ES2259727T3 - Agente oftalmico que contiene heparina. - Google Patents
Agente oftalmico que contiene heparina.Info
- Publication number
- ES2259727T3 ES2259727T3 ES02791625T ES02791625T ES2259727T3 ES 2259727 T3 ES2259727 T3 ES 2259727T3 ES 02791625 T ES02791625 T ES 02791625T ES 02791625 T ES02791625 T ES 02791625T ES 2259727 T3 ES2259727 T3 ES 2259727T3
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- hyaluronate
- pharmaceutical composition
- use according
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229920000669 heparin Polymers 0.000 title claims abstract description 58
- 239000003732 agents acting on the eye Substances 0.000 title description 4
- 229940125702 ophthalmic agent Drugs 0.000 title description 4
- 229960002897 heparin Drugs 0.000 claims abstract description 53
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 40
- 230000000694 effects Effects 0.000 claims abstract description 28
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 24
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 28
- 229920002674 hyaluronan Polymers 0.000 claims description 28
- 229960003160 hyaluronic acid Drugs 0.000 claims description 28
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 24
- 229940014041 hyaluronate Drugs 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 17
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 16
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 15
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 15
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 14
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- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
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- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
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- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 4
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- 238000012360 testing method Methods 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 2
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- 239000008215 water for injection Substances 0.000 description 2
- OOSZCNKVJAVHJI-UHFFFAOYSA-N 1-[(4-fluorophenyl)methyl]piperazine Chemical compound C1=CC(F)=CC=C1CN1CCNCC1 OOSZCNKVJAVHJI-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
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- 206010011026 Corneal lesion Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- QEVGBDAVCSPCLP-UHFFFAOYSA-N acetic acid;boric acid Chemical compound CC(O)=O.OB(O)O QEVGBDAVCSPCLP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10161149A DE10161149B4 (de) | 2001-12-12 | 2001-12-12 | Verwendung von Heparin-haltigem Ophthalmikum |
| DE10161149 | 2001-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2259727T3 true ES2259727T3 (es) | 2006-10-16 |
Family
ID=7709005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02791625T Expired - Lifetime ES2259727T3 (es) | 2001-12-12 | 2002-12-11 | Agente oftalmico que contiene heparina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050043271A1 (enExample) |
| EP (1) | EP1453523B1 (enExample) |
| JP (1) | JP2005513106A (enExample) |
| CN (1) | CN1604784A (enExample) |
| AT (1) | ATE318607T1 (enExample) |
| AU (1) | AU2002357972A1 (enExample) |
| CA (1) | CA2468775A1 (enExample) |
| DE (2) | DE10161149B4 (enExample) |
| ES (1) | ES2259727T3 (enExample) |
| MX (1) | MXPA04005390A (enExample) |
| WO (1) | WO2003053452A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001244713A1 (en) * | 2000-04-03 | 2001-10-15 | Santen Pharmaceutical Co. Ltd. | Transporters and drug delivery system by using the same |
| WO2004093878A1 (en) * | 2003-04-16 | 2004-11-04 | Alcon, Inc. | Use of fused pyridazine derivatives for treating dry eye disorders |
| DE10360425A1 (de) * | 2003-12-19 | 2005-07-28 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Hyaluronsäure, Hyaluronat und/oder deren Derivate zur Herstellung einer pharmazeutischen Zusammensetzung |
| JP2005187407A (ja) * | 2003-12-25 | 2005-07-14 | Lion Corp | アレルギー眼疾患用眼科組成物 |
| DE102004002001A1 (de) | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
| DE102005035986B4 (de) * | 2005-07-28 | 2009-10-15 | Bausch & Lomb Incorporated | Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat |
| DE102005055275A1 (de) * | 2005-11-17 | 2007-05-24 | Ursapharm Arzneimittel Gmbh & Co. Kg | Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung |
| DE102006049091A1 (de) * | 2006-10-18 | 2008-04-24 | Dr. Gerhard Mann Chem.-Pharm. Fabrik Gmbh | Emulgatorfreies ophthalmisches Präparat enthaltend Pflanzenöl |
