis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/224—Haemostasis or coagulation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/22—Haematology
- G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/60—ICT specially adapted for the handling or processing of medical references relating to pathologies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US345080 | 1999-06-30 | ||
| US09/345,080 US6502040B2 (en) | 1997-12-31 | 1999-06-30 | Method for presenting thrombosis and hemostasis assay data |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2270850T3 true ES2270850T3 (es) | 2007-04-16 |
Family
ID=23353417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00947001T Expired - Lifetime ES2270850T3 (es) | 1999-06-30 | 2000-06-30 | Procedimiento y aparato de presentacion de datos de ensayos de trombosis/hemostasia. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6502040B2 (enExample) |
| EP (1) | EP1188060B1 (enExample) |
| JP (1) | JP2003529046A (enExample) |
| KR (1) | KR20020042539A (enExample) |
| AT (1) | ATE328327T1 (enExample) |
| AU (1) | AU768436B2 (enExample) |
| CA (1) | CA2377528C (enExample) |
| DE (1) | DE60028374T2 (enExample) |
| ES (1) | ES2270850T3 (enExample) |
| WO (1) | WO2001001152A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1436628A2 (en) * | 2001-06-29 | 2004-07-14 | BioMerieux, Inc. | A method for predicting an increased likelihood of antiphospholipid syndrome in a patient |
| US9125989B2 (en) | 2003-01-23 | 2015-09-08 | Debiotech S.A. | Device for determining the characteristics of peritoneal membrane |
| ATE479456T1 (de) * | 2002-01-28 | 2010-09-15 | Debiotech Sa | Peritonealdialysesystem |
| ES1063877Y (es) | 2006-10-02 | 2007-03-16 | Lafuente Flo Rosa | Funda perfeccionada para cascos de motocicleta |
| WO2009101242A1 (en) * | 2008-02-14 | 2009-08-20 | Orion Diagnostica Oy | Method for predicting a future property |
| WO2009135205A2 (en) * | 2008-05-02 | 2009-11-05 | Advanced Liquid Logic, Inc. | Droplet actuator techniques using coagulatable samples |
| WO2009142744A2 (en) * | 2008-05-20 | 2009-11-26 | The University Of Vermont And State Agriculture College | Predicting hemostatic risk; dependence on plasma composition |
| JP5982976B2 (ja) * | 2012-04-13 | 2016-08-31 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析方法及びそのプログラム |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3307392A (en) | 1964-05-04 | 1967-03-07 | Research Corp | Automatic prothrombin timer apparatus and method |
| US3458287A (en) | 1965-04-29 | 1969-07-29 | Medical Laboratory Automation | Method and means of determining endpoint times in blood clotting tests |
| US3658480A (en) | 1970-04-13 | 1972-04-25 | Bio Data Corp | Coagulation timing apparatus, and method |
| US4047890A (en) | 1973-11-01 | 1977-09-13 | Bio/Data Corporation | Method and apparatus for determining deficiencies in enzymatic reactors particularly clotting factor levels in blood plasmas |
| SU590665A1 (ru) | 1976-02-11 | 1978-01-30 | Новосибирский государственный медицинский институт | Способ исследовани процесса свертывани крови |
| US4040788A (en) | 1976-04-05 | 1977-08-09 | Sanford L. Simons | Apparatus, instrumentation, and method for comparing samples |
| DE2635081C3 (de) | 1976-08-04 | 1980-08-07 | Bio/Data Corp., Willow Grove, Pa. (V.St.A.) | Verfahren und Vorrichtung zur Bestimmung von Blutplasma-Gerinnungsfaktorpegeln |
| FR2364453A1 (fr) | 1976-09-08 | 1978-04-07 | Lacombe Pierre | Dispositif electronique apportant un perfectionnement aux appareils destines a analyser la coagulation sanguine : prothrombinometre citrate-oxalate |
| US4199748A (en) | 1976-11-01 | 1980-04-22 | Rush-Presbyterian-St. Luke's Medical Center | Automated method and apparatus for classification of cells with application to the diagnosis of anemia |
| JPS5451893A (en) | 1977-09-30 | 1979-04-24 | Sankyo Co | Measuring of blood coagulating time |
| JPS5822703B2 (ja) | 1978-08-30 | 1983-05-10 | 三共株式会社 | 血液凝固測定方法 |
| US4289498A (en) | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
| US4766083A (en) | 1982-04-04 | 1988-08-23 | Wako Pure Chemical Industries, Ltd. | Method for the photometric determination of biological agglutination |
| SU1076086A1 (ru) | 1982-12-28 | 1984-02-29 | Всесоюзный Научно-Исследовательский И Конструкторский Институт Медицинской Лабораторной Техники | Гемокоагулограф |
| US4705756A (en) | 1983-01-26 | 1987-11-10 | University Of Medicine And Dentistry Of New Jersey | Method of determining the existence and/or the monitoring of a pathological condition in a mammal |
| EP0115459A3 (en) | 1983-01-26 | 1986-11-20 | University Of Medicine And Dentistry Of New Jersey | Hematological prediction of sepsis and other disease states |
| JPS59203959A (ja) | 1983-05-04 | 1984-11-19 | Toa Medical Electronics Co Ltd | 血液凝固時間測定装置 |
| JPH0695095B2 (ja) | 1983-11-25 | 1994-11-24 | 株式会社島津製作所 | 全自動血液分析装置 |
| DE3502878A1 (de) | 1985-01-29 | 1986-07-31 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung des fibrinolytischen zustands von plasma |
| JPS61272655A (ja) | 1985-05-28 | 1986-12-02 | Iryo Kogaku Kenkyusho:Kk | 血小板凝集能の定量的判定方法 |
| GB8516081D0 (en) | 1985-06-25 | 1985-07-31 | Ciba Geigy Ag | Assay & purification of amyloid components |
| US4902630A (en) | 1985-07-22 | 1990-02-20 | Abbott Laboratories | Fluorescence polarization immunoassy and reagents for measurement of c-reactive protein |
| US5593897A (en) | 1988-04-04 | 1997-01-14 | Northwestern University | Binding of immune complexes by modified forms of C-reactive protein |
| AU633488B2 (en) | 1988-04-04 | 1993-02-04 | Northwestern University | Binding of immune complexes by modified forms of c-reactive protein |
| US4965725B1 (en) | 1988-04-08 | 1996-05-07 | Neuromedical Systems Inc | Neural network based automated cytological specimen classification system and method |
| US5156974A (en) | 1988-05-27 | 1992-10-20 | Biodata Corporation | Method for determining the fibrinogen level of a blood sample |
| US5003065A (en) | 1988-06-14 | 1991-03-26 | Carey Merritt | Compounds and process for measuring c-reactive protein |
| US5697369A (en) * | 1988-12-22 | 1997-12-16 | Biofield Corp. | Method and apparatus for disease, injury and bodily condition screening or sensing |
| US5055412A (en) | 1989-03-21 | 1991-10-08 | Proksch Gary J | Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same |
| US5500345A (en) | 1989-04-25 | 1996-03-19 | Iatron Laboratories, Inc. | Hybridomas producing monoclonal antibodies specific for C-reactive protein and methods for detection of C-reactive protein |
| JPH04505857A (ja) | 1989-06-27 | 1992-10-15 | ラッシュ―プレズビティリアン―セント ルークス メディカル センター | C反応性蛋白質に対するモノクローナル抗体 |
| WO1991001383A1 (en) | 1989-07-14 | 1991-02-07 | Michigan State University | Method for diagnosing blood clotting disorders |
| US5051357A (en) | 1989-07-14 | 1991-09-24 | Board Of Trustees Operating Michigan State University | Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor |
| JP3055933B2 (ja) | 1989-07-20 | 2000-06-26 | アナリティカル・コントロール・システムズ・インコーポレーテッド | 改良された安定な凝固対照 |
| SU1691741A1 (ru) | 1989-08-25 | 1991-11-15 | Донецкий государственный медицинский институт | Способ прогнозировани геморрагических осложнений при травматической болезни |
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| US5262303A (en) | 1989-10-13 | 1993-11-16 | Trustees Of Boston University | Ligand/anti-ligand assays for adherent proteins |
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- 2000-06-30 AT AT00947001T patent/ATE328327T1/de not_active IP Right Cessation
- 2000-06-30 CA CA002377528A patent/CA2377528C/en not_active Expired - Lifetime
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| WO2001001152A1 (en) | 2001-01-04 |
| CA2377528C (en) | 2008-02-05 |
| CA2377528A1 (en) | 2001-01-04 |
| KR20020042539A (ko) | 2002-06-05 |
| EP1188060A4 (en) | 2005-04-13 |
| AU768436B2 (en) | 2003-12-11 |
| EP1188060A1 (en) | 2002-03-20 |
| JP2003529046A (ja) | 2003-09-30 |
| ATE328327T1 (de) | 2006-06-15 |
| AU6067600A (en) | 2001-01-31 |
| US20020010553A1 (en) | 2002-01-24 |
| DE60028374D1 (de) | 2006-07-06 |
| EP1188060B1 (en) | 2006-05-31 |
| WO2001001152A9 (en) | 2002-05-02 |
| DE60028374T2 (de) | 2007-06-06 |
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