| FR2919185B1 (fr) | 2007-07-23 | 2010-09-10 | Ard Sa | Utilisation d'acide hyaluronique pour la preparation de compositions destinees a l'amelioration notamment de l'etat des muqueuses |
| HRP20140862T1 (hr) * | 2008-11-20 | 2014-11-07 | Laboratori Derivati Organici S.P.A. | Uporaba heparan sulfata u kozmetiäśkim i dermatološkim pripravcima |
| US20110065643A1 (en) | 2009-06-12 | 2011-03-17 | University Of Southern California | Clusterin Pharmaceuticals and Treatment Methods Using the Same |
| FR2962044B1 (fr) * | 2010-04-21 | 2013-02-22 | Horus Pharma | Emulsion lacrymimetique |
| JP2016185940A (ja) * | 2014-06-10 | 2016-10-27 | ロート製薬株式会社 | 眼科用組成物 |
| DE102016203696A1 (de) * | 2016-03-07 | 2017-09-07 | Ursapharm Arzneimittel Gmbh | Ophthalmologische Zusammensetzung |
| KR20190068575A (ko) * | 2016-10-14 | 2019-06-18 | 이콤 메디칼 게엠베하 | 안구 표면 항상성의 확립, 회복 및 보존 방법 |
| WO2019005222A1 (en) * | 2017-06-29 | 2019-01-03 | Advaite LLC. | TREATMENT AND DIAGNOSIS OF OCULAR SURFACE DISORDERS |
| JP7333919B2 (ja) * | 2017-09-05 | 2023-08-28 | エクセル メッド、エルエルシー | 虚血を治療するためのヘパリン組成物 |
| SI3740191T1 (sl) * | 2018-01-18 | 2021-09-30 | Faes Farma, S.A. | Očesna sestava, obsegajoča bilastin, beta ciklodekstrin in vsaj eno želirno sredstvo |
| CN112292135A (zh) | 2018-04-18 | 2021-01-29 | I.Com医疗有限责任公司 | 用于治疗和预防严重眼表疾病的高分子量透明质酸 |
| US12268706B2 (en) | 2019-01-31 | 2025-04-08 | i.com medical GmbH | Hyaluronic acid for relief of idiopathic ocular pain |
| CN116139067B (zh) * | 2021-11-22 | 2024-03-22 | 华熙生物科技股份有限公司 | 透明质酸锌形成凝胶的方法及含有透明质酸锌的滴眼凝胶及其制备 |
| WO2024024920A1 (ja) * | 2022-07-29 | 2024-02-01 | マルホ株式会社 | 眼科用組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1730M (fr) * | 1962-01-17 | 1963-03-18 | Charles Riviere | Nouvelle composition de collyre. |
| DE3440352A1 (de) * | 1984-11-05 | 1986-05-07 | Dr. Thilo & Co GmbH, 8029 Sauerlach | Dry-eye-packung |
| ATE93708T1 (de) * | 1986-04-04 | 1993-09-15 | Allergan Inc | Zaehfluessiges praeparat zur anwendung bei wunden in der augenhornhaut. |
| JPS6479103A (en) * | 1987-06-09 | 1989-03-24 | Lion Corp | External preparation |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| JPH02167233A (ja) * | 1988-11-10 | 1990-06-27 | Kiyoshi Kita | 眼内手術補助剤 |
| US5141741A (en) * | 1988-12-09 | 1992-08-25 | Lion Corporation | Anti-sunburn skin-care preparation |
| US5358706A (en) * | 1992-09-30 | 1994-10-25 | Union Carbide Chemicals & Plastics Technology Corporation | Muco-adhesive polymers |
| IT1273011B (it) * | 1994-07-25 | 1997-07-01 | Trhecnopharma S A | Preparato oftalmico per l'uso come lacrima artificiale |
| DE19520575A1 (de) * | 1995-06-06 | 1996-12-12 | Permselect Ges Fuer Zellstrukt | Hautwirksame Kombination von Mucopolysacchariden |
| DE19547972A1 (de) * | 1995-12-21 | 1997-07-10 | Weropharm Gmbh | Heparin zur Prophylaxe und akuten Therapie der allergischen Konjunktivitis |
| US6372755B2 (en) * | 1997-07-11 | 2002-04-16 | Toray Industries, Inc. | Stable medicinal compositions containing 4,5-epoxymorphinan derivatives |
| US6348508B1 (en) * | 2000-04-04 | 2002-02-19 | Bausch & Lomb Incorporated | Method for treating dry eye |
-
2001
- 2001-12-12 DE DE10161149A patent/DE10161149B4/de not_active Expired - Lifetime
-
2002
- 2002-02-11 US US10/496,330 patent/US20050043271A1/en not_active Abandoned
- 2002-12-11 CN CNA028250079A patent/CN1604784A/zh active Pending
- 2002-12-11 ES ES02791625T patent/ES2259727T3/es not_active Expired - Lifetime
- 2002-12-11 MX MXPA04005390A patent/MXPA04005390A/es active IP Right Grant
- 2002-12-11 EP EP02791625A patent/EP1453523B1/de not_active Expired - Lifetime
- 2002-12-11 AT AT02791625T patent/ATE318607T1/de active
- 2002-12-11 AU AU2002357972A patent/AU2002357972A1/en not_active Abandoned
- 2002-12-11 DE DE50205968T patent/DE50205968D1/de not_active Expired - Lifetime
- 2002-12-11 WO PCT/DE2002/004526 patent/WO2003053452A1/de not_active Ceased
- 2002-12-11 JP JP2003554209A patent/JP2005513106A/ja active Pending
- 2002-12-11 CA CA002468775A patent/CA2468775A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1453523B1 (de) | 2006-03-01 |
| CA2468775A1 (en) | 2003-07-03 |
| DE10161149B4 (de) | 2007-03-08 |
| WO2003053452A1 (de) | 2003-07-03 |
| DE50205968D1 (de) | 2006-04-27 |
| DE10161149A1 (de) | 2003-06-26 |
| US20050043271A1 (en) | 2005-02-24 |
| CN1604784A (zh) | 2005-04-06 |
| MXPA04005390A (es) | 2005-10-18 |
| JP2005513106A (ja) | 2005-05-12 |
| ATE318607T1 (de) | 2006-03-15 |
| AU2002357972A1 (en) | 2003-07-09 |
| EP1453523A1 (de) | 2004-09-08 |
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